Citric Acid
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Citric Acid

Citric Acid supplier bulk factory Wholesale buy Extract factory

  1. English Name: Citric Acid
  1. Specification
    • Purity: ≥ 99.5% (HPLC)
    • Solubility: Extremely soluble in water (133 g/100 mL at 20°C), soluble in ethanol (≥ 50 g/100 mL)
    • Appearance – associated: Loss on drying ≤ 0.5%, Heavy metals ≤ 5 ppm, Residual solvents ≤ 0.2%
    • Melting Level: 153°C
  1. Appearance
    • Colorless clear crystals or white crystalline powder, odorless, with a powerful, acidic style, not associated to chocolate
  1. CAS NO.：77 – 92 – 9
  1. Lead time: 3 – 7 Working Days
  1. Package
    • 25kg/drum (polyethylene bag inside cardboard drum), 1000kg/bag (large bag)
  1. Main Market
    • International market, with vital demand in North America, Europe, Asia, primarily utilized in meals and beverage, pharmaceutical, cosmetics, and chemical industries
  1. Application Scenarios

Core Properties

  • Chemical Construction: An organic tricarboxylic acid with the molecular method C₆H₈O₇. It has three carboxyl (-COOH) teams, which endow it with sturdy acidic properties.
  • Key Options
    • Acidity Regulation: As a weak organic acid, it might successfully modify the pH worth of options, offering a steady acidic surroundings.
    • Chelating Means: It may type steady complexes with steel ions equivalent to calcium, iron, and copper, stopping steel – catalyzed oxidation and bettering product stability.
    • Antimicrobial Impact: Inhibits the expansion of micro organism, yeast, and mould in acidic circumstances, enjoying a job in meals preservation.
    • Taste Enhancement: Its bitter style can improve the flavour of meals and drinks, and stability sweetness.

Application Scenarios

1. Meals and Beverage Business

  • Acidulant and Taste Enhancer
    • Extensively utilized in smooth drinks, fruit juices, jams, candies, and dairy merchandise. In carbonated drinks, it supplies a refreshing bitter style and helps to stability the sweetness of sugar. For instance, in cola – sort drinks, the addition of 0.1 – 0.3% citric acid can improve the general taste.
    • In canned fruits and jams, it not solely adjusts the acidity but in addition inhibits the expansion of microorganisms, extending the shelf lifetime of merchandise.
  • pH Regulator
    • Utilized in cheese manufacturing to regulate the pH worth of milk, selling the coagulation of casein and the formation of cheese curds.
    • Within the manufacturing of pickles, it controls the pH of the brine to make sure the conventional progress of lactic acid micro organism and the standard of pickles.

2. Pharmaceutical Business

  • Acid – base Regulator in Drug Formulations
    • Within the preparation of oral liquids, syrups, and injection options, it’s used to regulate the pH worth to make sure the steadiness and efficacy of medication. For instance, in some vitamin C injection options, citric acid is added to take care of an acceptable pH surroundings.
  • Chelating Agent
    • As a chelating agent, it might complicated with steel ions in medicine to stop drug oxidation and degradation, and enhance the steadiness of medication.

3. Cosmetics and Private Care

  • pH Adjustment
    • Added to facial cleansers, toners, and lotions to regulate the pH worth of merchandise to a degree appropriate for the pores and skin (often barely acidic), serving to to take care of the conventional perform of the pores and skin barrier.
  • Antioxidant and Preservative
    • In some pores and skin – care merchandise, its chelating means can forestall the catalytic oxidation of steel ions within the method, and on the identical time, its acidic surroundings can inhibit the expansion of microorganisms, enjoying a job in product preservation.

4. Chemical Business

  • Chelating Agent in Electroplating
    • Within the electroplating course of, it’s used as a chelating agent to complicated with steel ions within the plating answer, bettering the uniformity and high quality of the plating layer.
  • Water Remedy
    • As a water – softening agent, it might chelate with calcium and magnesium ions in water, lowering water hardness and stopping the formation of scale in water – utilizing gear.

5. Different Industries

  • Feed Business
    • Added to animal feed as an acidulant and taste enhancer, which might enhance the palatability of feed, promote the digestion and absorption of feed by animals, and on the identical time inhibit the expansion of dangerous microorganisms in feed.
  • Textile Business
    • Used within the textile dyeing and ending course of as a pH regulator and chelating agent to enhance the dyeing impact and shade fastness of materials.

Detection Strategies

  • Excessive – Efficiency Liquid Chromatography (HPLC)
    • Column: C18 (250 × 4.6 mm, 5 μm), Cellular Section: 0.1% phosphoric acid answer – methanol (95:5, v/v), Circulation Fee: 1.0 mL/min, Detection Wavelength: 210 nm. This technique can precisely quantify the content material of citric acid in numerous samples.
  • Titration Methodology
    • Utilizing a normal sodium hydroxide answer for acid – base titration, with phenolphthalein as an indicator, to find out the content material of citric acid. This can be a traditional and generally used detection technique, particularly appropriate for easy samples.
  • Ion Chromatography
    • Can concurrently separate and detect numerous anions together with citrate ions, with excessive sensitivity and good reproducibility, appropriate for the evaluation of complicated samples containing a number of elements.

Supply & Benefits

  • Manufacturing Strategies
    • Primarily produced by fermentation of carbohydrates (equivalent to glucose) utilizing Aspergillus niger. This organic fermentation technique has the benefits of excessive yield, low value, and environmental friendliness.
  • Versatile Purposes
    • Its a number of properties equivalent to acidity, chelating means, and taste – enhancing perform make it broadly utilized in numerous industries, assembly the various wants of various fields.
  • Secure Provide
    • With mature manufacturing expertise and a big – scale industrial manufacturing mannequin, it might guarantee a steady market provide, and the worth is comparatively steady.
  • Regulatory Approval
    • Usually acknowledged as protected (GRAS) in lots of international locations and areas, and has clear rules and requirements for its use in numerous industries, which is conducive to its broad utility.
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Citric Acid: Nature’s Versatile Natural Powerhouse | Shaanxi Zhonghong Funding Expertise

1. What is Citric Acid?

Citric acid (C₆H₈O₇) is a weak, tricarboxylic organic acid naturally occurring in citrus fruits like lemons, limes, oranges, and grapefruits. It serves as a key intermediate metabolite within the Krebs cycle (citric acid cycle), the first energy-producing pathway in cardio organisms. Industrially, it is one of the crucial broadly used organic acids as a result of its glorious solubility, nice bitter style, chelating properties, and buffering capability. It exists as a white, crystalline powder and is extremely water-soluble.

2. Supply, Chemical Properties & Key Identifiers

  • Main Supply: Traditionally extracted from citrus juice. Trendy industrial manufacturing (><｜finish▁of▁pondering｜> of world provide) makes use of submerged fermentation of carbohydrate sources (e.g., molasses, corn starch hydrolysates) by the filamentous fungus Aspergillus niger.

  • Chemical Properties:

    • Molecular System: C₆H₈O₇

    • Appearance: Colorless crystals or white crystalline powder.

    • Odor: Odorless.

    • Style: Strongly acidic, nice bitter style.

    • Solubility: Extremely soluble in water, ethanol, and diethyl ether.

    • pKa Values: pKa₁ = 3.13, pKa₂ = 4.76, pKa₃ = 6.40 (at 25°C). This makes it an efficient buffer over a spread related to meals and organic methods.

    • Chelation: Types secure complexes (chelates) with steel ions (e.g., Ca²⁺, Mg²⁺, Fe³⁺), essential for its position in cleansing brokers, meals preservation, and stopping oxidation.

  • Key Identifiers:

    • CAS Registry Quantity: 77-92-9 (Anhydrous) | 5949-29-1 (Monohydrate)

    • Molecular System (MF): C₆H₈O₇

    • Molecular Weight (MW): 192.124 g/mol (Anhydrous) | 210.14 g/mol (Monohydrate)

    • EINECS Quantity: 201-069-1

3. Benefits, Security, & Issues

  • “Greatest” Citric Acid: The “finest” depends upon software. Meals/pharma grades require excessive purity (USP/BP/EP/FCC). Beauty grades want particular purity and microbial management. Shaanxi Zhonghong ensures >99.5% purity, exceeding typical business requirements (typically ~99%), guaranteeing superior efficiency and security.

  • Pores and skin Benefits:

    • Alpha Hydroxy Acid (AHA): Features as a gentle AHA, selling light exfoliation by breaking down desmosomes between corneocytes.

    • pH Adjustment: Vital for formulating inside the pores and skin’s optimum acidic mantle (pH 4.5-5.5), enhancing barrier operate.

    • Antioxidant & Chelation: Mitigates oxidative stress from free radicals and steel ions (e.g., Fe²⁺ concerned in Fenton reactions).

    • Brightening: Inhibits tyrosinase exercise and reduces melanin switch, aiding in hyperpigmentation administration. Enhances penetration of different energetic elements.

  • Well being Benefits & Dietary Consumption:

    • Power Metabolism: Central to the mitochondrial Krebs cycle (ATP manufacturing).

    • Mineral Absorption: Chelates minerals, probably enhancing bioavailability (e.g., some types of calcium citrate).

    • Urinary Well being: Alkalinizes urine, probably stopping sure varieties of kidney stones (uric acid, cystine stones).

    • Antioxidant Properties: Contributes to mobile antioxidant defenses.

    • Each day Consumption: Citric acid is Typically Acknowledged As Protected (GRAS) by the FDA and authorised globally (EFSA, JECFA). No established Acceptable Each day Consumption (ADI) exists as a result of it is a regular physique metabolite. Consumption is restricted by palatability and gastrointestinal tolerance. Typical consumption is by way of meals and drinks.

  • Potential Facet Results & Precautions:

    • Dental Erosion: Extremely acidic meals/drinks containing citric acid can erode tooth enamel with frequent publicity.

    • GI Irritation: Excessive concentrations might trigger heartburn or abdomen upset in delicate people.

    • Pores and skin Irritation: Undiluted citric acid powder or high-concentration options could cause irritation, stinging, or chemical burns. Beauty formulations are rigorously pH-balanced.

    • Eye Contact: Extreme irritant. Requires fast flushing.

    • Chelation: Can bind important minerals; important dietary imbalance is unlikely however potential with extreme supplementation.

    • Drug Interactions: Might have an effect on absorption of sure drugs (e.g., aluminum-containing antacids, some antibiotics). Seek the advice of a healthcare supplier.

4. Shaanxi Zhonghong Funding Expertise: Your Trusted Citric Acid Companion

Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a premier high-tech enterprise integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising and marketing. We concentrate on serving the chemical, materials, and life science sectors, with deep experience within the extraction, separation, purification, and market software of bioactive plant constituents.

  • Core Competencies:

    • Scientific Prowess: Strategic alliances with 5 main universities underpin our 20+ patented applied sciences and distinctive international compound library.

    • Manufacturing Excellence: Using cutting-edge analytical instrumentation together with Excessive-Efficiency Liquid Chromatography (HPLC) and Superconducting Nuclear Magnetic Resonance (NMR) spectrometers. Our stringent high quality management ensures citric acid purity exceeding business benchmarks by >20%.

    • International Attain: An intensive distribution community serving 80+ international locations throughout Asia, Europe, and the Americas. We offer bespoke ingredient options to multinational pharmaceutical firms, analysis establishments, and main producers.

    • Confirmed Experience: Leveraging 28 years of devoted expertise within the bioactive compounds business.

5. Product Specs: Rigorous High quality Assurance

Shaanxi Zhonghigh’s Citric Acid meets or exceeds main pharmacopoeial requirements (USP/BP/EP) and FCC necessities for meals grade. Our dedication to purity and security is demonstrated via complete testing:

Contaminant Class Parameter Specification Check Technique
Pesticide Residues Chlorpyrifos ≤ 0.01 mg/kg GC-MS/MS, LC-MS/MS
Dichlorvos ≤ 0.01 mg/kg GC-MS/MS, LC-MS/MS
Cypermethrin ≤ 0.01 mg/kg GC-MS/MS, LC-MS/MS
DDT (Complete Isomers) ≤ 0.05 mg/kg GC-ECD, GC-MS/MS
Hexachlorobenzene ≤ 0.01 mg/kg GC-MS/MS
Heavy Metals Lead (Pb) ≤ 1.0 mg/kg ICP-MS, AAS (Graphite Furnace)
Arsenic (As) ≤ 1.0 mg/kg ICP-MS, HG-AAS
Cadmium (Cd) ≤ 0.5 mg/kg ICP-MS, AAS (Graphite Furnace)
Mercury (Hg) ≤ 0.1 mg/kg CV-AAS, ICP-MS
Microbiological Complete Plate Rely ≤ 1000 CFU/g ISO 4833-1
Yeast & Mildew ≤ 100 CFU/g ISO 21527-1, -2
Escherichia coli Absent in 10g ISO 16649-2
Salmonella spp. Absent in 25g ISO 6579-1
Staphylococcus aureus Absent in 1g ISO 6888-1, -2

6. Manufacturing Course of: Precision Fermentation & Purification

Our citric acid manufacturing leverages state-of-the-art submerged fermentation expertise:

  1. Substrate Preparation: Excessive-quality carbohydrate sources (e.g., non-GMO corn starch hydrolysate) are sterilized and conditioned.

  2. Fermentation: Aspergillus niger is cultivated beneath meticulously managed situations (pH, temperature, aeration, nutrient feed) to maximise citric acid yield.

  3. Mycelium Separation: The fungal biomass is eliminated by way of filtration or centrifugation.

  4. Purification: The broth undergoes lime remedy (precipitation as calcium citrate), adopted by sulfuric acid regeneration to yield citric acid answer.

  5. Crystallization: The answer is concentrated and crystallized (anhydrous or monohydrate types).

  6. Drying & Milling: Crystals are dried to express moisture specs and milled to desired particle dimension distribution.

  7. High quality Management: Rigorous in-process and ultimate product testing (HPLC, NMR, ICP-MS, microbiological) ensures compliance with specs.

7. Application Scenarios

Citric acid’s versatility spans quite a few industries:

  • Meals & Beverage (F&B): Main acidulant (tender drinks, juices, candies), taste enhancer, pH adjuster, preservative (chelates steel catalysts of oxidation), antioxidant synergist, emulsifying support in processed cheeses.

  • Prescribed drugs: Excipient (effervescent formulations, taste masking, pH adjustment in syrups and injections), anticoagulant (blood assortment tubes), chelator in steel cleansing.

  • Cosmetics & Private Care: pH adjuster (lotions, lotions, shampoos), chelating agent (stabilizes formulations, enhances preservative efficacy), AHA for exfoliation and brightening (serums, peels), antioxidant.

  • Family & Industrial Cleaners: Key chelating agent in descaling brokers, dishwasher detergents, lavatory cleaners (removes onerous water stains, rust, lime scale), biodegradable various to phosphates.

  • Water Remedy: pH adjustment, chelation of steel ions to forestall scaling/corrosion.

  • Different: Textile processing (dyeing, printing), pictures, oilfield chemical substances, concrete setting retardant.

8. High quality Management (QC): Dedication to Excellence

At Shaanxi Zhonghong, QC is paramount. Our built-in QC system ensures constant, premium citric acid:

  • Uncooked Materials Vetting: Strict protocols for incoming carbohydrate sources and different inputs, together with id, purity, and contaminant testing.

  • In-Course of Controls: Actual-time monitoring of crucial fermentation parameters (pH, dissolved oxygen, temperature, sugar focus) and purification steps. Automated methods set off alerts for deviations.

  • Superior Analytics: Our ISO 17025 accredited lab makes use of HPLC-UV/ELSD/RID for exact quantification and impurity profiling, ICP-MS/OES for hint heavy metals, GC-MS/MS/LC-MS/MS for pesticide residues, validated microbiological strategies (ISO requirements), Karl Fischer titration for moisture, and Potentiometric Titration for assay. FTIR and NMR verify structural id.

  • Stability Research: Ongoing research beneath ICH tips to ascertain shelf life and storage suggestions.

  • Documentation & Traceability: Complete batch information and digital knowledge administration guarantee full traceability from uncooked materials to completed product.

  • Compliance: Adherence to cGMP, HACCP, ISO 9001, and related pharmacopoeial/meals security rules (FDA, EFSA).

9. Packaging & Logistics

  • Packaging: Provided in numerous codecs to go well with buyer wants: 25kg multi-layer kraft paper baggage with polyethylene liner (normal), 1000kg bulk baggage (FIBCs), or customized packaging upon request. All packaging ensures product integrity, moisture safety, and meets worldwide transport rules (IMDG, IATA).

  • Logistics: Leveraging our international community, we offer environment friendly, dependable logistics options by way of sea, air, or land freight. Experience in dealing with customs clearance and documentation for seamless worldwide supply.

10. Well being Efficacy, Functions & Analysis Frontiers

  • Well being Mechanisms: Past its position within the Krebs cycle, analysis explores citric acid’s potential in modulating irritation, enhancing mineral solubility within the intestine, and its position in bone well being (by way of citrate in apatite). Its urinary alkalinization mechanism includes metabolism to bicarbonate.

  • Industrial Innovation: Focus areas embody optimizing fermentation strains (A. niger engineering) for greater yields and lowered byproducts, growing novel purification methods (e.g., membrane filtration, steady chromatography) for sustainability, and exploring new functions in inexperienced chemistry (biodegradable chelators, catalyst synthesis).

  • Analysis Challenges: Key challenges embody decreasing the environmental footprint of manufacturing (water/vitality use, waste streams), enhancing cost-effectiveness for bulk functions, and absolutely elucidating its therapeutic potential at supra-dietary doses in particular situations.

11. Citric Acid FAQ

  • Q: Is citric acid pure? A: Sure, it happens naturally in citrus fruits. Most business citric acid is produced by way of microbial fermentation, a pure course of, utilizing plant-derived carbohydrates.

  • Q: Is citric acid protected? A: Sure, citric acid is GRAS (Typically Acknowledged As Protected) by the FDA and authorised globally to be used in meals, prescription drugs, and cosmetics when used appropriately.

  • Q: Can citric acid expire? A: When saved correctly (cool, dry place in sealed containers), high-purity citric acid is extraordinarily secure. It could take up moisture over very lengthy intervals however stays functionally efficient. Shelf life is usually 3-5 years.

  • Q: Does citric acid kill micro organism? A: Whereas acidic situations can inhibit some microbial progress, citric acid is primarily a preservative enhancer via chelation and pH discount. It really works synergistically with different preservatives (e.g., in meals and cosmetics).

  • Q: Can I exploit citric acid for cleansing? A: Completely! It is extremely efficient as a descaling agent for kettles, espresso makers, showerheads, and eradicating onerous water stains. Dilute 1-2 tablespoons per cup of heat water.

  • Q: How does citric acid profit pores and skin? A: As an AHA, it gently exfoliates useless pores and skin cells, improves texture and radiance, helps fade darkish spots, adjusts pH to help the pores and skin barrier, and acts as an antioxidant.

12. The place to Purchase Excessive-Purity Citric Acid?

Supply premium, high-purity (>99.5%) Citric Acid instantly from the producer:

13. Conclusion

Citric acid is an indispensable, multi-functional compound with profound significance throughout organic methods and huge industrial functions. From energizing mobile metabolism to preserving meals, enhancing cosmetics, and powering eco-friendly cleaners, its versatility is unmatched. Shaanxi Zhonghong Investment Technology Co., Ltd. delivers citric acid of outstanding purity and consistency, backed by superior fermentation expertise, rigorous high quality management exceeding business requirements, and 28 years of experience in bioactive compounds. We’re dedicated to offering tailor-made, dependable options for international companions in prescription drugs, meals, cosmetics, and past. Contact us in the present day in your citric acid necessities.

14. References

  1. PubChem Compound Abstract: Citric Acid. Nationwide Library of Drugs. https://pubchem.ncbi.nlm.nih.gov/compound/Citric-acid

  2. Meals and Agriculture Group (FAO). Citric Acid. JECFA Monographs. https://www.fao.org/

  3. U.S. Meals & Drug Administration (FDA). SCOGS Database: Citric Acid. https://www.fda.gov/

  4. European Meals Security Authority (EFSA). Re-evaluation of citric acid (E 330)… EFSA Journal.

  5. Soccol, C. R., et al. (2006). Citric acid manufacturing. Meals Expertise and Biotechnology.

  6. Beauty Ingredient Evaluate (CIR). Security Evaluation of Citric Acid… Worldwide Journal of Toxicology.

  7. Max, B., et al. (2010). Citric acid manufacturing. Latest Patents on Biotechnology.

  8. Related Pharmacopoeias: United States Pharmacopeia (USP), European Pharmacopoeia (Ph. Eur.), British Pharmacopoeia (BP), Meals Chemical substances Codex (FCC).

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