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Citric Acid: Nature’s Versatile Natural Powerhouse | Shaanxi Zhonghong Funding Expertise

1. What is Citric Acid?

Citric acid (C₆H₈O₇) is a weak, tricarboxylic organic acid naturally occurring in citrus fruits like lemons, limes, oranges, and grapefruits. It serves as a key intermediate metabolite within the Krebs cycle (citric acid cycle), the first energy-producing pathway in cardio organisms. Industrially, it is one of the crucial broadly used organic acids as a result of its glorious solubility, nice bitter style, chelating properties, and buffering capability. It exists as a white, crystalline powder and is extremely water-soluble.

۲. منبع، خواص شیمیایی و شناسه‌های کلیدی

• منبع تغذیه اصلی: Traditionally extracted from citrus juice. Trendy industrial manufacturing (><｜finish▁of▁pondering｜> of world provide) makes use of submerged fermentation of carbohydrate sources (e.g., molasses, corn starch hydrolysates) by the filamentous fungus آسپرژیلوس نیجر.

• خواص شیمیایی:

  • سیستم مولکولی: C₆H₈O₇

  • ظاهر: Colorless crystals or white crystalline powder.

  • بو: Odorless.

  • Style: Strongly acidic, nice bitter style.

  • حلالیت: Extremely soluble in water, ethanol, and diethyl ether.

  • pKa Values: pKa₁ = 3.13, pKa₂ = 4.76, pKa₃ = 6.40 (at 25°C). This makes it an efficient buffer over a spread related to meals and organic methods.

  • Chelation: Types secure complexes (chelates) with steel ions (e.g., Ca²⁺, Mg²⁺, Fe³⁺), essential for its position in cleansing brokers, meals preservation, and stopping oxidation.

• شناسه‌های کلیدی:

  • تعداد ثبت CAS: 77-92-9 (Anhydrous) | 5949-29-1 (Monohydrate)

  • سیستم مولکولی (MF): C₆H₈O₇

  • وزن مولکولی (MW): 192.124 g/mol (Anhydrous) | 210.14 g/mol (Monohydrate)

  • مقدار EINECS: 201-069-1

3. Benefits, Security, & Issues

• “Greatest” Citric Acid: The “finest” depends upon software. Meals/pharma grades require excessive purity (USP/BP/EP/FCC). Beauty grades want particular purity and microbial management. Shaanxi Zhonghong ensures >99.5% purity, exceeding typical business requirements (typically ~99%), guaranteeing superior efficiency and security.

• Pores and skin Benefits:

  • Alpha Hydroxy Acid (AHA): Features as a gentle AHA, selling light exfoliation by breaking down desmosomes between corneocytes.

  • pH Adjustment: Vital for formulating inside the pores and skin’s optimum acidic mantle (pH 4.5-5.5), enhancing barrier operate.

  • Antioxidant & Chelation: Mitigates oxidative stress from free radicals and steel ions (e.g., Fe²⁺ concerned in Fenton reactions).

  • Brightening: Inhibits tyrosinase exercise and reduces melanin switch, aiding in hyperpigmentation administration. Enhances penetration of different energetic elements.

• Well being Benefits & Dietary Consumption:

  • متابولیسم قدرتی: Central to the mitochondrial Krebs cycle (ATP manufacturing).

  • Mineral Absorption: Chelates minerals, probably enhancing bioavailability (e.g., some types of calcium citrate).

  • Urinary Well being: Alkalinizes urine, probably stopping sure varieties of kidney stones (uric acid, cystine stones).

  • خواص آنتی اکسیدانی: Contributes to mobile antioxidant defenses.

  • میزان مصرف روزانه: Citric acid is Typically Acknowledged As Protected (GRAS) by the FDA and authorised globally (EFSA, JECFA). No established Acceptable Each day Consumption (ADI) exists as a result of it is a regular physique metabolite. Consumption is restricted by palatability and gastrointestinal tolerance. Typical consumption is by way of meals and drinks.

• Potential Facet Results & Precautions:

  • Dental Erosion: Extremely acidic meals/drinks containing citric acid can erode tooth enamel with frequent publicity.

  • GI Irritation: Excessive concentrations might trigger heartburn or abdomen upset in delicate people.

  • Pores and skin Irritation: Undiluted citric acid powder or high-concentration options could cause irritation, stinging, or chemical burns. Beauty formulations are rigorously pH-balanced.

  • Eye Contact: Extreme irritant. Requires fast flushing.

  • Chelation: Can bind important minerals; important dietary imbalance is unlikely however potential with extreme supplementation.

  • تداخلات دارویی: Might have an effect on absorption of sure drugs (e.g., aluminum-containing antacids, some antibiotics). Seek the advice of a healthcare supplier.

4. Shaanxi Zhonghong Funding Expertise: Your Trusted Citric Acid Companion

Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a premier high-tech enterprise integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising and marketing. We concentrate on serving the chemical, materials, and life science sectors, with deep experience within the extraction, separation, purification, and market software of bioactive plant constituents.

• شایستگی‌های اصلی:

  • 🔹قدرت علمی: Strategic alliances with 5 main universities underpin our 20+ patented applied sciences and distinctive international compound library.

  • تعالی تولید: Using cutting-edge analytical instrumentation together with کروماتوگرافی مایع با راندمان بیش از حد (HPLC) و رزونانس مغناطیسی هسته ای ابررسانا (NMR) spectrometers. Our stringent high quality management ensures citric acid purity exceeding business benchmarks by >20%.

  • دستاوردهای بین‌المللی: An intensive distribution community serving 80+ international locations throughout Asia, Europe, and the Americas. We offer bespoke ingredient options to multinational pharmaceutical firms, analysis establishments, and main producers.

  • تجربه تایید شده: Leveraging 28 years of devoted expertise within the bioactive compounds business.

5. Product Specs: Rigorous High quality Assurance

Shaanxi Zhonghigh’s Citric Acid meets or exceeds main pharmacopoeial requirements (USP/BP/EP) and FCC necessities for meals grade. Our dedication to purity and security is demonstrated via complete testing:

6. Manufacturing Course of: Precision Fermentation & Purification

Our citric acid manufacturing leverages state-of-the-art submerged fermentation expertise:

1. Substrate Preparation: Excessive-quality carbohydrate sources (e.g., non-GMO corn starch hydrolysate) are sterilized and conditioned.

2. تخمیر: آسپرژیلوس نیجر is cultivated beneath meticulously managed situations (pH, temperature, aeration, nutrient feed) to maximise citric acid yield.

3. Mycelium Separation: The fungal biomass is eliminated by way of filtration or centrifugation.

4. تصفیه: The broth undergoes lime remedy (precipitation as calcium citrate), adopted by sulfuric acid regeneration to yield citric acid answer.

5. تبلور: The answer is concentrated and crystallized (anhydrous or monohydrate types).

6. خشک کردن و آسیاب کردن: Crystals are dried to express moisture specs and milled to desired particle dimension distribution.

7. High quality Management: Rigorous in-process and ultimate product testing (HPLC, NMR, ICP-MS, microbiological) ensures compliance with specs.

۷. سناریوهای کاربردی

Citric acid’s versatility spans quite a few industries:

• Meals & Beverage (F&B): Main acidulant (tender drinks, juices, candies), taste enhancer, pH adjuster, preservative (chelates steel catalysts of oxidation), antioxidant synergist, emulsifying support in processed cheeses.

• داروهای تجویز شده: Excipient (effervescent formulations, taste masking, pH adjustment in syrups and injections), anticoagulant (blood assortment tubes), chelator in steel cleansing.

• لوازم آرایشی و مراقبت شخصی: pH adjuster (lotions, lotions, shampoos), chelating agent (stabilizes formulations, enhances preservative efficacy), AHA for exfoliation and brightening (serums, peels), antioxidant.

• Family & Industrial Cleaners: Key chelating agent in descaling brokers, dishwasher detergents, lavatory cleaners (removes onerous water stains, rust, lime scale), biodegradable various to phosphates.

• Water Remedy: pH adjustment, chelation of steel ions to forestall scaling/corrosion.

• Different: Textile processing (dyeing, printing), pictures, oilfield chemical substances, concrete setting retardant.

8. High quality Management (QC): Dedication to Excellence

At Shaanxi Zhonghong, QC is paramount. Our built-in QC system ensures constant, premium citric acid:

• بررسی مواد خام: Strict protocols for incoming carbohydrate sources and different inputs, together with id, purity, and contaminant testing.

• کنترل‌های حین اجرا: Actual-time monitoring of crucial fermentation parameters (pH, dissolved oxygen, temperature, sugar focus) and purification steps. Automated methods set off alerts for deviations.

• Superior Analytics: Our ISO 17025 accredited lab makes use of HPLC-UV/ELSD/RID for exact quantification and impurity profiling, ICP-MS/OES for hint heavy metals, GC-MS/MS/LC-MS/MS for pesticide residues, validated microbiological strategies (ISO requirements), تیتراسیون کارل فیشر for moisture, and Potentiometric Titration for assay. FTIR و NMR verify structural id.

• تحقیقات پایداری: Ongoing research beneath ICH tips to ascertain shelf life and storage suggestions.

• مستندسازی و ردیابی: Complete batch information and digital knowledge administration guarantee full traceability from uncooked materials to completed product.

• انطباق: Adherence to cGMP, HACCP, ISO 9001, and related pharmacopoeial/meals security rules (FDA, EFSA).

۹. بسته‌بندی و لجستیک

• بسته بندی: Provided in numerous codecs to go well with buyer wants: 25kg multi-layer kraft paper baggage with polyethylene liner (normal), 1000kg bulk baggage (FIBCs), or customized packaging upon request. All packaging ensures product integrity, moisture safety, and meets worldwide transport rules (IMDG, IATA).

• لجستیک: Leveraging our international community, we offer environment friendly, dependable logistics options by way of sea, air, or land freight. Experience in dealing with customs clearance and documentation for seamless worldwide supply.

10. Well being Efficacy, Functions & Analysis Frontiers

• مکانیسم‌های سلامت: Past its position within the Krebs cycle, analysis explores citric acid’s potential in modulating irritation, enhancing mineral solubility within the intestine, and its position in bone well being (by way of citrate in apatite). Its urinary alkalinization mechanism includes metabolism to bicarbonate.

• نوآوری صنعتی: Focus areas embody optimizing fermentation strains (A. niger engineering) for greater yields and lowered byproducts, growing novel purification methods (e.g., membrane filtration, steady chromatography) for sustainability, and exploring new functions in inexperienced chemistry (biodegradable chelators, catalyst synthesis).

• Analysis Challenges: Key challenges embody decreasing the environmental footprint of manufacturing (water/vitality use, waste streams), enhancing cost-effectiveness for bulk functions, and absolutely elucidating its therapeutic potential at supra-dietary doses in particular situations.

11. Citric Acid FAQ

• Q: Is citric acid pure? A: Sure, it happens naturally in citrus fruits. Most business citric acid is produced by way of microbial fermentation, a pure course of, utilizing plant-derived carbohydrates.

• Q: Is citric acid protected? A: Sure, citric acid is GRAS (Typically Acknowledged As Protected) by the FDA and authorised globally to be used in meals, prescription drugs, and cosmetics when used appropriately.

• Q: Can citric acid expire? A: When saved correctly (cool, dry place in sealed containers), high-purity citric acid is extraordinarily secure. It could take up moisture over very lengthy intervals however stays functionally efficient. Shelf life is usually 3-5 years.

• Q: Does citric acid kill micro organism? A: Whereas acidic situations can inhibit some microbial progress, citric acid is primarily a preservative enhancer via chelation and pH discount. It really works synergistically with different preservatives (e.g., in meals and cosmetics).

• Q: Can I exploit citric acid for cleansing? A: Completely! It is extremely efficient as a descaling agent for kettles, espresso makers, showerheads, and eradicating onerous water stains. Dilute 1-2 tablespoons per cup of heat water.

• Q: How does citric acid profit pores and skin? A: As an AHA, it gently exfoliates useless pores and skin cells, improves texture and radiance, helps fade darkish spots, adjusts pH to help the pores and skin barrier, and acts as an antioxidant.

12. The place to Purchase Excessive-Purity Citric Acid?

Supply premium, high-purity (>99.5%) Citric Acid instantly from the producer:

• وب‌سایت: https://www.aiherba.com

• تماس: آقای لیائو دائوهای

• پست الکترونیکی: liaodaohai@gmail.com

• ارائه دهنده: شرکت فناوری سرمایه‌گذاری شانشی ژونگ‌هونگ

۱۳. نتیجه‌گیری

Citric acid is an indispensable, multi-functional compound with profound significance throughout organic methods and huge industrial functions. From energizing mobile metabolism to preserving meals, enhancing cosmetics, and powering eco-friendly cleaners, its versatility is unmatched. Shaanxi Zhonghong Investment Technology Co., Ltd. delivers citric acid of outstanding purity and consistency, backed by superior fermentation expertise, rigorous high quality management exceeding business requirements, and 28 years of experience in bioactive compounds. We’re dedicated to offering tailor-made, dependable options for international companions in prescription drugs, meals, cosmetics, and past. Contact us in the present day in your citric acid necessities.

۱۴. منابع

1. PubChem Compound Abstract: Citric Acid. Nationwide Library of Drugs. https://pubchem.ncbi.nlm.nih.gov/compound/Citric-acid

2. Meals and Agriculture Group (FAO). Citric Acid. JECFA Monographs. https://www.fao.org/

3. U.S. Meals & Drug Administration (FDA). SCOGS Database: Citric Acid. https://www.fda.gov/

4. European Meals Security Authority (EFSA). Re-evaluation of citric acid (E 330)… EFSA Journal.

5. Soccol, C. R., et al. (2006). Citric acid manufacturing. Meals Expertise and Biotechnology.

6. Beauty Ingredient Evaluate (CIR). Security Evaluation of Citric Acid… Worldwide Journal of Toxicology.

7. Max, B., et al. (2010). Citric acid manufacturing. Latest Patents on Biotechnology.

8. Related Pharmacopoeias: United States Pharmacopeia (USP), European Pharmacopoeia (Ph. Eur.), British Pharmacopoeia (BP), Meals Chemical substances Codex (FCC).