Экстракт коры белой ивы
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Экстракт коры белой ивы

  1. Английское имя: White Willow Bark Extract
  1. Спецификация
    • Salicin Content: ≥ 15% (HPLC, standardized extract)
    • Растворимость: Partially soluble in water; soluble in ethanol and methanol
    • Содержание влаги: ≤ 5% (в форме порошка)
    • Тяжелые металлы: ≤ 10 частей на миллион
    • Ash Content: ≤ 8%
  1. Появление: Light brown to tan powder, with a mild herbal aroma; no chocolate-related properties
  1. Номер CAS: N/A (plant extract); Key component Salicin: 138-52-3
  1. Время выполнения: 3-7 рабочих дней
  1. Упаковка: 1 кг/мешок из алюминиевой фольги, 25 кг/бочка (внутри двухслойный полиэтиленовый мешок)
  1. Главный рынок: Европа, Северная Америка, Азия и т. д.
  1. Сценарии применения

Ключевые свойства

  • Natural Analgesic: Salicin converts to salicylic acid in the body, providing mild pain-relieving effects
  • Противовоспалительное средство: Inhibits cyclooxygenase (COX) enzymes, reducing inflammation and swelling
  • Exfoliating: Salicylic acid derivatives gently exfoliate skin by dissolving dead skin cells
  • Антимикробный: Exhibits mild antibacterial properties, supporting skin and scalp health
  • Антиоксидант: Contains polyphenols that scavenge free radicals, protecting cells from oxidative damage

Сценарии применения

  1. Пищевые добавки
    • Pain Relief: Used in capsules (500-1000 mg per serving) for supporting joint comfort and muscle relaxation
    • Anti-inflammatory Blends: Included in formulations targeting inflammation-related discomfort
  1. Косметика и уход за кожей
    • Anti-Acne Products: Added to cleansers, toners, and spot treatments (0.5-2% concentration) for exfoliating and antimicrobial effects
    • Exfoliating Formulations: Used in peels and masks to unclog pores and smooth skin texture
    • Scalp Treatments: Included in shampoos for dandruff control, reducing flakiness
    • Joint & Muscle Rubs: Added to topical creams for soothing sore muscles
  1. Фармацевтические исследования
    • Investigated as a natural alternative to synthetic anti-inflammatory drugs (for mild conditions)
    • Studied for potential use in topical formulations for psoriasis and eczema
  1. Традиционная медицина
    • Used in herbal remedies for headaches, fever, and rheumatic pain (similar to historical “willow bark tea”)

Методы обнаружения

  • ВЭЖХ: Column C18 (250×4.6 mm, 5μm), Mobile Phase: Methanol-water (30:70) with 0.1% formic acid, Flow Rate: 1.0 mL/min, Detection Wavelength: 270 nm
  • УФ-видимая спектроскопия: Quantified at 270 nm using a salicin standard curve
  • ТСХ: Used for qualitative identification, with characteristic bands under UV light

Преимущества

  • Натуральное происхождение: Derived from the bark of Salix alba, a plant with centuries of medicinal use
  • Gentle Efficacy: Provides milder effects than synthetic alternatives, suitable for long-term use
  • Многофункциональный: Combines pain-relieving, anti-inflammatory, and exfoliating benefits
  • Потребительская привлекательность: Aligns with demand for natural ingredients in health and beauty products
Категории: , , ,

White Willow Bark Extract: Nature’s Ancient Answer to Modern Discomforts

1. What is White Willow Bark Extract?
White Willow Bark Extract (Salix alba) is a bioactive botanical derived from the bark of the white willow tree. Historically revered as “nature’s aspirin,” its primary active constituent, salicin, undergoes metabolism to salicylic acid, delivering analgesic, anti-inflammatory, and antipyretic effects. Unlike synthetic NSAIDs, it offers a gentler, time-released action, making it a cornerstone of evidence-based phytotherapy.

2. Source, Chemistry & Specifications

  • Ботанический источник: Salix alba L. (Salicaceae family)

  • Key Active: Salicin (typically standardized to 15-25%)

  • КАС: 138-52-3 (Salicin)

  • МФ: C₁₃H₁₈O₇

  • МВ: 286.28 g/mol

  • EINECS: 205-331-3

  • Появление: Fine, hygroscopic powder; light tan to off-white

  • Растворимость: Soluble in water, ethanol; insoluble in non-polar solvents

3. Defining “Best” White Willow Bark Extract: Key Criteria
The optimal extract balances bioactive potency, safety, and regulatory compliance:

  • Стандартизация: ≥ 15% Salicin content (HPLC-UV validated).

  • Efficacy (Compliant):

    • Pain Relief: Inhibits COX enzymes, reducing prostaglandin synthesis (J Ethnopharmacol. 2009).

    • Противовоспалительное средство: Modulates TNF-α, IL-1β cytokines (Phytomedicine. 2010).

    • Антиоксидант: Scavenges ROS via phenolic glycosides.

  • Источник: Sustainably harvested European or North American Salix alba.

  • Дозировка: 120-240mg salicin daily (EMA monograph). Max 240mg/day.

  • Использование: Capsules/tablets, functional foods, topical analgesics.

  • Target Users: Adults seeking natural joint/muscle support.*

  • Critical Contraindications:

    • Salicylate allergy or aspirin sensitivity.

    • Children/teens (Reye’s syndrome risk).

    • Pregnancy, lactation, renal impairment, anticoagulant use (warfarin interaction).

  • Побочные эффекты: Rare GI upset at high doses; discontinue if tinnitus occurs.

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Phytochemistry Partner
As a 28-летний новатор in bioactive compounds, Zhonghong integrates cutting-edge science with global supply chain excellence. Our vertically controlled process ensures traceability from raw bark to GMP-certified extract.

  • Основные компетенции:

    • Deep Extraction Expertise: Supercritical CO₂, ultrasonic-assisted ethanol/water extraction.

    • Очищение: Industrial-scale preparative HPLC, membrane filtration.

    • Analytical Rigor:

      • HPLC-DAD/ELSD: Quantification of salicin, salicylic acid, flavonoids.

      • GC-MS: Residual solvent profiling (ICH Q3C).

      • ICP-MS: Heavy metal detection (ppb level).

    • Patent Portfolio: 20+ patents covering novel extraction methodologies (e.g., CN107118222A).

5. COA Specifications: Guaranteed Purity & Safety

Параметр Тестовый элемент Спецификация Method
Остатки пестицидов Хлорпирифос ≤ 0,01 ppm ГХ-МС/МС (ЕС 396/2005)
Циперметрин ≤ 0,05 частей на миллион ГХ-МС/МС
Глифосат ≤ 0,1 ppm HPLC-FLD (AOAC 2008.01)
Тяжелые металлы Мышьяк (As) ≤ 1,0 ppm ICP-MS (USP <232>)
Свинец (Pb) ≤ 3,0 частей на миллион ИСП-МС
Кадмий (Cd) ≤ 0,5 частей на миллион ИСП-МС
Ртуть (Hg) ≤ 0,1 ppm CVAAS
Микробиология Общее количество аэробных нагрузок ≤ 1000 КОЕ/г USP <61>
Дрожжи и плесень ≤ 100 КОЕ/г USP <61>
Кишечная палочка Negative USP <62>
Сальмонелла виды Negative ИСО 6579-1

6. Расширенный производственный процесс

  1. Источники: Ethically wildcrafted Salix alba bark (EU PEFC-certified).

  2. Comminution: Cryogenic milling preserves thermolabile actives.

  3. Извлечение: Dynamic maceration (food-grade ethanol/water, 70:30 v/v).

  4. Концентрация: Low-temperature vacuum evaporators.

  5. Стандартизация: Salicin adjustment via chromatographic isolation.

  6. Spray Drying: Maltodextrin carrier (inlet temp ≤ 180°C).

7. Multisector Applications

  • Нутрицевтики: Joint health supplements (capsules, gummies).

  • Космецевтика: Anti-redness serums, soothing creams.

  • Functional Foods: Pain-management beverages.

  • Veterinary: Equine osteoarthritis support.

8. Uncompromising Quality Control
Zhonghong’s QbD (Quality by Design) framework exceeds ISO 9001:2015. Every batch undergoes:

  • Identity Confirmation: HPTLC fingerprint vs. Salix alba reference standard (EMA/HMPC).

  • Potency Assay: Salicin quantification via validated HPLC-UV (λ=270nm).

  • Остаточные растворители: GC-FID per ICH Q3C (Class 2 solvents < 50ppm).

  • Стабильность: ICH accelerated (40°C/75% RH) & real-time protocols.
    Наш proprietary QC algorithms detect batch-to-batch variability at σ > 1.5, ensuring pharmaceutical-grade consistency.

9. Health Mechanisms & Research Frontiers

  • MOA: Salicin → Saligenin → Hepatic conversion to salicylic acid → Systemic COX-1/COX-2 inhibition.

  • Clinical Evidence: Meta-analysis confirms efficacy vs. placebo for chronic low-back pain (Cochrane Database 2016).

  • Инновации: Nanoemulsion delivery systems enhancing salicin bioavailability (Int J Nanomedicine 2021).

  • Проблемы: Standardizing polyphenol synergies (flavonoids, tannins) beyond salicin.

10. Packaging & Logistics

  • Начальный: Double polyethylene-lined kraft paper drums (25kg net).

  • Хранилище: <25°C; 40-60% RH; protected from light.

  • Срок годности: 24 months (validated).

  • Глобальное соответствие: FDA GRAS, REACH, FSSC 22000, Kosher/Halal.

11. FAQ: Addressing Critical Queries

  • Q: Is this suitable for vegetarians?
    A: Yes, entirely plant-derived. Ethanol extraction is non-animal.

  • Q: Typical lead time for bulk orders?
    A: 15-25 days post-PO confirmation (MOQ: 25kg).

  • Q: Can you provide salicin 25% + polyphenol complex?
    A: Yes – our patented ZH-WB25+ includes synergistic flavonoids.

  • Q: Stability in liquid formulations?
    A: Use buffered pH 4.5-5.5; recommend antioxidants (e.g., ascorbyl palmitate).

12. Procure Premium White Willow Bark Extract
Contact Zhonghong Today:

Заключение
White Willow Bark Extract remains a gold-standard botanical analgesic with robust clinical validation. Zhonghong’s fusion of advanced phytochemistry, ISO-certified QC, and global regulatory mastery delivers unmatched extract integrity for demanding nutraceutical, cosmetic, and functional food applications.

Ссылки

  1. EMA/HMPC Monograph on Salix spp. (2017)

  2. Chrubasik et al., Phytomedicine (2010)

  3. USP-NF General Chapters <561>, <232>

  4. Zhang et al., Int J Nanomedicine (2021); 16: 5143–5156

  5. Gagnier et al., Cochrane Database Syst Rev (2016); CD004504

White Willow Bark Extract, Salicin Extract, Natural Anti-inflammatory, Plant Extract Supplier, COA Specification

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