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Sulforaphane Supplement

sulforaphane supplement
Source : Extracted from high-quality broccoli sprouts, a rich natural source of sulforaphane.
Appearance : Fine green powder with a mild, slightly bitter taste.
Specifications : Sulforaphane content ≥0.3%; Moisture ≤5%; Particle size 80 mesh.
Certification : Certified Organic, ISO 9001, and Non-GMO.
Testing methods : Verified using HPLC (High-Performance Liquid Chromatography) for sulforaphane content.
Major markets : North America, Europe, and Asia.
Delivery : Available for worldwide shipping via air, sea, and express courier services.
Storage : Store in a cool, dry place, away from direct sunlight.
Shelf life : 24 months under proper storage conditions.
Packaging : Sealed in double-layer PE bags, packed in fiber drums.

Efficacy: Studies have shown that sulforaphane has anti-tumor effects, helps clear lung bacteria, and prevents gout. It can also be used as an adjuvant treatment for leukemia.

Sulforaphane Supplement: The Ultimate Guide to Nature’s Potent Antioxidant Powerhouse

1. What Is Sulforaphane Supplement?

Sulforaphane is a bioactive isothiocyanate derived from cruciferous vegetables like broccoli sprouts, renowned for its exceptional antioxidant and detoxification properties. As a dietary supplement, it harnesses the power of nature to support cellular health by activating the Nrf2 pathway, a master regulator of the body’s antioxidant and detoxification responses. This makes it a key ingredient in functional nutrition, pharmaceuticals, and cosmeceuticals, backed by decades of scientific research.

2. Product Origin & Chemical Properties

2.1 Source

Sulforaphane is extracted from 7 – day old broccoli sprouts (Brassica oleracea var. italica), where its precursor glucoraphanin reaches peak concentration. Our proprietary process uses non – GMO, sustainably sourced sprouts to ensure maximum yield and purity, leveraging enzymatic conversion to transform glucoraphanin into bioactive sulforaphane.

2.2 Chemical Profile

  • CAS Number: 4478 – 93 – 7
  • Molecular Formula (MF): C₁₀H₁₁NOS₂
  • Molecular Weight (MW): 217.33 g/mol
  • EINECS: 224 – 768 – 7
  • Physical State: White crystalline powder with minimal odor
  • Solubility: Sparingly soluble in water; highly soluble in ethanol and DMSO

3. Company Profile: Shaanxi Zhonghong Investment Technology Co., Ltd.

With 28 years of expertise in bioactive compound extraction, we are a global leader integrating:
  • Research Excellence: 5 university – affiliated labs, 20+ patents, and an exclusive global compound library for innovative formulations.
  • Technical Superiority: State – of – the – art HPLC/NMR systems ensuring purity ≥ 98%, 20% above industry standards.
  • Global Reach: Serving 80+ countries with GMP – compliant APIs and custom solutions for pharma, nutraceutical, and cosmetic industries.

4. Health Benefits & Mechanisms of Action

4.1 Key Health Advantages

Sulforaphane Supplement
Sulforaphane Supplement Benefits Aiherba

4.1.1 Antioxidant Defense

Activates the Nrf2 pathway, upregulating enzymes like glutathione S – transferase to neutralize reactive oxygen species (ROS). This protects cells from oxidative damage linked to aging, cardiovascular disease, and neurodegeneration.

4.1.2 Inflammation Regulation

Inhibits the NF – κB pathway, reducing pro – inflammatory cytokines (TNF – α, IL – 6). Beneficial for managing arthritis, metabolic syndrome, and promoting heart health by improving endothelial function.

4.1.3 Cancer Preventive Effects

Preclinical studies show:
  • Induction of apoptosis in cancer cells (breast, prostate, lung models)
  • Inhibition of angiogenesis (tumor blood vessel formation)
  • Enhancement of DNA repair mechanisms

4.1.4 Neuroprotection

Crosses the blood – brain barrier to protect neurons from amyloid β toxicity and oxidative stress, positioning it for Alzheimer’s and Parkinson’s disease research.

4.2 Optimal Dosage & Bioavailability

  • Daily Intake: 50–200 mg for general health; clinical trials use up to 500 mg for specific conditions.
  • Best Form: Sprout – derived supplements offer 30% higher bioavailability than mature broccoli due to enhanced glucoraphanin conversion.

5. Usage Guidelines & Precautions

5.1 Recommended Use

  • Dietary Supplements: Take 50–100 mg capsules/tablets with food to enhance absorption.
  • Cosmetic Applications: 0.1–0.5% in serums/creams for UV protection and collagen synthesis.
  • Pharmaceutical Use: Custom formulations for preclinical trials (contact for GMP – certified APIs).

5.2 Safety Considerations

  • Contraindications: Avoid if sensitive to thiocyanates; consult a physician if pregnant, nursing, or taking anticoagulants (may interact with blood thinners).
  • Side Effects: Rare gastrointestinal discomfort at doses > 500 mg/day; start with lower doses to assess tolerance.

6. Product Specifications

Category
Test Items
Standards
Detection Methods
Pesticide Residues
Chlorpyrifos
< 0.01 ppm
GC – MS
Carbendazim
< 0.05 ppm
HPLC – MS/MS
Heavy Metals
Lead (Pb)
< 0.5 ppm
ICP – MS
Mercury (Hg)
< 0.01 ppm
CVAAS
Microbial Safety
Total Viable Count
< 100 CFU/g
Microbiological plating
Pathogens (E. coli/Salmonella)
Absent
PCR – based detection

7. Production Process

  1. Sprout Cultivation: Organically grown broccoli sprouts (7 – day old) for maximal glucoraphanin content.
  1. Enzymatic Conversion: Myrosinase – mediated hydrolysis to convert glucoraphanin to sulforaphane.
  1. Supercritical CO₂ Extraction: Solvent – free process for pure, bioactive compound isolation.
  1. HPLC Purification: Preparative chromatography to achieve ≥ 98% purity, verified by NMR and HPLC.
  1. Formulation: Custom particle size (10–50 μm) for enhanced dissolution in supplements and pharmaceuticals.

8. Industrial Applications

8.1 Pharmaceuticals

  • Anticancer adjuvants in combination therapies
  • Orphan drug development for neurodegenerative disorders

8.2 Nutraceuticals

  • Immune support supplements (synergizes with vitamins C/E)
  • Functional foods (fortified powders, sports drinks)

8.3 Cosmetics

  • Antioxidant serums for anti – aging and UV protection
  • Anti – inflammatory formulations for acne and rosacea

9. Quality Control

Quality control at Shaanxi Zhonghong is a comprehensive and stringent process for our sulforaphane supplements. At the raw material stage, broccoli sprouts are tested for genetic purity via DNA barcoding and screened for over 200 pesticide residues using GC-MS, ensuring compliance with international standards. During enzymatic activation and extraction, real-time HPLC monitors sulforaphane conversion rates, with process parameters optimized to maintain a yield of 95% or higher.​ Post-extraction, each batch undergoes extensive analysis. ICP-MS measures heavy metal levels, ensuring they remain well below regulatory limits (e.g., Pb < 0.1 ppm, As < 0.05 ppm). Microbiological safety is guaranteed through PCR-based pathogen detection and agar plate counting, with a strict requirement of total plate counts < 100 CFU/g and no detection of harmful bacteria. Purity is verified by HPLC, ensuring sulforaphane content meets or exceeds 98%. Stability testing subjects products to accelerated aging conditions (40°C/75% RH for 4 weeks) to assess shelf life and resistance to degradation. Our commitment to quality control ensures that every batch of sulforaphane supplements meets and exceeds industry standards.

10. Research Frontiers & Innovations

10.1 Technological Advancements

  • Nanoformulations: Liposomal delivery systems boost bioavailability by 50%, enabling targeted cellular absorption.
  • Synthetic Biology: Microbial biosynthesis for consistent supply and cost – efficient production.

10.2 Challenges

  • Stability: Oxygen and light sensitivity require airtight, amber packaging (store at 2–8°C).
  • Clinical Evidence: Large – scale human trials ongoing to validate disease – specific benefits (e.g., cancer prevention).

11. Packaging & Logistics

  • Packaging: Food – grade aluminum foil bags (1 kg), fiber drums (25 kg); custom packaging for bulk orders.
  • Storage: Cool, dry place away from light; shelf life of 24 months under recommended conditions.
  • Delivery: Worldwide shipping via DHL/FedEx (samples in 3 days, bulk orders in 7–15 days).

12. FAQ

12.1 Where to Purchase?

  • Documentation: COA, MSDS, and regulatory dossiers available upon request.

12.2 Is Sulforaphane Safe for Long – Term Use?

Yes, when taken within recommended doses; consult a healthcare provider for personalized guidance.

12.3 Can It Be Combined with Other Supplements?

Synergizes well with omega – 3s and vitamin D; avoid concurrent use with thiocyanate – sensitive medications.

13. Conclusion

Sulforaphane supplements offer a convenient and potent way to harness the health-promoting benefits of this remarkable bioactive compound. Shaanxi Zhonghong Investment Technology Co., Ltd., with our 28 years of industry expertise and commitment to innovation, is dedicated to providing high-quality sulforaphane supplements that meet the highest standards of purity, safety, and efficacy. As research continues to uncover new applications and benefits, our products remain at the forefront of natural health solutions, empowering individuals to achieve optimal well-being.

14. References

  1. Zhang, Y. et al. (1992). Proc Natl Acad Sci USA. 89: 2399–2403.
  1. Fahey, J. W. et al. (1997). Proc Natl Acad Sci USA. 94: 10367–10372.
  1. European Food Safety Authority (2017). EFSA Journal. 15: 4702.
  2. “Sulforaphane: A Review of Its Biological Activities and Therapeutic Potential.” Molecular Nutrition & Food Research, 2022.
  3. ​”Nrf2 Activation by Sulforaphane: Mechanisms and Implications for Health.” Antioxidants, 2023.
  4. “Sulforaphane in Cancer Prevention and Treatment: Current Status and Future Perspectives.” Cancer Letters, 2021.

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