Unlocking the Energy of Flavonol Glycosides: Nature’s Bioactive Treasures| Supplier & Manufacturer

1. What are Flavonol Glycosides?

Flavonol glycosides are a outstanding subclass of flavonoids, characterised by a flavonol aglycone core (like quercetin, kaempferol, or myricetin) conjugated to a number of sugar moieties (glycosylation). This glycosylation considerably enhances their water solubility and bioavailability in comparison with their aglycone counterparts. They’re ubiquitous secondary metabolites within the plant kingdom, serving very important features in plant physiology (UV safety, pigmentation, protection) and imparting important bioactive properties useful to human well being.

2. Sources, Chemical Id & Properties

• Main Botanical Sources: Plentiful in fruits (apples, berries, grapes, citrus), greens (onions, kale, broccoli, tomatoes), tea (particularly inexperienced tea), cocoa, pink wine, and particular medicinal herbs (ginkgo biloba, St. John’s Wort, sophora japonica).

• Core Chemical Construction: Includes a 15-carbon skeleton (C6-C3-C6) with a carbonyl group at C4, a hydroxyl group at C3, and a double bond between C2 and C3. Glycosylation usually happens on the C3 or C7 hydroxyl place. Widespread sugar items embrace glucose, galactose, rhamnose, and rutinose.

• Key Chemical Properties:

  • Solubility: Hydrophilic attributable to glycosylation, soluble in water, methanol, ethanol; insoluble in non-polar solvents.

  • Stability: Delicate to extended warmth, alkaline situations, UV gentle, and oxidation; optimum stability in acidic pH.

  • Reactivity: Possess antioxidant capability primarily through phenolic hydroxyl teams. Can bear hydrolysis (enzymatic or acid-catalyzed) to launch the aglycone and sugar.

• Chemical Identifiers (Consultant – Quercetin-3-O-glucoside/Isoquercitrin):

  • CAS: 482-35-9

  • MF: C₂₁H₂₀O₁₂

  • MW: 464.38 g/mol

  • EINECS: 207-580-9
    (Notice: Particular identifiers differ considerably relying on the precise aglycone and glycoside mixture).

3. Efficacy, Well being Benefits & Security

• What is “Greatest”? The “finest” flavonol glycoside relies upon closely on the specified utility and mechanism. Quercetin glycosides (particularly isoquercitrin and rutin) are probably the most extensively researched and generally present in excessive concentrations inside vegetation and industrial extracts. They’re usually thought of benchmarks for bioavailability and broad-spectrum exercise.

• Highest Content Sources: Meals exceptionally wealthy in particular flavonol glycosides embrace:

  • Quercetin Glycosides: Onions (esp. pink), apples (pores and skin), capers, kale, broccoli, tea.

  • Kaempferol Glycosides: Kale, broccoli, tea, grapefruit, ginkgo biloba.

  • Myricetin Glycosides: Berries (cranberries, blackcurrants), walnuts, fennel.

• Well being Benefits & Mechanisms:

  • Potent Antioxidant Exercise: Scavenge free radicals (ROS/RNS), upregulate endogenous antioxidant enzymes (SOD, CAT, GPx) through Nrf2 pathway activation.

  • Cardiovascular Help: Enhance endothelial operate (stimulate NO manufacturing), cut back LDL oxidation, inhibit platelet aggregation, modulate blood stress.

  • Anti-inflammatory Results: Inhibit pro-inflammatory enzymes (COX-2, LOX) and cytokines (TNF-α, IL-6) through NF-κB and MAPK signaling modulation.

  • Metabolic Well being: Enhance insulin sensitivity, assist glucose uptake, regulate lipid metabolism (AMPK activation).

  • Neuroprotective Potential: Cross BBB, cut back neuroinflammation, defend neurons from oxidative stress (potential in cognitive decline).

  • Vasoprotective & Anti-edema: Rutin particularly strengthens capillaries and reduces permeability.

• Day by day Consumption: There isn’t a established Advisable Dietary Allowance (RDA). Observational research hyperlink well being advantages to intakes of >500 mg complete flavonoids per day, primarily from numerous entire meals. Supplemental doses in scientific trials usually vary from 100-1000 mg/day of particular flavonol glycosides (e.g., isoquercitrin, rutin).

• Concerns & Aspect Results:

  • Typically Acknowledged as Protected (GRAS) at dietary and typical supplemental ranges.

  • Potential Aspect Results (Excessive Doses): Delicate GI upset (nausea, heartburn), headache.

  • Drug Interactions: Could work together with blood thinners (warfarin), antibiotics (quinolones), and medicines metabolized by CYP3A4/P-gp (seek the advice of doctor).

  • Allergy symptoms: Uncommon, however doable, particularly if delicate to supply vegetation.

  • High quality Issues: Supply from respected suppliers making certain purity and absence of contaminants (heavy metals, solvents, pesticides).

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Associate in Bioactives
Shaanxi Zhonghong stands as a premier high-tech enterprise devoted to excellence within the chemistry, supplies, and life science sectors. With 28 years of specialised experience in bioactive compounds, we’re leaders within the extraction, isolation, and purification of potent plant constituents.

• Core Focus: Superior extraction of plant lively elements for numerous markets: pure extracts, beauty actives, nutraceuticals, pharmaceutical intermediates, pure pigments (anthocyanins, carotenoids), and sweeteners (mogrosides).

• Unmatched Scientific Rigor:

  • Analysis Fortress: Collaborative Joint Laboratories with 5 elite universities.

  • IP Management: Portfolio of 20+ patented applied sciences and a globally unique compound library.

  • Chopping-Edge Analytics: Outfitted with HPLC, UPLC, GC-MS, and Superconducting NMR for unparalleled characterization. Our dedication to >98% purity (validated by HPLC) exceeds business requirements by >20%, guaranteeing premium high quality.

• International Attain & Customization: Our in depth community seamlessly serves 80+ international locations throughout Asia, Europe, and the Americas. We excel in delivering personalized, cGMP-compliant ingredient options tailor-made to the precise R&D and manufacturing wants of multinational pharmaceutical companies, analysis establishments, and main nutraceutical manufacturers.

5. Flavonol Glycosides: Sourcing, Benefits & Steerage

• Premium Sourcing: Zhonghong makes use of licensed, sustainably harvested botanical uncooked supplies (e.g., Sophora japonica buds for rutin, ginkgo leaves for quercetin/kaempferol glycosides, onion skins for isoquercitrin) sourced globally. Our vertically built-in course of ensures traceability from farm to last product.

• Well being Benefits Recap: As detailed in Part 3, key advantages focus on highly effective antioxidant protection, cardiovascular and metabolic assist, anti-inflammatory motion, and neuroprotection.

• Utilization Tips:

  • Dietary: Prioritize consumption by way of flavonol-rich fruits, greens, tea, and cocoa.

  • Supplementation: Observe product-specific labeling. Typical doses vary from 50mg to 500mg of standardized extract per serving. Typically taken with meals.

  • Beauty: Included into serums, lotions (0.1-5%) for antioxidant and anti-aging advantages.

  • Analysis: Used as reference requirements or bioactive probes in biochemical assays.

• Key Precautions:

  • Seek the advice of a healthcare supplier earlier than supplementation, particularly if pregnant, breastfeeding, taking drugs, or having a medical situation.

  • Adhere to really helpful dosages.

  • Select merchandise with verified purity and focus (COA out there).

6. Rigorous Product Specs

(Specs are indicative; precise limits topic to particular product & grade. Compliant with USP, EP, CP, FDA, and EU laws).

7. Superior Manufacturing Course of
Zhonghong employs state-of-the-art, cGMP-compliant manufacturing:

1. Uncooked Materials Qualification: Rigorous ID testing (HPLC, TLC) and contaminant screening.

2. Extraction: Optimized solvent extraction (e.g., ethanol/water) or supercritical fluid extraction (SFE-CO2) for heat-sensitive compounds.

3. Main Purification: Macroporous resin adsorption chromatography for environment friendly enrichment.

4. Excessive-Decision Separation: Preparative HPLC or counter-current chromatography (CCC) for isolating particular flavonol glycosides to ultra-high purity (>95-98%).

5. Focus & Drying: Vacuum evaporation adopted by lyophilization (freeze-drying) or spray drying to protect bioactivity.

6. Mixing & Standardization: Exact formulation to fulfill goal efficiency specs.

7. Packaging: Below managed humidity/temperature in food-grade, light-protected containers.

8. Numerous Application Scenarios

• Nutraceuticals & Useful Meals: Key elements in capsules, tablets, powders, drinks, and fortified meals concentrating on antioxidant assist, coronary heart well being, cognitive operate, and anti-aging.

• Cosmeceuticals: Valued in anti-aging serums, lotions, and sunscreens for potent antioxidant safety, UV harm mitigation, collagen synthesis assist, and anti inflammatory results (cut back redness).

• Pharmaceutical Intermediates: Function precursors or lively elements for creating medicine concentrating on irritation, metabolic issues, or vascular ailments.

• Analysis Reagents: Excessive-purity requirements (>98% HPLC) used as reference supplies in biochemical, pharmacological, and metabolic research.

9. Stringent High quality Management (QC)
Zhonghong’s QC paradigm is constructed on id, purity, efficiency, and security, exceeding pharmacopeial requirements:

• Id Affirmation: FT-IR, UV-Vis spectroscopy, and co-injection with reference requirements on HPLC-DAD/ELSD.

• Purity & Assay: Validated HPLC-UV/DAD strategies (ICH Q2(R1) compliant) quantify complete and particular person flavonol glycosides towards licensed reference requirements. UPLC-MS/MS confirms id and detects hint impurities. Superconducting NMR (600MHz+) gives definitive structural elucidation.

• Contaminant Management: Strict adherence to specs for residual solvents (GC-HS/FID), heavy metals (ICP-MS), pesticides (GC-MS/MS, LC-MS/MS), and microbiological load (as per desk above). Common Elemental Impurities testing (USP <232>/<233>).

• Stability Research: Conducting ICH Q1A(R2) compliant accelerated & long-term stability research to outline shelf life, storage situations, and retest durations. Parameters embrace assay, associated substances, water content material (KF), and bodily attributes.

• Documentation: Complete Certificates of Evaluation (CoA) for each batch, traceable manufacturing data, and strict adherence to ISO 9001 & cGMP high quality programs.

10. Safe Packaging & International Logistics

• Packaging: Multi-barrier packaging ensures stability: inside double polyethylene luggage sealed inside food-grade HDPE drums or kraft foil luggage. Desiccants and oxygen scavengers included as required. Mild-protected supplies used.

• Storage: Keep in a cool (<25°C), dry (RH<60%) surroundings, protected against gentle. Lengthy-term storage really helpful at 2-8°C for optimum stability.

• Logistics: Environment friendly international transport through air freight (DAP, DDP) or sea freight (FOB, CIF). Experience in dealing with temperature-sensitive cargo and navigating complicated customs clearance and import laws worldwide. Complete documentation supplied.

11. Analysis Insights: Mechanisms, Functions & Future

• Well being Mechanisms: Ongoing analysis delves deeper into signaling pathways (Nrf2, AMPK, SIRT1, NF-κB), epigenetic modulation, intestine microbiota interactions (bioconversion to lively metabolites), and mobile senescence regulation. Quercetin-3-glucoside’s superior bioavailability through SGLT1 transport is well-established.

• Industrial Innovation: Focus areas embrace enzymatic glycosylation to create novel, extra bioavailable analogs, inexperienced extraction applied sciences (eutectic solvents, pressurized liquids), nanocarrier programs (liposomes, PLGA NPs) for enhanced supply and stability, and biotechnological manufacturing utilizing engineered microbes or plant cell cultures.

• Analysis Frontiers & Challenges: Key challenges contain understanding complicated metabolite profiles in vivo, scientific translation of mechanistic findings (large-scale, long-term human trials), establishing definitive dose-response relationships and well being declare substantiation (EFSA/FDA), and bettering stability in formulated merchandise. Synergistic results throughout the “flavonoidome” are a serious frontier.

12. Regularly Requested Questions (FAQ)

1. Q: What is the distinction between flavonols and flavonol glycosides?

   • A: Flavonols (e.g., quercetin) are the aglycone core. Flavonol glycosides have sugars hooked up, enhancing water solubility and sometimes bioavailability.

2. Q: Which meals has the very best flavonol glycoside content material?

   • A: Onions (quercetin glycosides), kale (kaempferol glycosides), and berries/capers are exceptionally wealthy sources.

3. Q: Are flavonol glycosides secure?

   • A: Typically secure at dietary and customary supplemental ranges. Seek the advice of a health care provider earlier than high-dose supplementation, particularly if on remedy.

4. Q: What is the really helpful each day consumption?

   • A: No official RDA. Intention for numerous flavonoid-rich meals (>500mg complete flavonoids/day). Dietary supplements usually present 100-500mg particular glycosides.

5. Q: Can I take flavonol glycosides with drugs?

   • A: Potential interactions exist (blood thinners, antibiotics, CYP3A4 substrates). At all times seek the advice of your doctor or pharmacist.

6. Q: How does Zhonghong guarantee purity?

   • A: By way of patented purification, HPLC/UPLC (>98% purity), NMR affirmation, and strict contaminant management exceeding pharmacopeial requirements (see QC part).

7. Q: Do you supply customization?

   • A: Sure! We specialise in customized extraction, isolation of particular glycosides, and tailor-made formulations (efficiency, ratios, supply programs) for B2B shoppers.

8. Q: What is your minimal order amount (MOQ)?

   • A: MOQ varies by product and purity grade. Contact us for particular particulars (analysis customary vs. bulk ingredient).

9. Q: The place can I purchase Zhonghong’s Flavonol Glycosides?

13. The place to Purchase & Contact Data
Supply premium, high-purity Flavonol Glycosides straight from the producer:

• Web site: Discover our product portfolio: aiherba.com

• E-mail: Contact our gross sales and technical crew: liaodaohai@gmail.com

• Request: For particular inquiries, quotations, or to request a Certificates of Evaluation (CoA), please e mail us.

14. Conclusion
Flavonol glycosides signify a cornerstone of plant-based bioactivity, providing profound antioxidant, anti-inflammatory, cardioprotective, and neuromodulatory advantages. Integrating them by way of a food regimen wealthy in colourful vegetables and fruit is good. For focused purposes in nutraceuticals, cosmeceuticals, or analysis, high-purity, standardized extracts are paramount. Shaanxi Zhonghong Investment Technology Co., Ltd. leverages 28 years of experience, cutting-edge expertise (HPLC, NMR), patented purification processes, and uncompromising high quality management to ship the business’s purest and most dependable flavonol glycoside elements. Our dedication to innovation, customization, and international provide chain excellence makes us the associate of alternative for discerning shoppers worldwide. Contact us right now to boost your product pipeline.

15. References

1. Hollman, P.C.H., et al. (1999). Absorption of dietary quercetin glycosides and quercetin in wholesome ileostomy volunteers. Am J Clin Nutr.

2. Williamson, G., & Manach, C. (2005). Bioavailability and bioefficacy of polyphenols in people. II. Assessment of 93 intervention research. Am J Clin Nutr.

3. Li, Y., et al. (2016). Quercetin, Irritation and Immunity. Vitamins.

4. Larson, A.J., et al. (2012). Therapeutic potential of quercetin to lower blood stress: overview of efficacy and mechanisms. Adv Nutr.

5. Křížová, L., et al. (2019). Flavonolignans and Flavonoids from Silybum marianum: UPLC-ESI-MS/MS Profiles and Antioxidant Capability. Antioxidants.

6. European Meals Security Authority (EFSA) Scientific Opinions on Well being Claims (e.g., ID 1648, 1410).

7. United States Pharmacopeia (USP) Monographs & Basic Chapters (<232>, <61>, <62>).

8. European Pharmacopoeia (EP) Monographs. (Particular references depend upon precise compounds mentioned).