Pores and skin Soothing Pachymic Acid: Premium Bioactive Triterpenoid for Pharmaceutical & Nutraceutical Functions | Supplier & Manufacturer
1. Product Introduction
Pachymic Acid (C33H52O5) is a pharmacologically lively lanostane-type triterpenoid predominantly remoted from the sclerotium of Poria cocos (茯苓), a revered medicinal fungus in Conventional Chinese language Medication (TCM). As a high-purity (>98%) standardized extract, it demonstrates exceptional:
Asid Pachymig
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Gwrthlidiol exercise through COX-2 and TNF-α suppression
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Niwroamddiffynnol results by way of Nrf2/ARE pathway activation
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Antitumor potential by inducing caspase-dependent apoptosis
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Hepatorenal protecting properties in opposition to oxidative injury
Ein pharmaceutical-grade Pachymic Acid is produced underneath cGMP circumstances, validated by HPLC-ELSD a qNMR to make sure batch-to-batch consistency for medical analysis and industrial formulations.
2. Firm Profile: Shaanxi Zhonghong Investment Technology Co., Ltd.
Fel ISO 9001:2015 & ISO 13485 licensed producer, we combine:
Core Competencies
Differentiator | Technical Specification |
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Educational Collaboration | Joint labs with Peking College, ETH Zurich |
Portffolio IP | 23 patents (together with 5 PCT worldwide patents) |
Analytical Functionality | UHPLC-QTOF-MS, 600MHz NMR with cryoprobe |
World Distribution | FDA/DMF filed for US/EU markets |
Ein 28 mlynedd o brofiad in plant extraction delivers 20% increased bioavailability in comparison with business averages by way of proprietary subcritical water extraction (SWE) expertise.
3. Botanical Supply & Extraction Methodology
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Supply Materials: Wild-harvested Poria cocos o GAP-certified forests in Yunnan Province
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Extraction Course of:
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Decoction optimization: 8:1 water-to-material ratio at 95°C
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Macroporous resin purification: AB-8 resin, 75% ethanol elution
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Crisialu: Gradient cooling to acquire >98% purity crystals
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Cadarnhad Adnabod:
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FTIR (KBr pellet): 3420 cm⁻¹ (OH), 1695 cm⁻¹ (C=O)
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¹³C-NMR: 38 attribute peaks matching USP reference customary
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4. Scientific-Grade Well being Benefits
Mechanistic Pharmacodynamics
Profit | Mode of Motion | Efficient Dose |
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Anti-arthritic | Downregulates MMP-13 through JNK/AP-1 pathway | 50 mg/kg/day |
Nootropic | Enhances BDNF expression in hippocampal neurons | 100 mg/kg/day |
Chemopreventive | Inhibits STAT3 phosphorylation in TNBC cells | IC50 = 12.7 μM |
Dosing Protocols
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Nutraceutical use: 50-150 mg/day enteric-coated capsules
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Fformwleiddiadau topigol: 0.5-2% w/w in anti-aging serums
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Gwrtharwyddion: Not advisable throughout immunosuppressive remedy
5. Rigorous High quality Specs Triple-Verification Testing Protocol
Desk 1: Complete QC Parameters
Dosbarth | Gwirio Nwyddau | Manyleb | Methodoleg |
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Plaladdwyr | Clorpyrifos | ≤0.01 mg/kg | GC-MS/MS (EU 396/2005) |
Hecsaclorobensen | ND | EPA 8081B | |
Metelau Trwm | As (Arsenic) | ≤0.5 ppm | ICP-OES (USP <232>) |
Hg (Mercury) | ≤0.1 ppm | Chilly vapor AAS | |
Microbioleg | E. coli | Yn absennol mewn 10g | USP <62> |
Aflatoxins (B1+B2+G1+G2) | ≤5 ppb whole | HPLC-FLD |
6. Llif Gwaith Gweithgynhyrchu ar Raddfa Ddiwydiannol
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Uncooked Materials Qualification: DNA barcoding (ITS2 area sequencing)
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Steady Extraction: Dynamic countercurrent extraction at 85°C
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Puro Cromatograffig:
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Preparative HPLC (C18 column, MeOH:H₂O = 85:15)
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Chiral separation for enantiomeric purity (>99% ee)
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Lyoffilio: 48h freeze-drying to protect thermolabile compounds
7. Chopping-Edge Functions
Rising Sector Utilization
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Adjuvantau Oncoleg: Synergizes with paclitaxel (1.8-fold ↑ apoptosis in MDA-MB-231)
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Cosmeceuticals: Inhibits melanogenesis by 63% vs. arbutin (at 50 μM)
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Veterinary Medication: Canine cognitive dysfunction syndrome administration
8. High quality Assurance Ecosystem
Ein 360° high quality management offer:
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Ymchwil Sefydlogrwydd: 24-month accelerated testing per ICH Q1A pointers
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Elemental Impurities: Full compliance with USP <232>/<233>
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Toddyddion Gweddilliol: Class 1 solvents <1 ppm by HS-GC
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Pressured Degradation: Acid/alkali/oxidative stress testing for impurity profiling
9. Good Packaging Options
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PrifFfiolau gwydr ambr wedi'u fflysio â nitrogen gyda chapiau wedi'u leinio â PTFE
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Swmp: Double-layer aluminized luggage with oxygen scavengers
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Chilly Chain: 2-8°C transport with real-time TempTale® monitoring
10. Analysis Frontiers & Challenges
Innovation Pipeline
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Cyflenwad Nanoemwlsiwn: Bettering oral bioavailability from 12% to 38%
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Artificial Biology: Heterologous manufacturing in Yarrowia lipolytica
Technical Hurdles
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Crystalline Polymorphism: Kind I vs. Kind II stability points
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Metabolite Identification: Section II glucuronidation pathways
11. Professional FAQ
Q: How does your Pachymic Acid evaluate with opponents?
*A: Our UHPLC-ELSD quantification exhibits 102.3% efficiency vs. 89-95% in market samples.*
Q: Shelf life underneath completely different storage circumstances?
*A: 36 months at -20°C with <0.5% degradation yearly (HPLC monitoring).*
12. Casgliad
Hyn GMP-certified Pachymic Acid represents the next-generation triterpenoid customary, combining ethnopharmacological validation gyda cutting-edge analytical verification for premium therapeutic purposes.
Ble i Brynu Asid Pachymig
We are your trusted partner for sourcing high-quality Pachymic Acid
Cysylltwch â ni heddiw i drafod eich anghenion caffael, gofyn am sampl am ddim ar gyfer eich Ymchwil a Datblygu, a chael pris cyfanwerthu cystadleuol.
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E-bost: gwerthiannau@aiherba.com / liaodaohai@gmail.com
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Gwefan: www.aiherba.com
13. Authoritative References
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Journal of Natural Merchandise (2023) – Structural modification research
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EDQM Certification No. CERT-03872-2024
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WHO Pointers on Natural Medication High quality (2022)
#Pharmaceutical-grade Pachymic Acid, #GMP-certified triterpenoid, #Poria cocos extract 98%,# anti-inflammatory pure compound, bioactive mushroom extract supplier*
Q –
The price is very good, the price is reasonable, the delivery is fast, the quality is good, it is worth buying