Berberine Hydrochloride
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Berberine Hydrochloride Powder​

Berberine Hydrochloride Powder supplier Extract factory

  1. English Name: Berberine Hydrochloride Powder
  1. Specification
    • Purity: ≥ 98% (HPLC)
    • Solubility: Sparingly soluble in water (0.12 g/100 mL at 25°C), more soluble in hot water; soluble in ethanol (≥ 5 g/100 mL)
    • Appearance – related: Loss on drying ≤ 1.0%, Heavy metals ≤ 10 ppm, Residual solvents ≤ 0.5%
    • Particle Size: ≤ 100 mesh (standard), can be customized according to requirements
  1. Appearance
    • Bright yellow crystalline powder, odorless, with an intensely bitter taste, no relation to chocolate in terms of color or aroma
  1. CAS NO.：633 – 65 – 8
  1. Lead time: 5 – 7 Working Days
  1. Package
    • 1 kg/aluminum foil bag, 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Main Market
    • Global market, with significant demand in Asia (China, India), Europe, and North America, mainly applied in pharmaceuticals, dietary supplements, veterinary medicine, and cosmetics industries
  1. Application Scenarios

Core Properties

  • Chemical Structure: An isoquinoline alkaloid with the molecular formula C₂₀H₁₈ClNO₄. Its unique heterocyclic structure endows it with multiple biological activities.
  • Key Features
    • Antimicrobial: Effective against a wide range of pathogens, including bacteria like Escherichia coli and Staphylococcus aureus, fungi such as Candida albicans, by disrupting cell membranes and inhibiting essential enzyme functions.
    • Antioxidant: Scavenges free radicals like hydroxyl and superoxide anions, protecting cells from oxidative damage and reducing the risk of aging – related diseases.
    • Anti – inflammatory: Suppresses the activation of inflammatory pathways, reducing the production of pro – inflammatory cytokines (TNF – α, IL – 6), which helps relieve inflammation – related symptoms.
    • Hypoglycemic: Regulates glucose metabolism by enhancing insulin sensitivity, inhibiting intestinal glucose absorption, and promoting cellular glucose uptake, making it useful for managing blood sugar.
    • Lipid – lowering: Reduces hepatic cholesterol synthesis and promotes cholesterol excretion, contributing to lower blood lipid levels.

Application Scenarios

1. Pharmaceutical Industry

  • Oral Medications:
    • Used in tablets, capsules, and oral solutions for treating gastrointestinal infections, diarrhea caused by bacteria, and as an adjuvant treatment for mild to moderate type 2 diabetes to regulate blood glucose.
  • Topical Formulations:
    • Incorporated into creams, ointments, and gels for treating skin infections, acne, and eczema, leveraging its antimicrobial and anti – inflammatory properties.
  • Clinical Research:
    • Under investigation for potential applications in treating cardiovascular diseases, neurodegenerative disorders, and certain cancers due to its broad – spectrum bioactivity.

2. Dietary Supplements

  • Health – Management Supplements:
    • Sold as standalone capsules or combined with other ingredients (e.g., gymnema sylvestre, chromium) to help individuals manage blood sugar, improve cardiovascular health, and boost immune function.

3. Veterinary Medicine

  • Animal Health Products:
    • Added to livestock and poultry feed or used in oral medications to treat digestive tract infections, diarrhea, and enteritis, and enhance animal growth performance.
  • Pet Care:
    • Prescribed for pets with bacterial infections, skin problems, or to support metabolic health in diabetic pets.

4. Cosmetics & Personal Care

  • Anti – Acne Products:
    • Added to facial cleansers, toners, and spot – treatment creams (0.5 – 2% concentration) to combat acne – causing bacteria, reduce inflammation, and prevent breakouts.
  • Anti – Aging Products:
    • Some high – end anti – aging serums and creams contain berberine hydrochloride to protect skin from oxidative stress and reduce the appearance of fine lines and wrinkles.

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% phosphoric acid (30:70, v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 345 nm, for accurate quantification.
  • Liquid Chromatography – Mass Spectrometry (LC – MS):
    • Ideal for analyzing berberine hydrochloride in complex samples, providing high sensitivity and the ability to detect trace amounts and identify impurities.
  • Fourier Transform Infrared Spectroscopy (FTIR):
    • Analyzes the characteristic absorption peaks of functional groups to confirm the chemical structure, aiding in quality control during production.

Source & Advantages

  • Natural & Synthetic Sources: Extracted from plants like Coptis chinensis, Berberis vulgaris, and can also be synthesized chemically, ensuring a stable supply.
  • Versatile Applications: Its multifunctional bioactivity makes it valuable across multiple industries, meeting diverse health and beauty needs.
  • Market Growth: With the rising demand for natural remedies and preventive healthcare products, the market for berberine hydrochloride powder continues to expand.
  • Regulatory Oversight: Recognized and regulated in many regions for use in pharmaceuticals, supplements, and cosmetics, though regulations on dosage and claims vary by country.
Categories: , , ,

High-Purity Berberine Hydrochloride Powder – Bulk Supplier & GMP-Certified Manufacturer

1. Product Overview

Berberine Hydrochloride Powder is a high-purity plant alkaloid extracted from traditional medicinal plants such as Coptis chinensis and Berberis vulgaris. Widely recognized for its potent bioactive properties, this compound has become a staple in dietary supplements, functional foods, and pharmaceutical health products. AIHerba® provides GMP-certified bulk supply, OEM & ODM solutions, and traceable manufacturing for global buyers.

Key Highlights:

  • Supplier: AIHerba® – China Natural Plant Extracts Manufacturer

  • Purity: ≥97% Berberine Hydrochloride (HPLC tested)

  • Form: Fine yellow powder

  • MOQ: 1 kg, customizable packaging options

  • Applications: Nutraceuticals, functional foods, dietary supplements, cosmetics

2. Product Source & Extraction

Berberine Hydrochloride is primarily sourced from the rhizomes of Coptis chinensis and other Berberis species. Using modern water-ethanol extraction and supercritical CO₂ extraction, our factory ensures high bioavailability and chemical stability. Microbial fermentation technology is also applied in select batches to enhance purity and sustainability.

3. Benefits & Health Effects

  1. Metabolic Support: Studies show berberine can help maintain healthy blood glucose and lipid levels (PubMed: PMID 27370163).

  2. Cardiovascular Health: May support blood pressure and cholesterol balance.

  3. Gut Microbiota: Exhibits prebiotic-like effects, promoting digestive wellness.

  4. Weight Management: Evidence suggests potential synergy with diet and exercise for healthy weight regulation.

Expert Quote: “Berberine is one of the most clinically studied plant alkaloids for metabolic and cardiovascular health, with proven efficacy and safety when used appropriately.” – Dr. James Liu, PhD, Nutraceutical Sciences

4. Recommended Dosage & Usage Guidelines

  • Standard Dosage: 500 mg, 2–3 times daily, or as advised by a healthcare professional.

  • Formulation Guidance: Compatible with capsules, tablets, powders, and functional beverages.

  • Best Practices: Combine with piperine or bioperine for enhanced absorption.

5. Traditional & Modern Applications

  • Traditional Chinese Medicine: Used for digestive support and “heat-clearing” effects.

  • Modern Use: Nutraceuticals, dietary supplements, functional beverages, cosmetic formulations (skin brightening and antioxidant synergy).

6. Product Specifications & COA

Category Item Specification Test Method
Purity & Identity Berberine Hydrochloride ≥97% HPLC
Appearance Color Yellow powder Visual
Loss on Drying Moisture ≤5% GB/T 5009.3
Ash Content Total ash ≤2% USP <281>

Pesticide Residues

Name Limit Test Method
Methamidophos ND GC-MS
Chlorpyrifos ND GC-MS
DDT ND GC-MS

Heavy Metals

Name Limit Test Method
Lead (Pb) ≤2 ppm ICP-MS
Arsenic (As) ≤1 ppm ICP-MS
Mercury (Hg) ≤0.1 ppm ICP-MS
Cadmium (Cd) ≤1 ppm ICP-MS

Microbiological Standards

Item Limit Test Method
Total Plate Count ≤1000 CFU/g AOAC 990.12
Yeast & Mold ≤100 CFU/g AOAC 997.02
E. coli Negative AOAC 966.24
Salmonella Negative ISO 6579

7. Manufacturing Process & Flow

  1. Raw material selection → high-quality Coptis chinensis rhizomes

  2. Cleaning & drying → size reduction

  3. Extraction → water-ethanol or supercritical CO₂ methods

  4. Filtration & concentration → removal of impurities

  5. Purification → crystallization and drying

  6. Quality control → HPLC, microbial, heavy metal testing

  7. Packaging → GMP-compliant, traceable batches

8. Storage & Shelf Life

  • Storage: Keep in a cool, dry, dark environment, away from moisture and direct sunlight.

  • Shelf Life: 24 months when stored in original sealed packaging.

9. Packaging & Sample Policy

  • Bulk Packaging: 25 kg/drum, 5 kg/drum, or customized as requested.

  • Sample Availability: Free sample herbal extract available for qualified buyers.

  • Transportation: Air, sea, or courier; export-ready packaging.

10. Industry Applications & Use Cases

  • Cosmetics: Antioxidant formulations, anti-inflammatory skin products

  • Dietary Supplements: Blood sugar management capsules, weight management blends

  • Functional Foods: Beverages, teas, energy bars, nutraceutical powders

  • Pharmaceuticals: Clinical-grade Berberine formulations

Usage Example:
Mix 500 mg of Berberine Hydrochloride powder with standard capsule excipients for dietary supplement production.

11. Certifications & Quality Assurance

  • GMP-certified plant extract for cosmetics

  • ISO9001, ISO22000 compliance

  • COA and testing reports available upon request

12. FAQ

Q1: Can I buy Berberine Hydrochloride in bulk?
A: Yes, AIHerba® is a trusted wholesale supplier and factory manufacturer offering bulk quantities.

Q2: Is the Berberine powder suitable for dietary supplements?
A: Absolutely. Our Berberine meets food-grade and nutraceutical standards.

Q3: Can you provide a free sample?
A: Yes, free sample herbal extract is available for qualified buyers.

Q4: What is the recommended storage condition?
A: Keep sealed in a cool, dry, dark place away from moisture.

Q5: Are custom formulations available?
A: Yes, we provide OEM & ODM services for customized herbal extract products.

13. References

  1. PubMed: Berberine and Metabolic Health

  2. NIH: Berberine Clinical Trials

  3. FDA: Dietary Supplement Guidelines

  4. Imenshahidi M, Hosseinzadeh H. Berberine and barberry (Berberis vulgaris): A medical assessment. Phytother Res. 2019.

  5. Pang B, et al. Software of berberine on treating kind 2 diabetes mellitus. Int J Endocrinol. 2015.

  6. Koppen LM, et al. Efficacy of berberine in heart problems threat discount. Nutr Metab Cardiovasc Dis. 2020.

  7. ICH Q7: Good Manufacturing Observe Information for Energetic Pharmaceutical Substances.

  8. USP-NF Monograph: Berberine Hydrochloride. (Accessed July 2025).

14. Contact & Ordering Information

AIHerba® is your trusted supplier and manufacturer for high-purity Berberine Hydrochloride powder. With 28+ years of production experience, GMP certification, and global shipping capability, we help professional buyers streamline procurement and product innovation.

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