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ราพามัยซิน

Rapamycin factory supplier bulk Wholesale Extract factory

  1. ชื่อภาษาอังกฤษ: Rapamycin (also known by its brand name Sirolimus—pronounced “ray-puh-MY-sin”; it’s a prescription-only medication, not a supplement!)
  1. ข้อมูลจำเพาะ
    • ความบริสุทธิ์: ≥ 99.5% (HPLC tested—pharmaceutical grade, critical for consistent medical effects)
    • รูปร่าง: Available as oral tablets (0.5mg, 1mg, 2mg), oral solution (1mg/mL), or injectable for research use
    • ความสามารถในการละลาย: Insoluble in water; dissolves well in ethanol, DMSO, and vegetable oils (formulated into tablets/solutions for medical use)
    • สิ่งเจือปน: ≤ 0.1% (strict pharmaceutical standards—no harmful byproducts)
    • Storage Stability: Stable for 2+ years when stored at 2–8°C (refrigerated, away from light/moisture)
  1. รูปร่าง: White to off-white crystalline powder (pure form) or white/cream tablets (pharmaceutical form). It has a mild, neutral aroma—อย่างแน่นอน no chocolate aroma! Odorless in tablet form, so it’s easy to take as prescribed.
  1. หมายเลข CAS: 53123-88-9 (this is the official CAS for rapamycin—critical for pharmaceutical labeling and regulatory compliance)
  1. ระยะเวลาดำเนินการ: 3–7 Working Days (for pharmaceutical distributors; research-grade versions also in stock, but note: prescription-only for medical use)
  1. บรรจุุภัณฑ์:
    • Pharmaceutical: Blister packs (10 tablets/ pack) or amber glass bottles (oral solution) to protect from light
    • Research-grade: 1g/10g amber glass vials (light-resistant, airtight) or 25kg sealed pharmaceutical drums (for bulk medical manufacturing)
  1. ตลาดหลัก: Global (Europe, North America, Asia)—used in hospitals and clinics for organ transplants, cancer treatment, and rare diseases. Research-grade versions are popular in biotech labs.
  1. สถานการณ์การใช้งาน (Critical Note: Rapamycin is a prescription drug—must be used under medical supervision)

Key Features (Medical Focus)

  • Immunosuppressant Power: Slows the immune system to prevent organ rejection (e.g., kidney, liver transplants)—saves lives post-transplant
  • Anti-Cancer Effects: Inhibits cell growth—used to treat rare cancers (e.g., renal cell carcinoma, mantle cell lymphoma)
  • Targeted Action: Works on the mTOR pathway (a key cell growth regulator)—fewer off-target side effects than older immunosuppressants
  • Pharmaceutical Grade Only: No over-the-counter versions—requires a doctor’s prescription to ensure safe dosing
  • ศักยภาพการวิจัย: Studied for age-related diseases (e.g., Alzheimer’s) in labs, but these uses are not yet approved for medical practice

Industry Applications (Medical & Research Only)

  1. Organ Transplant Medicine
    • Kidney/Liver Transplants: Prescribed daily (0.5–2mg) to prevent immune rejection—often combined with other immunosuppressants (e.g., tacrolimus) for better results
    • Heart/Lung Transplants: Used in select cases to support long-term graft survival (dosing adjusted for patient weight/health)
  1. Oncology (Cancer Treatment)
    • Rare Cancers: Prescribed for advanced renal cell carcinoma (kidney cancer) or mantle cell lymphoma—slows tumor growth by blocking mTOR
    • Kaposi’s Sarcoma: Used to treat this AIDS-related cancer in patients who can’t tolerate other treatments
  1. Rare Disease Treatment
    • Tuberous Sclerosis Complex (TSC): Approved for treating seizures and kidney tumors in adults/children with TSC—targets abnormal cell growth caused by TSC mutations
    • Lymphangioleiomyomatosis (LAM): A rare lung disease—reduces lung lesions and improves breathing in affected patients
  1. Biotech Research
    • Age-Related Disease Studies: Used in labs to study mTOR’s role in aging, Alzheimer’s, and Parkinson’s—no approved medical use for these yet
    • Cell Biology: A tool for researching cell growth and survival pathways (common in academic and pharmaceutical labs)
  1. Veterinary Medicine (Specialized)
    • Pet Organ Transplants: Rarely used in dogs/cats post-kidney transplants (veterinarian-prescribed, adjusted for animal size)

Critical Safety Note

Rapamycin has serious side effects (e.g., increased infection risk, high cholesterol, kidney issues) and interacts with many drugs. It is not a supplement—do not use without a doctor’s prescription and close medical monitoring.
หมวดหมู่:

Rapamycin: Pharmaceutical-Grade mTOR Inhibitor for Research & Medical Applications – Manufacturer & Exporter Guide

1. What is Rapamycin?
For research institutions and pharmaceutical companies exploring longevity and immune modulation, Rapamycin (Sirolimus) represents one of the most significant discoveries in molecular biology. This macrocyclic lactone compound, originally isolated from Streptomyces hygroscopicus found in Easter Island soil, has revolutionized our understanding of cellular metabolism and aging processes. As a potent mTOR (mechanistic target of rapamycin) inhibitor, it serves as a critical tool for research into aging, cancer, and autoimmune disorders. While primarily used as an immunosuppressant drug in transplant medicine, its research applications continue to expand into novel therapeutic areas.

2. แหล่งที่มา เคมี และข้อมูลจำเพาะ

  • แหล่งที่มา: Fermentation product of Streptomyces hygroscopicus

  • Chemical Identity: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

  • โปรไฟล์ทางเคมี:

    • หมายเลข CAS: 53123-88-9

    • เอ็มเอฟ: C₅₁H₇₉NO₁₃

    • มว.: 914.17 g/mol

    • EINECS: 610-535-3

  • รูปร่าง: ผงผลึกสีขาวถึงขาวออกเหลือง

  • ความสามารถในการละลาย: ละลายได้ใน DMSO, เอธานอล ไม่ละลายในน้ำ

3. Research and Pharmaceutical Applications
Important Notice: Rapamycin is a prescription drug with significant side effects and must be used only under medical supervision. This information is for research purposes only.

  • Key Mechanism: Potent and specific inhibitor of mTOR pathway

  • Research Applications:

    • Longevity Research: Investigating effects on lifespan extension

    • Oncology Research: Studying tumor suppression mechanisms

    • Immunology Research: Exploring immune system modulation

    • Metabolic Studies: Researching metabolic pathway regulation

  • Pharmaceutical Grade: ≥98% purity for research applications

  • Storage Requirements: -20°C protected from light

  • การจัดการ: Requires specialized handling and containment procedures

4. Zhonghong Biotech: Your Research Compound Partner
Sourcing high-purity rapamycin requires pharmaceutical-grade expertise.บริษัท เทคโนโลยีการลงทุน Shaanxi Zhonghong จำกัด brings 28 years of experience in advanced compound production to serve the global research community.

  • Technical Capabilities:

    • Fermentation Expertise: Advanced fermentation technology for consistent production

    • Purification Technology: Chromatographic purification to pharmaceutical standards

    • การรับรองคุณภาพ: Comprehensive analytical testing and characterization

  • การปฏิบัติตามกฎระเบียบ: Meets ISO 9001 and cGMP standards

5. Scientific Significance: mTOR Inhibition Mechanism
Rapamycin’s research value stems from its unique mechanism:

  • Forms complex with FKBP12 protein

  • Binds to and inhibits mTORC1 specifically

  • Modulates protein synthesis and cell growth

  • Influences autophagy and metabolic processes

6. Pharmaceutical-Grade Quality Assurance
Our rigorous quality control ensures research-ready material:

Certificate of Analysis (COA) Summary – Rapamycin (Research Grade)

หมวดหมู่ พารามิเตอร์ ข้อมูลจำเพาะ วิธีทดสอบ
ตัวตน HPLC Retention Matches Reference HPLC-UV
การวิเคราะห์ Rapamycin Content ≥ 98.0% HPLC-UV
ความบริสุทธิ์ สารที่เกี่ยวข้อง ≤ 2.0% HPLC-UV
ความปลอดภัย โลหะหนัก ≤ 10 ppm ไอซีพี-เอ็มเอส
ตัวทำละลายที่เหลือ Meet ICH Guidelines จีซี-เอ็มเอส
จุลชีววิทยา Endotoxin < 0.5 EU/mg LAL Test
ความเป็นหมัน Sterile การกรองด้วยเมมเบรน

7. Advanced Manufacturing Process
Our pharmaceutical-grade production ensures highest quality:

  1. การหมัก: Controlled fermentation of Streptomyces hygroscopicus

  2. การสกัด: Solvent extraction of crude product

  3. การชำระล้าง: Multi-stage chromatographic purification

  4. การตกผลึก: Controlled crystallization process

  5. การแช่เยือกแข็ง: Freeze-drying for stability

  6. การควบคุมคุณภาพ: Comprehensive analytical testing

8. Research Applications

  • Academic Research: University and institutional research programs

  • การวิจัยและพัฒนายา: Drug discovery and development

  • Biotech Research: Molecular biology and biochemistry studies

  • Medical Research: Translational medicine investigations

9. Specialized Handling & Logistics

  • บรรจุภัณฑ์: Sealed vials with argon atmosphere

  • พื้นที่จัดเก็บ: -20°C protected from light and moisture

  • การส่งสินค้า: Cold chain logistics with temperature monitoring

  • เอกสารประกอบ: Comprehensive research-use documentation

10. Research Partnership Opportunities
เราให้บริการ:

  • Research-grade materials for scientific investigation

  • Technical documentation for research applications

  • Custom quantities for research programs

  • Analytical support for research projects

Contact Our Scientific Team:

11. Research FAQ

  • Q: What purity grade do you offer?
    A: We provide research-grade rapamycin with ≥98% purity

  • Q: Do you provide analytical data?
    A: Yes, comprehensive COA and characterization data provided

  • Q: What’s the minimum order quantity?
    A: MOQ varies based on research requirements

  • Q: Do you offer custom synthesis?
    A: We offer custom quantities and specialized packaging

  • Q: What documentation is provided?
    A: Full analytical data, MSDS, and research-use documentation

12. Important Disclaimer
Rapamycin is a potent pharmaceutical compound with significant side effects. It must be used only by qualified researchers in appropriate facilities following all safety guidelines. This product is for research use only and not for human consumption.

บทสรุป
Rapamycin remains a cornerstone compound in molecular biology research and pharmaceutical development. Zhonghong’s pharmaceutical-grade manufacturing capabilities ensure consistent, high-quality material for research applications. Our commitment to quality and technical excellence makes us a reliable partner for the research community.

Contact us for research inquiries and availability.

อ้างอิง:

  1. Brown, E.J., et al. (1994). A mammalian protein targeted by G1-arresting rapamycin. ธรรมชาติ

  2. Sabatini, D.M., et al. (1994). RAFT1: A mammalian protein that binds to FKBP12. เซลล์

  3. Blagosklonny, M.V., et al. (2019). Rapamycin for longevity. การแก่ชรา

  4. US Pharmacopeia. (2023). Sirolimus monograph. USP-NF

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