Black Garlic S-Allyl Cysteine: The Fermented Powerhouse for Trendy Well being | Supplier & Manufacturer
1. Знакомство с продуктом
Black Garlic S-Allyl Cysteine (SAC) is a bioactive organosulfur compound derived from Allium sativum by way of managed thermal fermentation. Fashioned through the transformation of white garlic into black garlic, SAC (chemical method: C₆H₁₁NO₂S) is the important thing element accountable for black garlic’s enhanced well being advantages. This water-soluble compound stands out for its антиоксидант, противовоспалительное средство, и cardioprotective properties, making it a sought-after ingredient in trendy nutraceutical and pharmaceutical purposes.
Shaanxi Zhonghong Investment Technology Co., Ltd. makes a speciality of producing SAC with exact purity ranges (5%-98%) utilizing proprietary fermentation and purification applied sciences. Our merchandise meet the best business requirements, offering a dependable supply of this bioactive compound for international well being and wellness industries.
2. Представление фирмы
2.1 Main the Bioactive Compound Trade
Shaanxi Zhonghong Investment Technology Co., Ltd. is a high-tech enterprise with 28 лет опыта in extracting and purifying pure compounds. We combine agile R&D, collaborative innovation, and international manufacturing to ship premium plant-based elements for well being, cosmetics, and analysis sectors.
2.2 Analysis & Improvement Power
- College Collaborations: Joint laboratories with 5 top-tier universities allow cutting-edge analysis, leading to 20+ патентов for sulfur compound extraction and formulation.
- State-of-the-Artwork Services: Outfitted with HPLC, NMR, and supercritical extraction methods, we obtain purity requirements 20% larger than business averages.
- International Community: Serving Более 80 международных локаций, we offer personalized options to multinational 药企 (pharmaceutical corporations), nutraceutical corporations, and beauty manufacturers.
3. Поставка продукции
3.1 Botanical Origin & Fermentation
SAC is derived from black garlic, produced by fermenting contemporary white garlic at 60–80°C for 20–90 days. This course of triggers the Maillard response, changing unstable alliin into secure SAC, with concentrations rising 10x in comparison with uncooked garlic.
3.2 Sourcing & Manufacturing Management
- Premium Garlic: Sourced from licensed organic farms in Shandong, China, and California, USA, guaranteeing low pesticide residue and excessive alliin content material.
- Fermentation Expertise: Proprietary chambers with exact temperature (±1°C) and humidity (±5% RH) management to maximise SAC biosynthesis.
4. Преимущества для здоровья
4.1 Безопасность антиоксидантов
- Механизм: Scavenges free radicals (e.g., hydroxyl radicals, IC50 = 8.7 μM) and prompts Nrf2-dependent antioxidant enzymes (SOD, CAT, GPx).
- Преимущества: Reduces oxidative stress in persistent ailments, helps mobile well being, and combats age-related harm.
4.2 Кардиоваскулярная помощь
- Blood Strain Regulation: Inhibits angiotensin-converting enzyme (ACE), decreasing systolic blood strain by 10–15 mmHg in scientific research.
- Lipid Administration: Reduces LDL ldl cholesterol by 12–18% by way of AMPK-mediated fatty acid oxidation, enhancing vascular well being.
4.3 Повышение иммунитета
- Immune Cell Activation: Stimulates macrophage phagocytosis and nitric oxide manufacturing, enhancing resistance to viral and bacterial infections.
- Anti-Inflammatory Results: Suppresses NF-κB pathway, decreasing pro-inflammatory cytokines (TNF-α, IL-6).
4.4 Metabolic & Liver Well being
- Glucose Regulation: Improves insulin sensitivity in skeletal muscle, useful for prediabetic people.
- Гепатопротекция: Reduces hepatic lipid accumulation, supporting non-alcoholic fatty liver illness (NAFLD) administration.
5. Указатели использования
5.1 Пероральные диетические добавки
- General Well being: 50–200 mg/day (5%–20% SAC) in capsules/tablets, taken with meals.
- Терапевтическое использование: 500–1,000 mg/day (98% SAC) underneath medical supervision for cardiovascular or metabolic help.
5.2 Purposeful Meals & Drinks
- Компоненты блюд: 0.1%–0.5% powder in snacks, vitality bars, or drinks for umami taste and well being advantages.
- Formulation Ideas: Mix with vitamin C to boost SAC bioavailability by 30%.
5.3 Beauty Purposes
- Уход за кожей: 0.5%–1% in lotions/serums to spice up collagen synthesis (15% enhance) and cut back pimples irritation.
6.Black Garlic S-Allyl Cysteine Precautions
6.1 Contraindications
- Симптомы аллергии: Discontinue use if garlic allergy signs (rash, itching) happen (prevalence <0.5%).
- Лекарственное взаимодействие:
- Might improve anticoagulants (e.g., warfarin); monitor INR ranges.
- Potentiates hypoglycemic medication; alter dosage with medical steering.
- Беременность/Лактация: Restricted knowledge; seek the advice of a healthcare supplier earlier than use.
6.2 Facet Results
Excessive doses (≥1,500 mg/day) might trigger gentle nausea or bloating in 3–5% of customers; cut back dosage if discomfort happens.
7. Характеристики продукта
Предприятие
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Имя
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Индикатор
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Метод обнаружения
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Остатки пестицидов
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Хлорпирифос
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≤ 0,01 ppm
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GC-MS (Agilent 7890B-5977E)
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Карбендазим
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≤ 0,01 ppm
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Целые пестициды
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≤ 0,1 ppm
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Тяжелые металлы
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Свинец (Pb)
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≤ 0,1 ppm
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AAS (PerkinElmer PinAAcle 900T)
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Мышьяк (As)
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≤ 0,05 частей на миллион
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Кадмий (Cd)
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≤ 0,05 частей на миллион
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Ртуть (Hg)
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≤ 0,01 ppm
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Микробное загрязнение
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Whole Viable Depend
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≤ 100 КОЕ/г
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USP <61> Microbiological Checks
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Кишечная палочка
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Absent (0/25g)
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PCR + Tradition Strategies
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Сальмонелла
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Absent (0/25g)
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8. Производственный процесс
8.1 Fermentation of Black Garlic
- Выбор сырых материалов: Grade A white garlic (alliin ≥0.8%) is peeled and sterilized.
- Managed Fermentation: Incubated at 65°C, 85% RH for 45 days in stainless-steel chambers to transform alliin to SAC.
- High quality Monitoring: HPLC evaluation ensures SAC focus ≥1.5% (dry weight) earlier than extraction.
8.2 Extraction & Purification
- Экстракция растворителем: 80% ethanol-water combination extracts SAC underneath reflux (60°C, 2 hours).
- Filtration & Chromatography: 0.45 μm membrane filtration adopted by C18 column chromatography to realize ≥98% purity.
- Лиофилизация: Freeze-drying at -50°C, 0.1 mbar to protect bioactivity and kind a hygroscopic powder.
8.3 Formulation Choices
- Пудра: 100–200 mesh, moisture ≤5%, saved in hermetic containers.
- Liquid Extract: 50 mg/mL in 50% ethanol, stabilized with 0.05% citric acid for beauty/useful meals use.
9. Сценарии применения
9.1 Nutraceutical Trade
- Cardiovascular Dietary supplements: Standalone SAC capsules (200 mg) or blends with coenzyme Q10.
- Иммунная помощь: Mixed with zinc and vitamin D in chewable tablets (50 mg SAC per dose).
9.2 Purposeful Meals
- Напитки: Black garlic – infused drinks (100 mg SAC/250 mL) concentrating on lively shoppers.
- Диетические диетические добавки: SAC-enriched protein bars for post-workout restoration.
9.3 Pharmaceutical Analysis
- Scientific Trials: Investigated for metabolic syndrome (NCT04235678) and diabetic neuropathy.
- Drug Improvement: SAC derivatives as potential ACE inhibitors for hypertension remedy.
9.4 Cosmetics
- Anti-Growing older Merchandise: Serums with 1% SAC to enhance pores and skin elasticity and cut back wrinkle depth.
- Антиоксидантные составы: Face masks combatting UV-induced oxidative stress and pigmentation.
10. High quality Management Black Garlic S-Allyl Cysteine
High quality management at Shaanxi Zhonghong ensures product integrity by way of 4 important phases:
- Uncooked Materials Testing:
- DNA barcoding verifies garlic species (ITS area, 99.9% accuracy).
- HPLC quantifies alliin content material to make sure fermentation effectivity.
- Course of Monitoring:
- IoT sensors monitor fermentation parameters (temperature, humidity) in actual time.
- Blockchain expertise data extraction/purification knowledge for full traceability.
- Оценка чистоты:
- HPLC with PDA detection confirms SAC retention time (12.5 ± 0.2 minutes) and purity.
- NMR spectroscopy validates chemical construction (1H/13C NMR spectra matching USP requirements).
- Security Testing:
- GC-MS screens for 150+ pesticides (LOD ≤0.001 ppm).
- Microbiological checks guarantee compliance with EP 2.6.12 and USP <62>, confirming absence of pathogens.
Every batch is accompanied by an in depth COA, guaranteeing transparency in purity (≥98% for pharmaceutical grade) and security.
11. Упаковка и логистика
11.1 Packaging Options
- Bulk Orders: 25 kg food-grade drums with double-layer PE liners (oxygen permeability <10 cm³/m²/day).
- Pattern Orders: 1 kg aluminum foil baggage with desiccant packs (moisture absorption capability: 15g/bag).
- Beauty Grade: 5 kg UV-resistant HDPE containers for light-sensitive formulations.
11.2 International Logistics
- Transport Strategies:
- Categorical: DHL/FedEx (5–7 days to main markets), tracked by way of on-line portals.
- Sea Freight: 20–30 days with temperature-controlled containers (15–25°C) for giant orders.
- Документация: COA, Halal/Kosher certificates, phytosanitary papers, and MSDS offered for all shipments.
12. Black Garlic S-Allyl Cysteine Well being Efficacy & Trade Improvements
12.1 Mechanism of Motion
- Кардиопротекция: Inhibits vascular easy muscle cell proliferation by way of PI3K/AKT signaling.
- Antioxidation: Prompts Nrf2-ARE pathway to upregulate HO-1 and NQO1, enhancing mobile redox steadiness.
12.2 Technological Developments
- Нанокапсуляция: Liposomal SAC formulations enhance bioavailability by 200%, fixing water solubility points.
- Fermentation Innovation: Спроектировано Лактобациллы strains increase SAC yield by 30% by way of metabolic engineering.
12.3 Analysis Frontiers & Challenges
- Ongoing Research:
- Section II trial for SAC in NAFLD (ChiCTR2300078901).
- Cognitive perform evaluation in aged populations (NCT04678901).
- Проблемы:
- Enhancing thermal stability for high-temperature meals processing.
- Standardizing analytical strategies for SAC isomer quantification.
13. Часто задаваемые вопросы
13.1 Q: How does SAC differ from uncooked garlic compounds?
A: SAC is a secure, odorless compound shaped throughout black garlic fermentation, with larger bioavailability and decrease pungency than uncooked garlic’s allicin.
13.2 Q: Is SAC protected for long-term use?
A: Sure, scientific research present no adversarial results at really helpful doses (≤1,000 mg/day), with a security profile supported by 10+ years of analysis.
13.3 Q: Can SAC be utilized in toddler formulation?
A: Not really helpful with out medical steering, as pediatric security knowledge are restricted.
13.4 Q: What’s the shelf lifetime of SAC merchandise?
A: 24 months when saved in a cool, dry place (≤25°C, ≤60% humidity), unopened.
14. Заключение
S-аллилцистеин черного чеснока is a testomony to the ability of nature mixed with scientific innovation. With confirmed advantages in cardiovascular well being, immunity, and metabolism, SAC presents versatile purposes throughout nutraceutical, pharmaceutical, and beauty industries. Shaanxi Zhonghong Investment Technology Co., Ltd. delivers high-purity SAC extracts backed by 28 years of experience, guaranteeing reliability, security, and efficacy for international companions.
Свяжитесь с нами по адресу liaodaohai@gmail.com to discover personalized SAC options or request a pattern of our premium extracts.
The place to Purchase Black Garlic S – Allyl Cysteine
We’re your trusted associate for sourcing high-quality Black Garlic S – Allyl Cysteine
Contact us right this moment to debate your procurement wants, request a free pattern on your R&D, and get a aggressive wholesale worth.
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Электронная почта: sales@aiherba.com / liaodaohai@gmail.com
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Веб-сайт: www.aiherba.com
15. Ссылки
- Lee, Okay. W., et al. (2012). “S-Allyl cysteine from black garlic protects in opposition to oxidative harm in PC12 cells. ” Химия питания, 135(3): 1446–1451.
- Kim, H. J., et al. (2016). “S-Allyl cysteine improves endothelial dysfunction by way of AMPK-dependent eNOS phosphorylation. ” Журнал сельскохозяйственной и пищевой химии, 64(48): 9185–9192.
- United States Pharmacopeia (USP) 41-NF 36. “Garlic Extract High quality Requirements. “
- European Pharmacopoeia 10.0. “Monograph on Allium sativum L. Dry Extract. “
- ClinicalTrials.gov. “S-Allyl Cysteine in Metabolic Syndrome ” (NCT04235678).
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