equol supplement

Equol Supplement: Premium Manufacturer & Global Supplier for Menopausal Health & Antioxidant Support | Aiherba

Source high-purity Equol from Zhonghong, a leading manufacturer and bulk supplier. Potent soy isoflavonoid metabolite for women’s health. Request a free sample and get a competitive price quote.

1. What is an Equol Supplement?

An Equol supplement provides a direct source of S-Equol, a potent isoflavandiol metabolite produced from the natural conversion of daidzein (a soy isoflavone) by specific gut bacteria. Crucially, only about 30-50% of humans (known as “equol producers”) possess the gut microbiota necessary to efficiently convert dietary daidzein into equol. This means a significant portion of the population cannot benefit fully from soy consumption. For B2B clients in the nutraceutical and functional food sectors, a reliable Equol supplement manufacturer provides a direct, potent, and bioavailable ingredient that bypasses this gut conversion limitation, offering consistent benefits to all consumers.

2. Source, Chemical Properties, and Identifiers

• Product Source: Produced via a patented process of fermenting soy isoflavones (specifically daidzein) with specific bacterial strains (Lactococcus and Slackia species) that efficiently convert daidzein to S-Equol, followed by purification.

• Primary Active Compound: S-Equol (the biologically active enantiomer).

• Standardization: Typically standardized to a high percentage of S-Equol (e.g., 10%, 20% or higher in a carrier).

• CAS Number: 531-95-3 (for Racemic Equol); 94105-90-5 (for S-Equol)

• Molecular Formula (MF): C15H14O3

• Molecular Weight (MW): 242.27 g/mol

• EINECS: 208-517-4 (for Racemic Equol)

3. What Defines the Best Equol Supplement? A B2B Buyer’s Guide

For international supplement brands and exporters, the “best” Equol is defined by its enantiomeric purity (must be >99% S-Equol), high potency, proven bioavailability, and the supplier’s technical data on stability and efficacy.

• Key Ingredient & Efficacy: Premium Equol is standardized to S-Equol content and must be enantiomerically pure. Its research-backed benefits include:

  • Menopausal Symptom Relief: Demonstrates a strong affinity for estrogen receptors, effectively reducing the frequency and severity of hot flashes and night sweats without the risks associated with hormone replacement therapy (HRT).

  • Skin Health & Anti-Aging: Helps support skin collagen production, improve skin elasticity, and reduce the appearance of wrinkles, particularly in postmenopausal women.

  • Bone Health Support: Shows potential in supporting bone density by modulating bone remodeling processes.

  • Potent Antioxidant: Acts as a powerful antioxidant, protecting cells from free radical damage.

  • (Compliant for use in dietary supplements. Generally Recognized As Safe (GRAS) status exists for specific, well-characterized ingredients.)

• Origin & Quality: Our starting material is non-GMO soy isoflavones. The fermentation and purification process is tightly controlled to ensure the output is exclusively the beneficial S-enantiomer.

• Usage & Dosage:

  • Typical Use: Incorporated into capsules, tablets, and softgels targeting women’s health, antioxidant support, and healthy aging.

  • Recommended Dosage: Clinical studies often use doses of 10mg to 30mg of pure S-Equol per day. Formulation dosage should be developed based on the standardized potency.

• Applicable Audience: Formulators developing women’s health supplements, menopause support products, anti-aging formulas, bone health products, and general antioxidant complexes.

• Notes & Side Effects:

  • Precautions: Generally well-tolerated. As with any estrogenic compound, individuals with a history of hormone-sensitive conditions (e.g., certain cancers) should consult a healthcare professional before use.

  • Side Effects: Rare and mild. May include minor digestive upset in a small number of individuals.

4. Why Partner with Zhonghong (Aiherba) as Your Equol Manufacturer?

Shaanxi Zhonghong Investment Technology Co., Ltd. (Global Marketing: Aiherba) is a certified high-tech enterprise and a trusted exporter specializing in advanced bioconversion and purification of premium, bioactive ingredients for the global B2B market.

• Scientific Excellence: Our joint laboratories with 5 leading universities and portfolio of 20+ patents allow us to optimize the fermentation and chiral separation processes for maximum yield of enantiomerically pure S-Equol.

• Unmatched Quality Control: Our investment in advanced Chiral HPLC is critical to distinguish and quantify S-Equol from its inactive R-form, ensuring biological efficacy. Our purity standards exceed industry norms.

• Global B2B Network: With 28 years of experience, we supply customized ingredients and wholesale quantities to multinational nutraceutical brands, wholesale distributors, and supplement manufacturers across 80+ countries.

• Technical Support: We provide comprehensive technical dossiers, clinical research summaries, and formulation guidance, making us more than just a supplier but a true innovation partner.

5. Detailed Product Specifications (COA)

Every batch is accompanied by a comprehensive Certificate of Analysis (COA) to guarantee its potency and safety.

6. Production Process & Quality Control

Our production of S-Equol is a sophisticated biotechnological process. It begins with the fermentation of purified daidzein (from non-GMO soy) using specific, proprietary bacterial strains known for their high conversion efficiency to S-Equol. After fermentation, the broth undergoes a series of extraction and purification steps, which may include centrifugation, solvent extraction, and advanced chromatographic techniques to isolate the S-Equol from the fermentation media and other components. A critical final step involves chiral purification to ensure the removal of any residual R-Equol, resulting in a high-purity, enantiomerically pure S-Equol powder.

Our Quality Control is integrated into every step. It starts with the verification of the raw daidzein and the viability of the bacterial culture. In-process testing during fermentation monitors the conversion rate from daidzein to Equol. The final product undergoes rigorous analysis. The most crucial test is Chiral High-Performance Liquid Chromatography (HPLC), which is the only method capable of separating and accurately quantifying the S and R enantiomers to confirm enantiomeric purity. Standard HPLC is used to determine the total Equol content and assay. We also employ GC-MS for pesticide screening and ICP-MS for heavy metal detection. This multi-tiered QC protocol guarantees a product that is not only potent and pure but also biologically active due to its correct chiral configuration.

7. Application Scenarios

S-Equol is a specialized ingredient for targeted health applications:

• Nutraceuticals & Dietary Supplements: The primary application is in women’s health supplements for menopause support (reducing hot flashes, night sweats), promoting skin health, supporting bone density, and providing antioxidant protection.

• Functional Foods: Potential for inclusion in functional foods targeted towards women’s health and healthy aging (subject to regulatory approval in target markets).

• Cosmeceuticals: Incorporated into topical skincare products for its anti-aging and collagen-supporting properties.

8. Health Benefits, Research, and Innovation

S-Equol’s primary mechanism is its ability to bind preferentially to estrogen receptor-beta (ERβ), which is associated with beneficial effects on bone, brain, and cardiovascular health, rather than the ERα receptor linked to proliferative effects. This selective estrogen receptor modulation (SERM-like activity) is key to its efficacy and safety profile. Current research frontiers are exploring its benefits for prostate health and cognitive function. The main challenge and area of innovation is the complex and costly bioconversion and chiral purification process. At Zhonghong, our R&D is focused on optimizing fermentation yields and developing more efficient downstream processing to provide our B2B partners with a high-quality, cost-effective ingredient.

9. FAQ – Frequently Asked Questions

Q: Why is enantiomeric purity so important?
A: Only the S-enantiomer of Equol has significant biological activity and affinity for estrogen receptors. The R-form is largely inactive. Therefore, high S-Equol purity is directly linked to the supplement’s efficacy.

Q: Can you customize the powder concentration?
A: Yes, we specialize in customized herbal extract solutions. We can provide S-Equol standardized to different potency levels (e.g., 10%, 20%) based on your formulation needs.

Q: Is your Equol suitable for vegetarian capsules?
A: Absolutely. Our S-Equol is produced via fermentation and is 100% vegan and vegetarian-friendly.

Q: Do you offer samples for our product development and testing?
A: Absolutely. We provide free sample herbal extract materials to qualified businesses for evaluation and application testing in their labs.

Q: What packaging do you use for international export?
A: We use sealed, double-layer plastic bags with desiccant inside foil-lined cardboard drums to protect the product from moisture and light during transit.

10. Where to Buy Equol and Request Free Samples

As a leading manufacturer and global supplier of advanced nutraceutical ingredients, we are your trusted partner for sourcing high-quality S-Equol.

Contact us today to discuss your procurement needs, request a free sample for your R&D, and get a competitive wholesale price.

• Email: sales@aiherba.com / liaodaohai@gmail.com

• Website: www.aiherba.com

11. Conclusion

For B2B clients in the nutraceutical industry, S-Equol offers a potent, science-backed solution for addressing the significant market need in women’s health and beyond. Choosing a supplier with advanced bioconversion technology, proven chiral separation capabilities, and global export experience is essential for product efficacy and brand reputation. Zhonghong (Aiherba) provides not just an ingredient, but a reliable partnership, offering a premium, well-documented product that will empower your formulations, backed by decades of experience.

12. References

• Journal of Nutrition: Clinical studies on the effects of S-Equol on menopausal symptoms.

• Menopause: The Journal of The North American Menopause Society: Research on Equol’s efficacy for hot flash reduction.

• Proceedings of the National Academy of Sciences: Studies on the enantiomer-specific biological activity of Equol.

• USP-NF Compendial Methods for dietary supplement ingredient testing.