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Bioperine®: The Gold Standard in Bioavailability Enhancement – A Manufacturer’s Guide

1. What is Bioperine®?

Let’s cut through the noise. Bioperine® is not just black pepper extract. It’s a patented, clinically-studied ingredient derived from the fruits of Piper nigrum L. (black pepper) and standardized to contain ≥95% piperine. Think of it as the key that unlocks the full potential of your supplements. Its primary, and most valuable, function is to significantly enhance the bioavailability of other active compounds, making your formulations more effective and efficient.

2. 原料、化学組成、仕様

• ソース： Sourced from the dried fruits of Piper nigrum L.

• 主な生物活性成分: Piperine (Standardized to ≥95%).

• 化学プロファイル:

  • CAS番号: 94-62-2

  • MF: C₁₇H₁₉NO₃

  • MW: 285.34 g/mol

  • EINECS: 202-348-0

• 外観： オフホワイトから淡黄色の結晶性粉末。

• 溶解度: Soluble in ethanol and chloroform; sparingly soluble in water.

3. The Zhonghong Standard: Why Our Bioperine® is Best for B2B
のために nutraceutical ingredients suppliers そして private label supplement manufacturers, consistency and proof are everything. Here’s what defines a premium-grade Bioperine®:

• Key Ingredient & Potency: ≥95% Piperine. This high level of purity is non-negotiable for reliable and potent bioavailability enhancement.

• Proven Efficacy (Compliant Claims):

  • Bioavailability Enhancer: Clinically shown to increase the absorption of various nutrients (e.g., Curcumin, CoQ10, Vitamins, Selenium).

  • Thermogenic Activity: Supports metabolic rate and nutrient utilization.

  • (Note: This product is not intended to diagnose, treat, cure, or prevent any disease. Structure/function claims must be compliant with local regulations).

• Optimal Use Level: Typically used at a 1-5% ratio relative to the active compound it is enhancing (e.g., 5-10mg of Bioperine® per 500mg of Curcumin). Dosage should be finalized based on the specific formulation.

• 原産地と品質: プレミアムから調達 Piper nigrum and processed to meet stringent international standards.

• 応用： Ideal for incorporation into tablets, capsules, and powder formulations for dietary supplements.

• Target Formulations: Essential for private label supplement manufacturers creating products with high-value actives like turmeric/curcumin, resveratrol, multivitamins, and cognitive health blends.

• Safety & Considerations:

  • 一般的に安全と認められている（GRAS）： At recommended levels.

  • 薬物相互作用: May affect the metabolism of certain pharmaceutical drugs by inhibiting cytochrome P450 enzymes and UDP-glucuronylation. Consult a medical expert if formulating for populations on medication.

  • 妊娠・授乳中: Recommended to avoid high doses.

4. Zhonghong Biotech: Your Strategic Ingredient Partner
When you need a reliable bulk botanical extracts partner, you need more than a vendor. You need a technical expert. 陝西中宏投資テクノロジー株式会社 認定された 栄養補助食品原料サプライヤー with 28 years of experience in bioactive compound manufacturing.

• コア専門知識: We are specialists in the precision extraction and purification of plant-derived actives. Our portfolio is built for B2B:

  • Standardized Botanical Extracts (like Bioperine®)

  • Cosmetic Raw Material Supplier offerings

  • 栄養補助食品成分 for supplements and functional foods

  • API Intermediates

• Our B2B Value Proposition:

  • Innovation-Driven: 20+ patents and university collaborations ensure we are at the forefront of extraction technology.

  • 品質保証： 当社の投資 HPLCとNMR分光法 guarantees a purity standard that is consistently 20% above common industry specs, providing you with a uncontested competitive edge.

  • Global B2B Network: 供給 植物エキスの卸売 そして カスタマイズされたソリューション に OEMハーブエキス partners and major brands in over 80 countries.

5. Technical Insight: Mechanism of Action
Piperine’s primary mechanism is two-fold:

1. Inhibition of Metabolism: It inhibits the enzymes in the liver and intestine (e.g., CYP3A4, UGT) that would normally break down and eliminate other compounds before they enter the bloodstream.

2. Enhancing Absorption: It stimulates amino acid transporters in the intestinal lining and increases blood supply to the GI tract, facilitating greater uptake of co-administered supplements.

6. Uncompromising Quality Control: The COA
Our Quality Control is your formulation’s insurance policy. Every batch is rigorously tested.

Certificate of Analysis (COA) Summary – Bioperine® (≥95% Piperine)

7. Advanced Production Process
Our GMP-compliant process ensures unmatched purity:

1. 調達と準備: Selection and cleaning of premium Piper nigrum 果物。

2. 抽出： Solvent extraction optimized for maximum piperine yield.

3. Filtration & Concentration: Removal of impurities and concentration of the extract.

4. Crystallization & Purification: Further refinement to achieve the ≥95% purity benchmark.

5. 標準化: Precise adjustment to meet the exact specification.

6. 乾燥と製粉： Conversion into a fine, free-flowing powder.

7. QCリリース: The batch is only released after passing all critical quality parameters.

8. Application in Nutraceutical Formulations
This ingredient is a cornerstone for effective supplement design. Its primary application is in:

• Enhanced Absorption Formulas: Curcumin supplements, multivitamins, coenzyme Q10, resveratrol, and antioxidant blends.

• Weight Management Products: Leveraging its mild thermogenic properties.

• スポーツ栄養： To improve the uptake of amino acids and other performance nutrients.

9. B2B Packaging & Logistics

• パッケージ: Standard 25kg/fiber drum with double polyethylene liners. Customized packaging available for 卸売 そして バルク 注文。

• ストレージ： Store in a cool, dry place away from strong light.

• 貯蔵寿命： 24 months when stored correctly.

• ロジスティクス： We handle global shipping and all export documentation (COA, MSDS, Certificate of Origin) for seamless delivery to OEM partners worldwide.

10. バルク原料のニーズには当社と提携しましょう
Zhonghong isn’t just a サプライヤー; we’re your innovation partner. We provide:

• 競争力のある大量購入価格: 直接連絡を取る 工場価格 大量注文の場合。

• カスタマイズとOEM: 提供 OEMハーブエキス そして カスタマイズされたソリューション tailored to your specific formulation requirements.

• Technical Support: Leverage our 28 years of expertise for your product development.

お見積もりまたはサンプルのリクエストについては、お問い合わせください。

• ウェブ： www.aiherba.com

• メールアドレス: sales@aiherba.com; liaodaohai@gmail.com

• キーワード: Bioperine supplier, bulk piperine, nutraceutical ingredients supplier, cosmetic raw material supplier, wholesale botanical extracts, private label supplement manufacturer, OEM herbal extracts, bulk organic ingredients.

11. B2Bクライアント向けFAQ

• Q: What is your Minimum Order Quantity (MOQ) for bulk orders?
  A: 最小発注量の詳細についてはお問い合わせください。柔軟な条件をご用意しております。 卸売 そして バルク パートナー。

• Q: Can you provide custom standardization for private label?
  A: Absolutely. As an OEMハーブエキス partner, we specialize in カスタマイズされたソリューション to meet your specific product specs.

• Q: Do you offer technical documentation and regulatory support?
  A: Yes. We provide full documentation (COA, MSDS) and can support with regulatory data for your market.

• Q: 大量注文の場合のリードタイムはどれくらいですか?
  A: Lead times vary based on order size. We maintain strategic stock for popular items and provide clear timelines for custom productions.

• Q: How do I start the qualification process?
  回答: メールでお問い合わせください sales@aiherba.com リクエストする 無料サンプル and discuss your specific needs. Our technical team will guide you through the process.

12. 結論
In the competitive world of supplement manufacturing, ingredient efficacy is paramount. Bioperine® is a proven, powerful tool to differentiate your products and guarantee customer results. Sourcing from a technically advanced, reliable manufacturer is critical. Zhonghong Biotech, with its scientific rigor, proven quality, and global B2B supply capability, is the optimal partner for nutraceutical ingredients suppliers そして プライベートラベル brands. Contact us today to discuss your project and request a sample.

参考文献:

• Majeed, M., et al. (1999). Piperine, a bioavailability enhancer. US Patent 5,972,382.

• Shoba, G., et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. プランタ・メディカ, 64(4), 353-356.

• Badmaev, V., et al. (2000). Piperine, an alkaloid derived from black pepper, increases serum response of beta-carotene during 14-days of oral supplementation. Nutrition Research, 20(3), 381-388.

• Johnson, J. J., et al. (2011). Enhancing the bioavailability of resveratrol by combining it with piperine. 分子栄養学と食品研究, 55(8), 1169-1176.