Натрий-медный хлорофиллин
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Натрий-медный хлорофиллин

Sodium Copper Chlorophyllin supplier bulk factory Wholesale buy Extract factory

  1. Английское имя: Sodium Copper Chlorophyllin
  1. Спецификация
    • Чистота: Copper Chlorophyllin ≥ 95% (HPLC), Copper content: 4.0 – 6.0% (atomic absorption spectroscopy)
    • Растворимость: Highly water – soluble (≥ 50 g/L at 25°C), insoluble in non – polar solvents like hexane
    • Внешний вид – Связанный: Loss on drying ≤ 5%, Heavy metals ≤ 10 ppm, Arsenic ≤ 2 ppm
    • Размер частиц: Standard powder ≤ 100 μm; micronized versions ≤ 5 μm for better dispersion
  1. Появление
    • Dark green to blackish – green powder, odorless or with a faint, characteristic plant – like smell
  1. Номер CAS：1406-65-1
  1. Время выполнения: 3–5 рабочих дней
  1. Упаковка
    • 1 кг/мешок (мешок из алюминиевой фольги), 25 кг/бочка (двухслойный полиэтиленовый пакет внутри картонной бочки)
  1. Главный рынок: Global market, with significant demand in Asia (China, Japan), North America, and Europe, especially in food, cosmetics, and pharmaceutical industries
  1. Сценарии применения

Основные свойства

  • Молекулярная структура: A semi – synthetic derivative of chlorophyll, with copper ions replacing the central magnesium in chlorophyll and sodium salts enhancing water solubility
  • Chemical Stability: More stable than natural chlorophyll under varying pH and temperature conditions
  • Ключевые особенности
    • Natural Green Colorant: Provides a vibrant green hue, heat – stable up to 120°C and maintains color in acidic (pH 4 – 8) environments.
    • Антиоксидантная активность: Удаляет свободные радикалы, такие как гидроксильные и супероксидные анионы, защищая клетки от окислительного повреждения.
    • Detoxifying Properties: Binds to toxins like indole compounds in the gut, aiding in their elimination.
    • Противовоспалительное средство: Inhibits the production of pro – inflammatory cytokines, reducing tissue inflammation.

Сценарии применения

1. Еда и напитки

  • Натуральный краситель:
    • Added to confectioneries (e.g., gummies, hard candies), baked goods (cakes, pastries), and dairy products (yogurt, ice cream) at 0.01 – 0.1% concentration to provide a green color.
    • Used in beverages such as green teas, sports drinks, and fruit – flavored drinks to enhance visual appeal without synthetic additives.
  • Модификатор вкуса:
    • In some meat products and seasonings, it can help mask off – flavors and improve overall taste.

2. Косметика и средства личной гигиены

  • Средства по уходу за кожей:
    • Incorporated into creams, lotions, and serums (0.5 – 2% concentration) for its antioxidant and anti – inflammatory properties, helping to soothe irritated skin and protect against environmental damage.
    • Used in anti – acne formulations to reduce inflammation and promote skin healing.
  • Уход за волосами:
    • Added to shampoos and conditioners to nourish the scalp, strengthen hair follicles, and give hair a natural shine.

3. Фармацевтика

  • Oral Health Products:
    • Included in toothpaste, mouthwashes, and chewing gum at 0.1 – 0.5% concentration to reduce bad breath by binding to odor – causing compounds in the mouth.
    • Investigated for its potential in preventing oral infections due to its antibacterial properties.
  • Пищевые добавки:
    • Capsules or tablets containing sodium copper chlorophyllin (200 – 500 mg per serving) are sold for detoxification support, immune system enhancement, and as an antioxidant supplement.

4. Корм для животных

  • Кормовая добавка:
    • Added to poultry, livestock, and aquaculture feed at 50 – 200 ppm to improve the color of egg yolks, meat, and fish, and to enhance the overall health of animals through its antioxidant and anti – inflammatory effects.
    • Helps reduce the occurrence of digestive disorders in animals by promoting a healthy gut environment.

Методы обнаружения

  • Высокоэффективная жидкостная хроматография (ВЭЖХ):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% formic acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 405 nm for quantification.
  • Атомно-абсорбционная спектроскопия (ААС):
    • Used to determine the copper content accurately, ensuring compliance with specification limits.
  • УФ-видимая спектроскопия:
    • Utilized for quick identification and quantification by analyzing the characteristic absorption peaks of the pigment in the UV – Vis range (around 400 – 700 nm).

Источник и преимущества

  • Натуральный источник: Derived from chlorophyll extracted from plants such as alfalfa, nettles, or mulberry leaves through a chemical modification process.
  • Устойчивое производство: The raw materials are renewable, and the manufacturing process can be optimized for environmental friendliness.
  • Versatile Use: Its multi – functional properties make it valuable across multiple industries, from food coloring to health – promoting applications.

Соблюдение нормативных требований

  • Управление по санитарному надзору за качеством пищевых продуктов и медикаментов США: Generally Recognized As Safe (GRAS) for use as a food color additive and dietary supplement ingredient.
  • Регламент ЕС: Approved as a food additive (E141ii) with specific usage limits in different food categories. Also compliant with cosmetic regulations for use in personal care products.
  • Китайская NMPA: Permitted for use in food, cosmetics, and pharmaceuticals, subject to strict quality control standards.
Категории: , ,

Sodium Copper Chlorophyllin: The Science-Backed Inexperienced Biomolecule for Well being & Trade | Supplier & Manufacturer

1. What is Sodium Copper Chlorophyllin?

Sodium Copper Chlorophyllin (SCC) is a semi-synthetic, water-soluble by-product of pure chlorophyll, the place the central magnesium ion is changed by copper and the phytol tail is eliminated by way of saponification. This transformation yields a steady, shiny inexperienced advanced (CIE 75810) proof against mild/warmth degradation189. In contrast to pure chlorophyll—which degrades quickly—SCC maintains its bioactive construction, enabling purposes in prescription drugs, meals expertise, and cosmetics. Its distinctive porphyrin-based construction permits electron switch reactions crucial for antioxidant and antiviral features59.

2. Поставка, химические свойства и идентификация

  • Поставлять: Primarily extracted from spinach, alfalfa, или silkworm excrement (referred to as “silkworm sand” or Cansha in conventional drugs)18. Uncooked supplies bear solvent extraction (ethanol/acetone), adopted by alkaline saponification и copper substitution to exchange Mg²⁺ with Cu²⁺9.

  • Химические свойства:

    • Номер CAS: 11006-34-1 (commonest), 65963-40-8, or 28302-36-5459

    • Молекулярная формула: C₃₄H₃₁CuN₄Na₃O₆ (main kind)4

    • Молекулярный вес: 724.15 g/mol4

    • EINECS: 234-242-54

    • Появление: Darkish inexperienced, metallic-lustered powder or liquid9

    • Растворимость: Extremely water-soluble; insoluble in lipids9

    • Стабильность: Degrades below sturdy mild/acidic situations; retailer at -20°С in darkish, hermetic containers5

3. Therapeutic Benefits, Dosage & Security

Highest Purity & Scientific Purposes

The “greatest” Натрий-медный хлорофиллин SCC prioritizes >95% purity (HPLC-verified), low heavy metals (Pb ≤3 ppm), and authorized low pesticide residues. Pharmaceutical-grade SCC (e.g., in Chlorophyllin Copper Sodium Capsules) incorporates standardized 20mg/capsule for exact dosing36.

Преимущества и механизмы благополучия:

  • Гепатопротекторное: Prompts liver reticuloendothelial cells, reduces hepatomegaly, and accelerates regeneration in continual hepatitis (30-day course, 20mg TID)36.

  • Hematopoietic: Stimulates bone marrow stem cells (CFU-S, CFU-E) to extend RBCs, platelets, and neutrophils in leukopenia/radiation-induced anemia36.

  • Противовирусное средство: Ингибирует HIV and influenza A (IC₅₀: 50–100 μM) by blocking viral fusion5.

  • Antioxidant/Wound Therapeutic: Neutralizes ROS and upregulates collagen synthesis in continual ulcers10.

Ежедневное потребление и безопасность:

  • Дозировка:

    • Терапевтический: 20mg capsules TID for 30 days6

    • Dietary (coloring agent): ≤1g/kg in meals (e.g., drinks, gums)9

  • Результаты анализа аспектов:

    • Inexperienced stool/urine (benign)

    • Gentle belly discomfort or urticaria-like rashes3

  • Противопоказания:

    • Copper metabolism issues (Wilson’s illness)

    • Salicylate allergy (in carbazochrome formulations)36

  • Меры предосторожности: Renal impairment sufferers require dose changes; keep away from throughout being pregnant as a result of restricted security information6.

4. Shaanxi Zhonghong: Innovating Sodium Copper Chlorophyllin SCC Manufacturing

Shaanxi Zhonghong Investment Technology Co., Ltd. рычаги 28 лет of experience in bioactive compound manufacturing to ship GMP-certified SCC. Our built-in strategy combines botanical extraction with cutting-edge purification:

  • Core Applied sciences:

    • Сверхкритическая экстракция CO₂: Preserves heat-sensitive alkaloids

    • Preparative HPLC/UHPLC: Achieves >98% purity (vs. trade avg. 80%)

  • Высококачественная инфраструктура:

    • Joint Labs with 5 High Universities: Centered on chlorophyll-derivative optimization

    • 20+ Patents: Together with SCC stabilization and nano-encapsulation methods

    • International Compound Library: 10,000+ pure molecules for customized formulations

  • International Provide: Serves 80+ international locations with tailor-made APIs for pharma (e.g., hemostats, antivirals), nutraceuticals, and cosmetics.

5. Строгие требования к продукту

Сорт Параметр Спецификация Проверить технику
Пестициды Хлорпирифос ≤0,01 мг/кг ГХ-МС/МС
Циперметрин ≤0,05 мг/кг ГХ-МС/МС
Тяжелые металлы Свинец (Pb) ≤3,0 мг/кг ИСП-МС
Мышьяк (As) ≤2,0 мг/кг ИСП-МС
Кадмий (Cd) ≤1,0 мг/кг ИСП-МС
Микробиология Целостная кардио-зависимость ≤1000 КОЕ/г USP <61>
Кишечная палочка Отсутствует в 1 г USP <62>
Сальмонелла виды Отсутствует в 10 г USP <62>
Lively Assay SCC (by HPLC) ≥95.0% ВЭЖХ-DAD/ELSD

6. Улучшенный производственный процесс

Shaanxi Zhonghong’s cGMP-compliant course of ensures traceability from farm to API:

  1. Поиск поставщиков: Natural spinach/alfalfa from audited farms.

  2. Извлечение: Ethanol/acetone leaching below nitrogen environment.

  3. Омыление: NaOH therapy to hydrolyze ester bonds.

  4. Copper Substitution: React with CuSO₄ at pH 9.5–10.5.

  5. Очищение: Хроматография (adsorption → prep-HPLC) to take away phytol/byproducts.

  6. Crystallization & Drying: Lyophilization yields steady powder (moisture ≤5%)9[citation:用户输入].

7. Multisector Purposes

  • Рецептурные препараты:

    • Tablets/capsules for hepatitis и chemotherapy-induced leukopenia6.

    • Topical gels for diabetic ulcers (1–2% SCC)10.

  • Meals Know-how: Natural inexperienced coloring in drinks, yogurts, and gums (E141(ii))9.

  • Космецевтика: Anti-aging lotions leveraging antioxidant properties1.

  • Анализ: Antiviral research (e.g., SARS-CoV-2 entry inhibition)5.

8. High quality Management & Stability

Наш High quality-by-Design (QbD) protocol exceeds pharmacopeial requirements:

  • Идентификация: FT-IR/NMR spectroscopy matched to USP reference requirements.

  • Чистота: UHPLC-MS/MS detects impurities ≤0.1% (e.g., pheophytins).

  • Загрязняющие вещества: ICP-MS screens for 14 heavy metals per ICH Q3D; LC-QTOF displays 500+ pesticides.

  • Стабильность: 24-month shelf life at -20°C validated by way of ICH Q1A(R2) accelerated/real-time research4[citation:用户输入].

9. Packaging & International Logistics

  • Основная упаковка: Amber glass vials (R&D) or HDPE drums with desiccants (bulk).

  • Хранилище: -20°С ± 5°С; shield from mild.

  • Срок годности: 24 months (powder), 12 months (resolution).

  • Транспорт: Dry ice (analysis grades) or climate-controlled freight (GMP batches) with GDP-compliant documentation.

10. Analysis Frontiers & Challenges

  • Rising Alternatives:

    • Nanocarrier Programs: Liposomal SCC for enhanced bioavailability in tumor concentrating on.

    • Antimicrobial Coatings: SCC-integrated polymers for wound dressings.

  • Key Challenges:

    • Dose Standardization: Assorted bioactivity throughout plant sources.

    • Нормативные препятствия: SCC classification as “artificial” limits pure product claims.

    • Copper Bioaccumulation: Lengthy-term security in renal-impaired populations59.

11. Часто задаваемые вопросы (FAQ)

Q: Is SCC protected for every day consumption?
A: Sure—in regulated doses. Meals-grade SCC is GRAS at ≤15 mg/kg/day; therapeutic use requires medical supervision79.

Q: Why does SCC flip urine inexperienced?
A: This benign impact stems from incomplete metabolism of the porphyrin ring—no toxicity issues3.

Q: Can SCC change artificial dyes?
A: Completely. Its stability (>90% shade retention at 100°C) and security make it preferrred for clean-label meals9.

Q: How does SCC differ from chlorophyll?
A: SCC replaces Mg²⁺ with Cu²⁺ and removes lipophilic phytol, enabling water solubility and enhanced stability8.

12. Ordering Data

Supply premium, GMP-certified Sodium Copper Chlorophyllin instantly:

13. Заключение

Sodium Copper Chlorophyllin bridges pure biochemistry and industrial utility—delivering validated advantages in hepatoprotection, hematopoiesis, and antimicrobial motion. Shaanxi Zhonghong Investment Technology Co., Ltd. комбайны 28 years of plant extract experience, НИОКР, поддерживаемые университетом, и cGMP analytical rigor (NMR/HPLC-MS/MS) to provide international companions with high-purity SCC. Our vertically built-in course of ensures batch-to-batch consistency for prescription drugs, nutraceuticals, and revolutionary purposes like antiviral coatings. Contact us to leverage our portfolio in your next-generation well being options.

14. Ссылки

  1. Nationwide Well being Analysis Institutes (Taiwan). Copper Chlorophyllin Q&A. (2013).

  2. European Meals Security Authority. *Re-evaluation of Chlorophyllins (E 141(ii)) as Meals Components*. (2015).

  3. Guangdong Xin Feng Pharma. Chlorophyllin Copper Sodium Capsules Package Insert. (2021).

  4. J&Ok Scientific. Sodium Copper Chlorophyllin Product Knowledge Sheet. (2023).

  5. Beijing BioLab. SCC Antiviral Mechanism Examine. (2022).

  6. Tencent Medical Dictionary. Scientific Use of SCC Capsules. (2023).

  7. Taiwan FDA. Regulatory Requirements for Meals Colorants. (2024).

  8. Chen, C. Copper Chlorophyll in Cosmetics. Dermatologist Weblog. (2021).

  9. Shenghua Chemical. SCC Manufacturing and Purposes. (2024).

  10. McCook, J.P. et al. Wound Restore with Topical SCC. Journal of Medicine in Dermatology. (2016).

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