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Adrenochrome: The Hemostatic Compound with Evolving Therapeutic Potential | Supplier & Manufacturer

1. What is Adrenochrome?
Adrenochrome (CAS 54-06-8) is the oxidation product of adrenaline (epinephrine), characterised by its distinct indole-5,6-quinone construction. Biochemically, it kinds spontaneously when adrenaline is uncovered to oxidizing brokers or gentle. Whereas traditionally related to cytotoxic properties in leukocyte-mediated bacterial killing 14, its significance in fashionable science lies in two domains: as a analysis device learning neurodegenerative pathways 酸化ストレス 10, and because the precursor to the broadly used hemostatic drug carbazochrome (adrenochrome monohydrazone) 28. Not like adrenaline, adrenochrome lacks important pressor results, making its derivatives clinically priceless for vascular integrity modulation with out impacting coronary heart charge or blood strain 58.

2. Supply, Chemical Properties & Specs

• 供給： Primarily synthesized through the chemical oxidation of epinephrine. Natural enzymatic formation happens in vivo however is unstable and never commercially viable for extraction 1410.

• Chemical Identification & Properties:

  • CAS No: 54-06-8

  • Molecular Method: C₉H₉NO₃

  • 分子量: 179.17 g/mol

  • EINECS: 200-192-8

  • 外観： Crimson crystalline powder

  • 溶解度: Soluble in water (with attribute absorbance maxima at 299-304 nm and 485-490 nm) and alcohols; insoluble in non-polar solvents 1410.

  • 安定性： Mild- and air-sensitive; requires storage at -20℃ in hermetic containers 110.

3. Therapeutic Spinoff: Carbazochrome (The “Greatest” Clinically Used Type)

Whereas pure adrenochrome is primarily a analysis chemical, its stabilized by-product, carbazochrome (adrenochrome monosemicarbazone sodium salicylate), is the dominant clinically related type resulting from enhanced stability and security.

• Highest Content & Purity: Pharmaceutical-grade carbazochrome targets >95% purity (HPLC assay). Respected producers obtain this through クロマトグラフィー精製 (e.g., preparative HPLC). No “pure” supply gives larger concentrations than artificial derivation 258.

• 健康上の利点とメカニズム:

  • Hemostasis: 強化 capillary endothelial resistance, stabilizes perivascular acidic mucopolysaccharides, and promotes contraction of broken capillary ends. Inhibits prostaglandin E1 (PGE1) synthesis/launch, decreasing vascular permeability and exudation 258.

  • Major Functions: Efficient for bleeding resulting from elevated capillary fragility (e.g., idiopathic thrombocytopenic purpura, retinal hemorrhage, continual pulmonary hemorrhage, GI bleeding, epistaxis, metrorrhagia, hematuria) 28.

• Each day Consumption & Dosage (Carbazochrome):

  • 大人: Oral: 2.5-5 mg, 2-3 instances each day; Extreme instances: 5-10 mg each 2-4 hours. IM: 5-10 mg, 2-3 instances each day; Extreme: 10-20 mg each 2-3 hours. IV use is contraindicated.

  • キッズ: Oral: 1.25-2.5 mg (≤5 yrs), 2.5-5 mg (>5 yrs). IM: 2.5-5 mg (≤5 yrs), 5-10 mg (>5 yrs) 258.
    No established RDI exists for pure adrenochrome; its use is restricted to analysis.

• Precautions & Aspect Results (Carbazochrome):

  • 禁忌: Hypersensitivity to carbazochrome or salicylates.

  • Opposed Results: Salicylate-like reactions – nausea, vomiting, dizziness, tinnitus, imaginative and prescient disturbances. Excessive doses could trigger neuropsychiatric results (psychological disturbances, irregular EEG, decreased efficacy of antipsychotics/antiepileptics) 258.

  • Warnings: Use cautiously in sufferers with epilepsy or psychiatric historical past. Keep away from concurrent use with antihistamines/anticholinergics (could scale back efficacy) and tetracyclines (incompatibility) 58.

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Supply for Premium Bioactives

Shaanxi Zhonghong stands as a premier ハイテク企業 (ISO 9001, ISO 22000, FDA-registered facility) with 28年の経験 within the analysis, growth, and large-scale manufacturing of high-purity bioactive compounds for the pharmaceutical, nutraceutical, and life science industries. We specialize within the 抽出、分離、精製 of complicated plant-derived and artificial molecules, together with research-grade adrenochrome and associated hemostatic intermediates 9.

• コアコンピテンシー:

  • 科学力: Joint laboratories with 5 main universities, 20以上の特許取得済み応用科学, and a proprietary international compound library enabling novel discovery and course of optimization.

  • 製造の卓越性： State-of-the-art GMP-compliant services 装備を整えて 超臨界CO2抽出, preparative HPLC/UHPLC、 そして 凍結乾燥 capabilities.

  • Analytical Supremacy: Extremely-conducting NMR spectrometers, HR-MS (Excessive-Decision Mass Spectrometry)、 そして validated HPLC-DAD/ELSD strategies guarantee purity requirements exceeding trade norms by >20%. Our QC protocols rigorously adhere to USP/EP/ICH pointers 9.

  • 世界達成: Provides tailor-made, cGMP準拠 elements to multinational pharmaceutical companies and analysis establishments throughout 80か国以上 アジア、ヨーロッパ、アメリカ大陸で。

5. Rigorous Product Specs (Carbazochrome Instance)

Specs are batch-specific; full particulars supplied on the Certificates of Evaluation (CoA).

6. Superior Manufacturing & High quality Management

• Synthesis & Purification Course of:

  1. Oxidation: Managed oxidation of pharmaceutical-grade epinephrine below inert ambiance and optimized pH/temperature.

  2. Derivatization (For Carbazochrome): Response with semicarbazide adopted by salicylate salt formation.

  3. 精製： 多段階 クロマトグラフィー精製 (Adsorption Chromatography → 分取HPLC) removes course of impurities and associated substances.

  4. 結晶化と分離： Managed crystallization for particle dimension distribution.

  5. 乾燥： Vacuum Tray Drying または 凍結乾燥 ensures stability and low residual moisture (<5%).

  6. Strict QC Launch Testing: Each batch undergoes full id affirmation (FT-IR, NMR), assay (HPLC-UV), impurity profiling (UHPLC-MS), residual solvent evaluation (HS-GC-MS), heavy metals (ICP-MS), microbiological testing (USP <61>/<62>)、 そして pesticide screening (GC-MS/MS/LC-MS/MS) 9.

• High quality Management Philosophy :
  陝西省中宏は、 quality-by-design (QbD) strategy built-in with cGMPのアイデア all through the manufacturing lifecycle. Our multi-layered QC system 保証する id, purity, efficiency, and security:

  • Uncooked Materials Management: Rigorous qualification of beginning supplies (epinephrine) towards pharmacopeial requirements (USP/EP).

  • 検査過程（IPC）： Actual-time monitoring of vital course of parameters (CPPs – e.g., response pH/Temp, solvent ratios, intermediate purity through UHPLC) ensures consistency and facilitates early deviation correction.

  • Stability-Indicating Strategies: Validated HPLC/UHPLC strategies able to resolving adrenochrome, carbazochrome, and potential degradation merchandise (e.g., adrenolutin, additional oxidation merchandise). Compelled degradation research (ICH Q1A(R2)) below acid/base, oxidative, thermal, and photolytic stress verify methodology specificity.

  • Hint Contaminant Evaluation: State-of-the-art ICP-MS ensures heavy metals meet ICH Q3D/ USP <232> limits. Residue Evaluation 雇用する LC-QTOF-MS そして GC-QqQ-MS/MS platforms screening for >500 pesticides per EU MRLs.

  • Microbiological Assurance: Testing per USP <61> (enumeration) and USP <62> (specified pathogens) in ISO Class 7 cleanrooms.

  • Stability & Shelf-Life: Actual-time そして accelerated stability research decide shelf-life (usually 24 months at -20°C for adrenochrome, 36 months for carbazochrome salts at managed room temperature).

  • Information Integrity: Adherence to ALCOA+ ideas と Digital Batch Data (EBR) そして LIMS (Laboratory Data Administration System). Complete CoAs present full traceability 9.

7. Application Scenarios & Analysis Frontiers

• Present Functions:

  • 処方薬： Lively ingredient in hemostatic medication (e.g., Carbazochrome salicylate injections and tablets for capillary hemorrhage).

  • 分析試薬: Excessive-purity adrenochrome (>98%, HPLC) is vital for learning 酸化ストレス in neuronal/cardiac cells 410, COMT (Catechol-O-Methyltransferase) inhibition10, and potential roles in neurodegenerative fashions (e.g., Parkinson’s, Alzheimer’s).

  • Radiation Safety: Derivatives like Adrenochrome monoguanylhydrazone methanesulfonate (S-Adchnone) present efficacy in defending hematopoietic organs from radiation harm 7.

• 分析の最前線と課題:

  • Neuroinflammation & Neuroprotection: Investigating adrenochrome’s twin function as a neurotoxin (through quinone-mediated oxidative stress) and potential protecting mechanisms at low concentrations or by way of particular derivatives.

  • 優れた医薬品供給： 成長中 nanoparticle-encapsulated または transdermal patch formulations of carbazochrome for sustained launch and enhanced bioavailability.

  • Novel Therapeutic Indications: Exploring potential in sepsis-associated coagulopathy, diabetic microangiopathy, and as an adjunct in chemotherapy-induced thrombocytopenia.

  • 課題: Overcoming adrenochrome’s inherent chemical instability, elucidating exact molecular targets past TRP channels/PGE1 inhibition, establishing sturdy scientific proof for brand spanking new indications, and navigating regulatory pathways for novel derivatives.

8. Packaging, Logistics & Ordering Data

• パッケージ:

  • Analysis Grade Adrenochrome: Amber glass vials with butyl rubber stoppers (1mg, 5mg, 25mg, 250mg), below inert gasoline (N₂/Ar), filled with desiccants.

  • Bulk Carbazochrome/Carbazochrome Salts: Meals-grade HDPE drums with double LDPE liners (1kg, 5kg, 25kg). Consists of desiccant packs and COA.

• ストレージ： -20°C ± 5°C, protected against gentle and moisture.

• 貯蔵寿命： 24 months (Adrenochrome), 36 months (Carbazochrome Salts) when saved accurately.

• 世界物流： Shipped on dry ice (analysis portions) or through climate-controlled freight (bulk). Experience in international customs clearance, together with documentation for DGR (Harmful Items) if relevant and GDP compliance for APIs.

The place to Purchase:

• Contact E mail: liaodaohai@gmail.com

• Firm Web site: https://www.aiherba.com

• Inquiries: For present pricing, bulk quotes (>1kg), pattern requests (R&D), Technical Dossiers (TDS), Certificates of Evaluation (CoA), and customized synthesis choices.

9. よくある質問（FAQ）

• Q: Is adrenochrome secure for human consumption?
  A: Pure adrenochrome is not permitted for direct human consumption and is strictly a analysis chemical. Its stabilized by-product, carbazochrome (e.g., Adrenobazone, Adrenosin), is a clinically permitted and secure hemostatic drug when used in response to prescribing pointers 258.

• Q: What is the distinction between Adrenochrome and Carbazochrome?
  A: Carbazochrome is a semi-synthetic stabilized by-product (adrenochrome monosemicarbazone sodium salicylate salt) developed for pharmaceutical use. It retains the hemostatic exercise of adrenochrome whereas providing superior chemical stability, decreased uncomfortable side effects, and predictable pharmacokinetics 28.

• Q: Can adrenochrome trigger psychiatric results?
  答え: Excessive doses of carbazochrome derivatives have been related to neuropsychiatric uncomfortable side effects (e.g., psychological disturbances, EEG abnormalities) and may intrude with antipsychotic/antiepileptic medication 58. Pure adrenochrome’s function in psychiatric problems stays a analysis speculation, not a longtime scientific truth.

• Q: What purity grades do you provide?
  A: Shaanxi Zhonghong provides:

  • Analysis Grade: ≥95% (HPLC), very best for in vitro research.

  • Excessive Purity Grade: ≥98% (HPLC), appropriate for analytical requirements and superior analysis.

  • Pharmaceutical Grade (Carbazochrome Salts): Conforms to USP/EP monographs, ≥95% assay, full GMP documentation.

• Q: Do you provide customized synthesis or derivatization?
  A: Sure. Our joint college labs そして proprietary compound library allow customized synthesis of adrenochrome analogs (e.g., S-Adchnone 7) and scale-up below cGMP. Contact R&D through liaodaohai@gmail.com for mission proposals.

10. 結論

Adrenochrome (CAS 54-06-8), significantly in its stabilized pharmaceutical type carbazochrome, represents an important hemostatic agent focusing on capillary fragility. Its mechanism—enhancing endothelial resistance and inhibiting PGE1-mediated permeability—gives a singular strategy to managing microvascular bleeding with out cardiovascular results. 陝西中宏投資テクノロジー株式会社 レバレッジ 28年間の生理活性化合物の経験, cutting-edge chromatographic purification (prep-HPLC, SFC)、 そして rigorous cGMP/QbD-compliant QC (NMR, ICP-MS, UHPLC-MS/MS) to provide the worldwide analysis and pharmaceutical markets with ultra-high-purity adrenochrome and carbazochrome. Our dedication to scientific innovation (20+ patents, college JVs), analytical excellence、 そして customized synthesis capabilities positions us because the premier accomplice for growing and manufacturing vital hemostatic brokers and novel adrenochrome derivatives. Contact us right this moment to debate your particular uncooked materials or analysis compound wants.

11. References

1. Sigma-Aldrich. Adrenochrome Product Data (CAS 54-06-8). http://www.chemdict.com/brand_sigma-aldrich/prodt280112.html

2. Chemsrc. *Adrenochrome (CAS 54-06-8) – Chemical Supply*. https://www.chemsrc.com/baike/1189877.html

3. Santa Cruz Biotechnology. *Adrenochrome (CAS 54-06-8) – Inhibitor*. https://www.scbt.com/zh/p/adrenochrome-54-06-8

4. TargetMol. *Adrenochrome monoguanylhydrazone methanesulfonate (S-Adchnone, T89273)*. https://www.targetmol.cn/compound/adrenochrome_monoguanylhydrazone_methanesulfonate

5. PCBShop. Shaanxi Zhonghong Investment Technology Co., Ltd. Profile. https://www.pcbshop.org/cn/supplier/profile.asp?SupID=7102

6. Harley-Mason, J. (1950). Adrenochrome. Journal of the Chemical Society (Resumed), 1276.

7. Hoffer, A., & Osmond, H. (1967). The Hallucinogens. Tutorial Press. (Word: Represents the largely discredited adrenochrome speculation).

8. Worldwide Council for Harmonisation (ICH) Tips: Q2(R1) Validation of Analytical Procedures, Q1A(R2) Stability Testing.

9. United States Pharmacopeia (USP) Basic Chapters: <61> Microbiological Examination of Nonsterile Merchandise, <62> Microbiological Procedures for Absence of Specified Microorganisms, <561> Articles of Botanical Origin.

10. European Pharmacopoeia (Ph. Eur.) Basic Strategies.

11. Instance Analysis on Authentic Plant Actives (Substitute with particular compound analysis): Aggarwal, B. B., & Harikumar, Ok. B. (2009). Potential therapeutic results of curcumin, the anti-inflammatory agent, towards neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic illnesses. The worldwide journal of biochemistry & cell biology, 41(1), 40–59.