Glycine alpha-cétoglutarate

Glycine Alpha-Ketoglutarate (GAK): Premium Bulk Provider for Optimum Well being & Efficiency

1. What’s Glycine Alpha-Ketoglutarate (GAK)?
Glycine Alpha-Ketoglutarate (GAK) is a specialised dipeptide compound shaped by bonding the amino acid Glycine with the important thing metabolic intermediate Alpha-Ketoglutarate (AKG). This secure molecular complicated leverages the synergistic advantages of each parts, enjoying essential roles in mobile power manufacturing (ATP synthesis through the Krebs cycle), amino acid metabolism (notably glutamine and glutamate), collagen synthesis, ammonia detoxing, and nitric oxide regulation. Its distinctive construction enhances bioavailability in comparison with administering the parts individually.

2. Fourniture du produit, propriétés chimiques et identification

• Fournir: Synthesized beneath managed circumstances utilizing premium pharmaceutical-grade Glycine and Alpha-Ketoglutarate precursors.

• Propriétés chimiques : Sometimes presents as a white to off-white crystalline powder. Extremely soluble in water.

• Quantité CAS : 2485-13-0

• Composants moléculaires (MF) : C₇H₁₁NO₆

• Poids moléculaire (PM) : 205,17 g/mol

• EINECS Quantity: 219-627-9

3. Why Select Our Premium Glycine Alpha-Ketoglutarate?
En tant que numéro un bulk provider et producteur, Shaanxi Zhonghong delivers GAK assembly the best world requirements:

• Pureté des ingrédients : >99.5% confirmed by superior HPLC and NMR evaluation, exceeding typical trade purity benchmarks by 20%.

• Key Efficacy & Well being Advantages:

  • Enhanced Mobile Power & Mitochondrial Operate: Instantly fuels the Krebs cycle (AKG), boosting ATP manufacturing important for muscle efficiency and restoration. Excellent for sports activities diet functions.

  • Ammonia Scavenging & Detoxing: Glycine binds ammonia, forming excretable glycine conjugates, decreasing fatigue and supporting liver well being.

  • Collagen Synthesis & Tissue Restore: Glycine is a main part of collagen, important for pores and skin, tendon, bone, and cartilage integrity.

  • Modulation des neurotransmetteurs : Precursor to inhibitory neurotransmitter glycine and influences glutamate/GABA pathways, supporting cognitive perform and temper.

  • Antioxidant & Anti-glycation Help: Could assist mitigate oxidative stress and the formation of superior glycation end-products (AGEs).

  • Précurseur du glutathion : Glycine is important for synthesizing the grasp antioxidant glutathione.

• Origine: Synthesized and rigorously quality-controlled at our GMP-certified services in China.

• Utilization Pointers: Primarily used as a purposeful ingredient in dietary dietary supplements, sports activities diet merchandise, medical diet, and analysis formulations. Typical day by day dosage ranges from 1-5 grams, typically divided. Seek the advice of a healthcare skilled for particular product formulation and dosing.

• Objectifs des téléspectateurs : Nutraceutical/sports activities diet producteurs, pharmaceutical R&D, purposeful meals builders, medical analysis establishments.

• Précautions et résultats d'aspect : Usually well-tolerated at beneficial doses. Potential delicate GI upset reported hardly ever. Contraindicated in extreme renal impairment. Keep away from in people with identified hypersensitivity.

• Optimum Dosage: Depending on utility (sports activities efficiency, basic wellness, medical help). Formulators ought to base dosage on the right track well being end result and product matrix. Security research help doses as much as 15g/day.

4. Firm Profile: Shaanxi Zhonghong Funding Expertise Co., Ltd.
Shaanxi Zhonghong is a premier high-tech enterprise integrating R&D, co-innovation, built-in manufacturing, and world advertising. With 28 ans d'expérience in bioactive compounds, we specialize within the extraction, isolation, purification, and superior utility of plant-derived and artificial molecules. Our portfolio spans:

• Premium Pure Plant Extracts

• Excessive-Purity Beauty Actives

• Pharmaceutical & Nutraceutical Components

• Pure Pigments & Sweeteners

• Composants des repas et des boissons

• Personalized Dietary Complement Components

Core Aggressive Benefits:

• Prouesses scientifiques : Strategic collaborations with 5 elite universities, establishing joint R&D labs. Holder of 20+ proprietary patents and a globally distinctive compound library.

• Infrastructure de pointe : Équipé de Spectroscopie HPLC-UV/ELSD/CAD, UPLC-Q-TOF-MS, GC-MS, FTIR, RMN, and ICP-MS, making certain purity and security requirements surpass trade norms by 20%.

• International Provide Chain Excellence: De confiance provider to multinational pharmaceutical companies, analysis establishments, and nutraceutical producteurs throughout 80+ nations in Asia, Europe, and the Americas. We excel in offering extrait naturel sur mesure options and sophisticated en gros approvisionnement en produits chimiques.

5. Glycine Alpha-Ketoglutarate Detailed Product Specs & Certificates of Evaluation (COA)
Our Glycine Alpha-Ketoglutarate undergoes exhaustive testing. Under is a abstract of our stringent high quality management parameters:

6. Cours de fabrication supérieure
Our GAK synthesis makes use of a meticulously managed, multi-step enzymatic response course of:

1. Pesée et dissolution de précision : Excessive-purity Glycine and Alpha-Ketoglutarate precursors are precisely weighed and dissolved beneath purified water.

2. Condensation catalysée : Response proceeds beneath optimized pH, temperature, and stress circumstances utilizing a proprietary enzymatic catalyst.

3. Cristallisation et isolement : The GAK dipeptide is selectively crystallized from the response combination.

4. Purification en plusieurs étapes : Sequential purification steps together with recrystallization, activated carbon therapy, and nanofiltration guarantee removing of impurities, residual solvents, and endotoxins.

5. Lyophilisation (lyophilisation) : The purified product undergoes managed lyophilization to realize the specified crystalline powder type with optimum stability.

6. Micronization (Optionally available): Particle dimension discount accessible for enhanced solubility in ultimate formulations.

7. Key Software Situations

• Activités sportives Vitamine : Enhances endurance, reduces fatigue, accelerates post-exercise restoration through improved ATP synthesis and ammonia clearance. Key ingredient in pre-/intra-/post-workout formulation.

• Anti-Getting old & Wellness Dietary supplements: Helps collagen manufacturing for pores and skin/joint well being, combats oxidative stress/glycation, promotes detoxing pathways.

• Medical Vitamin: Investigated for supporting muscle mass in sarcopenia/cachexia, liver well being (ammonia detoxing), and metabolic issues.

• Cognitive Well being Formulations: Potential function in neurotransmitter steadiness and neuroprotection.

• Repas et boissons pratiques : Included into protein shakes, well being drinks, and fortified meals concentrating on power and restoration.

8. Glycine Alpha-Ketoglutarate Rigorous High quality Management  
High quality is embedded at each stage. Our state-of-the-art QC laboratory, geared up with Excessive-Decision LC-MS (Q-TOF), GC-MS/MS, ICP-MS, and 600MHz NMR, offers unparalleled analytical functionality. We adhere strictly to cGMP, ISO 9001:2015, and ISO 22000:2018 requirements. Identification is confirmed through FTIR and NMR fingerprint matching in opposition to our authenticated reference commonplace. Efficiency (Assay) is set utilizing validated, stability-indicating HPLC-UV strategies with stringent system suitability standards. Impurity profiling employs UPLC-Q-TOF-MS to detect and quantify even trace-level process-related impurities and degradation merchandise all the way down to 0.05%. Heavy steel evaluation follows stringent ICH Q3D Choice 1 tips utilizing ICP-MS. Microbiological security is ensured by means of complete testing per USP <61>/<62> in our devoted ISO Class 7 cleanroom. Residual solvents are monitored per ICH Q3C utilizing GC-MS. All strategies are validated per ICH Q2(R1) rules. Batch information are absolutely traceable, and uncooked supplies endure equivalent scrutiny. Our stability program (accelerated & long-term per ICH Q1A) ensures product integrity all through its shelf life beneath beneficial storage circumstances (cool, dry place).

9. Safe Packaging & International Logistics

• Major Packaging: Double-sealed food-grade polyethylene luggage with moisture barrier.

• Emballage secondaire : Sturdy, tamper-evident fiberboard drums (25kg internet weight commonplace; customized en gros portions accessible).

• Étiquetage : Compliant with world requirements, together with LOT quantity, manufacturing/expiry dates, CAS, MF, storage directions, and full traceability.

• Logistique: Environment friendly world transport through air, sea, or specific courier (DDP/DAP choices). Experience in dealing with customs clearance and documentation (COA, MSDS, Certificates of Origin, Well being Certificates). Chilly chain choices accessible upon request.

10. Deep Dive: Well being Mechanisms, Analysis & Innovation

• Mécanismes de bien-être : GAK straight feeds into the mitochondrial Krebs cycle (through AKG), producing succinyl-CoA and ATP. Glycine conjugates with ammonia (forming glycine conjugates like hippurate) for renal excretion, decreasing systemic ammonia load. Glycine is important for synthesizing creatine (power metabolism), heme, glutathione, purines, and is a essential part (~33%) of collagen’s amino acid construction. AKG acts as a nitrogen scavenger and precursor for glutamate/glutamine synthesis.

• Present Analysis: Areas of energetic investigation embrace GAK’s function in mitigating sarcopenia, enhancing wound therapeutic, enhancing endothelial perform (through NO modulation), supporting intestine barrier integrity, and potential advantages in metabolic syndrome and liver fibrosis. Research discover optimum dosing regimens for particular functions.

• Trade Purposes: Rising demand in medical diet for essential sickness restoration, geriatric diet, and specialised sports activities efficiency merchandise.

• Innovation: Analysis focuses on novel supply techniques (liposomal, nanoparticle) to reinforce bioavailability and focused supply, and exploring synergistic mixtures with different bioactive elements (e.g., Creatine, HMB, Citrulline).

• Défis : Standardizing medical protocols for various functions, understanding long-term results of high-dose supplementation, and optimizing cost-effective large-scale synthesis whereas sustaining ultra-high purity.

11. Incessantly Requested Questions (FAQ)

• Q: Are you a manufacturing facility or buying and selling firm? A: We’re the direct producteur with built-in R&D and manufacturing services.

• Q: What’s the Minimal Order Amount (MOQ)? A: Commonplace MOQ is 1kg for preliminary trials; bigger en gros orders (25kg+) are commonplace for industrial provide. Contact us for specifics.

• Q: Are you able to present custom-made specs? A: Sure, we concentrate on extrait naturel sur mesure and chemical options, together with particle dimension, purity grades, and particular packaging.

• Q: Do you provide free samples? A: Sure, we offer extrait naturel de motif gratuit for certified B2B prospects and formulation builders. Contact us to request.

• Q : Quelle documentation présentez-vous ? A: Complete documentation consists of COA, MSDS, TDS, Certificates of Evaluation, GMP Certificates, and export documentation.

• Q: What are the lead instances? A: Samples: 3-5 days. Manufacturing lead instances fluctuate based mostly on order dimension and customization (usually 15-30 days). Inventory availability for well-liked gadgets.

• Q: Is that this appropriate for vegan/vegetarian merchandise? A: Sure, our artificial GAK is solely plant-free and appropriate for vegan/vegetarian formulations.

• Q: What’s the shelf life and storage suggestion? A: Commonplace shelf life is 24 months when saved in a cool, dry place (<25°C) within the unique sealed packaging.

12. The place to Purchase & Request Free Samples
Supply premium Glycine Alpha-Ketoglutarate (GAK) straight from the producer. Shaanxi Zhonghong is your trusted accomplice for en gros portions, extrait naturel sur mesure options, and dependable world provide.

• Get Your Free Pattern: Consider our superior high quality. Request your extrait naturel de motif gratuit in the present day!

• Contactez-nous pour des devis et des personnalisations :

  • E-mail: liaodaohai@gmail.com

  • Site web: https://www.aiherba.com (Discover our full catalog of fournisseur d'extraits naturels de plantes options)

13. Conclusion
Glycine Alpha-Ketoglutarate (GAK) stands as a scientifically supported ingredient with multifaceted advantages for power metabolism, detoxing, tissue restore, and general mobile well being. For producteurs searching for a dependable, high-purity supply backed by superior R&D and stringent high quality management, Shaanxi Zhonghong Funding Expertise Co., Ltd. is the premier provider et usine de fabrication. Our dedication to innovation, world logistics experience, and customer-centric strategy (together with extrait naturel de motif gratuit affords) ensures you obtain the optimum ingredient resolution to your subsequent profitable product. Accomplice with us for extrait naturel sur mesure excellence.

14. Références

• [Référence aux études cliniques pertinentes sur GAK/AKG/Glycine – par exemple, sur l'énergie, l'ammoniac, le collagène]

• [Méthodes pharmacopées de référence (USP, EP) pour les tests]

• [Lignes directrices de référence ICH (Q1A, Q2, Q3C, Q3D)]

• Shaanxi Zhonghong Inside High quality Management Documentation & Specs.