Unlocking the Energy of Flavonol Glycosides: Nature’s Bioactive Treasures| Supplier & Manufacturer

1. Flavonol qlikozidləri nədir?

Flavonol glycosides are a outstanding subclass of flavonoids, characterised by a flavonol aglycone core (like quercetin, kaempferol, or myricetin) conjugated to a number of sugar moieties (glycosylation). This glycosylation considerably enhances their water solubility and bioavailability in comparison with their aglycone counterparts. They’re ubiquitous secondary metabolites within the plant kingdom, serving very important features in plant physiology (UV safety, pigmentation, protection) and imparting important bioactive properties useful to human well being.

2. Sources, Chemical Id & Properties

• Əsas botanika mənbələri: Plentiful in fruits (apples, berries, grapes, citrus), greens (onions, kale, broccoli, tomatoes), tea (particularly inexperienced tea), cocoa, pink wine, and particular medicinal herbs (ginkgo biloba, St. John’s Wort, sophora japonica).

• Core Chemical Construction: Includes a 15-carbon skeleton (C6-C3-C6) with a carbonyl group at C4, a hydroxyl group at C3, and a double bond between C2 and C3. Glycosylation usually happens on the C3 or C7 hydroxyl place. Widespread sugar items embrace glucose, galactose, rhamnose, and rutinose.

• Əsas Kimyəvi Xüsusiyyətlər:

  • Həlletmə qabiliyyəti: Hydrophilic attributable to glycosylation, soluble in water, methanol, ethanol; insoluble in non-polar solvents.

  • Sabitlik: Delicate to extended warmth, alkaline situations, UV gentle, and oxidation; optimum stability in acidic pH.

  • Reaktivlik: Possess antioxidant capability primarily through phenolic hydroxyl teams. Can bear hydrolysis (enzymatic or acid-catalyzed) to launch the aglycone and sugar.

• Chemical Identifiers (Consultant – Quercetin-3-O-glucoside/Isoquercitrin):

  • CAS: 482-35-9

  • MF: C₂₁H₂₀O₁₂

  • MV: 464,38 q/mol

  • EINECS: 207-580-9
    (Notice: Particular identifiers differ considerably relying on the precise aglycone and glycoside mixture).

3. Efficacy, Well being Benefits & Security

• What is “Greatest”? The “finest” flavonol glycoside relies upon closely on the specified utility and mechanism. Quercetin qlikozidləri (particularly isoquercitrin and rutin) are probably the most extensively researched and generally present in excessive concentrations inside vegetation and industrial extracts. They’re usually thought of benchmarks for bioavailability and broad-spectrum exercise.

• Ən yüksək məzmun mənbələri: Meals exceptionally wealthy in particular flavonol glycosides embrace:

  • Quercetin qlikozidləri: Onions (esp. pink), apples (pores and skin), capers, kale, broccoli, tea.

  • Kaempferol qlikozidləri: Kələm, brokoli, çay, qreypfrut, ginkgo biloba.

  • Mirisetin qlikozidləri: Giləmeyvə (zoğal, qarağat), qoz, şüyüd.

• Sağlamlığın üstünlükləri və mexanizmləri:

  • Potent Antioxidant Exercise: Scavenge free radicals (ROS/RNS), upregulate endogenous antioxidant enzymes (SOD, CAT, GPx) through Nrf2 pathway activation.

  • Ürək-damar yardımı: Enhance endothelial operate (stimulate NO manufacturing), cut back LDL oxidation, inhibit platelet aggregation, modulate blood stress.

  • İltihab əleyhinə nəticələr: Inhibit pro-inflammatory enzymes (COX-2, LOX) and cytokines (TNF-α, IL-6) through NF-κB and MAPK signaling modulation.

  • Metabolik rifah: Enhance insulin sensitivity, assist glucose uptake, regulate lipid metabolism (AMPK activation).

  • Neyroprotektiv potensial: Cross BBB, cut back neuroinflammation, defend neurons from oxidative stress (potential in cognitive decline).

  • Vazoprotektiv və ödem əleyhinə: Rutin particularly strengthens capillaries and reduces permeability.

• Day by day Consumption: There isn’t a established Advisable Dietary Allowance (RDA). Observational research hyperlink well being advantages to intakes of >500 mg complete flavonoids per day, primarily from numerous entire meals. Supplemental doses in scientific trials usually vary from 100-1000 mq/gün of particular flavonol glycosides (e.g., isoquercitrin, rutin).

• Concerns & Aspect Results:

  • Typically Acknowledged as Protected (GRAS) at dietary and typical supplemental ranges.

  • Potential Aspect Results (Excessive Doses): Delicate GI upset (nausea, heartburn), headache.

  • Dərman qarşılıqlı təsiri: Could work together with blood thinners (warfarin), antibiotics (quinolones), and medicines metabolized by CYP3A4/P-gp (seek the advice of doctor).

  • Allergy symptoms: Uncommon, however doable, particularly if delicate to supply vegetation.

  • High quality Issues: Supply from respected suppliers making certain purity and absence of contaminants (heavy metals, solvents, pesticides).

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Associate in Bioactives
Shaanxi Zhonghong baş nazir kimi dayanır yüksək texnologiyalı müəssisə devoted to excellence within the chemistry, supplies, and life science sectors. With 28 years of specialised experience in bioactive compounds, we’re leaders within the extraction, isolation, and purification of potent plant constituents.

• Əsas diqqət: Superior extraction of plant lively elements for numerous markets: pure extracts, beauty actives, nutraceuticals, pharmaceutical intermediates, pure pigments (anthocyanins, carotenoids), and sweeteners (mogrosides).

• Bənzərsiz Elmi Sərtlik:

  • Analiz qalası: Əməkdaşlıq Birgə Laboratoriyalar 5 elit universitetlə.

  • IP Management: portfeli 20+ patentləşdirilmiş tətbiqi elmlər və a qlobal unikal mürəkkəb kitabxana.

  • Təcrübəli Analitika: ilə təchiz olunub HPLC, UPLC, GC-MS və Superkeçirici NMR for unparalleled characterization. Our dedication to >98% təmizlik (validated by HPLC) exceeds business requirements by >20%, guaranteeing premium high quality.

• Beynəlxalq Əldə və Fərdiləşdirmə: Our in depth community seamlessly serves 80+ beynəlxalq məkan throughout Asia, Europe, and the Americas. We excel in delivering personalized, cGMP-compliant ingredient options tailor-made to the precise R&D and manufacturing wants of multinational pharmaceutical companies, analysis establishments, and main nutraceutical manufacturers.

5. Flavonol Glycosides: Sourcing, Benefits & Steerage

• Premium Mənbə: Zhonghong makes use of licensed, sustainably harvested botanical uncooked supplies (e.g., Sophora japonica buds for rutin, ginkgo leaves for quercetin/kaempferol glycosides, onion skins for isoquercitrin) sourced globally. Our vertically built-in course of ensures traceability from farm to last product.

• Well being Benefits Recap: As detailed in Part 3, key advantages focus on highly effective antioxidant protection, cardiovascular and metabolic assist, anti-inflammatory motion, and neuroprotection.

• Utilization Tips:

  • Pəhriz: Prioritize consumption by way of flavonol-rich fruits, greens, tea, and cocoa.

  • Əlavə: Observe product-specific labeling. Typical doses vary from 50mg to 500mg of standardized extract per serving. Typically taken with meals.

  • Gözəllik: Included into serums, lotions (0.1-5%) for antioxidant and anti-aging advantages.

  • Təhlil: Used as reference requirements or bioactive probes in biochemical assays.

• Əsas ehtiyat tədbirləri:

  • Seek the advice of a healthcare supplier earlier than supplementation, particularly if pregnant, breastfeeding, taking drugs, or having a medical situation.

  • Adhere to really helpful dosages.

  • Select merchandise with verified purity and focus (COA out there).

6. Rigorous Product Specs

(Specs are indicative; precise limits topic to particular product & grade. Compliant with USP, EP, CP, FDA, and EU laws).

7. Üstün İstehsalat Kursu
Zhonghong ən müasir avadanlıqları işə götürür, cGMP-yə uyğun istehsal:

1. Bişməmiş Materialların Kvalifikasiyası: Ciddi şəxsiyyət sınağı (HPLC, TLC) və çirkləndiricilərin yoxlanılması.

2. Çıxarış: Optimallaşdırılmış həlledicinin çıxarılması (məsələn, etanol/su) və ya superkritik mayenin çıxarılması (SFE-CO2) istiliyə həssas birləşmələr üçün.

3. Əsas Təmizləmə: Makroməsaməli qatran adsorbsiya xromatoqrafiyası for environment friendly enrichment.

4. Excessive-Decision Separation: Hazırlayıcı HPLC və ya əks cərəyan xromatoqrafiyası (CCC) for isolating particular flavonol glycosides to ultra-high purity (>95-98%).

5. Focus & Drying: Vakuum buxarlanması adopted by liyofilizasiya (dondurularaq qurutma) və ya sprey qurutma to protect bioactivity.

6. Qarışdırma və Standartlaşdırma: Exact formulation to fulfill goal efficiency specs.

7. Qablaşdırma: Below managed humidity/temperature in food-grade, light-protected containers.

8. Numerous Application Scenarios

• Nutraceuticals & Useful Meals: Key elements in capsules, tablets, powders, drinks, and fortified meals concentrating on antioxidant assist, coronary heart well being, cognitive operate, and anti-aging.

• Kosmetika: Valued in anti-aging serums, lotions, and sunscreens for potent antioxidant safety, UV harm mitigation, collagen synthesis assist, and anti inflammatory results (cut back redness).

• Əczaçılıq vasitələri: Function precursors or lively elements for creating medicine concentrating on irritation, metabolic issues, or vascular ailments.

• Analysis Reagents: Excessive-purity requirements (>98% HPLC) used as reference supplies in biochemical, pharmacological, and metabolic research.

9. Stringent High quality Management (QC)
Zhonghong’s QC paradigm is constructed on id, purity, efficiency, and security, exceeding pharmacopeial requirements:

• İD təsdiqi: FT-IR, UV-Vis spektroskopiyası, and co-injection with reference requirements on HPLC-DAD/ELSD.

• Təmizlik və Təhlil: Validated HPLC-UV/DAD strategies (ICH Q2(R1) compliant) quantify complete and particular person flavonol glycosides towards licensed reference requirements. UPLC-MS/MS confirms id and detects hint impurities. Superkeçirici NMR (600MHz+) gives definitive structural elucidation.

• Çirkləndiricilərin İdarə Edilməsi: Strict adherence to specs for qalıq həlledicilər (GC-HS/FID), ağır metallar (ICP-MS), pestisidlər (GC-MS/MS, LC-MS/MS), və mikrobioloji yük (as per desk above). Common Elementar çirklərin sınağı (USP <232>/<233>).

• Sabitlik Araşdırması: Dirijorluq ICH Q1A(R2) compliant accelerated & long-term stability research to outline shelf life, storage situations, and retest durations. Parameters embrace assay, associated substances, water content material (KF), and bodily attributes.

• Sənədləşdirmə: Tamamlayın Certificates of Evaluation (CoA) for each batch, traceable manufacturing data, and strict adherence to ISO 9001 və cGMP high quality programs.

10. Safe Packaging & International Logistics

• Qablaşdırma: Multi-barrier packaging ensures stability: inside double polyethylene luggage sealed inside qida dərəcəli HDPE barabanları və ya kraft foil luggage. Quruducular və oksigen təmizləyiciləri included as required. Mild-protected supplies used.

• Yaddaş: Keep in a cool (<25°C), dry (RH<60%) surroundings, protected against gentle. Lengthy-term storage really helpful at 2-8°C for optimum stability.

• Logistika: Environment friendly international transport through air freight (DAP, DDP) or sea freight (FOB, CIF). Experience in dealing with temperatura həssas yük and navigating complicated gömrük rəsmiləşdirilməsi və import laws worldwide. Complete documentation supplied.

11. Analysis Insights: Mechanisms, Functions & Future

• Sağlamlıq mexanizmləri: Ongoing analysis delves deeper into siqnal yolları (Nrf2, AMPK, SIRT1, NF-κB), epigenetik modulyasiya, intestine microbiota interactions (bioconversion to lively metabolites), and mobile senescence tənzimləmə. Quercetin-3-qlükozidlər superior bioavailability through SGLT1 transport is well-established.

• Sənaye İnnovasiyası: Focus areas embrace enzimatik qlikozilləşmə to create novel, extra bioavailable analogs, inexperienced extraction applied sciences (evtektik həlledicilər, təzyiqli mayelər), nanocarrier programs (liposomes, PLGA NPs) for enhanced supply and stability, and biotechnological manufacturing utilizing engineered microbes or plant cell cultures.

• Təhlil Sərhədləri və Çağırışlar: Key challenges contain understanding complicated metabolite profiles in vivo, scientific translation mexaniki tapıntıların (geniş miqyaslı, uzunmüddətli insan sınaqları), qəti müəyyən edilməsi doza-cavab əlaqələri və well being declare substantiation (EFSA/FDA), and bettering sabitlik in formulated merchandise. Synergistic results throughout the "flavonoidom" are a serious frontier.

12. Regularly Requested Questions (FAQ)

1. Q: What is the distinction between flavonols and flavonol glycosides?

   • A: Flavonols (e.g., quercetin) are the aglycone core. Flavonol glycosides have sugars hooked up, enhancing water solubility and sometimes bioavailability.

2. Q: Which meals has the very best flavonol glycoside content material?

   • A: Onions (quercetin glycosides), kale (kaempferol glycosides), and berries/capers are exceptionally wealthy sources.

3. Q: Are flavonol glycosides secure?

   • A: Typically secure at dietary and customary supplemental ranges. Seek the advice of a health care provider earlier than high-dose supplementation, particularly if on remedy.

4. Q: What is the really helpful each day consumption?

   • A: No official RDA. Intention for numerous flavonoid-rich meals (>500mg complete flavonoids/day). Dietary supplements usually present 100-500mg particular glycosides.

5. Q: Can I take flavonol glycosides with drugs?

   • A: Potensial qarşılıqlı təsirlər mövcuddur (qan durulaşdırıcılar, antibiotiklər, CYP3A4 substratları). At all times seek the advice of your doctor or pharmacist.

6. Q: How does Zhonghong guarantee purity?

   • A: By way of patentləşdirilmiş təmizlənmə, HPLC/UPLC (>98% təmizlik), NMR affirmation, və sərt çirkləndiricilərin idarə edilməsi exceeding pharmacopeial requirements (see QC part).

7. S: Siz fərdiləşdirmə təmin edirsiniz?

   • A: Sure! We specialise in customized extraction, isolation of particular glycosides, və tailor-made formulations (efficiency, ratios, supply programs) for B2B shoppers.

8. Q: What is your minimal order amount (MOQ)?

   • A: MOQ varies by product and purity grade. Contact us for particular particulars (analysis customary vs. bulk ingredient).

9. Q: The place can I purchase Zhonghong’s Flavonol Glycosides?

13. The place to Purchase & Contact Data
Supply premium, high-purity Flavonol Glycosides straight from the producer:

• Veb sayt: Discover our product portfolio: aiherba.com

• E-poçt: Contact our gross sales and technical crew: liaodaohai@gmail.com

• Sorğu: For particular inquiries, quotations, or to request a Certificates of Evaluation (CoA), please e mail us.

14. Nəticə
Flavonol glycosides signify a cornerstone of plant-based bioactivity, providing profound antioxidant, anti-inflammatory, cardioprotective, and neuromodulatory advantages. Integrating them by way of a food regimen wealthy in colourful vegetables and fruit is good. For focused purposes in nutraceuticals, cosmeceuticals, or analysis, yüksək təmizlik, standartlaşdırılmış ekstraktlar əsasdır. Shaanxi Zhonghong Investment Technology Co., Ltd. rıçaqlar 28 years of experience, cutting-edge expertise (HPLC, NMR), patented purification processes, and uncompromising high quality management to ship the business’s purest and most dependable flavonol glycoside elements. Our dedication to innovation, customization, and international provide chain excellence makes us the associate of alternative for discerning shoppers worldwide. Contact us right now to boost your product pipeline.

15. İstinadlar

1. Hollman, PCH və başqaları. (1999). Absorption of dietary quercetin glycosides and quercetin in wholesome ileostomy volunteers. Mən J Clin Nutr.

2. Williamson, G. və Manach, C. (2005). Bioavailability and bioefficacy of polyphenols in people. II. Assessment of 93 intervention research. Mən J Clin Nutr.

3. Li, Y. və başqaları. (2016). Quercetin, Irritation and Immunity. Vitamins.

4. Larson, AJ və başqaları. (2012). Therapeutic potential of quercetin to lower blood stress: overview of efficacy and mechanisms. Adv Nutr.

5. Křížová, L. və başqaları. (2019). Flavonolignans and Flavonoids from Silybum marianum: UPLC-ESI-MS/MS Profiles and Antioxidant Capability. Antioksidantlar.

6. European Meals Security Authority (EFSA) Scientific Opinions on Well being Claims (e.g., ID 1648, 1410).

7. United States Pharmacopeia (USP) Monographs & Basic Chapters (<232>, <61>, <62>).

8. Avropa Farmakopeyası (EP) Monoqrafiyaları. (Particular references depend upon precise compounds mentioned).