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Hydroxypropyl Tetrahydropyrantriol (Pro-Xylane™): The Ultimate Guide by Zhonghong Tech

1. What is Hydroxypropyl Tetrahydropyrantriol?
Hydroxypropyl Tetrahydropyrantriol, commonly known by its trade name Pro-Xylane™, is a highly acclaimed cosmetic active ingredient derived from the natural sugar xylose. It is a C-glycoside derivative specifically engineered to mimic the structure of glycosaminoglycans (GAGs), fundamental components of the skin’s extracellular matrix (ECM). This biomimetic molecule is renowned for its potent propiedades antienvejecimiento, primarily through stimulating dermal matrix regeneration, mejorando skin firmness, and improving epidermal hydration.

2. Origen del producto, propiedades químicas e identificación

• Fuente: Synthesized from renewable plant-derived xylose via a complex green chemistry process involving hydrogenation and hydroxypropylation.

• Naturaleza química: A tetrasubstituted tetrahydropyran ring structure with hydroxypropyl chains. It is a soluble en agua, non-ionic molecule.

• Identificadores clave:

  • Número CAS: 439685-79-7

  • Fórmula molecular (MF): C₈H₁₆O₄

  • Peso molecular (PM): 176.21 g/mol

  • Número EINECS: Not formally assigned for this specific derivative, but compliance is ensured via full chemical characterization and safety dossiers (e.g., Cosmetic Ingredient Review, RIPT studies).

3. Why Zhonghong Tech’s Hydroxypropyl Tetrahydropyrantriol is the Best Choice
Shaanxi Zhonghong Investment Technology Co., Ltd. sets the industry benchmark for premium Hydroxypropyl Tetrahydropyrantriol:

• Ingrediente: High-Purity (>99.5%) Hydroxypropyl Tetrahydropyrantriol (Pro-Xylane™ grade).

• Eficacia (Cumplimiento):

  • Clinically Proven: Estimula fibroblast activity y collagen IV, laminin V, y glycosaminoglycan (GAG) synthesis.

  • Visible Results: Significantly improves skin firmness, elasticidad, and reduces wrinkle depth. Mejora hidratación de la piel and barrier function.

  • Full Compliance: Meets stringent global cosmetic regulations (EU Cosmetic Regulation 1223/2009, FDA guidelines, China NMPA). Supported by comprehensive safety assessments (including RIPT – Repeat Insult Patch Testing).

• Origen: Proudly manufactured in China under Buenas prácticas de fabricación actuales conditions at our state-of-the-art facility in Shaanxi.

• Uso: Typical incorporation levels range from 1% to 5% in final cosmetic formulations (creams, serums, lotions). Excellent compatibility with most cosmetic bases.

• Público objetivo: Formulators creating premium cuidado de la piel antienvejecimiento, firming treatments, hydrating serums, and products targeting dermal matrix rejuvenation.

• Beneficios para la salud y dosis:

  • Topical Application Only. Not for ingestion. Health benefits are strictly dermatological:

    • Enhanced dermal-epidermal junction (DEJ) integrity.

    • Increased skin density and thickness.

    • Improved skin moisturization and barrier resilience.

    • Reduction in visible signs of chronological and photo-aging.

  • Ingesta diaria: N/A (Topical use). Applied concentration in final product is key (1-5%).

• Precauciones y efectos secundarios:

  • Generally well-tolerated with an excellent safety profile.

  • Conducta patch testing during formulation development and as per standard cosmetic safety protocols.

  • Potential for mild, transient skin irritation in very sensitive individuals (rare).

  • Avoid contact with eyes. Discontinue use if irritation occurs. Consult a dermatologist if concerned.

4. Zhonghong Tech: Your Trusted Partner in Advanced Cosmetic Actives
Tecnología de inversión Shaanxi Zhonghong Co., Ltd. es un primer ministro empresa de alta tecnología integrating cutting-edge R&D, collaborative innovation, integrated manufacturing, and global distribution. We specialize in compuestos bioactivos for the chemical, material, and life science sectors, with a core expertise in extracción de plantas, purification, and advanced applications.

• Proeza científica: Apalancamientos 5 university joint-labs and holds Más de 20 patentes. Maintains a biblioteca de compuestos global propietaria.

• Liderazgo analítico: Equipado con HPLC (cromatografía líquida de alta resolución), UPLC (LC de ultra rendimiento), y NMR (Nuclear Magnetic Resonance) spectroscopy, asegurando estándares de pureza que superan las normas de la industria en >20%.

• Alcance global: Suministros soluciones de ingredientes personalizadas to multinational pharmaceutical corporations, research institutions, and leading cosmetic brands across más de 80 países en Asia, Europa y las Américas.

• Legado: 28 años de excelencia in sourcing, developing, and manufacturing high-grade bioactive molecules.

5. Product Benefits & Advantages

• Potent Anti-Aging: Directly targets dermal matrix components for visible rejuvenation.

• Proven Hydration: Enhances skin’s natural moisture retention capacity.

• Improved Skin Barrier: Strengthens the skin’s protective function.

• Biomimetic & Sustainable: Inspired by skin biology, derived from renewable xylose.

• Exceptional Stability & Compatibility: Easy to formulate with, high performance in diverse bases.

• Safety Assured: Backed by rigorous testing and regulatory compliance.

6. Application Guide

• Recommended Use Level: 1% – 5% in the final cosmetic formulation.

• Incorporation: Add to the water phase at temperatures below 40°C (104°F) for optimal stability. Compatible with most emulsifiers and common cosmetic ingredients.

• Formulaciones objetivo: Anti-aging creams/serums, firming lotions, hydrating masks, eye contour treatments, premium day/night care.

7. Product Specifications & Certificate of Analysis (COA)
Zhonghong Tech guarantees unparalleled quality and traceability. Our COA includes comprehensive testing:

8. Advanced Production Flow
Our manufacturing utilizes green chemistry principles:

1. Abastecimiento: Premium plant-derived Xylose.

2. Hydrogenation: Catalytic reduction under controlled conditions.

3. Hydroxypropylation: Selective addition of propylene oxide.

4. Purificación: Multietapa cromatografía (including HPLC preparativa) y nanofiltración.

5. Concentración: Liofilización (Freeze-drying) or low-temperature vacuum evaporation.

6. Strict Quality Control: In-process checks and final release testing per COA specs.

9. Key Application Scenarios

• Premium Anti-Aging Skincare (Serums, Creams, Lotions)

• Firming & Lifting Treatments

• Intensive Hydration & Barrier Repair Products

• Eye Contour Creams/Gels

• Neck & Décolleté Treatments

• Professional Spa & Clinical Formulations

10. Control de calidad riguroso
Zhonghong Tech’s QC is the cornerstone of our reliability. Our ISO 17025-accredited quality control laboratory employs a multi-tiered analytical strategy:

• Confirmación de identidad: Espectroscopia FTIR, NMR (1H, 13C), y HPLC-UV/MS ensure molecular integrity.

• Purity & Potency: UPLC/HPLC with ELSD/CAD/UV detection provides precise quantification (>99.5% purity standard). HPLC quiral confirms stereochemical purity.

• Impurity Profiling: LC-MS/MS y GC-MS detect and quantify trace organic impurities and residual solvents per ICH Q3A/Q3C pautas.

• Elemental Analysis: ICP-MS guarantees compliance with global heavy metal limits (As, Pb, Cd, Hg) for cosmetics.

• Microbiological Safety: Sterility testing y bioburden assessment (TAMC, TYMC, pathogen screening) following USP <61>/<62> y EP 2.6.12/2.6.13.

• Estudios de estabilidad: ICH Q1A-Q1E compliant real-time and accelerated stability programs ensure product shelf-life and performance under various conditions. Robustness testing validates method reliability. Batch traceability is absolute.

11. Embalaje seguro y logística global

• Embalaje: 1kg, 5kg HDPE bottles; 25kg HDPE drums. Custom packaging available. Tamper-evident seals.

• Almacenamiento: Store tightly sealed in a cool (<25°C), dry place, protected from light. Shelf life: 24 months from manufacture date.

• Logística: Efficient global shipping via air/sea freight. Comprehensive cold chain management available. Expertise in export documentation and customs clearance.

12. Health Efficacy, Mechanism & Industry Innovation

• Mecanismo de acción: Pro-Xylane™ acts as a biomimetic glycosaminoglycan (GAG) precursor. It penetrates the epidermis and stimulates dermal fibroblasts to synthesize key extracellular matrix (ECM) components:

  • Collagen IV & Laminin V: Crucial proteins forming the dermal-epidermal junction (DEJ), enhancing skin firmness and resilience.

  • Glycosaminoglycans (GAGs): Like hyaluronic acid, improving hydration and skin plumping.

  • Elastin: Contributing to skin elasticity. This ECM remodeling visibly reduces wrinkles and improves skin tone.

• Evidencia clínica: Numeroso in vivo studies demonstrate significant improvements in skin firmness, elasticity, wrinkle depth, and hydration within weeks of topical application.

• Industry Application: A gold-standard ingredient in high-efficacy anti-aging cosmetics globally.

• Innovación: Research focuses on novel delivery systems (liposomes, nanoemulsions) for enhanced penetration and sustained release. Synergistic combinations with peptides, retinoids, and antioxidants are actively explored.

• Fronteras y desafíos de la investigación: Ongoing work aims to fully elucidate signaling pathways. Challenges include optimizing cost-effective large-scale synthesis while maintaining ultra-high purity and exploring new dermatological indications.

13. Preguntas frecuentes (FAQ)

• Q1: Is Hydroxypropyl Tetrahydropyrantriol natural? A: It is derived from natural xylose but is synthetically modified (nature-identical). It is considered a green chemistry ingredient.

• Q2: What is the recommended usage level? A: Typically 1% to 5% in the final cosmetic formulation.

• Q3: Is it safe for sensitive skin? A: It has an excellent safety profile. However, as with any active, patch testing is recommended during formulation and for end-users with known sensitivities.

• Q4: Does it replace Retinol or Vitamin C? A: It works differently, targeting the dermal matrix. It is often used synergistically with retinoids (cell renewal) and antioxidants (protection) for comprehensive anti-aging.

• Q5: What is the shelf life? A: 24 months when stored properly (cool, dry, dark place).

• Q6: Is it vegan and cruelty-free? A: Yes, Zhonghong Tech’s ingredient is vegan and not tested on animals. We comply with international cruelty-free standards.

• Q7: What certifications do you hold? A: We operate under cGMP, ISO 9001, ISO 14001, and ISO 45001. Specific product certifications (e.g., COSMOS, Ecocert) depend on the final formulation.

14. Where to Buy & Request Samples
Elevate your formulations with premium Hydroxypropyl Tetrahydropyrantriol from Zhonghong Tech.

• Purchase Inquiries & Bulk Orders: Contact our global sales team.

• Request Your FREE Sample: Experience the Zhonghong Tech quality difference firsthand! Email: liaodaohai@gmail.com

• Learn More & Explore Our Portfolio: Visit our website: https://aiherba.com

15. Conclusión
Hydroxypropyl Tetrahydropyrantriol (Pro-Xylane™) remains a cornerstone anti-aging active ingredient due to its proven efficacy in stimulating dermal matrix regeneration and improving skin hydration and firmness. Choosing a supplier like Tecnología de inversión Shaanxi Zhonghong Co., Ltd. guarantees access to the highest purity standard (>99.5%), respaldado por 28 años de experiencia en compuestos bioactivos, cutting-edge analytical capabilities (HPLC, UPLC, NMR), y rigorous QC exceeding industry normsNuestro compromiso con scientific innovation y global compliance makes us the ideal partner for cosmetic brands formulating high-performance, evidence-based skincare solutions. Contact us today for samples and technical data sheets.

16. Referencias

1. L’Oréal Research Publications on Pro-Xylane™ (Original Patent Holder – Mechanism & Efficacy).

2. Cosmetic Ingredient Review (CIR) Safety Assessment of Glycosides.

3. International Journal of Cosmetic Science: Articles on Biomimetic Ingredients & Skin Aging.

4. Journal of Investigative Dermatology: Research on ECM Synthesis & Skin Rejuvenation.

5. ICH Guidelines (Q1A-Q1E Stability, Q3A-Q3D Impurities).

6. USP/EP Pharmacopoeial Methods (Microbiology, Heavy Metals).

7. Zhonghong Tech Internal Research & Validation Data (Available upon request under NDA).