Paeonol: The Multifunctional Bioactive Compound with Diverse Health Benefits
1. What is Paeonol?
Paeonol is a phenolic compound renowned for its extensive pharmacological activities. As a key bioactive ingredient, it has been used for centuries in Traditional Chinese Medicine (TCM) for its anti – inflammatory, analgesic, and antioxidant properties. Derived primarily from the roots of Paeonia suffruticosa Andr. (tree peony) and Paeonia lactiflora Pall. (Chinese peony), paeonol has gained significant attention in modern scientific research for its potential applications in treating various diseases and promoting overall health.
2. Product Origin and Chemical Properties
2.1 Source
Paeonol is mainly extracted from the dried roots of Paeonia suffruticosa and Paeonia lactiflora. These plants are cultivated in regions with suitable climates, such as Anhui, Sichuan, and Zhejiang in China. At Shaanxi Zhonghong Investment Technology Co., Ltd., we source high – quality peony roots from certified cultivation bases, ensuring the raw materials meet strict quality standards for optimal paeonol extraction.
2.2 Chemical Profile
- CAS Number: 552 – 41 – 0
- Molecular Formula (MF): C₉H₁₀O₃
- Molecular Weight (MW): 166.17 g/mol
- EINECS: 209 – 016 – 0
- Physical State: White to light yellow crystalline powder
- Solubility: Sparingly soluble in water; soluble in ethanol, ether, and chloroform
3. Optimal Product, Health Benefits, Dosage, Precautions and Side Effects
3.1 Best Products and Content
The highest – quality paeonol products typically feature a purity of 98% or higher. Our company employs advanced extraction and purification technologies, including supercritical fluid extraction and high – performance liquid chromatography (HPLC), to achieve a purity level 20% above the industry average. This ensures maximum bioactivity and reliability for various applications.
3.2 Health Benefits
3.2.1 Anti – Inflammatory and Analgesic Effects
Paeonol inhibits the production of pro – inflammatory cytokines (such as TNF – α and IL – 6) and blocks the activation of inflammatory signaling pathways. This makes it effective in reducing inflammation and alleviating pain, applicable for conditions like arthritis, headache, and menstrual cramps.
3.2.2 Antioxidant Defense
It acts as a potent antioxidant by scavenging free radicals, including hydroxyl and superoxide radicals. Paeonol can enhance the activity of antioxidant enzymes like superoxide dismutase (SOD) and catalase, protecting cells from oxidative damage associated with aging, cardiovascular diseases, and neurodegenerative disorders.
3.2.3 Anti – Allergic and Anti – Asthmatic Properties
Paeonol suppresses the release of histamine and other allergic mediators, relieving allergic symptoms. It also relaxes bronchial smooth muscles, making it beneficial for managing asthma and allergic rhinitis.
3.2.4 Skin Health Improvement
In topical applications, paeonol can soothe irritated skin, reduce redness, and promote wound healing. Its anti – inflammatory and antioxidant effects help protect the skin from environmental damage and improve skin texture.
3.3 Recommended Dosage
In traditional Chinese medicine, the daily dosage of paeonol from herbal decoctions is usually 6 – 12 grams. For purified paeonol supplements, clinical studies often use doses ranging from 50 – 200 mg per day. However, individual dosages should be determined under the guidance of a healthcare professional.
3.4 Precautions and Side Effects
Paeonol is generally well – tolerated, but some individuals may experience mild gastrointestinal discomfort, such as nausea or diarrhea. It may also interact with certain medications, including anticoagulants and anti – epileptic drugs. Pregnant or nursing women, individuals with liver or kidney disorders, and those with known allergies to peony plants should avoid use or consult a doctor before consumption.
4. Company Introduction
With 28 years of experience in the bioactive compound industry, Shaanxi Zhonghong Investment Technology Co., Ltd. is a leading high – tech enterprise. Our operations span agile research and development, collaborative innovation, integrated manufacturing, and global marketing, serving the chemical, materials, and life science sectors.
- Research Edge: Our partnerships with 5 top – tier universities through joint laboratories, along with over 20 patented technologies and a unique global compound library, drive continuous innovation in paeonol extraction and application.
- Technological Superiority: Equipped with state – of – the – art facilities, including high – performance liquid chromatography (HPLC) and superconducting nuclear magnetic resonance spectrometers, we ensure product purity standards 20% higher than the industry average.
- Global Reach: Our extensive network covers more than 80 countries across Asia, Europe, and the Americas. We offer customized raw material solutions for multinational pharmaceutical companies, research institutions, and consumer product manufacturers.
5. Product Specifications
Project | Name | Indicator | Detection Method |
Pesticide Residues | Chlorpyrifos | < 0.01 ppm | Gas Chromatography – Mass Spectrometry (GC – MS) |
Cypermethrin | < 0.02 ppm | GC – MS | |
Carbendazim | < 0.05 ppm | High – Performance Liquid Chromatography – Mass Spectrometry (HPLC – MS/MS) | |
Heavy Metals | Lead (Pb) | < 0.5 ppm | Inductively Coupled Plasma – Mass Spectrometry (ICP – MS) |
Mercury (Hg) | < 0.01 ppm | Cold Vapor Atomic Absorption Spectroscopy (CVAAS) | |
Cadmium (Cd) | < 0.05 ppm | ICP – MS | |
Microbial Contamination | Total viable count | < 100 CFU/g | Standard microbiological plating techniques |
Escherichia coli | Absent | Polymerase Chain Reaction (PCR) and plating | |
Salmonella | Absent | PCR and plating | |
Listeria monocytogenes | Absent | PCR and plating |
6. Production Process
- Raw Material Selection: Source high – quality peony roots from reliable cultivation bases. Conduct strict quality inspection, including visual inspection, determination of active ingredient content, and identification of plant species.
- Cleaning and Drying: Thoroughly clean the roots to remove soil, impurities, and foreign matters. Then, dry them under controlled temperature and humidity conditions to reduce moisture content.
- Extraction: Use methods such as ethanol extraction or supercritical fluid extraction. Ethanol extraction involves soaking the powdered roots in ethanol to dissolve paeonol, while supercritical fluid extraction with carbon dioxide offers a more environmentally friendly and efficient extraction process.
- Purification: Employ chromatographic techniques, such as silica gel column chromatography and preparative HPLC, to separate paeonol from other components in the extract. This step removes impurities, ensuring high – purity product.
- Concentration and Drying: Concentrate the purified paeonol solution through evaporation. Then, use spray – drying or freeze – drying methods to obtain the final powder product, preserving its bioactivity.
- Quality Inspection: Conduct comprehensive quality testing on the finished product, including purity determination, identification, and inspection of pesticide residues, heavy metals, and microbial contamination.
7. Application Scenarios
7.1 Pharmaceuticals
- Traditional Chinese Medicine Formulations: Paeonol is a key ingredient in many TCM prescriptions for treating inflammatory diseases, pain syndromes, and allergic conditions.
- Modern Drug Development: It serves as a valuable lead compound in the development of new drugs for arthritis, asthma, and neurodegenerative diseases.
7.2 Nutraceuticals
- Dietary Supplements: Formulated into capsules, tablets, or powders, paeonol supplements are popular among consumers seeking to relieve pain, reduce inflammation, and boost antioxidant protection.
- Functional Foods: Added to beverages, health foods, and dietary bars to enhance their health – promoting properties.
7.3 Cosmetics
- Skin – Care Products: Used in creams, lotions, serums, and masks for its anti – inflammatory, antioxidant, and skin – soothing effects. It helps in treating acne, eczema, and other skin irritations, and also promotes anti – aging benefits.
8. Quality Control
Quality control is the cornerstone of our paeonol production. At the raw material stage, we use DNA fingerprinting to authenticate the peony species and near – infrared spectroscopy to rapidly assess the quality and active ingredient content of the roots. During extraction, real – time monitoring of temperature, pressure, and solvent – to – raw material ratio ensures consistent extraction efficiency. In the purification process, HPLC is employed for precise separation and purity analysis, with each purification step closely monitored. After production, the final product undergoes comprehensive testing, including determining chemical purity, detecting pesticide residues and heavy metals using advanced analytical instruments, and performing microbial safety checks. Our quality control laboratory adheres to strict international standards, holding certifications like ISO 9001 for quality management and Good Manufacturing Practice (GMP). This multi – step, meticulous quality control system guarantees that every batch of paeonol meets the highest quality and safety benchmarks, providing reliable products to our global customers.
9. Packaging and Logistics
- Packaging: Our paeonol products are packaged in air – tight, light – resistant containers. For small orders, we use aluminum foil bags or amber glass bottles, while for bulk orders, fiber drums are utilized. Each package is labeled with detailed information, including product name, batch number, purity, expiration date, and storage instructions.
- Storage: Store in a cool, dry place, away from direct sunlight, at temperatures between 2 – 8°C. Under proper storage conditions, the shelf life of our paeonol products can reach up to 36 months.
- Shipping: We partner with reliable international logistics providers to ensure prompt and secure delivery. Samples can be shipped via express services like DHL or FedEx within 3 – 5 business days, while bulk orders are transported by sea or air freight according to customer requirements.
10. Health Efficacy Research, Industrial Application Innovation, and Challenges
10.1 Research Frontiers
- Mechanistic Studies: Scientists are exploring the detailed molecular mechanisms of paeonol, aiming to understand how it interacts with various signaling pathways in the body to exert its therapeutic effects.
- Nano – formulations: Research is underway to develop nano – delivery systems for paeonol, which can improve its bioavailability and targeted delivery, enhancing its therapeutic potential.
10.2 Challenges
- Sustainable Sourcing: As the demand for paeonol increases, ensuring the sustainable cultivation and sourcing of peony plants to maintain ecological balance and product quality is a significant challenge.
- Standardization: Establishing unified international standards for paeonol products in terms of quality, testing methods, and dosage recommendations is crucial for promoting its widespread use and ensuring consumer safety.
11. FAQ
11.1 Where can I buy Paeonol?
- Email: liaodaohai@gmail.com
- Website: aiherba.com
- We offer a variety of paeonol products with different purity levels and packaging options to meet diverse customer needs.
11.2 Is Paeonol safe for long – term use?
Paeonol is generally safe for long – term use when taken within recommended dosages. However, it is advisable to consult a healthcare professional, especially if you have underlying health conditions or are taking other medications.
11.3 Can Paeonol be used in cosmetics?
Yes, due to its anti – inflammatory and antioxidant properties, paeonol is widely used in cosmetics to soothe and protect the skin.
11.4 Does Paeonol interact with other medications?
Paeonol may interact with certain medications, such as anticoagulants and anti – epileptic drugs. It is important to inform your doctor about all the medications you are taking before using paeonol supplements.
12. Conclusion
Paeonol, a remarkable bioactive compound from traditional Chinese medicine, offers a wide range of health benefits and diverse applications. As a leading provider in the industry, Shaanxi Zhonghong Investment Technology Co., Ltd. is committed to delivering high – quality paeonol products, backed by advanced technology, strict quality control, and extensive global reach. Whether for pharmaceutical research, nutraceutical development, or cosmetic innovation, our paeonol offerings provide reliable solutions for enhancing human health and well – being.
13. References
- Li, Y., et al. (2015). Chemical constituents and pharmacological activities of Paeonia suffruticosa. Molecules, 20(10), 18431 – 18449.
- Wang, X., et al. (2018). Paeonol: A review of its pharmacological activities and molecular mechanisms. Evidence – Based Complementary and Alternative Medicine, 2018, 3816709.
- Chinese Pharmacopoeia Commission. (2020). Chinese Pharmacopoeia. China Medical Science Press.
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