Экстракт лимонника

Schisandra Extract: Nature’s Adaptogenic Powerhouse | Premium Supplier Guide

1. What is Schisandra Extract?

Schisandra extract is a potent bioactive concentrate derived from the dried berries of лимонник китайский (Chinese Magnolia Vine) or лимонник сфенантера. Revered for millennia in Traditional Chinese Medicine (TCM) as a premier adaptogen, it contains a unique complex of dibenzocyclooctadiene lignans—primarily schisandrin, deoxyschisandrin, γ-schisandrin, schisantherin A/B, and gomisins. These lignans are responsible for its characteristic “five flavors” (sweet, sour, salty, pungent, bitter) and its diverse physiological effects, particularly supporting hepatic function, cognitive performance, stress resilience, and cellular antioxidant defense.

2. Источник продукта, химические свойства и идентификаторы

• Ботанический источник: лимонник китайский (Turcz.) Baill. berries.

• Primary Active Constituents: Schisandra Lignans (≥1.5% – 10%+, standardized by HPLC).

• Основные химические свойства:

  • Появление: Fine reddish-brown to brown powder.

  • Растворимость: Soluble in ethanol, methanol; slightly soluble in water; insoluble in non-polar solvents.

  • Стабильность: Sensitive to light, heat, and oxidation. Requires cool, dry storage.

• КАС: 7432-28-2 (Schisandra extract); Specific lignans have individual CAS (e.g., Schisandrin: 61281-37-6).

• МФ: Varies per compound (e.g., Schisandrin: C24H32O7).

• МВ: Varies per compound (e.g., Schisandrin: 432.5 g/mol).

• EINECS: 284-118-3 (Schisandra chinensis extract).

3. What is the Best Schisandra Extract? Key Considerations
Selecting the optimal Schisandra extract demands scrutiny across multiple parameters:

• Key Ingredient & Standardization: Premium extracts are standardized to Schisandra Lignans content (e.g., 5%, 9%, or higher). Lignan profile consistency is critical for efficacy. Look for HPLC-verified standardization.

• Efficacy & Compliance (Regulatory): Ensure compliance with target market regulations (e.g., FDA GRAS, EU Novel Food considerations, FSANZ, pharmacopoeial standards like USP/EP). Validated hepatoprotective, adaptogenic, and antioxidant effects are core.

• Происхождение и выращивание: Sustainably cultivated berries from pristine regions (e.g., Northeast China, Korea) are ideal. Certifications (Organic, GACP) enhance quality assurance. Traceability to origin is crucial.

• Method of Use: Common formats include powder (encapsulated, in blends), liquid extracts (tinctures), and functional food/beverage fortification. Typical oral dosage: 250mg – 1500mg daily, often divided. Consult product label and healthcare provider.

• Целевая аудитория: Adults seeking natural support for stress management, liver health, physical endurance, cognitive function, or general antioxidant protection. Not intended for children.

• Health Benefits (Science-Backed):

  • Гепатопротекция: Enhances liver detoxification enzymes (Phase I & II), protects hepatocytes from toxins (e.g., ethanol, CCl4), promotes regeneration.

  • Адаптогенные: Modulates HPA axis, reduces cortisol elevation under stress, improves resilience.

  • Антиоксидант: Potent free radical scavenger, boosts endogenous glutathione (GSH) and superoxide dismutase (SOD).

  • Нейропротекция: May improve cognitive function, focus, and protect against neuronal damage.

  • Физическая работоспособность: Enhances endurance and reduces fatigue.

  • Здоровье кожи: Topical application may improve skin barrier function and combat oxidative stress.

• Рекомендуемая суточная норма потребления: 500mg – 1500mg of standardized extract (e.g., 9% lignans), dependent on application and individual needs. Start lower and adjust.

• Меры предосторожности и побочные эффекты: Generally well-tolerated. Potential mild GI upset (heartburn, acid reflux). Contraindicated: Pregnancy, lactation. Caution: With anticoagulant/antiplatelet drugs (potential interaction), gastroesophageal reflux disease (GERD), epilepsy/seizure disorders. Consult physician before use if taking medications or have underlying conditions.

4. Premium Supplier: Shaanxi Zhonghong Investment Technology Co., Ltd.
Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a vertically integrated высокотехнологичное предприятие at the forefront of plant extraction technology. For over 28 years, we have specialized in the advanced extraction, isolation, purification, and global commercialization of high-purity bioactive compounds for the chemical, materials, and отрасли естественных наук.

• Основные компетенции:

  • Advanced Botanical Extraction: Expertise in supercritical CO2 extraction, molecular distillation, preparative HPLC, membrane separation for unparalleled purity.

  • Broad Product Portfolio: High-grade Экстракт лимонника, other standardized botanical extracts, cosmetic actives, nutraceutical ingredients (dietary supplements), pharmaceutical intermediates, natural pigments, food & beverage additives, plant-based sweeteners.

  • Global Sourcing: Importation of premium raw materials under strict quality protocols.

• Scientific & Technological Barriers:

  • Joint Innovation Labs: Collaborative R&D with 5 ведущих университетов, driving innovation in phytochemistry and process optimization.

  • Портфель интеллектуальной собственности: Владелец 20+ патентов на изобретения и уникальная в мире библиотека соединений.

  • Передовой контроль качества: Инвестиции в HPLC-DAD/ELSD/CAD, UPLC-QTOF-MS, GC-MS, ICP-MS, and 600MHz NMR ensures purity standards превышение отраслевых норм к 20%+. Full identity, purity, and potency verification.

• Глобальный охват: Trusted B2B supplier to multinational pharmaceutical companies, research institutions, and manufacturers across 80+ countries in Asia, Europe, and the Americas. Experts in индивидуальные решения на основе ботанических ингредиентов.

5. Comprehensive Certificate of Analysis (COA) Specifications
Our Schisandra Extract undergoes rigorous testing to meet international safety standards. Below is a summary table of key specifications:

Table: Schisandra Extract Standard COA Specifications

6. Расширенный производственный процесс
Our manufacturing adheres to cGMP and integrates cutting-edge technology:

1. Sourcing & Identification: Raw berries sourced from qualified growers; authenticated via macroscopic/microscopic evaluation & TLC/HPLC fingerprinting.

2. Предварительная обработка: Cleaning, drying (<40°C), milling under controlled humidity.

3. Селективная экстракция: Optimized ethanol/water solvent systems using dynamic counter-current extraction or pressurized low-temperature extraction (PLTE) to preserve thermolabile lignans.

4. Первичная очистка: Macroporous resin adsorption chromatography for targeted lignan enrichment and removal of polysaccharides/sugars.

5. Расширенное разделение: Employing preparative HPLC or high-speed counter-current chromatography (HSCCC) for isolation of specific high-purity fractions if required.

6. Концентрация и сушка: Low-temperature vacuum concentration followed by spray drying (inlet/outlet temp controlled) or freeze-drying.

7. Стандартизация: Precise blending to achieve guaranteed lignan content (HPLC-controlled).

8. Строгий контроль качества: Full battery of identity, purity, potency, and safety tests (as per COA above) before release.

7. Разнообразные сценарии применения

• Нутрицевтики и диетические добавки: Capsules, tablets, softgels, powders for liver support, stress relief, energy, and antioxidant formulas.

• Функциональные продукты питания и напитки: Fortified juices, health drinks, energy bars, confectionery.

• Космецевтика: Active ingredient in anti-aging, antioxidant, and protective skincare serums, creams, lotions (topical antioxidant, collagen protection).

• Фармацевтические промежуточные продукты: Source of purified lignans (e.g., Schisandrin C) for drug discovery and development.

• Traditional Herbal Products: TCM formulations and granules.

8. Rigorous Quality Control 
Quality is embedded in every stage at Shaanxi Zhonghong. Our ISO 17025 accredited QC laboratory, оснащенный Agilent 1290 Infinity II UPLC-DAD-QTOF, Shimadzu HPLC-ELSD/CAD, PerkinElmer ICP-MS NexION 2000, and Bruker Avance III HD 600MHz NMR, provides unparalleled analytical capability. We implement a multipronged QC strategy:

• Incoming Material Control: Strict vendor qualification, Certificate of Analysis review, and full identity/purity testing on all raw materials using compendial methods (EP, USP, ChP) and advanced spectroscopy (FTIR, NMR for structure confirmation).

• In-Process Control (IPC): Critical process parameters (CPPs – solvent ratio, temp, pressure, time) and critical quality attributes (CQAs – intermediate lignan profile, residual solvents) are monitored in real-time using PAT (Process Analytical Technology) tools like inline NIR spectroscopy and automated HPLC sampling. This ensures process consistency and enables immediate corrective actions.

• Finished Product Release: Every batch undergoes exhaustive testing per a comprehensive, validated specification (Identity by TLC/HPLC fingerprint vs. reference standard; Assay for lignan content by HPLC-UV; Purity – Residual solvents by GC-HS-FID, Heavy metals by ICP-MS; Safety – Pesticides by GC-MS/MS & LC-MS/MS, Microbiology per USP/EP; Physical tests – LOD, Ash, Bulk Density, Particle Size Distribution). Исследования стабильности (ICH Q1A) under accelerated and long-term conditions define shelf-life and storage requirements. Our commitment to data integrity (ALCOA+ principles) and continuous method validation ensures results are reliable and defensible globally.

9. Безопасная упаковка и глобальная логистика

• Первичная упаковка: Food-grade polyethylene-lined kraft paper bags (5kg, 10kg, 25kg) or UN-certified HDPE drums (25kg, 50kg). Optional vacuum packing or nitrogen flushing for oxygen-sensitive extracts. Tamper-evident seals standard.

• Вторичная упаковка: Sturdy export cartons or fiber drums.

• Маркировка: Compliant with destination regulations. Includes Product Name, Batch #, MFG/EXP Date, Net Weight, Lignan Content %, COA QR Code, GMP/ISO Certifications.

• Хранилище: Store in a cool (<25°C), dry place (RH <60%), protected from light. -20°C long-term storage available for high-value fractions.

• Логистика: Expertise in global shipping (DDP, DAP, FOB). Documentation includes Commercial Invoice, Packing List, Certificate of Analysis, Certificate of Origin, Health Certificate (if required), MSDS. Compliant with international hazardous goods (if applicable) and customs regulations.

10. Deep Dive: Health Efficacy, Research & Industry Trends

• Механизм действия: Schisandra lignans exert effects via multiple pathways:

  • Гепатопротекция: Induction of Phase II detox enzymes (GST, UGT), upregulation of antioxidant genes via Nrf2 pathway, inhibition of CYP450-mediated toxin activation, stabilization of hepatocyte membranes.

  • Адаптогенные: Modulation of HPA axis, reduction of plasma cortisol and NO under stress, regulation of heat shock proteins (HSP70).

  • Антиоксидант: Direct ROS scavenging, regeneration of vitamins C & E, elevation of intracellular GSH and SOD/GPx activity.

  • Нейропротекция: Reduction of glutamate excitotoxicity, inhibition of MAO-B, potential enhancement of BDNF signaling, anti-neuroinflammatory effects.

  • Anti-fatigue: Enhancement of mitochondrial function and ATP synthesis, reduction of lactic acid accumulation.

• Промышленные приложения и инновации: Beyond supplements, research explores Schisandra in:

  • Hepatology: Adjunctive therapy in NAFLD, chemical hepatotoxicity, viral hepatitis.

  • Онкология: Chemopreventive potential via antioxidant/anti-inflammatory pathways; adjunct to reduce chemotherapy side effects (e.g., cisplatin nephrotoxicity).

  • Нейродегенеративные заболевания: Potential in Alzheimer’s (Aβ aggregation inhibition) and Parkinson’s (dopaminergic protection).

  • Метаболическое здоровье: Improving insulin sensitivity, lipid profile modulation.

  • Современные системы доставки: Liposomal encapsulation, nanoemulsions, phytosome complexes (e.g., Schisandra Phytosome®) to enhance bioavailability of hydrophobic lignans.

• Границы и проблемы исследований:

  • Границы: Elucidating specific receptor targets of individual lignans; large-scale human clinical trials for specific indications (e.g., cognitive decline, NAFLD); exploring synergistic effects in multi-botanical formulations; microbiome interactions.

  • Проблемы: Standardization complexities due to diverse lignan profiles; optimizing bioavailability of high-MW lignans; securing sustainable wildcrafting/cultivation; navigating complex global regulatory landscapes for health claims; cost-effective production of ultra-high purity (>98%) single lignans.

11. Часто задаваемые вопросы (FAQ)

• Q: What makes your Schisandra Extract superior? A: Our extract boasts industry-leading purity (>99.5% solvent-free, minimal impurities), guaranteed high lignan standardization (HPLC-verified), absence of harmful residues (full compliance testing), and is produced under strict cGMP using state-of-the-art extraction technology (PLTE, HSCCC) and QC (HPLC-MS, NMR).

• Q: Is Schisandra Extract safe? A: Generally safe for adults at recommended dosages. Possible mild GI upset. Contraindicated in pregnancy/lactation. Consult a doctor if taking anticoagulants, have GERD, epilepsy, or underlying health conditions. See Precautions (Section 3).

• Q: What is the recommended daily dosage? A: Typically 500mg – 1500mg daily of a standardized extract (e.g., 9% lignans), often divided. Start at the lower end. Follow product label or healthcare provider advice.

• Q: How long does it take to see benefits? A: Effects like stress resilience may be noticeable within weeks. Liver protective or significant cognitive benefits may require consistent use over several months.

• Q: Can it be used topically? A: Yes, Schisandra extract is valued in cosmetics for its antioxidant and protective properties, helping combat skin aging and environmental damage.

• В: Взаимодействует ли препарат с лекарственными препаратами? A: Potential interaction with blood thinners (warfarin, clopidogrel) and drugs metabolized by CYP3A4/CYP2C9 enzymes. Consult your physician.

• Q: Is it Organic or Non-GMO? A: We offer both conventional and certified organic (e.g., USDA, EU) Schisandra Extract. All are Non-GMO. Specify your requirement.

12. Where to Buy & Request Samples
Source premium, certified Schisandra Extract directly from the manufacturer: Shaanxi Zhonghong Investment Technology Co., Ltd.

• Contact for Quotes & Customization: liaodaohai@gmail.com

• Explore Our Portfolio: www.aiherba.com

• Request Your Free Sample: Email us (liaodaohai@gmail.com) with your company details, intended use, and desired specification (e.g., Lignan %). Experience the Zhonghong quality difference.

13. Заключение
Schisandra extract, standardized for its bioactive lignans, represents a scientifically validated adaptogen with significant benefits for liver health, stress management, cognitive function, and antioxidant defense. Choosing a high-quality extract is paramount for efficacy and safety. Shaanxi Zhonghong Investment Technology Co., Ltd., with its 28-year legacy, cutting-edge extraction and analytical technology, unwavering commitment to cGMP quality, and global supply chain expertise, stands as a trusted partner for premium Schisandra Extract. We provide not just an ingredient, but a commitment to purity, potency, and scientific rigor for demanding nutraceutical, cosmetic, and pharmaceutical applications.

14. Ссылки

1. Panossian, A., & Wikman, G. (2008). Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine. Journal of Ethnopharmacology, 118(2), 183-212. (Mechanisms, Adaptogenic Effects)

2. Lu, Y., & Chen, D. F. (2009). Analysis of Schisandra chinensis and Schisandra sphenanthera. Journal of Chromatography A, 1216(11), 1980-1990. (Analytical Methods, Lignan Profiles)

3. Nowak, A., Zakłos-Szyda, M., Błasiak, J., Nowak, A., Zhang, Z., & Zhang, B. (2019). Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review. Current Issues in Molecular Biology, 31(1), 1-24. (Comprehensive Health Benefits Review)

4. EMA. (2016). Assessment report on лимонник китайский (Turcz.) Baill., fructus. European Medicines Agency. (Regulatory Perspective, Traditional Uses)

5. USP-NF. (2023). United States Pharmacopeia and National Formulary. (General Quality Standards)

6. ICH Q7. Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients. (GMP Standards)

7. ICH Q1A(R2). Stability Testing of New Drug Substances and Products. (Stability Guidelines)

8. Shaanxi Zhonghong Internal Research Data & Process Validation Reports. (Proprietary Extraction & QC Data – Available under NDA).