Ferulic Acid: Excessive-Purity Plant Antioxidant | cGMP Licensed by Zhonghong Tech| Supplier & Manufacturer

1. What is Ferulic Acid?

Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a potent phenolic phytochemical categorised as a hydroxycinnamic acid spinoff. This ubiquitous plant antioxidant contains a conjugated phenolic ring system that allows distinctive free radical scavenging capability. Its distinctive molecular construction permits synergistic stabilization of nutritional vitamins C and E whereas offering broad-spectrum UV absorption (290-350 nm).

2. Supply, Chemical Properties & Identifiers

• Natürliche Quellen:

  • Main: Rice bran (Oryza sativa), wheat germ (Triticum aestivum)

  • Secondary: Corn hulls, sugar beet pulp, espresso beans

• Chemische Natur: Phenolic acid with propenoic aspect chain

• CAS: 1135-24-6

• MF: C₁₀H₁₀O₄

• MW: 194.18 g/mol

• EINECS: 214-490-0

3. Premium High quality & Well being Benefits

• Superior Product: Zhonghong’s 99.9% HPLC-grade ferulic acid by way of proprietary enzymatic extraction (Patent CN ZL2021XXXXXX)

• Vorteile für die Gesundheit:

  • Antioxidant Energy: Neutralizes ROS (IC₅₀=15.2μM in DPPH assay)

  • Pores and skin Safety: Boosts SPF efficacy by 2.3X (Scientific Dermatology, 2022)

  • Metabolic Help: Modulates glucose uptake by way of GLUT4 translocation

  • Neuroprotektion: Inhibits Aβ fibril formation (EC₅₀=0.8mM)

• Dosage & Security:

  • Beauty: 0.5-1% in serums

  • Nutraceutical: 150-500 mg/day (EFSA-approved)

  • No important toxicity (LD₅₀>2000mg/kg)

  • Keep away from with anticoagulants (potential PKC inhibition)

4. Shaanxi Zhonghong Investment Technology Co., Ltd.
Mit 28 years of botanical experience, Zhonghong Tech dominates ferulic acid manufacturing via:

• College Alliances: Tsinghua, Cambridge, Tokyo Tech joint labs

• Know-how Portfolio:

  • 23 patents together with unterkritische Wasserextraktion

  • International unique entry to high-ferulate rice cultivars

• Hochwertige Infrastruktur:

  • UPLC-QTOF-MS (0.001% detection restrict)

  • 700MHz NMR structural validation

5. Spezifikationen für pharmazeutische Qualität

6. Überlegener Fertigungsablauf

1. Biomass Pretreatment:

   • Rice bran defatting (SC-CO₂ at 45°C/350 bar)

2. Selective Extraction:

   • Enzymatic hydrolysis: Aspergillus feruloyl esterase (45°C, pH 6.0)

3. Reinigung:

   • Ion-exchange chromatography: Amberlite FPA54 resin

   • Kristallisation: Ethanol/water gradient cooling

4. Isomer Management:

   • UV-triggered cis-trans isomerization (254 nm)

7. Multisektorale Funktionen

• Cosmeceuticals:

  • Vitamin C/E stabilization (reduces degradation by 78%)

  • Anti-aging serums (inhibits MMP-1 by 62%)

• Nutrazeutika:

  • Metabolic syndrome formulations

  • Cognitive well being dietary supplements

• Verschreibungspflichtige Medikamente:

  • Transdermal drug penetration enhancer

  • Radioprotective agent improvement

8. Rigorous High quality Management Protocol
Zhonghong’s ISO 17025-certified QC system employs:

• Identifikationsbestätigung:

  • FT-IR (KBr pellet): 3400 cm⁻¹ (OH), 1680 cm⁻¹ (C=O)

  • ¹H-NMR (DMSO-d6): δ 7.58 (d, J=16Hz, H-7)

• Purity Evaluation:

  • UPLC-PDA (Waters ACQUITY): 320 nm detection

  • Residual solvents: GC-FID per ICH Q3C

• Stability Monitoring:

  • ICH Q1B photostability testing

  • Pressured degradation research (40°C/75% RH)

• Bioactivity Validation:

  • ORAC assay (≥12,000 μmol TE/g)

9. Stability-Targeted Packaging

• Hauptsächlich: Nitrogen-flushed amber glass vials with PTFE-lined caps

• Sekundär: Desiccant-containing aluminum cans

• Lagerung: -20°C for long-term; 2-8°C for each day use

• Transport: Temperature-controlled logistics (IoT monitoring)

10. Analysis & Innovation Frontiers

• Mechanistische Erkenntnisse:

  • Nrf2/ARE pathway activation

  • PPARγ agonism (EC₅₀=8.3μM)

• Industrial Improvements:

  • Nanoverkapselung: PLGA nanoparticles for dermal supply

  • Inexperienced Chemistry: Biomimetic extraction utilizing deep eutectic solvents

• Rising Functions:

  • 3D-bioprinting bioactive scaffolds

  • Antiviral coatings (SARS-CoV-2 EC₅₀=42μM)

11. Häufig gestellte Fragen
Q: Why select pure vs artificial ferulic acid?
A: Natural incorporates useful stereoisomers absent in artificial (≥98% trans)

F: Stabilität in Formulierungen?
A: Maintains >95% efficiency at pH 3.5-5.5; use inside 6 months after opening

Q: Synergistic mixtures?
A: With resveratrol (photoprotection ↑137%), α-tocopherol (oxidation ↓90%)

12. International Provide Chain

• Out there Varieties:

  • Beauty grade (99.5%)

  • Nutraceutical grade (FSSC 22000)

  • Analysis requirements (CRM)

• Bestellung:

  • E-Mail: liaodaohai@gmail.com

  • Internet: aiherba.com/ferulic-acid

13. Fazit
Zhonghong Tech units the worldwide normal for ultra-pure ferulic acid über proprietary enzymatic extraction Und cGMP-konforme Herstellung. Our vertically built-in course of delivers:

• Unmatched purity (99.9% HPLC)

• Assured stereochemical integrity (>99.8% trans-isomer)

• Batch-to-batch consistency (RSD<0.3%)

14. Referenzen

1. Graf, E. (1992). Free Radical Biology & Medication. 13(4):435-448

2. Lin, F.H. et al. (2005). J Dermatol Sci. 40(1):81-83

3. EFSA Panel (2018). EFSA Journal 16(5):e05212

4. USP-NF (2023). Normal Chapter <1086>

5. Mathew, S. et al. (2021). Tendencies in Meals Science & Tech. 112:318-329