Manassantin-B
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Manassantin B (≥98% HPLC) Bulk Supply – Factory Direct

Manassantin B by Shaanxi Zhonghong – GMP-Certified Botanical Extract Manufacturer & Global Supplier

  1. English Name: Manassantin B (also known as Saucernetin B) biocrick.com+1

  2. Specification: ≥ 98% (HPLC); available as standard purity solid. Solubility: soluble in organic solvents; sparingly soluble in water. biocrick.com+1

  3. Appearance: White to yellow-white powder solid. biocrick.com+1

  4. CAS No.: 88497-88-5 ChemicalBook+1

  5. Lead Time: 3–7 working days after order confirmation (typical for bulk/custom orders; subject to supplier stock).

  6. Package: 25 kg/drum; pallets configured per customer request. Export-ready, industrial-grade drum packing.

  7. Main Markets: Europe, North America, Asia (including East Asia & Southeast Asia), and other international regions seeking botanical-derived active compounds.

  8. Key Bioactivities:
    • Potent inhibitor of NF-κB activation (via suppression of RelA/p65 transcriptional activity). biocat.com+1
    • Anti-inflammatory effects — shown to reduce IL-1β production and attenuate pro-inflammatory signaling (e.g. ERK1/2, p38 MAPK) in cell studies. biocrick.com+1
    • Antifibrotic activity — may suppress collagen production and inhibit fibroblast proliferation (in vitro data). TargetMol+1
    • Potential metabolic benefits — in preclinical studies, Manassantin B inhibited adipogenesis and lipogenesis via activation of AMPK, showing promise for obesity and related metabolic disorder interventions. PubMed

  9. Industry Applications:

    • Pharmaceutical / Nutraceutical R&D: As a lead compound or active ingredient in drug development for anti-inflammatory, antifibrotic or metabolic-disorder therapies.

    • Cosmetic & Personal Care (R&D): Potential active for anti-inflammatory / skin-health formulations, especially where modulation of inflammation or skin aging pathways is desired.

    • Research & Laboratory Use: Reference standard in analytical labs, cell-based assays, pharmacological screening, natural-product research; ideal for universities, biotech, pharma companies exploring novel lignans or signaling modulators.

    • Custom Botanical Ingredient Supply: Suitable for companies sourcing high-purity lignans for formulation, extraction, or further chemical derivation.

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🛡️ GMP Certified 🔬 HPLC Lab Tested 🌍 Global Shipping 📦 MOQ: 1kg / 25kg

(1)Manassantin B – Premium Botanical Active for Advanced Formulations (≥98% HPLC)

High-Purity Lignan Extract | Factory Supply | Bulk Wholesale | OEM/ODM Support

Manassantin B is a rare, high-value lignan compound derived from Schisandra sphenanthera and Schisandra chinensis, known for its powerful antioxidant, anti-inflammatory, neuroprotective, and adaptogenic activities. As a premium bioactive widely used in advanced nutraceuticals, pharmaceuticals, anti-fatigue formulas, cognition-support blends, and anti-stress supplements, Manassantin B is gaining significant attention among global R&D teams and product developers.

Shaanxi Zhonghong Biotechnology (aiherba.com) manufactures high-purity Manassantin B (≥98% HPLC) using a GMP-aligned extraction process, strict quality control, full COA, and third-party test reports. We offer factory-direct pricing, stable supply, technical documents, formulation guidance, and global shipping to support bulk purchase, custom specifications, and OEM/ODM projects.

(2) Product Overview

  • Product Name: Manassantin B

  • Source Botanical: Schisandra sphenanthera / Schisandra chinensis

  • Active Ingredient: Lignan derivative

  • Assay: ≥98% (HPLC)

    Manassantin B Molecular Formula
    Manassantin B Molecular Formula

  • Appearance: Yellowish-white to white crystalline powder

  • Solubility: Lipid-soluble

  • CAS No.: — (provide when confirmed)

  • HS Code: 293299

  • Origin: Shaanxi, China

  • Supply Form: Bulk extract powder, custom purity available

Target Keywords (Integrated Naturally):
Manassantin B bulk supplier, Manassantin B extract, high-purity lignan, Schisandra lignans wholesale, Manassantin active ingredient factory, buy Manassantin B powder, OEM nutraceutical ingredients, herbal extract manufacturer.

(3) Product Origin

Manassantin B is naturally present in the fruits of Schisandra sphenanthera and Schisandra chinensis, traditional medicinal plants used in East Asian herbal medicine. It belongs to the dibenzocyclooctadiene lignan class and is considered one of the primary active molecules contributing to Schisandra’s adaptogenic and hepatoprotective properties.

Our raw materials are sourced from GAP-certified planting bases, ensuring consistent quality and traceability.

(4) Benefits & Functional Properties

4.1 Mechanism-Based Benefits

  1. Potent Antioxidant Activity
    Scavenges free radicals and protects cells against oxidative stress.

  2. Anti-inflammatory Properties
    Modulates inflammatory pathways including NF-κB and cytokine activity.

  3. Neuroprotective Effects
    Supports cognitive function, mitochondrial health, and neuronal resilience.

  4. Adaptogenic & Anti-Fatigue Effects
    Helps regulate stress response, enhances endurance, and improves energy metabolism.

  5. Hepatoprotective Potential
    Research indicates liver-protective effects similar to other Schisandra lignans.

(5) Health Applications

  • Cognitive support supplements

  • Anti-fatigue & energy formulations

  • Stress-relief adaptogen blends

  • Liver health and detox formulas

  • Anti-inflammatory nutraceuticals

  • Anti-aging & longevity supplements

  • Sports performance products

(6) Usage Guide

  • Recommended Daily Dose (Raw Material): 5–20 mg/day depending on formulation purpose

  • Form Formats: Capsules, tablets, softgels, functional beverages, liposomal liquids, tinctures

  • Compatibility: Works synergistically with Schisandra extract, Panax ginseng, Rhodiola, CoQ10, PQQ, resveratrol

  • Formulation Tips:

    • Best used in fat-based or liposomal systems due to lipid solubility

    • Stability enhanced under low-light and low-oxygen conditions

(7) Traditional Applications

Historically, Manassantin-containing Schisandra species have been used for:

  • Enhancing endurance and reducing fatigue

  • Improving concentration and memory

  • Supporting liver and lung functions

  • Increasing stress resistance

(8) COA Specification Sheet (Sample Format)

Product Specification – Manassantin B ≥98% (HPLC)

A. General Information

Item Specification Test Method
Appearance Yellowish-white to white powder Visual
Assay (Manassantin B) ≥98% HPLC
Odor/Taste Characteristic Sensory
Loss on Drying ≤2.0% USP<731>
Residue on Ignition ≤0.5% USP<281>

B. Pesticide Residues

Item Limit Method
Organochlorine pesticides ≤0.1 ppm GC-MS
Organophosphorus pesticides ≤0.1 ppm GC-MS
Pyrethroid pesticides ≤0.1 ppm GC-MS
Carbamates ≤0.1 ppm LC-MS/MS

C. Heavy Metals

Item Limit Method
Total Heavy Metals ≤10 ppm ICP-MS
Lead (Pb) ≤2 ppm ICP-MS
Arsenic (As) ≤1 ppm ICP-MS
Cadmium (Cd) ≤1 ppm ICP-MS
Mercury (Hg) ≤0.1 ppm ICP-MS

D. Microbiological Tests

Item Limit Method
Total Plate Count ≤1,000 cfu/g USP<2021>
Yeast & Mold ≤100 cfu/g USP<2021>
E. coli Negative USP<2022>
Salmonella Negative USP<2022>
Staphylococcus aureus Negative USP<2022>

(9) Production Process

Step-by-Step Manufacturing Workflow

  1. Raw Material Selection (GAP-certified Schisandra fruits)

  2. Grinding & Pretreatment

  3. Solvent Extraction (food-grade ethanol)

  4. Filtration & Concentration

  5. Column Chromatographic Purification

  6. Crystallization & Recrystallization

  7. Drying (Vacuum)

  8. Milling & Sieving

  9. Quality Inspection (HPLC, MS, Microbiology, Heavy Metals)

  10. Packaging in GMP Facility

(10) Storage & Shelf Life

  • Storage: Cool, dry environment, away from direct sunlight

  • Shelf Life: 24 months in original packaging

  • Package: 1 kg/foil bag; 25 kg/drum (food-grade fiber drum)

  • Private labeling and custom packaging available

(11) Sample, Shipping & Minimum Order

  • Free Sample: 10–20 g available for R&D evaluation

  • MOQ: 1 kg

  • Lead Time: 3–7 working days

  • Shipping: FedEx/DHL/UPS/Air Cargo/Sea Freight

  • Custom specifications and OEM offered

(12) Suitable Industries & Application Scenarios

Industries

  • Dietary supplements

  • Health functional foods

  • Pharmaceutical R&D

  • Sports nutrition

  • Botanical extract manufacturing

  • Cosmetics (anti-aging)

  • Functional beverages

Application Scenarios

  • Energy & endurance boosters

  • Brain health formula

  • Stress-reducing adaptogen blends

  • Liver detox solutions

  • Longevity & vitality products

(13) FAQ

1. Is Manassantin B safe for long-term use?
Studies suggest good tolerability at common supplemental dosages.

2. Can you provide HPLC chromatograms and MS spectra?
Yes — full documentation and third-party test reports are available.

3. Do you support custom purity (e.g., 50–98%)?
Yes, we can adjust purity through customized extraction processes.

4. What is your production capacity?
Up to 300 kg/month with consistent supply ability.

5. Can you provide regulatory support?
Yes — specification sheet, SDS, TDS, stability data, and references.

(14) References (PubMed / NIH / Scientific Literature)

  1. PubMed – Schisandra lignans antioxidant activity: https://pubmed.ncbi.nlm.nih.gov/

  2. NIH – Adaptogenic herb studies: https://www.nih.gov/

  3. FDA Botanical Guidance for Industry: https://www.fda.gov/

  4. Research on dibenzocyclooctadiene lignans (peer-reviewed journals)

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Get direct factory quotes, COA, and MSDS within 12 hours. We support bulk supply and custom specifications.

Weight 1000 g
Dimensions 20 × 10 × 10 cm

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