Полисахариды Ganoderma Lucidum
Ganoderma Lucidum Polysaccharide — Изображение 2
, , , , , , ,

Полисахарид Ganoderma lucidum

Рейтинг 4.00 из 5 на основе опроса 1 пользователя
(1 отзыв клиента)

Ganoderma lucidum Polysaccharide Product Introduction

  1. Английское имя: Ganoderma lucidum Polysaccharide
  1. Спецификация: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa
  1. Появление: Light brown to tan powder; mild earthy aroma, slightly sweet taste
  1. Номер CAS：66060-20-8
  1. Время выполнения: 3-7 рабочих дней
  1. Упаковка: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)
  1. Главный рынок: Asia (China, Japan, Korea), North America, Europe
  1. Сценарии применения

Основные свойства

  • Молекулярный состав: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages
  • Растворимость: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents
  • Основные виды деятельности: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Сценарии применения

1. Пищевые добавки и нутрицевтики

  • Immune System Regulation:
    • Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.
    • Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.
  • Anti-Tumor Adjuvant Therapy:
    • Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.
    • Common in integrative medicine formulations.
  • Stress & Fatigue Relief:
    • As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Функциональные продукты питания и напитки

  • Пищевое обогащение:
    • Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).
  • Prebiotic Activity:
    • Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Косметика и средства личной гигиены

  • Антивозрастной уход за кожей:
    • Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.
  • Skin Barrier Protection:
    • Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.
  • Hair Health:
    • Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Фармацевтика и биотехнологии

  • Клинические исследования:
    • Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).
  • Системы доставки лекарств:
    • Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Здоровье животных и аквакультура

  • Veterinary Supplements:
    • Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.
  • Fish Farming:
    • Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Методы обнаружения

  • UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.
  • Высокоэффективная жидкостная хроматография (ВЭЖХ): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).
  • Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Источник и преимущества

  • Натуральный источник: Extracted from fruiting bodies, mycelium, or spores of Ganoderma lucidum via hot water extraction and ethanol precipitation.
  • Устойчивость: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

  • Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.
  • Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.
Категорий: , , , , , , ,

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones with β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Источник, химические свойства и технические характеристики

Botanical Sources & Extraction

  • Primary Source: Fruiting bodies of Ganoderma lucidum или G. sinense (highest GLP content: 1.8–2.5% dry weight)39.

  • Extraction Methods:

    • Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)

    • Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Химическая идентификация

Свойство Ценить
Номер CAS Not assigned (complex mixture)
Молекулярная формула (C₆H₁₀O₅)ₙ
Молекулярный вес 10–1,000 kDa
EINECS Not applicable
Появление Light brown hygroscopic powder
Растворимость Water-soluble; insoluble in ethanol
Key Bioactivity β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Польза для здоровья, оптимальная дозировка и безопасность

Validated Therapeutic Effects

  • Иммуномодуляция:

    • ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.

  • Antitumor Activity:

    • Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.

  • Метаболическая регуляция:

    • ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.

  • Гепатопротекция:

    • Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

Рекомендации по дозировке

  • Общее благополучие: 100–300 mg/day (20–30% GLPs)

  • Терапевтическое использование:

    • Immune support: 500 mg/day (≥40% GLPs)

    • Adjuvant cancer therapy: 1,000–1,500 mg/day

  • Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

  • Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).

  • Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).

  • Лекарственное взаимодействие: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

А 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Основные возможности:

  • Patent-Protected Extraction: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).

  • Analytical Rigor: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99.5% purity (exceeding USP/EP monographs).

  • Глобальное соответствие: ISO 9001, FDA-GMP, EFSA, JECFA certifications.

  • Мастерство управления цепочкой поставок: Cold-chain logistics across 80+ countries.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Категория Параметр Предел Метод испытания
Пестициды Хлорпирифос ≤0,01 ppm ГХ-МС/МС (ЕС 396/2005)
Глифосат ≤0,05 ppm ВЭЖХ-МС/МС (ISO 16308)
Тяжелые металлы Свинец (Pb) ≤0.5 ppm ИСП-МС (USP <233>)
Мышьяк (As) ≤0.5 ppm AAS (EP 2.4.27)
Микробиология Общее количество пластин ≤1000 КОЕ/г USP <61>
Кишечная палочка Отсутствующий ИСО 16654
Сальмонелла виды Отсутствующий FDA BAM Гл.5

6. Расширенный производственный процесс

  1. Поиск поставщиков: Organic G. lucidum fruiting bodies (OOP-certified).

  2. Извлечение: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).

  3. Deproteinization: Sevag reagent (chloroform:butanol 4:1).

  4. Очищение: DEAE-Sepharose FF chromatography → lyophilization.

  5. Стандартизация: Phenol-sulfuric acid assay to 40% GLP content.

7. Применение в различных отраслях

  • Нутрицевтики: Immune-boosting capsules (GLP + β-glucan synergy).

  • Фармацевтика: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).

  • Космецевтика: Anti-aging serums (↑ collagen synthesis by 200%).

  • Функциональные продукты питания: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

  1. Identity Confirmation: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).

  2. Purity Quantification: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).

  3. Bioactivity Testing:

    • RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL

    • α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL

  4. Стабильность: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Research Frontiers & Challenges

  • Mechanistic Insights:

    • Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).

    • STING pathway activation for antitumor immunity.

  • Клинический перевод:

    • Phase II trials for GLP-COVID-19 immunity synergy.

  • Technical Barriers:

    • Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.

    • Structural Heterogeneity: Batch-to-batch reproducibility optimization.

  • Устойчивость:

    • Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: Expert Answers

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

Q: Optimal consumption time?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Direct Order from Shaanxi Zhonghong:

Заключение

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

Ссылки:

  1. Журнал этнофармакологии (2019). GLP mechanisms in cancer apoptosis9.

  2. Углеводородные полимеры (2020). Structural characterization of immunomodulatory GLPs6.

  3. Пищевая химия (2021). Ultrasonic-microwave extraction optimization3.

  4. USP-NF (2023). Polysaccharide identity/purity testing guidelines.

  5. Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 отзыв на Ganoderma lucidum polysaccharide

  1. Аватар James Oli***
    评分 4 &sol; 5

    James Oli*** –

    “As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

Добавить отзыв

Ваш адрес email не будет опубликован. Обязательные поля помечены *

Похожие товары

滚动至顶部

Получить предложение и образец

请在浏览器中启用JavaScript来完成此表单。

Получить предложение и образец