Glutaminsäure
, , ,

Glutaminsäure

Glutamic Acid supplier bulk factory Wholesale buy Extract factory

  1. Englischer Name: Glutamic Acid; 2-Aminopentanedioic acid
  1. Spezifikation
    • Reinheit: Glutamic Acid ≥ 99.0% (HPLC)
    • Optical Purity: L – Glutamic Acid ≥ 99.0% (for chiral products), D – Glutamic Acid available for specific applications
    • Löslichkeit: Sparingly soluble in cold water (0.86 g/100 mL at 25°C), soluble in hot water and strong acids/alkalis; water – soluble salts (e.g., monosodium glutamate) have higher solubility
    • Partikelgröße: Standard powder ≤ 150 μm; spray – dried powder ≤ 50 μm for better flowability
  1. Aussehen
    • Powder: White to off – white crystalline powder, odorless, slightly acidic taste
  1. CAS-NR.：56 – 86 – 0 (L – Glutamic Acid); 6893 – 11 – 8 (D – Glutamic Acid)
  1. Lieferzeit: 3 – 5 Working Days
  1. Paket
    • 25 kg/drum (polyethylene bag inside cardboard drum), 1000 kg/super sack for bulk orders
  1. Hauptmarkt: Global market, with significant demand in Asia (China, Japan), North America, and Europe
  1. Anwendungsszenarien

Kerneigenschaften

  • Summenformel: C₅H₉NO₄
  • Ionization Behavior: Amphoteric compound with three ionizable groups (α – amino, α – carboxyl, and γ – carboxyl), pKa values: 2.19 (α – COOH), 4.25 (γ – COOH), 9.67 (α – NH₂)
  • Hauptmerkmale
    • Protein Building Block: One of the 20 standard amino acids, essential for protein synthesis in living organisms.
    • Neurotransmitter Precursor: In the human body, L – Glutamic Acid is a precursor to the neurotransmitter glutamate, crucial for nerve signal transmission.
    • Flavor Enhancer: Its sodium salt, monosodium glutamate (MSG), provides umami taste, widely used in the food industry.
    • Metabolic Intermediate: Involved in the Krebs cycle and nitrogen metabolism, playing a key role in energy production and amino acid balance.

Anwendungsszenarien

1. Essen & Getränke

  • Geschmacksverstärkung:
    • As the raw material for monosodium glutamate (MSG), added to soups, sauces, snacks, and instant noodles at 0.1 – 1% concentration to enhance umami flavor.
    • Used in meat – based products, seasonings, and vegetarian dishes to improve taste.
  • Nährstoffanreicherung:
    • Added to infant formulas, sports drinks, and nutritional supplements to increase protein content and support amino acid balance.
    • In baked goods, it can improve dough elasticity and shelf – life.

2. Pharmazeutika

  • Nutraceuticals and Supplements:
    • Capsules or tablets containing L – Glutamic Acid (500 – 1000 mg per serving) are sold for brain health support, as it aids in neurotransmitter synthesis and may improve cognitive function.
    • Used in amino acid infusion solutions for patients with nutritional deficiencies or recovering from surgery.
  • Drug Synthesis:
    • Serves as an intermediate in the synthesis of various drugs, such as anticonvulsants and antidepressants, due to its role in the nervous system.

3. Tierfutter

  • Protein Source:
    • Added to livestock, poultry, and aquaculture feed at 0.5 – 2% to improve the amino acid profile, enhance growth performance, and increase feed efficiency.
    • In pet food, it helps meet the protein requirements of animals, especially during growth and recovery periods.

4. Kosmetik und Körperpflege

  • Skin Moisturizer:
    • Incorporated into creams, lotions, and serums (0.5 – 2% concentration) to improve skin hydration, as it has water – binding properties.
    • Used in anti – aging products for its potential to stimulate collagen synthesis.
  • Haarpflege:
    • Added to shampoos and conditioners to strengthen hair fibers and improve hair elasticity.

5. Industrielle Anwendungen

  • Biodegradable Plastics:
    • As a raw material for the synthesis of poly(glutamic acid), which is used to produce biodegradable polymers for packaging materials.
  • Wasseraufbereitung:
    • Its derivatives can be used as chelating agents to remove heavy metals from water, binding to metal ions and facilitating their removal.

Nachweismethoden

  • Hochleistungsflüssigkeitschromatographie (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: 0.1% phosphoric acid – acetonitrile (95:5 v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 210 nm for quantification.
  • Ion – Exchange Chromatography:
    • Used for separating and analyzing different forms of glutamic acid (e.g., L – and D – isomers) based on their ionic properties.
  • Amino Acid Analyzer:
    • Specifically designed equipment that uses ion – exchange chromatography and post – column derivatization with ninhydrin to accurately measure the concentration of glutamic acid in complex samples.

Quelle & Vorteile

  • Natürliche Quelle: Produced by fermentation of carbohydrates (e.g., molasses, glucose) using microorganisms like Corynebacterium glutamicum.
  • Cost – Effective: Large – scale industrial fermentation processes ensure a stable and affordable supply.
  • Vielseitig: Its wide range of applications from food to industrial sectors makes it a valuable commodity in the global market.

Einhaltung gesetzlicher Vorschriften

  • US-amerikanische FDA: GRAS – listed for use as a flavor enhancer and nutrient in food products. Meets cGMP requirements for pharmaceutical – grade products.
  • EU-Verordnung: Approved as a food additive (E620 for glutamic acid and its salts) with specific usage limits in different food categories.
  • China NMPA: Permitted for use in food, pharmaceuticals, and animal feed, subject to strict quality control standards.
Kategorien: , , ,

The Complete Information to Glutamic Acid: Science, Benefits & Premium Sources | Supplier & Manufacturer

1. What is Glutamic Acid?

Glutamic acid (C₅H₉NO₄), a non-essential α-amino acid, is without doubt one of the 20 basic proteinogenic amino acids and the most ample excitatory neurotransmitter within the vertebrate central nervous system37. Naturally occurring as L-glutamic acid (the biologically lively type), it serves twin roles:

  • Metabolic gasoline: Key in mobile vitality manufacturing by way of the citric acid cycle

  • Neurochemical signaling: Mediates cognitive features like studying and reminiscence by NMDA/AMPA receptors310
    Found in 1866 by German chemist Karl Ritthausen, its flavor-enhancing property (umami) was recognized by Japanese scientist Kikunae Ikeda in 1908, resulting in monosodium glutamate (MSG) manufacturing3.

2. Supply, Chemical Properties & Specs

Liefern:

  • Natural: Considerable in protein-rich meals (cheese, soy sauce, seafood, meat)14

  • Industrial: Fermentation of carbohydrates (e.g., sugarcane molasses) or hydrolysis of plant proteins like wheat gluten3

Chemical Profile:

EigentumWert
CAS Quantity (L-isomer)56-86-03
Molecular FormulationC₅H₉NO₄
Molekulargewicht147.13 g/mol
EINECS200-293-7
Melting Level247–249°C
Löslichkeit8.57 g/L (water), low in ethanol3
pKa Values2.10, 4.07, 9.473
Key Options:

  • Exists as a zwitterion at physiological pH

  • Precursor to GABA (γ-aminobutyric acid), the first inhibitory neurotransmitter3

3. Well being Benefits, Dosage & Security

What is the “Greatest” Type?

  • L-glutamic acid (CAS: 56-86-0) is the biologically lively isomer, constituting >90% of high-purity dietary supplements38. D-glutamic acid (CAS: 6893-26-1) lacks metabolic exercise.

Vorteile und Mechanismen für das Wohlbefinden:

  1. Neurological Well being:

    • Enhances synaptic plasticity for studying and reminiscence

    • Lowers blood ammonia, assuaging hepatic encephalopathy710

  2. Metabolic Assist:

    • Facilitates nitrogen transport for protein synthesis

    • Steigert intestine integrity by fueling intestinal cells4

  3. Train Efficiency:

    • Will increase endurance and muscle restoration (dose: 4g/day)1

Each day Consumption & Security:

  • Erwachsene: 4000 mg/day as dietary complement1

  • Medical Use: As much as 30g/day for chemotherapy-induced mucositis (underneath medical supervision)4
    Facet Results:

  • Gentle: Facial flushing, nausea, diarrhea at excessive doses7

  • Kontraindikationen: Renal impairment, lively ulcers10

4. Supply Chief: Shaanxi Zhonghong Investment Technology Co., Ltd.

Als 28-year pioneer in bioactive compounds, Shaanxi Zhonghong integrates cutting-edge R&D with international provide chain excellence:

  • Scientific Limitations:

    • 20+ patents and unique compound libraries

    • Joint labs with 5 prime universities

  • Hochwertige Infrastruktur:

    • HPLC/UPLC & NMR spectrometry making certain purity >99% (20% above business requirements)

    • GMP-compliant fermentation and purification services

  • International Attain:

    • Provides 80+ nations throughout prescription drugs, nutraceuticals, and cosmetics25

Product Portfolio: Pharmaceutical-grade L-glutamic acid, plant extracts, pure sweeteners, and beauty actives.

5. Rigorous Product Specs

Shaanxi Zhonghong’s L-glutamic acid exceeds worldwide pharmacopeial requirements (USP, FCC):

Desk 1: Heavy Metallic & Contaminant Limits

KlasseParameterBeschränkenSchauen Sie sich die Technik an
SchwermetalleBlei (Pb)≤1,0 ppmICP-MS
Arsen (As)≤1,0 ppmICP-MS
Cadmium (Cd)≤0,5 ppmICP-MS
Quecksilber (Hg)≤0,1 ppmCVAAS
MikrobiologieGesamte kardiomikrobielle Zählung≤1.000 KBE/gUSP <61>
E. coliFehlt in 10 gUSP <62>
PestizideDDT isomers≤0,05 ppmGC-MS
BHC isomers≤0,05 ppmGC-MS

6. Fortschrittlicher Herstellungsprozess

A 9-step cGMP workflow ensures premium high quality:

  1. Uncooked Materials Choice: Non-GMO sugarcane/molasses

  2. Fermentation: Microbial (Corynebacterium glutamicum) batch tradition

  3. Separation: Centrifugation and ultrafiltration

  4. Reinigung: Ion-exchange chromatography

  5. Kristallisation: Vacuum-evaporative crystallization

  6. Trocknen: Spray drying → Free-flowing powder

  7. QC Testing: NMR identification affirmation, HPLC purity assay (>99%)5

7. Purposes Throughout Industries

  • Verschreibungspflichtige Medikamente: Hepatic coma remedy, IV diet7

  • Nutrazeutika: Sports activities dietary supplements, cognitive well being formulation

  • Speisen und Getränke: MSG for umami taste, protein fortification

  • Kosmetika: Moisturizing brokers in dermal serums14

8. Kompromissloses Qualitätsmanagement

Each batch undergoes 15+ checks by way of:

  • Chromatographie: HPLC/UPLC for enantiomeric purity and residual solvents

  • Spectroscopy: NMR for structural validation, ICP-MS for heavy metals

  • Mikrobiologie: USP-compliant pathogen screening
    Stability research (ICH Q1A) validate a 24-month shelf life at <25°C/65% RH5.

9. Verpackung & Logistik

  • Wesentlich: 25-kg food-grade kraft baggage with double PE liners

  • Lagerung: Cool (<25°C), dry circumstances; keep away from daylight

  • Transport: International door-to-door supply (4–10 days) with pay as you go tariffs

10. FAQs: Glutamic Acid Demystified

Q: Is glutamic acid the identical as MSG?
A: MSG is the sodium salt of glutamic acid. Each happen naturally however MSG is used as a taste enhancer3.

Q: Can vegans use L-glutamic acid?
A: Sure—artificial or plant-fermented variants are vegan-friendly1.

Q: Does it trigger “Chinese language Restaurant Syndrome”?
A: No sturdy proof helps this fantasy. FDA and EFSA classify MSG/glutamate as GRAS37.

Q: Why select pharmaceutical-grade purity?
A: Reduces contaminants (e.g., D-isomers, heavy metals) making certain security for medical use8.

The place to Purchase

Für high-purity L-glutamic acid (≥99% HPLC):

Abschluss

Glutamic acid’s twin position as a metabolic middleman and neurochemical makes it indispensable for well being and business. Shaanxi Zhonghong leverages 28 Jahre Erfahrung, unmatched chromatography tech, Und international compliance to ship premium L-glutamic acid. Associate with us for licensed, research-backed amino acid options.

Verweise

  1. JECFA. Glutamic Acid Monograph. WHO, 2023.

  2. EFSA Panel on Meals Components. Security of glutamic acid. EFSA Journal, 2010.

  3. Ritthausen, Ok. Discovery of glutamic acid. J Prakt Chem, 1866.

  4. KingNet Medical Database. Therapeutic makes use of of glutamic acid. 2024.

  5. Shandong Freda Biotech. Fermentation protocols. 2021.

  6. Zhonghong QC Guide. Analytical strategies for amino acids. 2023.

  7. Mattson, M. Glutamate signaling in mind improvement. Nat Rev Neurosci, 2008.

  8. NIH. D-amino acids in human physiology. PMC, 2020.

  9. BulkSupplements. L-glutamic acid security information. 2023.

  10. KingNet. Medical pharmacology of glutamic acid. 2024.

评价

目前还没有评价

Nur angemeldete Kunden, die dieses Produkt gekauft haben, dürfen eine Bewertung abgeben.

相关产品

滚动至顶部

Angebot und Muster anfordern

请在浏览器中启用JavaScript来完成此表单。

Angebot und Muster anfordern