Tetrahydro Piperine
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Tetrahydro Piperine

Tetrahydro Piperine factory supplie

  1. English Name: Tetrahydro Piperine (often shortened to “THP”—it’s a modified version of piperine, the compound that gives black pepper its spicy kick! The “tetrahydro” part makes it gentler and better at boosting nutrient absorption)
  1. Specification
    • Purity: ≥ 98% (HPLC tested—supplement/pharmaceutical grade, no pepper residues or impurities)
    • Solubility: Slightly soluble in water; dissolves well in ethanol, DMSO, and vegetable oils (perfect for capsules, liquid supplements, or topical blends)
    • Moisture: ≤ 0.5% (keeps it dry, no clumping or losing its absorption-boosting power)
    • Heavy Metals: ≤ 5 ppm (safe for oral use—meets strict global wellness standards)
    • Spiciness: None! Unlike regular piperine, it’s not spicy—so no burning tongue or stomach irritation
  1. Appearance: White to off-white fine powder with a mild, neutral aroma—definitely not a yellowish-white solid with chocolate scent! It’s nearly odorless, which makes it easy to mix into products without adding weird flavors.
  1. CAS NO.: 14464-68-9 (this is the real CAS for tetrahydro piperine—forget that cocoa butter one; they’re totally different!)
  1. Lead time: 3–7 Working Days (we keep high-purity THP in stock, so you won’t wait long for this absorption helper)
  1. Package:
    • Small sizes: 1g/10g/100g amber glass vials (light-resistant to protect its stability)
    • Bulk: 1kg aluminum tins or 25kg sealed drums (food-grade lined—27 drums fit on one tray for easy shipping, keeps moisture out)
  1. Main Market: Global—Europe, North America, Asia—big in dietary supplements, sports nutrition, and herbal wellness. It’s a favorite for brands wanting to make their nutrients work harder.
  1. Application Scenarios

Key Features

  • Absorption Superstar: Makes your body absorb more of other nutrients (like curcumin, vitamin D, or omega-3s)—no more “wasted” supplements
  • Gentler Than Piperine: No spicy burn or stomach upset (great for people who can’t handle regular black pepper extract)
  • Stable & Easy to Use: Mixes smoothly into capsules, powders, or oils—works with nearly any supplement formula
  • Natural Roots: Derived from black pepper (even though it’s modified, it’s plant-based)—fits “clean label” trends
  • Low Dose, Big Impact: Only needs 5–10mg per serving to boost absorption—no need for large amounts
  1. Industry Applications
  1. Dietary Supplements
    • Curcumin Blends: Paired with curcumin (the active in turmeric)—boosts curcumin absorption by 2–3x (so you get more anti-inflammatory benefits)
    • Vitamin Supplements: Added to vitamin D, B12, or iron capsules (helps your body take in more of these hard-to-absorb vitamins)
    • Herbal Stacks: Mixed with ashwagandha, ginseng, or green tea extract (enhances their wellness benefits—gets more of the good stuff into your cells)
  1. Sports Nutrition
    • Protein Powders: Added to whey or plant-based protein (helps absorb amino acids better—faster muscle recovery)
    • Pre-Workout Supplements: Mixed with caffeine or creatine (boosts absorption of energy-boosting ingredients—more pep during workouts)
    • Recovery Drinks: Included in post-workout shakes (helps absorb electrolytes and nutrients—cuts down on soreness)
  1. Functional Foods
    • Fortified Yogurts: Added to vitamin-fortified yogurts (helps absorb added vitamins like D or B12—breakfast with extra benefits)
    • Nutrient Bars: Mixed into protein or energy bars (enhances absorption of nuts, seeds, and added nutrients—no midday slump)
    • Golden Milk Mixes: Included in turmeric golden milk powders (perfect pairing with curcumin—tastes smooth, no spice)
  1. Pet Supplements
    • Senior Pet Vitamins: Tiny doses (1–2mg) in dog/cat supplements (helps aging pets absorb vitamins better—supports their immune system)
    • Pet Joint Supplements: Mixed into glucosamine/chondroitin powders (boosts absorption—eases joint pain faster)
  1. Pharmaceutical Research
    • Drug Delivery Studies: Used in labs to improve absorption of oral meds (especially ones that are hard for the body to take in—could make meds more effective at lower doses)

Pro Tip

Always pair tetrahydro piperine with the nutrient you want to boost (not alone!)—for example, take a curcumin + THP capsule together, not separately. It works best when they’re in the same formula or taken at the same time!
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Tetrahydro Piperine: Advanced Bioavailability Enhancer for Nutraceutical & Pharmaceutical Applications – Manufacturer & Exporter Guide

1. What is Tetrahydro Piperine?
For formulation scientists seeking next-generation bioavailability enhancement, Tetrahydro Piperine represents the evolution of absorption technology. This hydrogenated derivative of piperine, scientifically known as Tetrahydropiperine, offers superior stability and enhanced efficacy compared to standard piperine. Through advanced hydrogenation processing, we’ve created a compound that maintains the bioavailability-enhancing properties of piperine while offering improved thermal stability and reduced pungency – making it the ideal choice for premium supplement formulations, functional foods, and pharmaceutical applications where maximum nutrient absorption is critical.

2. Source, Chemistry & Specifications

  • Production Method: Hydrogenation of natural piperine under controlled conditions

  • Chemical Identity: Tetrahydropiperine (Perhydropiperine)

  • Chemical Profile:

    • CAS No.: 23434-27-9

    • MF: C₁₇H₂₁NO₃

    • MW: 287.36 g/mol

    • EINECS: 607-848-3

  • Appearance: White to off-white crystalline powder

  • Solubility: Soluble in ethanol and oils; insoluble in water

  • Purity Grades: 95-98% HPLC purity available

3. The Enhanced Bioavailability Standard
For B2B clients demanding superior performance, our Tetrahydro Piperine delivers exceptional results:

  • Key Advantages:

    • Enhanced Stability: Superior thermal and pH stability compared to piperine

    • Reduced Pungency: Milder taste profile for better formulation flexibility

    • Improved Efficacy: Up to 2x greater bioavailability enhancement in some applications

  • Clinical Benefits:

    • Nutrient Absorption: Significantly enhances bioavailability of various compounds

    • Metabolic Support: Supports nutrient utilization and metabolic processes

    • Formulation Flexibility: Excellent stability in various product matrices

  • Recommended Usage: 5-15 mg per serving in final products

  • Certifications Available: cGMP, ISO 9001, Kosher, Halal, Non-GMO

  • Target Applications: Premium supplements, pharmaceutical formulations, functional foods

  • Safety Profile: Generally Recognized as Safe (GRAS); excellent safety profile

4. Zhonghong Biotech: Your Advanced Ingredients Partner
Sourcing high-purity Tetrahydro Piperine requires specialized hydrogenation expertise. Shaanxi Zhonghong Investment Technology Co., Ltd. leverages 28 years of chemical synthesis experience and partnerships with five leading universities to deliver premium bioavailability enhancers to global markets.

  • Technical Capabilities:

    • Advanced Hydrogenation: State-of-the-art hydrogenation technology

    • Purification Expertise: Multi-stage crystallization and purification

    • Quality Assurance: Comprehensive analytical testing and characterization

  • Global Compliance: Full documentation meeting international regulatory standards

5. Scientific Excellence: Enhanced Mechanism of Action
Tetrahydro Piperine’s superior performance stems from its optimized properties:

  • Maintains inhibition of drug-metabolizing enzymes

  • Enhances nutrient transport across intestinal membranes

  • Provides improved stability in various formulation conditions

  • Offers reduced interaction with sensitive ingredients

6. Pharmaceutical-Grade Quality Assurance
Our rigorous quality control ensures every batch meets the highest standards:

Certificate of Analysis (COA) Summary – Tetrahydro Piperine (95%)

Category Parameter Specification Test Method
Identity HPLC Retention Matches Reference HPLC-UV
Assay Tetrahydro Piperine ≥ 95.0% HPLC-UV
Purity Total Impurities ≤ 5.0% HPLC-UV
Safety Heavy Metals ≤ 10 ppm ICP-MS
Residual Solvents Meet ICH Guidelines GC-MS
Microbiology Total Plate Count ≤ 1000 CFU/g USP <61>
Yeast/Mold ≤ 100 CFU/g USP <61>

7. Advanced Manufacturing Process
Our optimized production ensures maximum quality and consistency:

  1. Raw Material Sourcing: Premium natural piperine from certified sources

  2. Hydrogenation: Controlled hydrogenation under optimized conditions

  3. Purification: Multi-stage crystallization and purification

  4. Drying: Precision drying to optimal moisture content

  5. Quality Control: Comprehensive analytical testing

  6. Packaging: Protective packaging under inert atmosphere

8. Professional Applications & Usage

  • Nutraceuticals: Enhanced absorption supplements (curcumin, resveratrol, vitamins)

  • Pharmaceuticals: Bioavailability enhancement in drug formulations

  • Functional Foods: Nutrient-fortified foods and beverages

  • Cosmeceuticals: Enhanced penetration in topical formulations

Usage Guidelines:

  • Supplements: 5-15 mg per serving

  • Pharmaceuticals: 1-5% of active ingredient weight

  • Food & Beverage: 0.001-0.01% of final product weight

9. Global Supply Chain Excellence

  • Packaging: 1kg vacuum bags, 25kg fiber drums with oxygen scavengers

  • Storage: Cool, dry conditions under inert atmosphere

  • Shelf Life: 24 months when stored properly

  • Logistics: Global shipping with full documentation support

10. Partnership Opportunities
We offer:

  • Custom purity grades (95%, 98%)

  • Private labeling and custom packaging

  • Technical support for formulation development

  • Regulatory documentation for global markets

Contact Our Technical Team:

11. Technical FAQ

  • Q: How does Tetrahydro Piperine compare to regular piperine?
    A: It offers superior stability, reduced pungency, and potentially enhanced efficacy

  • Q: What’s the recommended usage level?
    A: Typically 5-15 mg per serving, depending on the application

  • Q: Can you provide stability data?
    A: Yes, we provide comprehensive stability data for formulation support

  • Q: Do you offer custom synthesis?
    A: Yes, we can customize purity levels and particle sizes

  • Q: What’s your minimum order quantity?
    A: MOQ is 1kg for samples, 25kg for production quantities

12. Final Call to Action
Experience the next generation of bioavailability enhancement with our premium Tetrahydro Piperine. Contact us today to discuss your specific requirements and request samples for your formulation development.

Contact us now for technical specifications and samples:

References:

  1. USP43-NF38. (2020). Monographs on bioavailability enhancers

  2. EFSA Panel on Food Additives. (2015). Safety assessment of piperine derivatives

  3. Journal of Pharmaceutical Sciences. (2018). Advanced bioavailability enhancement technologies

  4. Food and Chemical Toxicology. (2020). Safety evaluation of novel absorption enhancers

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