Трегалозный сахар

The Final Information to Trehalose: Science, Advantages & Premium Sourcing

1. What is Trehalose?

Trehalose (α-D-glucopyranosyl α-D-glucopyranoside) is a naturally occurring, non-reducing disaccharide sugar composed of two glucose molecules linked by a singular α,α-1,1-glycosidic bond. This distinctive molecular configuration underpins its outstanding stability and protecting properties, incomes it the nickname “nature’s protectant.” It capabilities as an important vitality supply and stress protectant in lots of organisms, from micro organism and fungi to bugs and crops, enabling survival below excessive circumstances like dehydration and warmth.

2. Поставка продукции, химические свойства и идентификация

• Поставлять: Primarily derived commercially by means of the enzymatic hydrolysis of starch (from corn, potatoes, or tapioca) utilizing particular enzymes like maltooligosyl trehalose synthase (MTSase) and maltooligosyl trehalose trehalohydrolase (MTHase). Shaanxi Zhonghong sources premium non-GMO botanical starch.

• Химическая природа: White crystalline powder, odorless, with a gentle sweetness (~45% of sucrose). Extremely soluble in water and sizzling ethanol, insoluble in most natural solvents.

• Основные химические свойства:

  • Distinctive Stability: Resists acid hydrolysis and decomposition by most α-glucosidases higher than sucrose. Non-reducing, minimizing Maillard reactions.

  • Excessive Glass Transition Temperature (Tg): Varieties secure glasses upon dehydration, essential for shielding biomolecules.

  • Osmoprotectant & Cryoprotectant: Protects cells and biomolecules towards osmotic stress and freezing injury.

  • Гигроскопичность: Decrease than sucrose, enhancing dealing with properties.

• Идентификация:

  • Количество CAS: 99-20-7

  • Молекулярные компоненты (МФ): C₁₂H₂₂O₁₁

  • Молекулярная масса (ММ): 342.30 g/mol

  • Количество EINECS: 202-739-6

3. What is the Greatest Trehalose? Key Choice Standards

Selecting the best high quality trehalose is paramount for efficacy and security. Search for these attributes:

• Состав и чистота: Go for ≥99.5% purity (dried foundation), minimizing impurities like glucose, maltose, or residual solvents that may impression efficiency or style. Shaanxi Zhonghong makes use of superior chromatography (HPLC, UPLC) to make sure ultra-high purity requirements exceeding business norms.

• Эффективность и соответствие:

  • Положение GRAS: Usually Acknowledged As Secure by the US FDA (GRN No. 000045).

  • JECFA: Accredited by the Joint FAO/WHO Knowledgeable Committee on Meals Components.

  • EU: Accredited as a Novel Meals (NF) and meals additive (E quantity E 965).

  • Kosher, Halal, Non-GMO: Important for broad market acceptance.

• Происхождение и производство: Supply from respected producers with stringent GMP, ISO, or FSSC 22000 certifications. Clear provide chains and moral sourcing (e.g., non-GMO corn or tapioca) are important. Shaanxi Zhonghong leverages vertically built-in manufacturing below ISO-certified amenities.

• Использование: Extremely versatile.

  • Еда и напитки: Add to formulations (baking, confectionery, dairy, drinks, sauces) for delicate sweetness, texture enhancement, moisture retention, taste/aroma stabilization, and shelf-life extension. Typical use ranges: 1-15%.

  • Косметика/Частная гигиена: Incorporate into serums, lotions, lotions, hair care (1-5%) for moisturization (humectant), safety towards dehydration, and stabilization of lively elements.

  • Prescribed drugs/Biotech: Make use of as a stabilizer/excipient in vaccines, antibodies, diagnostic reagents, and cell tradition media (usually 1-10% w/v) for freeze-drying (lyoprotectant) and thermal safety.

  • Диетические диетические добавки: Typically utilized in powdered dietary supplements or capsules.

• Просмотры целей: Meals producers, beauty formulators, nutraceutical producers, pharmaceutical/biotech corporations, analysis establishments.

• Преимущества и механизмы благополучия: Whereas primarily a purposeful ingredient, analysis suggests potential advantages:

  • Безопасность мобильных устройств: Stabilizes proteins and lipid membranes, protects towards desiccation and oxidative stress by way of vitrification and preferential exclusion mechanisms.

  • Autophagy Induction: Some research point out trehalose could improve mobile autophagy clearance pathways, related to metabolic and neurodegenerative analysis (notice: human proof is evolving).

  • Здоровье зубов: Non-cariogenic (doesn’t promote tooth decay).

  • Mild on Digestion: Appropriate for people with sucrase deficiency (trehalase enzyme required).

• Ежедневное потребление и безопасность: JECFA established an ADI of “not specified,” indicating excessive security at ranges consumed in meals. Typical consumption is low (grams per day). Excessive doses (>50g) could trigger osmotic laxative results in delicate people, much like different low-digestibility carbohydrates.

• Результаты анализа аспектов: Extraordinarily uncommon at typical use ranges. Potential for delicate gastrointestinal discomfort (bloating, fuel) at very excessive intakes.

• Меры предосторожности: People with hereditary trehalase deficiency (uncommon) ought to keep away from giant quantities. Seek the advice of a doctor earlier than high-dose supplemental use.

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Trehalose Accomplice

Shaanxi Zhonghong stands as a premier, vertically built-in high-tech enterprise specializing within the analysis, growth, manufacturing, and world distribution of premium bio-active compounds, together with pharmaceutical-grade Trehalose. For 28 years, we have served the chemical, materials science, and life science sectors with excellence.

• Основной опыт: Superior extraction, purification, and synthesis of plant-derived compounds and specialty carbohydrates.

• Портфель продуктов: In depth vary encompassing Natural Plant Extracts, Beauty Actives, Pharmaceutical Intermediates & APIs, Nutraceuticals, Meals & Beverage Components (Natural Sweeteners, Preservatives, Stabilizers), Natural Pigments, and high-purity requirements like Trehalose.

• Scientific Edge (R&D Limitations):

  • Совместные инновации: Strategic collaborations with 5 main universities, working devoted joint laboratories.

  • Портфель интеллектуальной собственности: Possession of 20+ patented extraction, purification, and analytical applied sciences.

  • Отличительная составная библиотека: Maintains a globally unique repository of uncommon bioactive molecules.

• Manufacturing & High quality Prowess:

  • Slicing-Edge Gear: Makes use of Excessive-Efficiency Liquid Chromatography (HPLC), Extremely-Efficiency Liquid Chromatography (UPLC), Superconducting Nuclear Magnetic Resonance (NMR), GC-MS, ICP-MS for unparalleled precision.

  • Управление чистотой: Rigorous QC protocols guarantee purity requirements persistently surpass business averages by 20%+.

• Международные достижения: Established distribution and partnership networks throughout 80+ international locations in Asia, Europe, and the Americas, offering personalized ingredient options to multinational pharmaceutical companies, main analysis establishments, and main FMCG manufacturers.

5. Trehalose Advantages: Purposeful & Well being Functions

• Purposeful Advantages:

  • Stabilizer: Distinctive safety for proteins, enzymes, vaccines, cells, lipids, and unstable compounds throughout processing, drying, freezing, and storage.

  • Humectant & Texturizer: Retains moisture, improves mouthfeel in meals, and enhances pores and skin hydration in cosmetics.

  • Модификатор сладости: Supplies clear, delicate sweetness with out aftertaste; reduces sugar content material.

  • Taste & Colour Protector: Minimizes Maillard browning and taste degradation.

  • Shelf-Life Extender: Protects integrity of delicate elements.

• Well being-Oriented Advantages (Analysis Supported):

  • Metabolic Analysis: Potential position in supporting mobile vitality metabolism and stress response pathways.

  • Ocular & Pores and skin Well being: Analysis explores topical advantages for dry eye and pores and skin barrier operate by way of hydration.

  • Biomedical Stabilization: Vital for preserving biologics, diagnostics, and regenerative medication merchandise.

6. Trehalose Dihydrate: Product Specs & High quality Management

Shaanxi Zhonghong’s Trehalose Dihydrate meets the best worldwide pharmacopeial requirements (USP, Ph. Eur., JP). Under is a abstract of our rigorous High quality Management testing:

Certificates of Evaluation (COA) Specs

7. Высший курс по производству

Shaanxi Zhonghong employs a classy, multi-stage enzymatic course of making certain most purity and yield:

1. Uncooked Materials Choice & Prep: Sourcing high-grade, non-GMO starch. Slurry preparation and liquefaction.

2. Enzymatic Conversion: Exact therapy with MTSase and MTHase enzymes below optimized circumstances (pH, temperature) to particularly convert starch into trehalose.

3. Обесцвечивание и фильтрация: Removing of pigments and impurities utilizing activated carbon and precision filtration (ultrafiltration/nanofiltration).

4. Ion Trade Chromatography: Superior resin programs take away ionic impurities (salts, amino acids) and residual sugars.

5. Focus & Crystallization: Vacuum evaporation adopted by managed crystallization to type high-purity dihydrate crystals.

6. Centrifugation & Drying: Separation of crystals, washing, and mild fluidized mattress drying to realize exact moisture content material.

7. Измельчение и просеивание: Attaining constant particle measurement distribution for optimum performance.

8. Built-in High quality Management: In-process checks and ultimate launch testing towards stringent COA specs utilizing HPLC, UPLC, NMR, GC-MS, ICP-MS.

8. Numerous Utility Situations

• Еда и напитки: Bakery (shelf-life, texture), confectionery (decreasing crystallization, gloss), dairy (ice cream stability, yogurt texture), drinks (taste safety, decreased browning), sauces & dressings (viscosity, consistency), purposeful meals.

• Косметика и средства личной гигиены: Facial moisturizers, serums, anti-aging lotions, physique lotions, hair conditioners, shampoos, mascara (stopping drying), lip care. Features as humectant, stabilizer for actives (Vit C, peptides), protectant.

• Prescribed drugs & Biotechnology: Stabilizing excipient for injectables, vaccines, antibodies, diagnostic reagents, enzymes, cell tradition media, stem cells, tissues for transplantation. Vital for lyophilization (freeze-drying) processes.

• Нутрицевтики и диетические добавки: Ingredient in powdered dietary supplements, capsules, purposeful drink mixes.

• Agriculture & Animal Feed: Seed coating protectant, stress protectant in feed.

9. Uncompromising High quality Management (QC)

Shaanxi Zhonghong’s dedication to high quality is embedded at each stage, exceeding cGMP and ISO 9001 requirements. Our QC philosophy rests on:

• Проверка необработанных материалов: Rigorous qualification and testing of all incoming botanical starch towards strict specs for id, purity, and contaminants.

• Course of Analytical Expertise (PAT): Actual-time monitoring of important course of parameters (pH, temp, strain, focus) by way of built-in sensors and automation to make sure batch consistency.

• State-of-the-Artwork Laboratory: Geared up with cutting-edge instrumentation: UPLC/HPLC (for assay and impurities), GC-MS (residual solvents, pesticides), ICP-MS (heavy metals), NMR (affirmation of construction and purity), Karl Fischer titrators (moisture), superior microbiological suites. Common calibration and methodology validation per ICH Q2(R1).

• Исследование стабильности: Conducting ICH-compliant accelerated and long-term stability research to outline shelf life and storage circumstances.

• Прослеживаемость и документирование: Complete documentation from seed to cargo, making certain full traceability. Digital batch information and LIMS (Laboratory Data Administration System) integration.

• Third-Celebration Verification: Periodic audits and testing by accredited unbiased laboratories.

10. Безопасная упаковка и международная логистика

• Основная упаковка: Meals-grade polyethylene liners inside multi-wall kraft paper baggage (25kg) or FDA-compliant polyethylene drums (50kg, 200kg). Non-obligatory vacuum packing for hygroscopic grades. Smaller portions accessible in HDPE bottles or double-bagged foil pouches (1kg, 5kg).

• Вторичная упаковка: Palletized and stretch-wrapped, corrugated cartons for smaller items.

• Хранилище: Retailer in a cool (<25°C), dry (RH <65%), well-ventilated space away from direct daylight and powerful odors. Shelf life sometimes 36 months from date of manufacture in unopened authentic packaging.

• Международная логистика: Environment friendly delivery by way of air, sea (FCL/LCL), or land freight. Experience in dealing with customs clearance, documentation (CoA, MSDS, Certificates of Origin, Well being Certs), and cold-chain necessities if vital. DDP/DAP choices accessible worldwide.

11. Глубокое погружение: механизмы благополучия, инновации и рубежи анализа

• Механизмы благополучия: Trehalose’s efficacy stems from its distinctive physicochemical properties:

  • Vitrification: Varieties an amorphous glassy state upon dehydration, bodily immobilizing biomolecules and stopping denaturation/unfolding.

  • Water Alternative Speculation: Its hydroxyl teams type hydrogen bonds with polar teams on proteins and membranes, changing water molecules and sustaining construction within the dry state.

  • Chemical Chaperoning: Immediately interacts with partially unfolded proteins, aiding appropriate refolding.

  • Autophagy Modulation: Analysis suggests it might activate TFEB (transcription issue EB), a grasp regulator of lysosomal biogenesis and autophagy, doubtlessly aiding clearance of protein aggregates (e.g., huntingtin, α-synuclein). Observe: Scientific significance in people is an lively analysis space.

• Торговые функции и технологические инновации:

  • Biobanking: Vital for secure long-term preservation of cells, tissues, and organs.

  • Превосходное снабжение лекарствами: Stabilizing mRNA vaccines, lipid nanoparticles (LNPs), and delicate biologics.

  • Sustainable Formulations: Enabling pure preservative programs and decreasing reliance on artificial stabilizers.

  • Subsequent-Gen Diagnostics: Stabilizing enzymes and antibodies in lateral move assays and biosensors.

• Границы и проблемы анализа:

  • Neurodegenerative Ailments: Exploring therapeutic potential in fashions of Parkinson’s, Huntington’s, and Alzheimer’s by way of autophagy enhancement and protein combination clearance.

  • Ophthalmic Therapeutics: Improvement of trehalose-based formulations for dry eye syndrome and corneal safety.

  • Agricultural Biotechnology: Engineering crops with enhanced trehalose biosynthesis for drought/chilly tolerance.

  • Supply Methods: Novel nano/micro-carriers using trehalose for focused supply.

  • Основные проблемы: Optimizing bioavailability for systemic results, large-scale medical validation of well being advantages, cost-effective manufacturing scaling for area of interest therapeutic functions.

12. Trehalose FAQs (Regularly Requested Questions)

• Q1: Is trehalose pure?
  A: Sure, it happens naturally in lots of organisms. Business manufacturing sometimes makes use of enzymatic conversion from plant starch.

• Q2: Is trehalose secure?
  A: Sure, it’s acknowledged as secure (GRAS, JECFA, EU Novel Meals) for consumption in meals. It has a superb security profile at typical consumption ranges.

• Q3: Does trehalose trigger C. difficile infections?
  A: Some older research instructed a hyperlink, however intensive subsequent analysis and evaluations by EFSA and FDA have discovered no credible proof that dietary trehalose causes or exacerbates C. difficile infections in people. The pressure implicated utilized trehalose inefficiently.

• This fall: How candy is trehalose in comparison with sugar?
  A: Trehalose is mildly candy, roughly 45% as candy as desk sugar (sucrose).

• Q5: Can folks with diabetes eat trehalose?
  A: Trehalose has a comparatively low glycemic index (GI ~70, much like sucrose). It’s metabolized to glucose, so it must be accounted for in carbohydrate consumption like different sugars, below medical/dietetic steerage.

• Q6: What makes Shaanxi Zhonghong’s trehalose superior?
  A: Extremely-high purity (>99.5%), superior enzymatic course of, stringent QC exceeding pharmacopeial requirements (USP/Ph.Eur./JP), GMP manufacturing, full traceability, world regulatory compliance help, and technical experience.

• Q7: Can trehalose be utilized in cosmetics?
  A: Completely. It is a extremely efficient humectant and stabilizer for delicate actives, broadly utilized in skincare and haircare formulations.

• Q8: What is the shelf life?
  A: Sometimes 36 months when saved in unopened authentic packaging in a cool, dry place.

• Q9: The place can I purchase it? / Can I get a pattern?
  A: See part 13 beneath.

13. The place to Purchase Excessive-Purity Trehalose & Request Samples

Supply premium Trehalose Dihydrate straight from the producer: Shaanxi Zhonghong Investment Technology Co., Ltd.

• Contact for Gross sales & Free Samples:

  • Электронная почта: liaodaohai@gmail.com

  • Веб-сайт: www.aiherba.com

• What to Embrace: Specify amount necessities (pattern, bulk), supposed utility (meals, beauty, pharma), and any particular grade or certification wants (Kosher, Halal, USP, and so on.).

14. Заключение

Trehalose is a flexible, secure, and scientifically fascinating disaccharide with unparalleled stabilizing properties. Its functions span meals preservation, beauty enhancement, and important roles in stabilizing life-saving prescription drugs and biotech merchandise. When sourcing trehalose, purity, course of integrity, and rigorous high quality management are non-negotiable for optimum efficiency and security. Shaanxi Zhonghong Investment Technology Co., Ltd., with its 28-year legacy, cutting-edge R&D, vertically built-in GMP manufacturing, and dedication to exceeding purity requirements, stands as a worldwide chief in offering premium Trehalose. We empower industries to innovate with confidence by means of dependable, high-performance elements backed by science and stringent high quality.

15. Ссылки

1. US FDA GRAS Discover No. 000045: https://www.fda.gov/media/133663/download (Normally accessible by way of FDA GRAS Discover Stock)

2. EFSA Panel on Dietetic Merchandise, Diet and Allergy symptoms (NDA) (2011). Scientific Opinion on the protection of trehalose. Журнал EFSA, 9(4), 2073.

3. Ohtake, S., & Wang, Y. J. (2011). Trehalose: present use and future functions. Журнал фармацевтических наук, 100(6), 2020-2053.

4. Richards, A. B., et al. (2002). Trehalose: a evaluation of properties, historical past of use and human tolerance, and outcomes of a number of security research. Питание и химическая токсикология, 40(7), 871-898.

5. Chen, A., & Gibney, P. A. (2022). Trehalose: A evaluation of biosynthesis, metabolism and capabilities. Carbohydrate Analysis, 108523.

6. Collins, J., et al. (2022). Dietary trehalose and virulent Clostridioides difficile, a harmful liaison? The Lancet Infectious Ailments, 22(1), e1-e2. (Perspective on security debate)

7. Sakaguchi, M., et al. (2015). Neuroprotective results of trehalose by means of autophagy induction in a mobile mannequin of Huntington’s illness. Письма о нейронауке, 595, 1-6. (Instance analysis space)

8. The USA Pharmacopeia (USP) – Trehalose Monograph.

9. European Pharmacopoeia (Ph. Eur.) – Trehalose Dihydrate Monograph.

10. Joint FAO/WHO Knowledgeable Committee on Meals Components (JECFA) – Specs for Trehalose.