Glutamic Acid
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Glutamic Acid

Glutamic Acid supplier bulk factory Wholesale buy Extract factory

  1. English Ngalan: Glutamic Acid; 2-Aminopentanedioic acid
  1. Espesipikasyon
    • Kaputli: Glutamic Acid ≥ 99.0% (HPLC)
    • Optical Purity: L – Glutamic Acid ≥ 99.0% (for chiral products), D – Glutamic Acid available for specific applications
    • Pagkamatunaw: Sparingly soluble in cold water (0.86 g/100 mL at 25°C), soluble in hot water and strong acids/alkalis; water – soluble salts (e.g., monosodium glutamate) have higher solubility
    • Gidak-on sa Partikulo: Standard powder ≤ 150 μm; spray – dried powder ≤ 50 μm for better flowability
  1. Panagway
    • Powder: White to off – white crystalline powder, odorless, slightly acidic taste
  1. CAS NO.：56 – 86 – 0 (L – Glutamic Acid); 6893 – 11 – 8 (D – Glutamic Acid)
  1. Panahon sa pagpanguna: 3 – 5 Working Days
  1. Pakete
    • 25 kg/drum (polyethylene bag inside cardboard drum), 1000 kg/super sack for bulk orders
  1. Panguna nga Merkado: Global market, with significant demand in Asia (China, Japan), North America, and Europe
  1. Mga Sitwasyon sa Aplikasyon

Panguna nga mga kabtangan

  • Molekular nga Pormula: C₅H₉NO₄
  • Ionization Behavior: Amphoteric compound with three ionizable groups (α – amino, α – carboxyl, and γ – carboxyl), pKa values: 2.19 (α – COOH), 4.25 (γ – COOH), 9.67 (α – NH₂)
  • Pangunang mga bahin
    • Protein Building Block: One of the 20 standard amino acids, essential for protein synthesis in living organisms.
    • Neurotransmitter Precursor: In the human body, L – Glutamic Acid is a precursor to the neurotransmitter glutamate, crucial for nerve signal transmission.
    • Flavor Enhancer: Its sodium salt, monosodium glutamate (MSG), provides umami taste, widely used in the food industry.
    • Metabolic Intermediate: Involved in the Krebs cycle and nitrogen metabolism, playing a key role in energy production and amino acid balance.

Mga Sitwasyon sa Aplikasyon

1. Pagkaon ug Ilimnon

  • Pagpalambo sa lami:
    • As the raw material for monosodium glutamate (MSG), added to soups, sauces, snacks, and instant noodles at 0.1 – 1% concentration to enhance umami flavor.
    • Used in meat – based products, seasonings, and vegetarian dishes to improve taste.
  • Pagpalig-on sa Nutrisyon:
    • Added to infant formulas, sports drinks, and nutritional supplements to increase protein content and support amino acid balance.
    • In baked goods, it can improve dough elasticity and shelf – life.

2. Pharmaceuticals

  • Nutraceuticals and Supplements:
    • Capsules or tablets containing L – Glutamic Acid (500 – 1000 mg per serving) are sold for brain health support, as it aids in neurotransmitter synthesis and may improve cognitive function.
    • Used in amino acid infusion solutions for patients with nutritional deficiencies or recovering from surgery.
  • Drug Synthesis:
    • Serves as an intermediate in the synthesis of various drugs, such as anticonvulsants and antidepressants, due to its role in the nervous system.

3. Pagpakaon sa Hayop

  • Protein Source:
    • Added to livestock, poultry, and aquaculture feed at 0.5 – 2% to improve the amino acid profile, enhance growth performance, and increase feed efficiency.
    • In pet food, it helps meet the protein requirements of animals, especially during growth and recovery periods.

4. Mga Kosmetiko ug Personal nga Pag-atiman

  • Skin Moisturizer:
    • Incorporated into creams, lotions, and serums (0.5 – 2% concentration) to improve skin hydration, as it has water – binding properties.
    • Used in anti – aging products for its potential to stimulate collagen synthesis.
  • Pag-atiman sa Buhok:
    • Added to shampoos and conditioners to strengthen hair fibers and improve hair elasticity.

5. Mga Aplikasyon sa Industriya

  • Biodegradable Plastics:
    • As a raw material for the synthesis of poly(glutamic acid), which is used to produce biodegradable polymers for packaging materials.
  • Water Treatment:
    • Its derivatives can be used as chelating agents to remove heavy metals from water, binding to metal ions and facilitating their removal.

Mga Pamaagi sa Deteksiyon

  • Taas - Pagganap nga Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: 0.1% phosphoric acid – acetonitrile (95:5 v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 210 nm for quantification.
  • Ion – Exchange Chromatography:
    • Used for separating and analyzing different forms of glutamic acid (e.g., L – and D – isomers) based on their ionic properties.
  • Amino Acid Analyzer:
    • Specifically designed equipment that uses ion – exchange chromatography and post – column derivatization with ninhydrin to accurately measure the concentration of glutamic acid in complex samples.

Tinubdan & Mga Kaayohan

  • Natural nga Tinubdan: Produced by fermentation of carbohydrates (e.g., molasses, glucose) using microorganisms like Corynebacterium glutamicum.
  • Cost – Effective: Large – scale industrial fermentation processes ensure a stable and affordable supply.
  • Daghag gamit: Its wide range of applications from food to industrial sectors makes it a valuable commodity in the global market.

Pagsunod sa Regulatoryo

  • US FDA: GRAS – listed for use as a flavor enhancer and nutrient in food products. Meets cGMP requirements for pharmaceutical – grade products.
  • Regulasyon sa EU: Approved as a food additive (E620 for glutamic acid and its salts) with specific usage limits in different food categories.
  • China NMPA: Permitted for use in food, pharmaceuticals, and animal feed, subject to strict quality control standards.
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The Complete Information to Glutamic Acid: Science, Benefits & Premium Sources | Supplier & Manufacturer

1. What is Glutamic Acid?

Glutamic acid (C₅H₉NO₄), a non-essential α-amino acid, is without doubt one of the 20 basic proteinogenic amino acids and the most ample excitatory neurotransmitter within the vertebrate central nervous system37. Naturally occurring as L-glutamic acid (the biologically lively type), it serves twin roles:

  • Metabolic gasoline: Key in mobile vitality manufacturing by way of the citric acid cycle

  • Neurochemical signaling: Mediates cognitive features like studying and reminiscence by NMDA/AMPA receptors310
    Found in 1866 by German chemist Karl Ritthausen, its flavor-enhancing property (umami) was recognized by Japanese scientist Kikunae Ikeda in 1908, resulting in monosodium glutamate (MSG) manufacturing3.

2. Suplay, Mga Kinaiya sa Kemikal ug Mga Espesipikasyon

Suplay:

  • Natural: Considerable in protein-rich meals (cheese, soy sauce, seafood, meat)14

  • Industrial: Fermentation of carbohydrates (e.g., sugarcane molasses) or hydrolysis of plant proteins like wheat gluten3

Chemical Profile:

Property Bili
CAS Quantity (L-isomer) 56-86-03
Molecular Formulation C₅H₉NO₄
Molekular nga Timbang 147.13 g/mol
EINECS 200-293-7
Melting Level 247–249°C
Pagkamatunaw 8.57 g/L (water), low in ethanol3
pKa Values 2.10, 4.07, 9.473
Key Options:

  • Exists as a zwitterion at physiological pH

  • Precursor to GABA (γ-aminobutyric acid), the first inhibitory neurotransmitter3

3. Well being Benefits, Dosage & Security

What is the “Greatest” Type?

  • L-glutamic acid (CAS: 56-86-0) is the biologically lively isomer, constituting >90% of high-purity dietary supplements38. D-glutamic acid (CAS: 6893-26-1) lacks metabolic exercise.

Mga Benepisyo ug Mekanismo sa Kaayohan:

  1. Neurological Well being:

    • Enhances synaptic plasticity for studying and reminiscence

    • Lowers blood ammonia, assuaging hepatic encephalopathy710

  2. Metabolic Assist:

    • Facilitates nitrogen transport for protein synthesis

    • Mga Boost intestine integrity by fueling intestinal cells4

  3. Train Efficiency:

    • Will increase endurance and muscle restoration (dose: 4g/day)1

Each day Consumption & Security:

  • Mga hamtong: 4000 mg/day as dietary complement1

  • Medical Use: As much as 30g/day for chemotherapy-induced mucositis (underneath medical supervision)4
    Mga Resulta sa Facet:

  • Gentle: Facial flushing, nausea, diarrhea at excessive doses7

  • Mga kontraindiksiyon: Renal impairment, lively ulcers10

4. Supply Chief: Shaanxi Zhonghong Investment Technology Co., Ltd.

Ingon sa usa ka 28-anyos nga payunir in bioactive compounds, Shaanxi Zhonghong integrates cutting-edge R&D with international provide chain excellence:

  • Scientific Limitations:

    • 20+ patents and unique compound libraries

    • Joint labs with 5 prime universities

  • Taas nga kalidad nga Infrastruktura:

    • HPLC/UPLC & NMR spectrometry making certain purity >99% (20% above business requirements)

    • GMP-compliant fermentation and purification services

  • International Attain:

    • Provides 80+ nations throughout prescription drugs, nutraceuticals, and cosmetics25

Product Portfolio: Pharmaceutical-grade L-glutamic acid, plant extracts, pure sweeteners, and beauty actives.

5. Rigorous Product Specs

Shaanxi Zhonghong’s L-glutamic acid exceeds worldwide pharmacopeial requirements (USP, FCC):

Desk 1: Heavy Metallic & Contaminant Limits

Klase Parameter Pagdili Tan-awa ang Teknik
Bug-at nga Metal Tingga (Pb) ≤1.0 ppm ICP-MS
Arsenic (As) ≤1.0 ppm ICP-MS
Cadmium (Cd) ≤0.5 ppm ICP-MS
Mercury (Hg) ≤0.1 ppm CVAAS
Microbiology Tibuok Cardio Microbial Nagdepende ≤1,000 CFU/g USP <61>
E. coli Wala sa 10g USP <62>
Mga pestisidyo DDT isomers ≤0.05 ppm GC-MS
BHC isomers ≤0.05 ppm GC-MS

6. Superior nga Kurso sa Paggama sa

A 9-step cGMP workflow ensures premium high quality:

  1. Uncooked Materials Choice: Non-GMO sugarcane/molasses

  2. Fermentasyon: Microbial (Corynebacterium glutamicum) batch tradition

  3. Pagbulag: Centrifugation and ultrafiltration

  4. Pagputli: Ion-exchange chromatography

  5. Crystallization: Vacuum-evaporative crystallization

  6. Pagpauga: Spray drying → Free-flowing powder

  7. QC Testing: NMR identification affirmation, HPLC purity assay (>99%)5

7. Mga Katuyoan sa Tibuok Industriya

  • Gireseta nga mga tambal: Hepatic coma remedy, IV diet7

  • Nutraceuticals: Sports activities dietary supplements, cognitive well being formulation

  • Pagkaon ug Ilimnon: MSG for umami taste, protein fortification

  • Mga kosmetiko: Moisturizing brokers in dermal serums14

8. Dili makompromiso nga Taas nga kalidad nga Pagdumala

Each batch undergoes 15+ checks by way of:

  • Chromatography: HPLC/UPLC for enantiomeric purity and residual solvents

  • Spectroscopy: NMR for structural validation, ICP-MS for heavy metals

  • Microbiology: USP-compliant pathogen screening
    Stability research (ICH Q1A) validate a 24-month shelf life at <25°C/65% RH5.

9. Packaging & Logistics

  • Major: 25-kg food-grade kraft baggage with double PE liners

  • Pagtipig: Cool (<25°C), dry circumstances; keep away from daylight

  • Transportasyon: International door-to-door supply (4–10 days) with pay as you go tariffs

10. FAQs: Glutamic Acid Demystified

Q: Is glutamic acid the identical as MSG?
A: MSG is the sodium salt of glutamic acid. Each happen naturally however MSG is used as a taste enhancer3.

Q: Can vegans use L-glutamic acid?
A: Sure—artificial or plant-fermented variants are vegan-friendly1.

Q: Does it trigger “Chinese language Restaurant Syndrome”?
A: No sturdy proof helps this fantasy. FDA and EFSA classify MSG/glutamate as GRAS37.

Q: Why select pharmaceutical-grade purity?
A: Reduces contaminants (e.g., D-isomers, heavy metals) making certain security for medical use8.

The place to Purchase

Kay high-purity L-glutamic acid (≥99% HPLC):

Panapos

Glutamic acid’s twin position as a metabolic middleman and neurochemical makes it indispensable for well being and business. Shaanxi Zhonghong leverages 28 ka tuig nga kasinatian, unmatched chromatography tech, ug international compliance to ship premium L-glutamic acid. Associate with us for licensed, research-backed amino acid options.

Mga pakisayran

  1. JECFA. Glutamic Acid Monograph. WHO, 2023.

  2. EFSA Panel on Meals Components. Security of glutamic acid. EFSA Journal, 2010.

  3. Ritthausen, Ok. Discovery of glutamic acid. J Prakt Chem, 1866.

  4. KingNet Medical Database. Therapeutic makes use of of glutamic acid. 2024.

  5. Shandong Freda Biotech. Fermentation protocols. 2021.

  6. Zhonghong QC Guide. Analytical strategies for amino acids. 2023.

  7. Mattson, M. Glutamate signaling in mind improvement. Nat Rev Neurosci, 2008.

  8. NIH. D-amino acids in human physiology. PMC, 2020.

  9. BulkSupplements. L-glutamic acid security information. 2023.

  10. KingNet. Medical pharmacology of glutamic acid. 2024.

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