Citronsyre

Citric Acid: Nature’s Versatile Natural Powerhouse | Shaanxi Zhonghong Funding Expertise

1. Hvad er citronsyre?

Citric acid (C₆H₈O₇) is a weak, tricarboxylic organic acid naturally occurring in citrus fruits like lemons, limes, oranges, and grapefruits. It serves as a key intermediate metabolite within the Krebs cycle (citric acid cycle), the first energy-producing pathway in cardio organisms. Industrially, it is one of the crucial broadly used organic acids as a result of its glorious solubility, nice bitter style, chelating properties, and buffering capability. It exists as a white, crystalline powder and is extremely water-soluble.

2. Forsyning, kemiske egenskaber og nøgleidentifikatorer

• Hovedforsyning: Traditionally extracted from citrus juice. Trendy industrial manufacturing (><｜finish▁of▁pondering｜> of world provide) makes use of submerged fermentation of carbohydrate sources (e.g., molasses, corn starch hydrolysates) by the filamentous fungus Aspergillus niger.

• Kemiske egenskaber:

  • Molecular System: C₆H₈O⇇

  • Udseende: Farveløse krystaller eller hvidt krystallinsk pulver.

  • Lugt: Lugtfri.

  • Style: Strongly acidic, nice bitter style.

  • Opløselighed: Extremely soluble in water, ethanol, and diethyl ether.

  • pKa-værdier: pKa₁ = 3.13, pKa₂ = 4.76, pKa₃ = 6.40 (at 25°C). This makes it an efficient buffer over a spread related to meals and organic methods.

  • Chelatdannelse: Types secure complexes (chelates) with steel ions (e.g., Ca²⁺, Mg²⁺, Fe³⁺), essential for its position in cleansing brokers, meals preservation, and stopping oxidation.

• Nøgleidentifikatorer:

  • CAS-registermængde: 77-92-9 (vandfri) | 5949-29-1 (monohydrat)

  • Molekylsystem (MF): C₆H₈O⇇

  • Molekylvægt (MW): 192,124 g/mol (vandfri) | 210,14 g/mol (monohydrat)

  • EINECS-mængde: 201-069-1

3. Benefits, Security, & Issues

• “Greatest” Citric Acid: The “finest” depends upon software. Meals/pharma grades require excessive purity (USP/BP/EP/FCC). Beauty grades want particular purity and microbial management. Shaanxi Zhonghong ensures >99.5% purity, exceeding typical business requirements (typically ~99%), guaranteeing superior efficiency and security.

• Pores and skin Benefits:

  • Alfahydroxysyre (AHA): Features as a gentle AHA, selling light exfoliation by breaking down desmosomes between corneocytes.

  • pH-justering: Vital for formulating inside the pores and skin’s optimum acidic mantle (pH 4.5-5.5), enhancing barrier operate.

  • Antioxidant og kelering: Mitigates oxidative stress from free radicals and steel ions (e.g., Fe²⁺ concerned in Fenton reactions).

  • Lysning: Inhibits tyrosinase exercise and reduces melanin switch, aiding in hyperpigmentation administration. Enhances penetration of different energetic elements.

• Well being Benefits & Dietary Consumption:

  • Kraftstofskifte: Central to the mitochondrial Krebs cycle (ATP manufacturing).

  • Mineralabsorption: Chelates minerals, probably enhancing bioavailability (e.g., some types of calcium citrate).

  • Urinary Well being: Alkalinizes urine, probably stopping sure varieties of kidney stones (uric acid, cystine stones).

  • Antioxidante egenskaber: Contributes to mobile antioxidant defenses.

  • Dagligt forbrug: Citric acid is Typically Acknowledged As Protected (GRAS) by the FDA and authorised globally (EFSA, JECFA). No established Acceptable Each day Consumption (ADI) exists as a result of it is a regular physique metabolite. Consumption is restricted by palatability and gastrointestinal tolerance. Typical consumption is by way of meals and drinks.

• Potential Facet Results & Precautions:

  • Tanderosion: Extremely acidic meals/drinks containing citric acid can erode tooth enamel with frequent publicity.

  • Gastrointestinal irritation: Excessive concentrations might trigger heartburn or abdomen upset in delicate people.

  • Pores and skin Irritation: Undiluted citric acid powder or high-concentration options could cause irritation, stinging, or chemical burns. Beauty formulations are rigorously pH-balanced.

  • Øjenkontakt: Extreme irritant. Requires fast flushing.

  • Chelatdannelse: Can bind important minerals; important dietary imbalance is unlikely however potential with extreme supplementation.

  • Lægemiddelinteraktioner: Might have an effect on absorption of sure drugs (e.g., aluminum-containing antacids, some antibiotics). Seek the advice of a healthcare supplier.

4. Shaanxi Zhonghong Funding Expertise: Your Trusted Citric Acid Companion

Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a premier high-tech enterprise integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising and marketing. We concentrate on serving the chemical, materials, and life science sectors, with deep experience within the extraction, separation, purification, and market software of bioactive plant constituents.

• Kernekompetencer:

  • Videnskabelig dygtighed: Strategic alliances with 5 main universities underpin our 20+ patented applied sciences and distinctive international compound library.

  • Fremstillingsekspertise: Using cutting-edge analytical instrumentation together with Ekstrem effektivitetsvæskekromatografi (HPLC) og Superledende kernemagnetisk resonans (NMR) spectrometers. Our stringent high quality management ensures citric acid purity exceeding business benchmarks by >20%.

  • International opnåelse: An intensive distribution community serving 80+ international locations throughout Asia, Europe, and the Americas. We offer bespoke ingredient options to multinational pharmaceutical firms, analysis establishments, and main producers.

  • Bekræftet erfaring: Leveraging 28 years of devoted expertise within the bioactive compounds business.

5. Produktspecifikationer: Strenge høj kvalitetssikring

Shaanxi Zhonghigh’s Citric Acid meets or exceeds main pharmacopoeial requirements (USP/BP/EP) and FCC necessities for meals grade. Our dedication to purity and security is demonstrated via complete testing:

6. Manufacturing Course of: Precision Fermentation & Purification

Our citric acid manufacturing leverages state-of-the-art submerged fermentation expertise:

1. Substratforberedelse: Excessive-quality carbohydrate sources (e.g., non-GMO corn starch hydrolysate) are sterilized and conditioned.

2. Fermentering: Aspergillus niger is cultivated beneath meticulously managed situations (pH, temperature, aeration, nutrient feed) to maximise citric acid yield.

3. Myceliumseparation: The fungal biomass is eliminated by way of filtration or centrifugation.

4. Rensning: The broth undergoes lime remedy (precipitation as calcium citrate), adopted by sulfuric acid regeneration to yield citric acid answer.

5. Krystallisering: The answer is concentrated and crystallized (anhydrous or monohydrate types).

6. Tørring og formaling: Crystals are dried to express moisture specs and milled to desired particle dimension distribution.

7. High quality Management: Rigorous in-process and ultimate product testing (HPLC, NMR, ICP-MS, microbiological) ensures compliance with specs.

7. Anvendelsesscenarier

Citric acid’s versatility spans quite a few industries:

• Meals & Beverage (F&B): Main acidulant (tender drinks, juices, candies), taste enhancer, pH adjuster, preservative (chelates steel catalysts of oxidation), antioxidant synergist, emulsifying support in processed cheeses.

• Receptpligtig medicin: Excipient (effervescent formulations, taste masking, pH adjustment in syrups and injections), anticoagulant (blood assortment tubes), chelator in steel cleansing.

• Kosmetik og privat pleje: pH adjuster (lotions, lotions, shampoos), chelating agent (stabilizes formulations, enhances preservative efficacy), AHA for exfoliation and brightening (serums, peels), antioxidant.

• Family & Industrial Cleaners: Key chelating agent in descaling brokers, dishwasher detergents, lavatory cleaners (removes onerous water stains, rust, lime scale), biodegradable various to phosphates.

• Water Remedy: pH adjustment, chelation of steel ions to forestall scaling/corrosion.

• Different: Textile processing (dyeing, printing), pictures, oilfield chemical substances, concrete setting retardant.

8. High quality Management (QC): Dedication to Excellence

At Shaanxi Zhonghong, QC is paramount. Our built-in QC system ensures constant, premium citric acid:

• Kontrol af ukogte materialer: Strict protocols for incoming carbohydrate sources and different inputs, together with id, purity, and contaminant testing.

• In-Course of Controls: Actual-time monitoring of crucial fermentation parameters (pH, dissolved oxygen, temperature, sugar focus) and purification steps. Automated methods set off alerts for deviations.

• Overlegen analyse: Our ISO 17025 accredited lab makes use of HPLC-UV/ELSD/RID for exact quantification and impurity profiling, ICP-MS/OES for hint heavy metals, GC-MS/MS/LC-MS/MS for pesticide residues, validated microbiological strategies (ISO requirements), Karl Fischer-titrering for fugt, og Potentiometrisk titrering til analyse. FTIR og NMR verify structural id.

• Stabilitetsforskning: Ongoing research beneath ICH tips to ascertain shelf life and storage suggestions.

• Dokumentation og sporbarhed: Complete batch information and digital knowledge administration guarantee full traceability from uncooked materials to completed product.

• Overholdelse: Adherence to cGMP, HACCP, ISO 9001, and related pharmacopoeial/meals security rules (FDA, EFSA).

9. Emballage og logistik

• Emballage: Provided in numerous codecs to go well with buyer wants: 25kg multi-layer kraft paper baggage with polyethylene liner (normal), 1000kg bulk baggage (FIBCs), or customized packaging upon request. All packaging ensures product integrity, moisture safety, and meets worldwide transport rules (IMDG, IATA).

• Logistik: Leveraging our international community, we offer environment friendly, dependable logistics options by way of sea, air, or land freight. Experience in dealing with customs clearance and documentation for seamless worldwide supply.

10. Well being Efficacy, Functions & Analysis Frontiers

• Velværemekanismer: Past its position within the Krebs cycle, analysis explores citric acid’s potential in modulating irritation, enhancing mineral solubility within the intestine, and its position in bone well being (by way of citrate in apatite). Its urinary alkalinization mechanism includes metabolism to bicarbonate.

• Industriel innovation: Focus areas embody optimizing fermentation strains (A. niger engineering) for greater yields and lowered byproducts, growing novel purification methods (e.g., membrane filtration, steady chromatography) for sustainability, and exploring new functions in inexperienced chemistry (biodegradable chelators, catalyst synthesis).

• Analysis Challenges: Key challenges embody decreasing the environmental footprint of manufacturing (water/vitality use, waste streams), enhancing cost-effectiveness for bulk functions, and absolutely elucidating its therapeutic potential at supra-dietary doses in particular situations.

11. Ofte stillede spørgsmål om citronsyre

• Q: Is citric acid pure? A: Sure, it happens naturally in citrus fruits. Most business citric acid is produced by way of microbial fermentation, a pure course of, utilizing plant-derived carbohydrates.

• Q: Is citric acid protected? A: Sure, citric acid is GRAS (Typically Acknowledged As Protected) by the FDA and authorised globally to be used in meals, prescription drugs, and cosmetics when used appropriately.

• Q: Kan citronsyre udløbe? A: When saved correctly (cool, dry place in sealed containers), high-purity citric acid is extraordinarily secure. It could take up moisture over very lengthy intervals however stays functionally efficient. Shelf life is usually 3-5 years.

• Q: Does citric acid kill micro organism? A: Whereas acidic situations can inhibit some microbial progress, citric acid is primarily a preservative forstærker via chelation and pH discount. It really works synergistically with different preservatives (e.g., in meals and cosmetics).

• Q: Can I exploit citric acid for cleansing? A: Completely! It is extremely efficient as a descaling agent for kettles, espresso makers, showerheads, and eradicating onerous water stains. Dilute 1-2 tablespoons per cup of heat water.

• Q: How does citric acid profit pores and skin? A: As an AHA, it gently exfoliates useless pores and skin cells, improves texture and radiance, helps fade darkish spots, adjusts pH to help the pores and skin barrier, and acts as an antioxidant.

12. The place to Purchase Excessive-Purity Citric Acid?

Supply premium, high-purity (>99.5%) Citric Acid instantly from the producer:

• Hjemmeside: https://www.aiherba.com

• Kontakte: Mr. Liao Daohai

• E-mail: liaodaohai@gmail.com

• Udbyder: Shaanxi Zhonghong Investment Technology Co., Ltd.

13. Konklusion

Citric acid is an indispensable, multi-functional compound with profound significance throughout organic methods and huge industrial functions. From energizing mobile metabolism to preserving meals, enhancing cosmetics, and powering eco-friendly cleaners, its versatility is unmatched. Shaanxi Zhonghong Investment Technology Co., Ltd. delivers citric acid of outstanding purity and consistency, backed by superior fermentation expertise, rigorous high quality management exceeding business requirements, and 28 years of experience in bioactive compounds. We’re dedicated to offering tailor-made, dependable options for international companions in prescription drugs, meals, cosmetics, and past. Contact us in the present day in your citric acid necessities.

14. Referencer

1. PubChem Compound Abstract: Citric Acid. Nationwide Library of Drugs. https://pubchem.ncbi.nlm.nih.gov/compound/Citric-acid

2. Meals and Agriculture Group (FAO). Citric Acid. JECFA Monographs. https://www.fao.org/

3. U.S. Meals & Drug Administration (FDA). SCOGS Database: Citric Acid. https://www.fda.gov/

4. European Meals Security Authority (EFSA). Re-evaluation of citric acid (E 330)… EFSA Journal.

5. Soccol, C. R., et al. (2006). Citric acid manufacturing. Meals Expertise and Biotechnology.

6. Beauty Ingredient Evaluate (CIR). Security Evaluation of Citric Acid… Verdensomspændende tidsskrift for toksikologi.

7. Max, B., et al. (2010). Citric acid manufacturing. Latest Patents on Biotechnology.

8. Related Pharmacopoeias: United States Pharmacopeia (USP), European Pharmacopoeia (Ph. Eur.), British Pharmacopoeia (BP), Meals Chemical substances Codex (FCC).