Unlocking the Energy of Flavonol Glycosides: Nature’s Bioactive Treasures| Supplier & Manufacturer

১/ ফ্লেভনল গ্লাইকোচাইড কি কি?

Flavonol glycosides are a outstanding subclass of flavonoids, characterised by a flavonol aglycone core (like quercetin, kaempferol, or myricetin) conjugated to a number of sugar moieties (glycosylation). This glycosylation considerably enhances their water solubility and bioavailability in comparison with their aglycone counterparts. They’re ubiquitous secondary metabolites within the plant kingdom, serving very important features in plant physiology (UV safety, pigmentation, protection) and imparting important bioactive properties useful to human well being.

2. Sources, Chemical Id & Properties

• মূল উদ্ভিদবিজ্ঞানৰ উৎস: Plentiful in fruits (apples, berries, grapes, citrus), greens (onions, kale, broccoli, tomatoes), tea (particularly inexperienced tea), cocoa, pink wine, and particular medicinal herbs (ginkgo biloba, St. John’s Wort, sophora japonica).

• Core Chemical Construction: Includes a 15-carbon skeleton (C6-C3-C6) with a carbonyl group at C4, a hydroxyl group at C3, and a double bond between C2 and C3. Glycosylation usually happens on the C3 or C7 hydroxyl place. Widespread sugar items embrace glucose, galactose, rhamnose, and rutinose.

• মূল ৰাসায়নিক ধৰ্ম:

  • দ্ৰৱণীয়তা: Hydrophilic attributable to glycosylation, soluble in water, methanol, ethanol; insoluble in non-polar solvents.

  • স্থিৰতা: Delicate to extended warmth, alkaline situations, UV gentle, and oxidation; optimum stability in acidic pH.

  • বিক্ৰিয়াশীলতা: Possess antioxidant capability primarily through phenolic hydroxyl teams. Can bear hydrolysis (enzymatic or acid-catalyzed) to launch the aglycone and sugar.

• Chemical Identifiers (Consultant – Quercetin-3-O-glucoside/Isoquercitrin):

  • CAS: 482-35-9

  • এম এফ: C2H2O22

  • মেগাৱাট: ৪৬৪.৩৮ গ্ৰাম/মল

  • EINECS: 207-580-9
    (Notice: Particular identifiers differ considerably relying on the precise aglycone and glycoside mixture).

3. Efficacy, Well being Benefits & Security

• What is “Greatest”? The “finest” flavonol glycoside relies upon closely on the specified utility and mechanism. কুৱেৰচেটিন গ্লাইকোচাইড (particularly isoquercitrin and rutin) are probably the most extensively researched and generally present in excessive concentrations inside vegetation and industrial extracts. They’re usually thought of benchmarks for bioavailability and broad-spectrum exercise.

• সৰ্বোচ্চ বিষয়বস্তুৰ উৎস: Meals exceptionally wealthy in particular flavonol glycosides embrace:

  • কুৱেৰচেটিন গ্লাইকোচাইড: Onions (esp. pink), apples (pores and skin), capers, kale, broccoli, tea.

  • Kaempferol গ্লাইকোচাইড: বন্ধাকবি, ব্ৰকলি, চাহ, গ্ৰেপফ্ৰুট, জিংকগো বাইলোবা।

  • মাইৰিচেটিন গ্লাইকোচাইড: জামু (ক্ৰেনবেৰী, ব্লেককাৰেণ্ট), আখৰোট, ভেন্দি।

• সুস্থতাৰ সুবিধা আৰু ব্যৱস্থা:

  • Potent Antioxidant Exercise: Scavenge free radicals (ROS/RNS), upregulate endogenous antioxidant enzymes (SOD, CAT, GPx) through Nrf2 pathway activation.

  • কাৰ্ডিঅ'ভাস্কুলাৰ সহায়: Enhance endothelial operate (stimulate NO manufacturing), cut back LDL oxidation, inhibit platelet aggregation, modulate blood stress.

  • এন্টি-ইনফ্লেমেটৰী ফলাফল: Inhibit pro-inflammatory enzymes (COX-2, LOX) and cytokines (TNF-α, IL-6) through NF-κB and MAPK signaling modulation.

  • বিপাকীয় সুস্থতা: Enhance insulin sensitivity, assist glucose uptake, regulate lipid metabolism (AMPK activation).

  • স্নায়ুৰক্ষামূলক সম্ভাৱনা: Cross BBB, cut back neuroinflammation, defend neurons from oxidative stress (potential in cognitive decline).

  • ভেছ'প্ৰটেক্টিভ আৰু এন্টি-এডিমা: Rutin particularly strengthens capillaries and reduces permeability.

• দিনক দিনে ব্যৱহাৰ: There isn’t a established Advisable Dietary Allowance (RDA). Observational research hyperlink well being advantages to intakes of >500 mg complete flavonoids per day, primarily from numerous entire meals. Supplemental doses in scientific trials usually vary from ১০০-১০০০ মিলিগ্ৰাম/দিন of particular flavonol glycosides (e.g., isoquercitrin, rutin).

• Concerns & Aspect Results:

  • Typically Acknowledged as Protected (GRAS) at dietary and typical supplemental ranges.

  • Potential Aspect Results (Excessive Doses): Delicate GI upset (nausea, heartburn), headache.

  • ঔষধৰ পাৰস্পৰিক ক্ৰিয়া: Could work together with blood thinners (warfarin), antibiotics (quinolones), and medicines metabolized by CYP3A4/P-gp (seek the advice of doctor).

  • Allergy symptoms: Uncommon, however doable, particularly if delicate to supply vegetation.

  • High quality Issues: Supply from respected suppliers making certain purity and absence of contaminants (heavy metals, solvents, pesticides).

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Associate in Bioactives
ছানচি ঝংহং প্ৰিমিয়াৰ হিচাপে থিয় দিছে উচ্চ প্ৰযুক্তিৰ উদ্যোগ devoted to excellence within the chemistry, supplies, and life science sectors. With 28 years of specialised experience in bioactive compounds, we’re leaders within the extraction, isolation, and purification of potent plant constituents.

• মূল ফোকাচ: Superior extraction of plant lively elements for numerous markets: pure extracts, beauty actives, nutraceuticals, pharmaceutical intermediates, pure pigments (anthocyanins, carotenoids), and sweeteners (mogrosides).

• অতুলনীয় বৈজ্ঞানিক কঠোৰতা:

  • বিশ্লেষণ দুৰ্গ: সহযোগিতামূলক যৌথ পৰীক্ষাগাৰ ৫ খন অভিজাত বিশ্ববিদ্যালয়ৰ সৈতে।

  • IP Management: ৰ পৰ্টফলিঅ' ২০+ পেটেণ্টযুক্ত প্ৰয়োগ বিজ্ঞান আৰু ক গোলকীয়ভাৱে অনন্য যৌগিক লাইব্ৰেৰী.

  • চপিং-এজ বিশ্লেষণ: আউটফিটেড ৱিথ এইচ পি এল চি, ইউ পি এল চি, জি চি-এম এছ, আৰু অতিপৰিবাহী এন এম আৰ for unparalleled characterization. Our dedication to >৯৮১টিপি৩টি বিশুদ্ধতা (validated by HPLC) exceeds business requirements by >২০১টিপি৩টি, guaranteeing premium high quality.

• আন্তৰ্জাতিক অৰ্জন আৰু কাষ্টমাইজেচন: Our in depth community seamlessly serves ৮০+ আন্তঃৰাষ্ট্ৰীয় স্থান throughout Asia, Europe, and the Americas. We excel in delivering personalized, cGMP-compliant ingredient options tailor-made to the precise R&D and manufacturing wants of multinational pharmaceutical companies, analysis establishments, and main nutraceutical manufacturers.

5. Flavonol Glycosides: Sourcing, Benefits & Steerage

• প্ৰিমিয়াম উৎস: Zhonghong makes use of licensed, sustainably harvested botanical uncooked supplies (e.g., Sophora japonica buds for rutin, ginkgo leaves for quercetin/kaempferol glycosides, onion skins for isoquercitrin) sourced globally. Our vertically built-in course of ensures traceability from farm to last product.

• Well being Benefits Recap: As detailed in Part 3, key advantages focus on highly effective antioxidant protection, cardiovascular and metabolic assist, anti-inflammatory motion, and neuroprotection.

• Utilization Tips:

  • খাদ্যাভ্যাস: Prioritize consumption by way of flavonol-rich fruits, greens, tea, and cocoa.

  • পৰিপূৰক: Observe product-specific labeling. Typical doses vary from 50mg to 500mg of standardized extract per serving. Typically taken with meals.

  • Beauty: Included into serums, lotions (0.1-5%) for antioxidant and anti-aging advantages.

  • বিশ্লেষণ: Used as reference requirements or bioactive probes in biochemical assays.

• মূল সাৱধানতাসমূহ:

  • Seek the advice of a healthcare supplier earlier than supplementation, particularly if pregnant, breastfeeding, taking drugs, or having a medical situation.

  • Adhere to really helpful dosages.

  • Select merchandise with verified purity and focus (COA out there).

6. Rigorous Product Specs

(Specs are indicative; precise limits topic to particular product & grade. Compliant with USP, EP, CP, FDA, and EU laws).

৭/ৰ উচ্চমানৰ উৎপাদন পাঠ্যক্ৰম
ঝংঘঙে অত্যাধুনিক নিয়োগ কৰে, cGMP-সঙ্গতিপূৰ্ণ উৎপাদন:

1. অৰন্ধা সামগ্ৰীৰ অৰ্হতা: কঠোৰ আইডি পৰীক্ষা (HPLC, TLC) আৰু দূষক পৰীক্ষণ।

2. নিষ্কাশন: অনুকূলিত কৰা হৈছে দ্রাৱক নিষ্কাশন (যেনে, ইথানল/পানী) বা অতি জটিল তৰল নিষ্কাশন (SFE-CO2) তাপ-সংবেদনশীল যৌগসমূহৰ বাবে।

3. মূল বিশুদ্ধকৰণ: মেক্ৰ’প’ৰাছ ৰেজিন এডছৰ্পচন ক্ৰ’মাট’গ্ৰাফী for environment friendly enrichment.

4. Excessive-Decision Separation: প্ৰস্তুতিমূলক এইচ পি এল চি অথবা কাউণ্টাৰ-কাৰেণ্ট ক্ৰ'মাট'গ্ৰাফী (CCC) for isolating particular flavonol glycosides to ultra-high purity (>95-98%).

5. ফোকাচ আৰু শুকান: ভেকুৱাম বাষ্পীভৱন দ্বাৰা গ্ৰহণ কৰা হৈছে লাইঅ'ফিলাইজেচন (ফ্ৰীজ-ড্ৰাইং) অথবা স্প্ৰে শুকুৱাই লোৱা to protect bioactivity.

6. মিশ্ৰণ আৰু প্ৰামাণিককৰণ: Exact formulation to fulfill goal efficiency specs.

7. পেকেজিং: Below managed humidity/temperature in food-grade, light-protected containers.

8. Numerous Application Scenarios

• নিউট্ৰাচিউটিকেলছ আৰু উপযোগী খাদ্য: Key elements in capsules, tablets, powders, drinks, and fortified meals concentrating on antioxidant assist, coronary heart well being, cognitive operate, and anti-aging.

• প্ৰসাধন সামগ্ৰী: Valued in anti-aging serums, lotions, and sunscreens for potent antioxidant safety, UV harm mitigation, collagen synthesis assist, and anti inflammatory results (cut back redness).

• ঔষধৰ মধ্যৱৰ্তী পদাৰ্থ: Function precursors or lively elements for creating medicine concentrating on irritation, metabolic issues, or vascular ailments.

• Analysis Reagents: Excessive-purity requirements (>98% HPLC) used as reference supplies in biochemical, pharmacological, and metabolic research.

9. Stringent High quality Management (QC)
Zhonghong’s QC paradigm is constructed on id, purity, efficiency, and security, exceeding pharmacopeial requirements:

• Id দৃঢ়তা: এফ টি-আই আৰ, ইউ ভি-ভিছ বৰ্ণালীবিজ্ঞান, and co-injection with reference requirements on এইচ পি এল চি-ডি এ ডি/ই এল এছ ডি.

• বিশুদ্ধতা আৰু পৰীক্ষা: Validated HPLC-UV/DAD strategies (ICH Q2(R1) compliant) quantify complete and particular person flavonol glycosides towards licensed reference requirements. ইউ পি এল চি-এম এছ/এম এছ confirms id and detects hint impurities. অতিপৰিবাহী এন এম আৰ (৬০০ মেগাহাৰ্টজ+) gives definitive structural elucidation.

• দূষক ব্যৱস্থাপনা: Strict adherence to specs for অৱশিষ্ট দ্রাৱক (GC-HS/FID), গধুৰ ধাতু (ICP-MS), কীটনাশক (GC-MS/MS, LC-MS/MS), আৰু অণুজীৱবিজ্ঞানসন্মত বোজা (as per desk above). Common মৌলিক অশুদ্ধি পৰীক্ষা (USP <232>/<233>).

• স্থিতিশীলতা গৱেষণা: পৰিচালনা কৰা ICH Q1A(R2) compliant accelerated & long-term stability research to outline shelf life, storage situations, and retest durations. Parameters embrace assay, associated substances, water content material (KF), and bodily attributes.

• নথিপত্ৰ: সম্পূৰ্ণ কৰা মূল্যায়নৰ প্ৰমাণপত্ৰ (CoA) for each batch, traceable manufacturing data, and strict adherence to আই এছ অ’ ৯০০১ আৰু চি জি এম পি high quality programs.

10. Safe Packaging & International Logistics

• পেকেজিং: Multi-barrier packaging ensures stability: inside double polyethylene luggage sealed inside খাদ্য-গ্ৰেডৰ এইচডিপিই ড্ৰাম অথবা kraft foil luggage. ডিচিকেণ্ট আৰু অক্সিজেন স্কেভেঞ্জাৰ included as required. Mild-protected supplies used.

• সংৰক্ষণ: Keep in a cool (<25°C), dry (RH<60%) surroundings, protected against gentle. Lengthy-term storage really helpful at ২-৮ ডিগ্ৰী চেলছিয়াছ for optimum stability.

• লজিষ্টিক: Environment friendly international transport through air freight (DAP, DDP) or sea freight (FOB, CIF). Experience in dealing with উষ্ণতা-সংবেদনশীল সামগ্ৰী and navigating complicated শুল্ক নিষ্পত্তি আৰু import laws worldwide. Complete documentation supplied.

11. Analysis Insights: Mechanisms, Functions & Future

• সুস্থতাৰ ব্যৱস্থা: Ongoing analysis delves deeper into সংকেত পথ (Nrf2, AMPK, SIRT1, এনএফ-কেবি), এপিজেনেটিক মডুলেচন, intestine microbiota interactions (bioconversion to lively metabolites), and mobile senescence নিয়ন্ত্ৰণ। কুৱেৰচেটিন-৩-গ্লুক’চাইডৰ superior bioavailability through SGLT1 transport is well-established.

• শিল্প উদ্ভাৱন: Focus areas embrace এনজাইমেটিক গ্লাইকোচাইলেচন to create novel, extra bioavailable analogs, inexperienced extraction applied sciences (ইউটেক্টিক দ্রাৱক, চাপযুক্ত তৰল), নেনোকেৰিয়াৰ প্ৰগ্ৰেম (liposomes, PLGA NPs) for enhanced supply and stability, and biotechnological manufacturing utilizing engineered microbes or plant cell cultures.

• বিশ্লেষণ সীমা আৰু প্ৰত্যাহ্বানসমূহ: Key challenges contain understanding complicated metabolite profiles ইন ভিভ', scientific translation যান্ত্ৰিক তথ্যৰ (বৃহৎ পৰিসৰৰ, দীৰ্ঘম্যাদী মানৱ পৰীক্ষা), নিৰ্দিষ্ট প্ৰতিষ্ঠা কৰা মাত্ৰা-প্ৰতিক্ৰিয়াৰ সম্পৰ্ক আৰু well being declare substantiation (EFSA/FDA), and bettering স্থিৰতা in formulated merchandise. Synergistic results throughout the “ফ্লেভন’ইডম” are a serious frontier.

১২) নিয়মিতভাৱে অনুৰোধ কৰা প্ৰশ্ন (FAQ)

1. Q: What is the distinction between flavonols and flavonol glycosides?

   • উঃ: Flavonols (e.g., quercetin) are the aglycone core. Flavonol glycosides have sugars hooked up, enhancing water solubility and sometimes bioavailability.

2. Q: Which meals has the very best flavonol glycoside content material?

   • উঃ: Onions (quercetin glycosides), kale (kaempferol glycosides), and berries/capers are exceptionally wealthy sources.

3. Q: Are flavonol glycosides secure?

   • উঃ: Typically secure at dietary and customary supplemental ranges. Seek the advice of a health care provider earlier than high-dose supplementation, particularly if on remedy.

4. Q: What is the really helpful each day consumption?

   • উঃ: No official RDA. Intention for numerous flavonoid-rich meals (>500mg complete flavonoids/day). Dietary supplements usually present 100-500mg particular glycosides.

5. Q: Can I take flavonol glycosides with drugs?

   • উঃ: সম্ভাৱ্য পাৰস্পৰিক ক্ৰিয়া আছে (তেজ পাতল কৰা, এন্টিবায়টিক, CYP3A4 ছাবষ্ট্ৰেট)। At all times seek the advice of your doctor or pharmacist.

6. Q: How does Zhonghong guarantee purity?

   • উঃ: By way of পেটেণ্টযুক্ত বিশুদ্ধকৰণ, এইচ পি এল চি/ইউ পি এল চি (>৯৮১টি পি ৩ টি বিশুদ্ধতা), NMR affirmation, আৰু কঠোৰ দূষক ব্যৱস্থাপনা exceeding pharmacopeial requirements (see QC part).

7. প্ৰশ্ন : আপুনি কাষ্টমাইজেচন যোগান ধৰেনে?

   • উঃ: Sure! We specialise in customized extraction, isolation of particular glycosides, আৰু tailor-made formulations (efficiency, ratios, supply programs) for B2B shoppers.

8. Q: What is your minimal order amount (MOQ)?

   • উঃ: MOQ varies by product and purity grade. Contact us for particular particulars (analysis customary vs. bulk ingredient).

9. Q: The place can I purchase Zhonghong’s Flavonol Glycosides?

13. The place to Purchase & Contact Data
Supply premium, high-purity Flavonol Glycosides straight from the producer:

• ৱেব চাইট: Discover our product portfolio: aiherba.com

• ই-মেইল: Contact our gross sales and technical crew: liaodaohai@gmail.com ত যোগাযোগ কৰক

• অনুৰোধ: For particular inquiries, quotations, or to request a Certificates of Evaluation (CoA), please e mail us.

১৪) উপসংহাৰ
Flavonol glycosides signify a cornerstone of plant-based bioactivity, providing profound antioxidant, anti-inflammatory, cardioprotective, and neuromodulatory advantages. Integrating them by way of a food regimen wealthy in colourful vegetables and fruit is good. For focused purposes in nutraceuticals, cosmeceuticals, or analysis, উচ্চ-বিশুদ্ধতা, মানক নিষ্কাশনসমূহ সৰ্বোচ্চ। Shaanxi Zhonghong বিনিয়োগ প্ৰযুক্তি কোম্পানী, লিমিটেড. লিভাৰেজ 28 years of experience, cutting-edge expertise (HPLC, NMR), patented purification processes, and uncompromising high quality management to ship the business’s purest and most dependable flavonol glycoside elements. Our dedication to innovation, customization, and international provide chain excellence makes us the associate of alternative for discerning shoppers worldwide. Contact us right now to boost your product pipeline.

১৫) তথ্যসূত্ৰ

1. হলমেন, পিচিএইচ, ইত্যাদি। (১৯৯৯)। Absorption of dietary quercetin glycosides and quercetin in wholesome ileostomy volunteers. এম জে ক্লিন নিউট্ৰ.

2. উইলিয়ামছন, জি., আৰু মানাচ, চি.(২০০৫)। Bioavailability and bioefficacy of polyphenols in people. II. Assessment of 93 intervention research. এম জে ক্লিন নিউট্ৰ.

3. লি, ৱাই, ইত্যাদি। (২০১৬)। Quercetin, Irritation and Immunity. Vitamins.

4. লাৰ্ছন, এ জে, ইত্যাদি। (২০১২)। Therapeutic potential of quercetin to lower blood stress: overview of efficacy and mechanisms. Adv Nutr.

5. ক্ৰিজোভা, এল., ইত্যাদি। (২০১৯)। Flavonolignans and Flavonoids from Silybum marianum: UPLC-ESI-MS/MS Profiles and Antioxidant Capability. এন্টিঅক্সিডেন্ট।

6. European Meals Security Authority (EFSA) Scientific Opinions on Well being Claims (e.g., ID 1648, 1410).

7. United States Pharmacopeia (USP) Monographs & Basic Chapters (<232>, <61>, <62>).

8. ইউৰোপীয় ফাৰ্মাকোপিয়া (EP) মনোগ্ৰাফ। (Particular references depend upon precise compounds mentioned).