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Resveratrol

Resveratrol Product Introduction

  1. Englischer Name: Resveratrol
  1. Spezifikation:
    • Resveratrol ≥ 98% (HPLC)
    • Water-soluble micronized powder: Resveratrol ≥ 95% (HPLC), particle size ≤5 μm
  1. Aussehen:
    • Powder: White to off-white crystalline powder, odorless, slightly bitter
    • Water-soluble: Off-white free-flowing powder, soluble in water (10 mg/mL at 25°C)
  1. CAS-NR.:501-36-0
  1. Lieferzeit: 3-7 Werktage
  1. Paket:
    • 25kg/drum (double-layer PE bag inside cardboard drum)
    • 1kg/bag (aluminum foil bag for samples)
  1. Hauptmarkt: North America, Europe, Asia (China, Japan, Korea)
  1. Anwendungsszenarien

Kerneigenschaften

  • Summenformel: C₁₄H₁₂O₃
  • Löslichkeit: Poorly soluble in water; oil-soluble (dissolves in ethanol, DMSO); water-soluble via micronization or cyclodextrin complex
  • Schlüsselaktivitäten: Antioxidant, anti-inflammatory, anti-aging, cardioprotective, anti-cancer (preclinical)

Anwendungsszenarien

1. Nahrungsergänzungsmittel und Nutraceuticals

  • Anti-Aging & Longevity:
    • Activates sirtuin proteins (e.g., SIRT1), promoting cellular longevity and delaying aging. Used in anti-aging capsules and “youth formula” blends.
  • Herz-Kreislauf-Gesundheit:
    • Improves endothelial function, reduces LDL oxidation, and lowers blood pressure. Popular in heart health supplements, often combined with omega-3s.
  • Stoffwechselunterstützung:
    • Enhances insulin sensitivity and fatty acid oxidation, supporting weight management and type 2 diabetes prevention.

2. Funktionelle Lebensmittel und Getränke

  • Natürliches Konservierungsmittel:
    • Antioxidant and antimicrobial properties extend shelf life in juices, snacks, and dairy products (e.g., yogurt, plant-based milks).
  • Fortified Products:
    • Added to red wine-inspired beverages, energy bars, and dietary shakes for “superfood” positioning.
  • Ernährung der alternden Bevölkerung:
    • Used in senior nutrition products to support joint health and cognitive function.

3. Kosmetik und Körperpflege

  • Anti-Aging-Hautpflege:
    • Inhibits collagenase activity, reducing wrinkle formation. Found in serums, creams, and masks for photoaging prevention.
  • UV Protection:
    • Scavenges free radicals from UV exposure, often included in sunscreen formulations (SPF-boosting effect).
  • Haarpflege:
    • Promotes hair follicle growth in shampoos and scalp treatments, targeting hair loss and thinning.

4. Pharmazeutika und Biotechnologie

  • Klinische Forschung:
    • Investigated for treating cancer (inhibits tumor angiogenesis), neurodegenerative diseases (e.g., Alzheimer’s), and metabolic syndrome.
  • Drug Delivery:
    • Liposomal or nanoemulsion formulations improve bioavailability for pharmaceutical use (e.g., oral tablets, injectables).

5. Animal Health & Agriculture

  • Tierärztliche Ergänzungsmittel:
    • Enhances fertility in livestock and reduces oxidative stress in high-performance animals (e.g., racehorses, dairy cows).
  • Aquakultur:
    • Added to fish feed to improve stress resistance and flesh quality in farmed seafood.

Nachweismethoden

  • Hochleistungsflüssigkeitschromatographie (HPLC):
    • Uses a C18 column with mobile phase acetonitrile-water (50:50 v/v), detected at 306 nm.
  • Gaschromatographie-Massenspektrometrie (GC-MS):
    • Confirms purity and identifies cis/trans isomers (trans-resveratrol is bioactive form).
  • Fourier-Transform-Infrarotspektroskopie (FTIR):
    • Verifies phenolic hydroxyl groups and double bonds characteristic of resveratrol.

Quelle & Vorteile

  • Natürliche Quelle: Extracted from grape skins, peanuts, andPolygonum cuspidatum (Japanese knotweed) via solvent extraction (ethanol, ethyl acetate).
  • Synthetic Option: Cost-effective for bulk industrial use, though natural extracts preferred in premium supplements.

Einhaltung gesetzlicher Vorschriften

  • GRAS-Status: Approved as a dietary ingredient in the US (2014).
  • EFSA Approval: Notified as a novel food ingredient in the EU for specific health claims (e.g., antioxidant activity).

Resveratrol: The Powerhouse Polyphenol Revolutionizing Health and Wellness

1. What is Resveratrol?

Resveratrol is a natural polyphenolic compound renowned for its potent antioxidant and anti – inflammatory properties. Classified as a stilbenoid, it acts as a phytoalexin in plants, produced in response to stressors like pathogens or UV radiation. In the health and wellness sphere, resveratrol has emerged as a star ingredient, attracting extensive scientific interest for its potential to combat aging, support cardiovascular health, and modulate cellular functions.

2. Produktherkunft und chemische Eigenschaften

2.1 Quelle

Resveratrol is primarily sourced from grapes (especially red grape skins), berries (such as blueberries and cranberries), peanuts, and Japanese knotweed (Polygonum cuspidatum). Commercially, Japanese knotweed serves as the main raw material due to its high resveratrol content. At Shaanxi Zhonghong Investment Technology Co., Ltd., we source top – quality Japanese knotweed from certified cultivation bases to ensure a consistent supply of high – purity resveratrol.

2.2 Chemisches Profil

  • CAS-Nummer: 501 – 36 – 0
  • Molekularformel (MF): C₁₄H₁₂O₃
  • Molekulargewicht (MW): 228.24 g/mol
  • EINECS: 207 – 929 – 5
  • Physischer Zustand: White to off – white crystalline powder
  • Löslichkeit: Sparingly soluble in water; soluble in ethanol, DMSO, and acetone

3. Optimal Product, Health Benefits, Dosage, Precautions and Side Effects

3.1 Beste Produkte und Inhalte

The most effective resveratrol products boast high purity, typically 98% or above. Our company utilizes advanced extraction and purification techniques, including supercritical fluid extraction and high – performance liquid chromatography (HPLC), to achieve a purity level 20% higher than the industry average. This ensures maximum bioactivity and efficacy in every batch.

3.2 Gesundheitliche Vorteile

3.2.1 Antioxidant Defense

Resveratrol scavenges free radicals and activates the Nrf2 pathway, boosting the production of antioxidant enzymes like superoxide dismutase (SOD) and catalase. This shields cells from oxidative damage associated with aging, cancer, and neurodegenerative diseases.

3.2.2 Cardiovascular Protection

It improves endothelial function, reduces LDL cholesterol oxidation, and inhibits platelet aggregation. Resveratrol also activates the AMP – activated protein kinase (AMPK) pathway, enhancing glucose metabolism and lipid homeostasis, thus reducing the risk of heart disease.

3.2.3 Anti – Aging Effects

By activating the longevity – associated protein SIRT1, resveratrol influences cellular processes related to aging, such as DNA repair and mitochondrial function. It may slow down the aging process at the cellular level and extend lifespan in pre – clinical models.

3.2.4 Anti – Cancer Potential

Studies suggest resveratrol can induce apoptosis in cancer cells, inhibit tumor angiogenesis, and block cancer cell invasion and metastasis. It targets multiple signaling pathways involved in cancer development, making it a promising candidate for cancer prevention and adjuvant therapy research.

3.3 Empfohlene Dosierung

For general health maintenance, a daily intake of 100 – 250 mg is recommended. In clinical trials exploring specific health benefits, dosages can range from 500 – 1000 mg per day. However, individual needs may vary, and it’s crucial to consult a healthcare professional for personalized dosage advice.

3.4 Vorsichtsmaßnahmen und Nebenwirkungen

Resveratrol is generally well – tolerated. Yet, high doses may cause mild gastrointestinal discomfort, including nausea, diarrhea, or abdominal pain. It may interact with medications like blood thinners (warfarin), anti – diabetic drugs, and certain statins. Pregnant or nursing women, individuals with liver or kidney disorders, should avoid use or seek medical advice before consumption.

4. Unternehmensvorstellung

Mit 28 Jahren Erfahrung in der Branche der bioaktiven Verbindungen ist Shaanxi Zhonghong Investment Technology Co., Ltd. ein weltweit führendes Unternehmen in den Bereichen Forschung, Entwicklung, Produktion und Marketing.
  • Forschungskompetenz: Our collaborations with 5 top – tier universities through joint laboratories, coupled with over 20 patented technologies and a unique global compound library, drive continuous innovation in resveratrol extraction and formulation.
  • Hochmoderne Ausrüstung: Equipped with state – of – the – art high – performance liquid chromatography (HPLC) and superconducting nuclear magnetic resonance spectrometers, we ensure product purity standards 20% higher than the industry norm.
  • Globale Reichweite: Unser umfangreiches Netzwerk erstreckt sich über mehr als 80 Länder in Asien, Europa und Amerika. Wir bieten maßgeschneiderte Rohstofflösungen für multinationale Pharmaunternehmen, Forschungseinrichtungen und Hersteller von Konsumgütern.

5. Produktspezifikationen

Projekt
Name
Indikator
Nachweismethode
Pestizidrückstände
Chlorpyrifos
< 0,01 ppm
Gaschromatographie – Massenspektrometrie (GC – MS)
Cypermethrin
< 0,02 ppm
GC – MS
Carbendazim
< 0,05 ppm
Hochleistungsflüssigkeitschromatographie – Massenspektrometrie (HPLC – MS/MS)
Schwermetalle
Blei (Pb)
< 0,5 ppm
Induktiv gekoppeltes Plasma – Massenspektrometrie (ICP – MS)
Quecksilber (Hg)
< 0,01 ppm
Kaltdampf-Atomabsorptionsspektroskopie (CVAAS)
Cadmium (Cd)
< 0,05 ppm
ICP – MS
Mikrobielle Kontamination
Gesamtkeimzahl
< 100 KBE/g
Standardmäßige mikrobiologische Beschichtungstechniken
Escherichia coli
Abwesend
Polymerase-Kettenreaktion (PCR) und Plattierung
Salmonellen
Abwesend
PCR und Plattierung
Listeria monocytogenes
Abwesend
PCR und Plattierung

6. Produktionsprozess

  1. Rohstoffbeschaffung: Source Japanese knotweed roots from sustainable cultivation areas. Conduct strict quality checks on the raw material, including visual inspection, moisture content measurement, and preliminary active ingredient analysis.
  1. Extraktion: Employ methods like ethanol extraction or supercritical fluid extraction with carbon dioxide. Ethanol extraction involves soaking the powdered roots in ethanol to dissolve resveratrol, while supercritical fluid extraction uses carbon dioxide under high pressure and temperature for a more environmentally friendly and efficient extraction process.
  1. Reinigung: Utilize chromatographic techniques, such as silica gel column chromatography and preparative HPLC, to separate resveratrol from other compounds in the extract. This step removes impurities, ensuring high – purity product.
  1. Concentration and Drying: Concentrate the purified resveratrol solution through evaporation. Then, use spray – drying or freeze – drying methods to obtain the final powder product, preserving its bioactivity.
  1. Quality Control: Conduct multiple rounds of testing on the finished product, including purity determination, identification, and inspection for pesticide residues, heavy metals, and microbial contamination.

7. Anwendungsszenarien

7.1 Nutrazeutika

  • Nahrungsergänzungsmittel: Resveratrol is commonly formulated into capsules, tablets, and softgels, often combined with other antioxidants or vitamins, to support overall health, boost immunity, and promote longevity.
  • Funktionelle Lebensmittel und Getränke: Added to juices, smoothies, and energy bars to enhance their health – promoting properties and appeal to health – conscious consumers.

7.2 Pharmazeutika

  • Forschung und Entwicklung: Serves as a valuable compound in drug discovery for treating cardiovascular diseases, cancer, and neurodegenerative disorders. Its ability to modulate multiple biological pathways makes it a promising candidate for new drug development.
  • Adjuvante Therapien: May be used alongside conventional treatments to enhance efficacy and reduce side effects, especially in cancer and metabolic disease management.

7.3 Kosmetik

  • Hautpflegeprodukte: Incorporated into creams, serums, and masks for its antioxidant and anti – aging effects. Resveratrol helps protect the skin from UV damage, reduces wrinkles, and improves skin texture and elasticity.
  • Haarpflegeprodukte: Used in shampoos and conditioners to strengthen hair follicles, prevent hair loss, and improve hair health by reducing oxidative stress on the scalp and hair strands.

8. Qualitätskontrolle

Quality control is the cornerstone of our resveratrol production. At the raw material stage, we authenticate the Japanese knotweed species using DNA fingerprinting and assess its quality through spectroscopic techniques like near – infrared spectroscopy. During extraction, we monitor parameters such as temperature, pressure, and solvent – to – raw material ratio in real – time to ensure consistent extraction efficiency. In the purification process, HPLC is employed for precise separation and purity analysis, with each purification step closely monitored. After production, the final product undergoes comprehensive testing, including determining chemical purity, detecting pesticide residues and heavy metals using advanced analytical instruments, and performing microbial safety checks. Our quality control laboratory adheres to strict international standards, holding certifications like ISO 9001 for quality management and Good Manufacturing Practice (GMP). This multi – step, meticulous quality control system guarantees that every batch of resveratrol meets the highest quality and safety benchmarks, providing reliable products to our global customers.

9. Verpackung und Logistik

  • Verpackung: Our resveratrol products are packaged in air – tight, light – resistant containers. For small orders, we use aluminum foil bags or amber glass bottles, while for bulk orders, fiber drums are utilized. Each package is labeled with detailed information, including product name, batch number, purity, expiration date, and storage instructions.
  • Lagerung: Store in a cool, dry place, away from direct sunlight, at temperatures between 2 – 8°C. Under proper storage conditions, the shelf life of our resveratrol products can reach up to 36 months.
  • Versand: We partner with reliable international logistics providers to ensure prompt and secure delivery. Samples can be shipped via express services like DHL or FedEx within 3 – 5 business days, while bulk orders are transported by sea or air freight according to customer requirements.

10. Forschung zur gesundheitlichen Wirksamkeit, Innovationen in der industriellen Anwendung und Herausforderungen

10.1 Forschungsgrenzen

  • Nanoformulations: Scientists are exploring nano – delivery systems, such as liposomes and nanoparticles, to improve resveratrol’s bioavailability and targeted delivery, enhancing its therapeutic potential.
  • Kombinationstherapien: Investigations into combining resveratrol with other bioactive compounds or drugs are underway, aiming to develop more effective treatment strategies for complex diseases.

10.2 Herausforderungen

  • Bioverfügbarkeit: Resveratrol has low bioavailability due to its poor solubility and rapid metabolism. Developing innovative formulations to overcome this limitation remains a significant challenge.
  • Standardization: Establishing unified international standards for resveratrol products, including quality testing methods and dosage recommendations, is crucial for ensuring product consistency and consumer safety.

11. Häufig gestellte Fragen

11.1 Where can I buy Resveratrol?

  • We offer a diverse range of resveratrol products with different purity levels and packaging options to meet various customer needs.

11.2 Is Resveratrol safe for long – term use?

Resveratrol is generally safe for long – term use within recommended dosages. However, it’s advisable to consult a healthcare professional, especially if you have underlying health conditions or are taking medications.

11.3 Can Resveratrol be taken with other supplements?

Resveratrol can potentially interact with other supplements. It’s best to check with a healthcare provider before combining it with other substances to avoid adverse interactions.

11.4 Does Resveratrol have any contraindications?

Individuals with liver or kidney problems, those taking blood – thinning medications, anti – diabetic drugs, or statins should exercise caution and consult a doctor before using resveratrol. Pregnant or nursing women should avoid it.

12. Fazit

Resveratrol, with its remarkable health – promoting properties and wide – ranging applications, represents a significant advancement in the field of natural health ingredients. As a leading manufacturer, Shaanxi Zhonghong Investment Technology Co., Ltd. is committed to providing high – quality resveratrol products, backed by cutting – edge technology, stringent quality control, and a global market reach. Whether for personal health enhancement, pharmaceutical innovation, or cosmetic development, our resveratrol offerings are designed to meet the highest standards and contribute to a healthier future.

13. Referenzen

  1. Baur, J. A., & Sinclair, D. A. (2006). Therapeutic potential of resveratrol: The in vivo evidence. Nature Reviews Drug Discovery, 5(6), 493 – 506.
  1. Russo, M., Spagnuolo, C., Tedesco, I., & Iacomino, I. (2012). Resveratrol, a natural compound with anti – inflammatory and anti – cancer properties: A review of its effects on human health. Nutrients, 4(7), 674 – 693.
  1. Williams, D. L., & Spencer, J. P. (2012). Resveratrol: A review of its “in vivo” pharmacological properties. British Journal of Pharmacology, 165(3), 619 – 638.

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