White Willow Bark Extract

White Willow Bark Extract: Nature’s Ancient Answer to Modern Discomforts

1. What is White Willow Bark Extract?
White Willow Bark Extract (Salix alba) is a bioactive botanical derived from the bark of the white willow tree. Historically revered as “nature’s aspirin,” its primary active constituent, salicin, undergoes metabolism to salicylic acid, delivering analgesic, anti-inflammatory, and antipyretic effects. Unlike synthetic NSAIDs, it offers a gentler, time-released action, making it a cornerstone of evidence-based phytotherapy.

2. Source, Chemistry & Specifications

• Botanical Source: Salix alba L. (Salicaceae family)

• Key Active: Salicin (typically standardized to 15-25%)

• CAS: 138-52-3 (Salicin)

• MF: C₁₃H₁₈O₇

• MW: 286.28 g/mol

• EINECS: 205-331-3

• Appearance: Fine, hygroscopic powder; light tan to off-white

• Solubility: Soluble in water, ethanol; insoluble in non-polar solvents

3. Defining “Best” White Willow Bark Extract: Key Criteria
The optimal extract balances bioactive potency, safety, and regulatory compliance:

• Standardization: ≥ 15% Salicin content (HPLC-UV validated).

• Efficacy (Compliant):

  • Pain Relief: Inhibits COX enzymes, reducing prostaglandin synthesis (J Ethnopharmacol. 2009).

  • Anti-inflammatory: Modulates TNF-α, IL-1β cytokines (Phytomedicine. 2010).

  • Antioxidant: Scavenges ROS via phenolic glycosides.

• Origin: Sustainably harvested European or North American Salix alba.

• Dosage: 120-240mg salicin daily (EMA monograph). Max 240mg/day.

• Usage: Capsules/tablets, functional foods, topical analgesics.

• Target Users: Adults seeking natural joint/muscle support.*

• Critical Contraindications:

  • Salicylate allergy or aspirin sensitivity.

  • Children/teens (Reye’s syndrome risk).

  • Pregnancy, lactation, renal impairment, anticoagulant use (warfarin interaction).

• Side Effects: Rare GI upset at high doses; discontinue if tinnitus occurs.

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Phytochemistry Partner
As a 28-year innovator in bioactive compounds, Zhonghong integrates cutting-edge science with global supply chain excellence. Our vertically controlled process ensures traceability from raw bark to GMP-certified extract.

• Core Competencies:

  • Deep Extraction Expertise: Supercritical CO₂, ultrasonic-assisted ethanol/water extraction.

  • Purification: Industrial-scale preparative HPLC, membrane filtration.

  • Analytical Rigor:

    • HPLC-DAD/ELSD: Quantification of salicin, salicylic acid, flavonoids.

    • GC-MS: Residual solvent profiling (ICH Q3C).

    • ICP-MS: Heavy metal detection (ppb level).

  • Patent Portfolio: 20+ patents covering novel extraction methodologies (e.g., CN107118222A).

5. COA Specifications: Guaranteed Purity & Safety

6. Advanced Production Workflow

1. Sourcing: Ethically wildcrafted Salix alba bark (EU PEFC-certified).

2. Comminution: Cryogenic milling preserves thermolabile actives.

3. Extraction: Dynamic maceration (food-grade ethanol/water, 70:30 v/v).

4. Concentration: Low-temperature vacuum evaporators.

5. Standardization: Salicin adjustment via chromatographic isolation.

6. Spray Drying: Maltodextrin carrier (inlet temp ≤ 180°C).

7. Multisector Applications

• Nutraceuticals: Joint health supplements (capsules, gummies).

• Cosmeceuticals: Anti-redness serums, soothing creams.

• Functional Foods: Pain-management beverages.

• Veterinary: Equine osteoarthritis support.

8. Uncompromising Quality Control
Zhonghong’s QbD (Quality by Design) framework exceeds ISO 9001:2015. Every batch undergoes:

• Identity Confirmation: HPTLC fingerprint vs. Salix alba reference standard (EMA/HMPC).

• Potency Assay: Salicin quantification via validated HPLC-UV (λ=270nm).

• Residual Solvents: GC-FID per ICH Q3C (Class 2 solvents < 50ppm).

• Stability: ICH accelerated (40°C/75% RH) & real-time protocols.
  Our proprietary QC algorithms detect batch-to-batch variability at σ > 1.5, ensuring pharmaceutical-grade consistency.

9. Health Mechanisms & Research Frontiers

• MOA: Salicin → Saligenin → Hepatic conversion to salicylic acid → Systemic COX-1/COX-2 inhibition.

• Clinical Evidence: Meta-analysis confirms efficacy vs. placebo for chronic low-back pain (Cochrane Database 2016).

• Innovation: Nanoemulsion delivery systems enhancing salicin bioavailability (Int J Nanomedicine 2021).

• Challenges: Standardizing polyphenol synergies (flavonoids, tannins) beyond salicin.

10. Packaging & Logistics

• Primary: Double polyethylene-lined kraft paper drums (25kg net).

• Storage: <25°C; 40-60% RH; protected from light.

• Shelf Life: 24 months (validated).

• Global Compliance: FDA GRAS, REACH, FSSC 22000, Kosher/Halal.

11. FAQ: Addressing Critical Queries

• Q: Is this suitable for vegetarians?
  A: Yes, entirely plant-derived. Ethanol extraction is non-animal.

• Q: Typical lead time for bulk orders?
  A: 15-25 days post-PO confirmation (MOQ: 25kg).

• Q: Can you provide salicin 25% + polyphenol complex?
  A: Yes – our patented ZH-WB25+ includes synergistic flavonoids.

• Q: Stability in liquid formulations?
  A: Use buffered pH 4.5-5.5; recommend antioxidants (e.g., ascorbyl palmitate).

12. Procure Premium White Willow Bark Extract
Contact Zhonghong Today:

• Email: liaodaohai@gmail.com

• Web: aiherba.com

• Request: COA documentation & FREE 100g SAMPLE (Technical grade available).

Conclusion
White Willow Bark Extract remains a gold-standard botanical analgesic with robust clinical validation. Zhonghong’s fusion of advanced phytochemistry, ISO-certified QC, and global regulatory mastery delivers unmatched extract integrity for demanding nutraceutical, cosmetic, and functional food applications.

References

1. EMA/HMPC Monograph on Salix spp. (2017)

2. Chrubasik et al., Phytomedicine (2010)

3. USP-NF General Chapters <561>, <232>

4. Zhang et al., Int J Nanomedicine (2021); 16: 5143–5156

5. Gagnier et al., Cochrane Database Syst Rev (2016); CD004504

White Willow Bark Extract, Salicin Extract, Natural Anti-inflammatory, Plant Extract Supplier, COA Specification