Hidroksipropil tetrahidropirantriol
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Hidroksipropil tetrahidropirantriol

1.Englesko ime: Hydroxypropyl Tetrahydropyrantriol

  1. Specifikacija
    • Čistoća: ≥ 98% (HPLC)
    • Rastvorljivost: Highly soluble in water (≥ 50 g/100 mL at 25°C), soluble in glycerin and propylene glycol
    • pH vrijednost: 5.0 – 7.0 (5% aqueous solution)
    • Gubitak pri sušenju: ≤ 1,0%
    • Teški metali: ≤ 10 ppm
  1. Izgled: Colorless to pale yellow transparent liquid, odorless, with no chocolate-related properties
  1. CAS BR.: 439685-79-7
  1. Vrijeme isporuke3 – 7 radnih dana
  1. Paket: 1 kg/bottle, 5 kg/barrel, 25 kg/drum (plastic or glass containers)
  1. Glavna pijacaEvropa, Sjeverna Amerika, Azija, itd.
  1. Scenariji primjene

Ključna svojstva

  • Collagen Stimulation: Promotes the synthesis of type I, III, and IV collagen, enhancing skin elasticity and firmness
  • Poboljšanje kožne barijere: Strengthens the extracellular matrix, improving the skin’s protective barrier function
  • Protiv starenja: Reduces the appearance of fine lines and wrinkles by supporting skin structure
  • Duboka penetracija: Easily penetrates the epidermis to reach the dermis, exerting long-term effects
  • Kompatibilnost: Stable in various formulations, compatible with most cosmetic ingredients (acids, alcohols, etc.)

Scenariji primjene

  1. Njega kože protiv starenja
    • Serumi za lice: Added at 2 – 5% concentration to target fine lines and improve skin firmness
    • Creams and Lotions: Used in day and night creams to support collagen production
    • Proizvodi za njegu očiju: Included in eye creams to reduce crow’s feet and under-eye wrinkles
  1. Repair and Recovery Formulations
    • Post-sun Products: Helps repair UV-damaged skin and restore barrier function
    • Post-treatment Care: Used in products after cosmetic procedures (peels, lasers) to aid skin recovery
  1. Njega tijela
    • Firming Lotions: Added to body creams to improve skin elasticity on areas like thighs and abdomen
    • Neck and Decolletage Products: Targets signs of aging in delicate areas
  1. Proizvodi za osjetljivu kožu
    • Formulated in gentle skincare lines to strengthen the skin barrier without irritation
  1. Men’s Skincare
    • Included in anti-aging products for men, addressing thicker skin texture and aging concerns

Metode detekcije

  • HPLC: Column C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (10:90, v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 210 nm
  • NMR Spectroscopy: ¹H NMR used to confirm chemical structure and purity
  • Indeks prelamanja: Measured at 20°C, typical range 1.460 – 1.470

Prednosti

  • Dokazana efikasnost: Backed by clinical studies demonstrating collagen-boosting and anti-aging effects
  • Nježan za kožu: Non-irritating, suitable for all skin types including sensitive skin
  • Stable Formulation: Maintains activity under normal storage and processing conditions (temperature ≤ 50°C)
  • Multifunkcionalno: Combines barrier repair, collagen stimulation, and anti-aging benefits in one ingredient
Kategorije: ,

Hydroxypropyl Tetrahydropyrantriol (Pro-Xylane™): The Ultimate Guide by Zhonghong Tech

1. What is Hydroxypropyl Tetrahydropyrantriol?
Hydroxypropyl Tetrahydropyrantriol, commonly known by its trade name Pro-Xylane™, is a highly acclaimed cosmetic active ingredient derived from the natural sugar xylose. It is a C-glycoside derivative specifically engineered to mimic the structure of glycosaminoglycans (GAGs), fundamental components of the skin’s extracellular matrix (ECM). This biomimetic molecule is renowned for its potent svojstva protiv starenja, primarily through stimulating dermal matrix regeneration, poboljšavajući skin firmness, and improving epidermal hydration.

2. Izvor proizvoda, hemijska svojstva i identifikacija

  • Izvor: Synthesized from renewable plant-derived xylose via a complex green chemistry process involving hydrogenation and hydroxypropylation.

  • Hemijska priroda: A tetrasubstituted tetrahydropyran ring structure with hydroxypropyl chains. It is a rastvorljiv u vodi, non-ionic molecule.

  • Ključni identifikatori:

    • CAS broj: 439685-79-7

    • Molekularna formula (MF): C₈H₁₆O₄

    • Molekularna težina (MW): 176.21 g/mol

    • EINECS broj: Not formally assigned for this specific derivative, but compliance is ensured via full chemical characterization and safety dossiers (e.g., Cosmetic Ingredient Review, RIPT studies).

3. Why Zhonghong Tech’s Hydroxypropyl Tetrahydropyrantriol is the Best Choice
Shaanxi Zhonghong Investment Technology Co., Ltd. sets the industry benchmark for premium Hydroxypropyl Tetrahydropyrantriol:

  • Sastojak: High-Purity (>99.5%) Hydroxypropyl Tetrahydropyrantriol (Pro-Xylane™ grade).

  • Efikasnost (Usklađenost):

    • Klinički dokazano: Stimuliše fibroblast activity i collagen IV, laminin Vi glycosaminoglycan (GAG) synthesis.

    • Vidljivi rezultati: Significantly improves skin firmness, elastičnost, and reduces wrinkle depthPoboljšava hidratacija kože and barrier function.

    • Full Compliance: Meets stringent global cosmetic regulations (EU Cosmetic Regulation 1223/2009, FDA guidelines, China NMPA). Supported by comprehensive safety assessments (including RIPT – Repeat Insult Patch Testing).

  • Porijeklo: Proudly manufactured in China under cGMP conditions at our state-of-the-art facility in Shaanxi.

  • Upotreba: Typical incorporation levels range from 1% to 5% in final cosmetic formulations (creams, serums, lotions). Excellent compatibility with most cosmetic bases.

  • Ciljna publika: Formulators creating premium anti-aging skincare, firming treatments, hydrating serums, and products targeting dermal matrix rejuvenation.

  • Zdravstvene prednosti i doziranje:

    • Topical Application Only. Not for ingestion. Health benefits are strictly dermatological:

      • Enhanced dermal-epidermal junction (DEJ) integrity.

      • Increased skin density and thickness.

      • Improved skin moisturization and barrier resilience.

      • Reduction in visible signs of chronological and photo-aging.

    • Dnevni unos: N/A (Topical use). Applied concentration in final product is key (1-5%).

  • Mjere opreza i nuspojave:

    • Generally well-tolerated with an excellent safety profile.

    • Ponašanje patch testing during formulation development and as per standard cosmetic safety protocols.

    • Potential for mild, transient skin irritation in very sensitive individuals (rare).

    • Avoid contact with eyes. Discontinue use if irritation occurs. Consult a dermatologist if concerned.

4. Zhonghong Tech: Your Trusted Partner in Advanced Cosmetic Actives
Shaanxi Zhonghong Investment Technology Co., Ltd. je premijer visokotehnološko preduzeće integrating cutting-edge R&D, collaborative innovation, integrated manufacturing, and global distribution. We specialize in bioaktivni spojevi for the chemical, material, and life science sectors, with a core expertise in ekstrakcija biljaka, purification, and advanced applications.

  • Naučna vještina: Poluge 5 zajedničkih univerzitetskih laboratorija i drži 20+ patenataOdržava vlasnička globalna biblioteka spojeva.

  • Analytical Leadership: Opremljen sa HPLC (visokoučinkovita tečna hromatografija), UPLC (ultra-performansna LC)i NMR (Nuclear Magnetic Resonance) spectroscopy, osiguravajući standardi čistoće premašuju industrijske norme za >20%.

  • Globalni doseg: Pribor prilagođena rješenja za sastojke to multinational pharmaceutical corporations, research institutions, and leading cosmetic brands across 80+ zemalja u Aziji, Evropi i Americi.

  • Naslijeđe: 28 years of excellence in sourcing, developing, and manufacturing high-grade bioactive molecules.

5. Product Benefits & Advantages

  • Potent Anti-Aging: Directly targets dermal matrix components for visible rejuvenation.

  • Proven Hydration: Enhances skin’s natural moisture retention capacity.

  • Improved Skin Barrier: Strengthens the skin’s protective function.

  • Biomimetic & Sustainable: Inspired by skin biology, derived from renewable xylose.

  • Exceptional Stability & Compatibility: Easy to formulate with, high performance in diverse bases.

  • Safety Assured: Backed by rigorous testing and regulatory compliance.

6. Application Guide

  • Recommended Use Level: 1% – 5% in the final cosmetic formulation.

  • Incorporation: Add to the water phase at temperatures below 40°C (104°F) for optimal stability. Compatible with most emulsifiers and common cosmetic ingredients.

  • Ciljane formulacije: Anti-aging creams/serums, firming lotions, hydrating masks, eye contour treatments, premium day/night care.

7. Product Specifications & Certificate of Analysis (COA)
Zhonghong Tech guarantees unparalleled quality and traceability. Our COA includes comprehensive testing:

Kategorija Parametar Specifikacija (Tipična) Metoda ispitivanja
Ostaci pesticida Ukupni organohlorni pesticidi ≤ 0,01 mg/kg GC-ECD/GC-MS
Ukupni organofosforni pesticidi ≤ 0,01 mg/kg GC-FPD/GC-MS
Piretroidi ≤ 0,01 mg/kg GC-ECD/GC-MS
Teški metali Arsen (As) ≤ 1,0 mg/kg ICP-MS (USP <232>/ICH Q3D)
Olovo (Pb) ≤ 1,0 mg/kg ICP-MS (USP <232>/ICH Q3D)
Kadmijum (Cd) ≤ 0,5 mg/kg ICP-MS (USP <232>/ICH Q3D)
Živa (Hg) ≤ 0,1 mg/kg ICP-MS/CVAAS (USP <232>/ICH Q3D)
Mikrobiološki Ukupan broj aerobnih mikroba (TAMC) ≤ 100 CFU/g USP <61>, EP 2.6.12
Ukupan broj kvasaca i plijesni (TYMC) ≤ 50 CFU/g USP <61>, EP 2.6.12
Ešerihija koli Odsutan u 1g USP <62>, EP 2.6.13
Salmonela vrste Odsutan u 10 g USP <62>, EP 2.6.13
Zlatni stafilokok Odsutan u 1g USP <62>, EP 2.6.13
Pseudomonas aeruginosa Odsutan u 1g USP <62>, EP 2.6.13
Općenito Izgled Clear, Colorless to Pale Yellow Liquid Vizualno
Test (HPLC) ≥ 99,5% Internal Validated HPLC/UPLC
pH (10% sol.) 5.0 – 7.0 EP 2.2.3
Water Content (KF) ≤ 0,5% Karl Fischer titracija

8. Advanced Production Flow
Our manufacturing utilizes green chemistry principles:

  1. Nabavka: Premium plant-derived Xylose.

  2. Hydrogenation: Catalytic reduction under controlled conditions.

  3. Hydroxypropylation: Selective addition of propylene oxide.

  4. Pročišćavanje: Multi-stage chromatography (including preparativna HPLC) i nanofiltracija.

  5. Koncentracija: Liofilizacija (Freeze-drying) or low-temperature vacuum evaporation.

  6. Stroga kontrola kvalitete: In-process checks and final release testing per COA specs.

9. Key Application Scenarios

  • Premium Anti-Aging Skincare (Serums, Creams, Lotions)

  • Firming & Lifting Treatments

  • Intensive Hydration & Barrier Repair Products

  • Eye Contour Creams/Gels

  • Neck & Décolleté Treatments

  • Professional Spa & Clinical Formulations

10. Rigorozna kontrola kvalitete (QC)
Zhonghong Tech’s QC is the cornerstone of our reliability. Our ISO 17025-accredited quality control laboratory employs a multi-tiered analytical strategy:

  • Potvrda identiteta: FTIR spektroskopija, NMR (1H, 13C)i HPLC-UV/MS ensure molecular integrity.

  • Purity & Potency: UPLC/HPLC with ELSD/CAD/UV detection provides precise quantification (>99.5% purity standard). Kiralna HPLC confirms stereochemical purity.

  • Impurity Profiling: LC-MS/MS i GC-MS detect and quantify trace organic impurities and residual solvents per ICH Q3A/Q3C guidelines.

  • Elemental Analysis: ICP-MS guarantees compliance with global heavy metal limits (As, Pb, Cd, Hg) for cosmetics.

  • Mikrobiološka sigurnost: Sterility testing i bioburden assessment (TAMC, TYMC, pathogen screening) following USP <61>/<62> i EP 2.6.12/2.6.13.

  • Studije stabilnosti: ICH Q1A-Q1E compliant real-time and accelerated stability programs ensure product shelf-life and performance under various conditions. Robustness testing validates method reliability. Batch traceability is absolute.

11. Sigurno pakovanje i globalna logistika

  • Pakovanje: 1kg, 5kg HDPE bottles; 25kg HDPE drums. Custom packaging available. Tamper-evident seals.

  • Skladištenje: Store tightly sealed in a cool (<25°C), dry place, protected from light. Shelf life: 24 months from manufacture date.

  • Logistika: Efficient global shipping via air/sea freight. Comprehensive cold chain management available. Expertise in export documentation and customs clearance.

12. Health Efficacy, Mechanism & Industry Innovation

  • Mehanizam djelovanja: Pro-Xylane™ acts as a biomimetic glycosaminoglycan (GAG) precursor. It penetrates the epidermis and stimulates dermal fibroblasts to synthesize key extracellular matrix (ECM) components:

    • Collagen IV & Laminin V: Crucial proteins forming the dermal-epidermal junction (DEJ), enhancing skin firmness and resilience.

    • Glycosaminoglycans (GAGs): Like hyaluronic acid, improving hydration and skin plumping.

    • Elastin: Contributing to skin elasticity. This ECM remodeling visibly reduces wrinkles and improves skin tone.

  • Klinički dokazi: Brojni in vivo studies demonstrate significant improvements in skin firmness, elasticity, wrinkle depth, and hydration within weeks of topical application.

  • Industry Application: A gold-standard ingredient in high-efficacy anti-aging cosmetics globally.

  • Inovacija: Research focuses on novi sistemi isporuke (liposomes, nanoemulsions) for enhanced penetration and sustained release. Synergistic combinations with peptides, retinoids, and antioxidants are actively explored.

  • Istraživačke granice i izazovi: Ongoing work aims to fully elucidate signaling pathways. Challenges include optimizing cost-effective large-scale synthesis while maintaining ultra-high purity and exploring new dermatological indications.

13. Često postavljana pitanja (FAQ)

  • Q1: Is Hydroxypropyl Tetrahydropyrantriol natural? A: It is derived from natural xylose but is synthetically modified (nature-identical). It is considered a green chemistry ingredient.

  • Q2: What is the recommended usage level? A: Typically 1% to 5% in the final cosmetic formulation.

  • Q3: Is it safe for sensitive skin? A: It has an excellent safety profile. However, as with any active, patch testing is recommended during formulation and for end-users with known sensitivities.

  • Q4: Does it replace Retinol or Vitamin C? A: It works differently, targeting the dermal matrix. It is often used synergistically with retinoids (cell renewal) and antioxidants (protection) for comprehensive anti-aging.

  • Q5: What is the shelf life? A: 24 months when stored properly (cool, dry, dark place).

  • Q6: Is it vegan and cruelty-free? A: Yes, Zhonghong Tech’s ingredient is vegan and not tested on animals. We comply with international cruelty-free standards.

  • Q7: What certifications do you hold? A: We operate under cGMP, ISO 9001, ISO 14001, and ISO 45001. Specific product certifications (e.g., COSMOS, Ecocert) depend on the final formulation.

14. Gdje kupiti i zatražiti uzorke
Elevate your formulations with premium Hydroxypropyl Tetrahydropyrantriol from Zhonghong Tech.

  • Purchase Inquiries & Bulk Orders: Contact our global sales team.

  • Request Your FREE Sample: Experience the Zhonghong Tech quality difference firsthand! Email: liaodaohai@gmail.com

  • Learn More & Explore Our Portfolio: Posjetite našu web stranicu: https://aiherba.com

15. Zaključak
Hydroxypropyl Tetrahydropyrantriol (Pro-Xylane™) remains a cornerstone anti-aging active ingredient due to its proven efficacy in stimulating dermal matrix regeneration and improving skin hydration and firmness. Choosing a supplier like Shaanxi Zhonghong Investment Technology Co., Ltd. guarantees access to the highest purity standard (>99.5%), podržan od strane 28 godina iskustva u bioaktivnim spojevima, cutting-edge analytical capabilities (HPLC, UPLC, NMR)i rigorous QC exceeding industry normsNaša posvećenost scientific innovation i global compliance makes us the ideal partner for cosmetic brands formulating high-performance, evidence-based skincare solutions. Contact us today for samples and technical data sheets.

16. Reference

  1. L’Oréal Research Publications on Pro-Xylane™ (Original Patent Holder – Mechanism & Efficacy).

  2. Cosmetic Ingredient Review (CIR) Safety Assessment of Glycosides.

  3. International Journal of Cosmetic Science: Articles on Biomimetic Ingredients & Skin Aging.

  4. Journal of Investigative Dermatology: Research on ECM Synthesis & Skin Rejuvenation.

  5. ICH Guidelines (Q1A-Q1E Stability, Q3A-Q3D Impurities).

  6. USP/EP Pharmacopoeial Methods (Microbiology, Heavy Metals).

  7. Zhonghong Tech Internal Research & Validation Data (Available upon request under NDA).

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