Pachymic Acid
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Pachymic Acid

Rated 5.00 out of 5 based on 1 customer rating
(1 customer review)
  1. Product Overview
    English Name: Pachymic Acid
    Biological Source: Pachymic acid is a triterpenoid compound mainly extracted from Poria cocos, a fungus with a long – standing use in traditional Asian medicine. This fungus grows on the roots of pine trees and has been valued for its various health – related properties.
  2. Specification:Purity: Pachymic Acid ≥ 98% (HPLC – tested). The extraction process is complex and involves multiple steps. Initially, Poria cocos is processed to break down the cell structure and release the compounds. Solvent – based extraction is often used to isolate pachymic acid from other components. This is followed by purification steps such as column chromatography to achieve the high – level purity required. Stringent quality control measures are implemented to limit heavy metals, pesticides, and microbial contaminants, ensuring compliance with international standards for pharmaceutical, cosmetic, and food – related applications.
  3. Appearance:It appears as a white to off – white crystalline powder. The powder is free – flowing and has a very faint, almost negligible odor.
  4. CAS  NO.: 16080 – 29 – 2. This unique identifier is crucial for chemical identification, research, and regulatory compliance in the global market.
  5. Lead Time: 3 – 7 Working Days. Minor adjustments may occur based on order volume and production capacity. Our production facilities are equipped with advanced extraction and purification equipment, and our logistics network is optimized for timely delivery. However, factors such as the availability of Poria cocos raw material (which can be influenced by environmental and seasonal factors) may slightly impact the lead time.
  6. Package: Usually packaged in 25kg food – grade drums, with 27 drums per tray for convenient transportation. The drums are made of materials that protect the product from moisture, light, and physical damage during storage and transportation. Custom packaging options, such as smaller containers for laboratory use or larger bulk containers for industrial applications, are available upon request.
  7. Main Market: European, North America, Asia etc. In Asia, especially in China, Japan, and Korea, Poria cocos and its derivatives have a long – standing traditional use. In Europe and North America, with the growing interest in natural health products and traditional medicine – derived ingredients, pachymic acid is gaining attention.
  8. Applications
    • Health Supplements:
      • Anti – inflammatory: Pachymic acid exhibits significant anti – inflammatory properties. It can inhibit the production of inflammatory mediators in the body, such as cytokines and prostaglandins. This makes it beneficial for conditions like arthritis, where it can reduce joint inflammation and pain. Inflammatory bowel disease patients may also experience relief as it can soothe the inflamed intestinal lining.
      • Antioxidant: Acting as a powerful antioxidant, it scavenges free radicals. Free radicals are highly reactive molecules that can cause oxidative damage to cells, leading to various chronic diseases. By neutralizing these free radicals, pachymic acid helps protect cells from damage, potentially reducing the risk of heart disease, cancer, and neurodegenerative disorders.
      • Immune System Modulation: It can modulate the immune system. Pachymic acid may enhance the activity of immune cells such as macrophages, which are responsible for engulfing and destroying pathogens. Additionally, it can stimulate the production of T – lymphocytes and B – lymphocytes, which are key players in the body\’s adaptive immune response. This immune – boosting effect helps the body defend against infections and diseases more effectively.
    • Cosmetics:
      • Skin Soothing: Its anti – inflammatory nature makes it effective in soothing irritated skin. For acne – prone skin, pachymic acid can reduce the redness and inflammation associated with breakouts. In cases of eczema and psoriasis, it can alleviate itching and calm the inflamed skin, promoting a more comfortable and healthier complexion.
      • Anti – aging: By protecting skin cells from oxidative stress, it helps reduce the appearance of fine lines, wrinkles, and age spots. It also promotes collagen synthesis, which is essential for maintaining skin elasticity. This results in a more youthful – looking and firm skin.
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Skin Soothing Pachymic Acid: Premium Bioactive Triterpenoid for Pharmaceutical & Nutraceutical Applications

1. Product Introduction

Pachymic Acid (C33H52O5) is a pharmacologically active lanostane-type triterpenoid predominantly isolated from the sclerotium of Poria cocos (茯苓), a revered medicinal fungus in Traditional Chinese Medicine (TCM). As a high-purity (>98%) standardized extract, it demonstrates remarkable:

Pachymic Acid Pachymic Acid

  • Anti-inflammatory activity via COX-2 and TNF-α suppression

  • Neuroprotective effects through Nrf2/ARE pathway activation

  • Antitumor potential by inducing caspase-dependent apoptosis

  • Hepatorenal protective properties against oxidative damage

Our pharmaceutical-grade Pachymic Acid is produced under cGMP conditions, validated by HPLC-ELSD and qNMR to ensure batch-to-batch consistency for clinical research and commercial formulations.

2. Company Profile: Shaanxi Zhonghong Investment Technology Co., Ltd.

As a ISO 9001:2015 & ISO 13485 certified manufacturer, we integrate:

Core Competencies

Differentiator Technical Specification
Academic Collaboration Joint labs with Peking University, ETH Zurich
IP Portfolio 23 patents (including 5 PCT international patents)
Analytical Capability UHPLC-QTOF-MS, 600MHz NMR with cryoprobe
Global Distribution FDA/DMF filed for US/EU markets

Our 28-year expertise in plant extraction delivers 20% higher bioavailability compared to industry averages through proprietary subcritical water extraction (SWE) technology.

3. Botanical Source & Extraction Methodology

  • Source Material: Wild-harvested Poria cocos from GAP-certified forests in Yunnan Province

  • Extraction Process:

    1. Decoction optimization: 8:1 water-to-material ratio at 95°C

    2. Macroporous resin purification: AB-8 resin, 75% ethanol elution

    3. Crystallization: Gradient cooling to obtain >98% purity crystals

  • Identity Confirmation:

    • FTIR (KBr pellet): 3420 cm⁻¹ (OH), 1695 cm⁻¹ (C=O)

    • ¹³C-NMR: 38 characteristic peaks matching USP reference standard

4. Clinical-Grade Health Benefits

Mechanistic Pharmacodynamics

Benefit Mode of Action Effective Dose
Anti-arthritic Downregulates MMP-13 via JNK/AP-1 pathway 50 mg/kg/day
Nootropic Enhances BDNF expression in hippocampal neurons 100 mg/kg/day
Chemopreventive Inhibits STAT3 phosphorylation in TNBC cells IC50 = 12.7 μM

Dosing Protocols

  • Nutraceutical use: 50-150 mg/day enteric-coated capsules

  • Topical formulations: 0.5-2% w/w in anti-aging serums

  • Contraindications: Not recommended during immunosuppressive therapy

5. Rigorous Quality Specifications

Triple-Verification Testing Protocol

Table 1: Comprehensive QC Parameters

Category Test Item Specification Method
Pesticides Chlorpyrifos ≤0.01 mg/kg GC-MS/MS (EU 396/2005)
Hexachlorobenzene ND EPA 8081B
Heavy Metals As (Arsenic) ≤0.5 ppm ICP-OES (USP <232>)
Hg (Mercury) ≤0.1 ppm Cold vapor AAS
Microbiology E. coli Absent in 10g USP <62>
Aflatoxins (B1+B2+G1+G2) ≤5 ppb total HPLC-FLD

6. Industrial-Scale Production Workflow

  1. Raw Material Qualification: DNA barcoding (ITS2 region sequencing)

  2. Continuous Extraction: Dynamic countercurrent extraction at 85°C

  3. Chromatographic Purification:

    • Preparative HPLC (C18 column, MeOH:H₂O = 85:15)

    • Chiral separation for enantiomeric purity (>99% ee)

  4. Lyophilization: 48h freeze-drying to preserve thermolabile compounds

7. Cutting-Edge Applications

Emerging Sector Utilization

  • Oncology Adjuvants: Synergizes with paclitaxel (1.8-fold ↑ apoptosis in MDA-MB-231)

  • Cosmeceuticals: Inhibits melanogenesis by 63% vs. arbutin (at 50 μM)

  • Veterinary Medicine: Canine cognitive dysfunction syndrome management

8. Quality Assurance Ecosystem

Our 360° quality control implements:

  • Stability Studies: 24-month accelerated testing per ICH Q1A guidelines

  • Elemental Impurities: Full compliance with USP <232>/<233>

  • Residual Solvents: Class 1 solvents <1 ppm by HS-GC

  • Forced Degradation: Acid/alkali/oxidative stress testing for impurity profiling

9. Smart Packaging Solutions

  • Primary: Nitrogen-flushed amber glass vials with PTFE-lined caps

  • Bulk: Double-layer aluminized bags with oxygen scavengers

  • Cold Chain: 2-8°C transport with real-time TempTale® monitoring

10. Research Frontiers & Challenges

Innovation Pipeline

  • Nanoemulsion Delivery: Improving oral bioavailability from 12% to 38%

  • Synthetic Biology: Heterologous production in Yarrowia lipolytica

Technical Hurdles

  • Crystalline Polymorphism: Form I vs. Form II stability issues

  • Metabolite Identification: Phase II glucuronidation pathways

11. Expert FAQ

Q: How does your Pachymic Acid compare with competitors?
*A: Our UHPLC-ELSD quantification shows 102.3% potency vs. 89-95% in market samples.*

Q: Shelf life under different storage conditions?
*A: 36 months at -20°C with <0.5% degradation annually (HPLC tracking).*

12. Conclusion

This GMP-certified Pachymic Acid represents the next-generation triterpenoid standard, combining ethnopharmacological validation with cutting-edge analytical verification for premium therapeutic applications.

13. Authoritative References

  1. Journal of Natural Products (2023) – Structural modification studies

  2. EDQM Certification No. CERT-03872-2024

  3. WHO Guidelines on Herbal Medicine Quality (2022)

#Pharmaceutical-grade Pachymic Acid, #GMP-certified triterpenoid, #Poria cocos extract 98%,# anti-inflammatory natural compound, bioactive mushroom extract supplier*

Weight 1000 克
Dimensions 20 × 10 × 10 厘米

1 review for Pachymic Acid

  1. Avatar Of Q
    评分 5 &sol; 5

    Q –

    The price is very good, the price is reasonable, the delivery is fast, the quality is good, it is worth buying

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