Бисаболол
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Бисаболол

Bisabolol supplier bulk factory Wholesale buy Extract factory

  1. Английское имя: Bisabolol; α-Bisabolol; (+)-α-Bisabolol
  1. Спецификация
    • Чистота: ≥ 98% (HPLC); high – purity grade: ≥ 99% (HPLC)
    • Растворимость: Sparingly soluble in water (0.1 g/L at 25°C), highly soluble in ethanol (≥ 50 g/100 mL), propylene glycol, and most organic solvents like ethyl acetate and isopropyl myristate
    • Внешний вид – связанный: Потеря при высыхании ≤ 1,0%, Тяжелые металлы ≤ 10 ppm, Остаточные растворители ≤ 0,5%
    • Размер частиц: For liquid form, not applicable; for solidified or powdered forms, standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better dispersion in formulations
  1. Появление
    • Colorless to pale yellow viscous liquid (natural form), or white to off – white crystalline solid (synthetic or purified form), with a mild, pleasant, slightly woody – floral aroma, not related to chocolate
  1. Номер CAS：515-69-5 (α-Bisabolol)
  1. Время выполнения: 5–7 рабочих дней
  1. Упаковка
    • Liquid form: 1 kg/bottle (glass or plastic container), 25 kg/drum (stainless steel or plastic drum with proper sealing)
    • Solid form: 1 kg/aluminum foil bag, 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Главный рынок
    • Global market, with significant demand in Europe (Germany, France), North America, and Asia (Japan, South Korea, China), mainly applied in cosmetics, pharmaceuticals, food, and personal care industries
  1. Сценарии применения

Основные свойства

  • Химическая структура: A sesquiterpene alcohol with the molecular formula C₁₅H₂₆O. It exists in different isomeric forms, with α-Bisabolol being the most common and bioactive form.
  • Ключевые особенности
    • Противовоспалительное средство: Inhibits the production of pro – inflammatory cytokines such as TNF – α and IL – 6, effectively reducing inflammation in tissues. It can alleviate redness, swelling, and discomfort associated with inflammation.
    • Антиоксидант: Scavenges free radicals like hydroxyl and superoxide anions, protecting cells from oxidative stress. This property helps prevent premature aging, DNA damage, and the development of chronic diseases.
    • Антимикробный: Exhibits inhibitory effects against various bacteria (e.g., Золотистый стафилококк) и грибы (например, Кандида альбиканс), making it useful for preventing and treating microbial infections, especially in skin care.
    • Skin – Soothing and Healing: Promotes skin repair by accelerating the regeneration of skin cells. It calms irritated skin, reduces itching, and is beneficial for sensitive, dry, or damaged skin types.
    • Стабильность: Stable under normal storage conditions away from heat, light, and strong oxidizing agents. However, in liquid form, it may oxidize slowly over time, so proper storage in air – tight containers is recommended.

Сценарии применения

1. Косметика и средства личной гигиены

  • Средства по уходу за кожей:
    • Увлажняющие средства и кремы: Added at concentrations of 0.5 – 3% to hydrate the skin, reduce redness, and soothe irritation. It helps improve skin texture and provides antioxidant protection against environmental stressors.
    • Serums: Used in anti – aging serums to combat free radical damage, promote collagen synthesis, and reduce the appearance of fine lines and wrinkles.
    • Солнцезащитные средства: Enhances the skin – protecting properties of sunscreens by reducing UV – induced inflammation and oxidative damage. It can also improve the skin – feel and texture of the sunscreen formulation.
    • Acne Treatments: Due to its antimicrobial and anti – inflammatory properties, it is included in acne – fighting products to reduce inflammation in acne lesions and prevent further bacterial growth.
  • Уход за волосами:
    • Shampoos and Conditioners: Added to soothe the scalp, reduce dandruff, and improve hair manageability. It can also protect hair from damage caused by styling products and environmental factors.
    • Маски для волос: Helps repair damaged hair, making it smoother and shinier by providing nourishment and reducing oxidative stress on hair follicles.

2. Фармацевтика

  • Местные лекарства:
    • Used in creams, ointments, and gels for treating skin conditions such as eczema, psoriasis, and dermatitis. Its anti – inflammatory and skin – healing properties help relieve symptoms and promote recovery.
    • Included in wound – healing products to accelerate the healing process, prevent infection, and reduce scarring.
  • Оральные добавки:
    • Currently under research for its potential health benefits when taken orally, such as reducing internal inflammation and providing antioxidant support. Although not as commonly used orally as topically, it shows promise in the prevention and treatment of certain chronic diseases.

3. Пищевая промышленность и производство напитков

  • Flavoring Agent:
    • Used in small amounts (ppm level) as a natural flavor enhancer in food and beverages, especially in products aiming for a mild, pleasant, and unique flavor profile. It can be added to confectionery, dairy products, and fruit – based drinks.
  • Антиоксидант и консервант:
    • Investigated for its potential use as a natural antioxidant and preservative in food products. By preventing oxidative spoilage, it can extend the shelf life of certain foods and maintain their quality.

4. Ароматерапия и оздоровление

  • Essential Oil Blends:
    • Blended with other essential oils in aromatherapy products due to its calming and soothing aroma. It can help reduce stress, anxiety, and promote relaxation when diffused or used in massage oils.

Методы обнаружения

  • Высокоэффективная жидкостная хроматография (ВЭЖХ):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 210 nm for quantification. This method accurately measures the purity and concentration of bisabolol in samples.
  • Газовая хроматография – масс-спектрометрия (ГХ – МС):
    • Ideal for analyzing volatile components and confirming the chemical structure of bisabolol. It provides detailed information about the sample’s chemical profile, including the identification of any impurities or related compounds.
  • Инфракрасная спектроскопия с преобразованием Фурье (ИКФС):
    • Helps in confirming the chemical structure of bisabolol by analyzing the characteristic absorption peaks of its functional groups. It is a quick and effective method for quality control and product identification during production.

Источник и преимущества

  • Натуральный источник: Naturally found in essential oils of plants such as German chamomile (Matricaria recutita), candeia tree (Eremanthus erythropappus), and others. It can be extracted from these plant sources through steam distillation or other extraction methods.
  • Синтетическое производство: Can also be produced synthetically, allowing for a more consistent supply and potentially lower cost. Synthetic bisabolol has the same chemical structure and properties as the natural form.
  • Универсальные приложения: Its multiple beneficial properties make it highly sought after in various industries, from beauty and health to food and fragrance, presenting a wide range of market opportunities.
  • Нормативное принятие: Generally recognized as safe for use in cosmetics, food, and pharmaceuticals in many regions. For example, in the US, it is considered safe for use in food and cosmetics; in the EU, it is approved for use in cosmetic products under the Cosmetics Regulation (EC) No 1223/2009.
Категорий: , , , , ,

Unlocking the Energy of Bisabolol: Nature’s Soothing Elixir from AIHerba | Supplier & Manufacturer

1. What is Bisabolol?
Bisabolol, primarily occurring as (-)-α-bisabolol, is a naturally occurring monocyclic sesquiterpene alcohol famend for its distinctive skin-soothing, anti-irritant, and anti inflammatory properties. This bioactive compound is a prized beauty and pharmaceutical ingredient, providing a delicate but potent resolution for delicate pores and skin and numerous inflammatory circumstances. Its delicate floral aroma additional enhances its enchantment in perfumery.

2. Поставка продукции, химические свойства и идентификация

  • Major Natural Supply: Немецкая ромашка (Matricaria chamomilla/recutita), particularly its important oil, is the richest pure supply of (-)-α-bisabolol. Additionally present in smaller portions in Candeia tree (Vanillosmopsis species) oil and different vegetation.

  • Химические свойства:

    • Количество CAS: 515-69-5 (Usually refers back to the racemic combination; pure (-)-α-Bisabolol is 23089-26-1)

    • МФ (молекулярная формула): C₁₅H₂₆O

    • МВ (молекулярная масса): 222,37 г/моль

    • EINECS: 207-454-3

    • Появление: Colorless to pale yellow viscous liquid.

    • Растворимость: Soluble in alcohols and oils, insoluble in water.

    • Optical Exercise: Natural (-)-α-Bisabolol is levorotatory. Artificial variations could also be racemic.

  • AIHerba Supply & Benefit: AIHerba makes use of premium German Chamomile flowers, using proprietary supercritical CO2 extraction and molecular distillation methods to yield (-)-α-Bisabolol with unparalleled purity (>98%) and stereochemical integrity, maximizing its bioactivity.

3. What is the Finest Bisabolol? Efficacy, Security & Utilization

  • “Finest” Outlined: The highest efficacy is constantly attributed to pure (-)-α-Bisabolol resulting from its particular stereochemistry. AIHerba’s concentrate on ultra-high purity pure (-)-α-Bisabolol ensures superior efficiency.

  • Наибольший запас контента: German Chamomile important oil usually comprises the very best pure focus (as much as ~50%, although AIHerba isolates it to >98%).

  • Well being & Pores and skin Benefits:

    • Мощное противовоспалительное средство: Inhibits COX-2, LOX, and inflammatory cytokines (TNF-α, IL-6).

    • Soothing & Anti-irritant: Quickly calms pores and skin irritation (e.g., from surfactants, UV, chemical peels).

    • Антиоксидант: Scavenges free radicals, defending pores and skin cells.

    • Wound Therapeutic & Regenerative: Stimulates fibroblast migration and promotes tissue restore.

    • Антимикробные: Displays exercise towards sure micro organism and fungi.

    • Улучшенное проникновение: Can enhance pores and skin absorption of different actives.

    • Помощь в укреплении барьера кожи и пор: Contributes to a more healthy pores and skin barrier operate.

  • Потребление за день: Bisabolol is primarily used topically (cosmetics, skincare). Oral consumption shouldn’t be frequent for bisabolol itself; security ranges depend upon the particular software (beauty, complement, pharmaceutical). Beauty use is usually thought to be secure at typical concentrations (0.2% – 2.0%).

  • Wants Consideration:

    • Sensitivity: Whereas usually well-tolerated, patch testing new merchandise is at all times beneficial.

    • Окисление: Pure bisabolol can oxidize over time; formulations ought to embrace antioxidants and use acceptable packaging (e.g., airless containers, nitrogen flushing).

  • Результаты аспекта: Uncommon. Potential for gentle pores and skin irritation or allergic response in extremely delicate people. Natural (-)-α-Bisabolol has a wonderful security profile.

4. Introducing AIHerba: Your Trusted Bisabolol Companion
Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba) является премьер-министром высокотехнологичное предприятие integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising. For over 28 лет, we have specialised in serving the chemical, supplies, and life sciences sectors, with core experience within the extraction, isolation, purification, and industrial software of bioactive plant constituents.

  • Научные достижения: 5+ strategic college joint labs, 20+ patented applied sciences, and a globally distinctive собственная библиотека соединений.

  • Chopping-Edge High quality: ВЭЖХ (высокоэффективная жидкостная хроматография), ГХ-МС (бензиновая хроматография-масс-спектрометрия), и Superconducting NMR (Nuclear Magnetic Resonance) guarantee purity requirements exceeding trade norms by 20%+.

  • Мир Достижения: Обслуживание 80+ стран throughout Asia, Europe, and the Americas, offering custom-made pure ingredient options to main multinational pharmaceutical corporations, analysis establishments, and beauty giants.

5. Характеристики продукта: Строгий контроль качества
AIHerba’s (-)-α-Bisabolol adheres to the strictest high quality requirements. Key specs embrace:

Desk 1: Pesticide Residue Evaluation

Pesticide Group Instance Compounds Ограничить (ppm) Detection Methodology (e.g.)
Хлорорганические соединения DDT, Lindane, Endosulfan < 0,01 ГХ-ЭЗД / ГХ-МС/МС
Organophosphates Chlorpyrifos, Malathion < 0,01 GC-FPD / GC-MS/MS
Пиретроиды Cypermethrin, Deltamethrin < 0,01 ГХ-ЭЗД / ГХ-МС/МС
Carbamates Carbaryl, Aldicarb < 0,01 ВЭЖХ-ФЛД / ЖХ-МС/МС
Другие Glyphosate, Amitrole < 0.05 HPLC-PCD / LC-MS/MS

Desk 2: Heavy Metals Evaluation

Heavy Steel Ограничить (ppm) Detection Methodology (e.g.)
Мышьяк (As) < 1.0 ICP-MS / Hydride Technology AAS
Свинец (Pb) < 3.0 ICP-MS / Graphite Furnace AAS
Кадмий (Cd) < 0.5 ICP-MS / Graphite Furnace AAS
Ртуть (Hg) < 0.1 Chilly Vapor AAS / ICP-MS
Complete Heavy Metals < 10.0 ICP-OES / ICP-MS

Desk 3: Microbial Evaluation

Microorganism Ограничивать Detection Methodology (e.g.)
Complete Cardio Microbial Rely < 100 КОЕ/г USP <61> / EP 2.6.12
Complete Mixed Yeasts/Molds < 50 CFU/g USP <61> / EP 2.6.12
Кишечная палочка Отсутствует в 1 г USP <62> / EP 2.6.13
Сальмонелла виды Отсутствует в 10 г USP <62> / ISO 6579-1
Золотистый стафилококк Отсутствует в 1 г USP <62> / EP 2.6.13
Синегнойная палочка Отсутствует в 1 г USP <62> / EP 2.6.13

6. Superior Manufacturing Move
AIHerba’s (-)-α-Bisabolol manufacturing exemplifies cutting-edge phytochemistry:

  1. Источники: Premium German Chamomile flowers from licensed sustainable farms.

  2. Основная добыча: Сверхкритическая CO2-экстракция (SFE) – Makes use of tunable strain/temperature for selective, solvent-free isolation of volatiles, preserving delicate actives.

  3. Фокус: Removing of waxes and non-target compounds.

  4. Isolation & Purification: Preparative HPLC and/or Excessive-Vacuum Fractional Distillation – Achieves focused separation of (-)-α-Bisabolol from different terpenes.

  5. Crystallization (Non-obligatory): For attaining highest purity grades (>99%).

  6. Стабилизация: Addition of synergistic antioxidants (e.g., Tocopherol).

  7. Строгий контроль качества: HPLC-DAD/ELSD, Chiral GC/HPLC, GC-MS, NMR for identification, purity (>98%), enantiomeric extra, and residual solvent evaluation. ИСП-МС for heavy metals. Microbiological testing per pharmacopeia.

  8. Упаковка: Underneath inert environment (Nitrogen) in light-protected, food-grade HDPE or glass containers.

7. Различные сценарии применения

  • Косметика и уход за кожей: Calming serums, delicate pores and skin lotions, after-sun merchandise, anti-redness remedies, child care, post-procedure formulations (laser, peels), zits remedies (mitigates irritation), pure deodorants.

  • Лекарственные препараты, отпускаемые по рецепту: Topical anti-inflammatory and wound therapeutic ointments/gels, mucoadhesive formulations, dental care merchandise (anti-gingivitis).

  • Perfumery: Gives a tender, candy, floral notice with fixative properties.

  • Нутрицевтики: Included into topical wellness merchandise (e.g., muscle soothing balms).

8. Complete High quality Management (QC)
AIHerba’s QC paradigm is constructed on Pharmaceutical cGMP ideas and leverages современное аналитическое оборудование. Identification affirmation makes use of FTIR (Fourier Remodel Infrared Spectroscopy) fingerprinting and Хиральная хроматография to confirm the (-)-enantiomer. Purity is quantified by way of validated HPLC-UV/ELSD strategies calibrated towards licensed reference requirements, constantly guaranteeing >98% (-)-α-Bisabolol content material. Residual Solvent Evaluation (Headspace GC-MS) ensures compliance with ICH Q3C tips. Исследование стабильности (ICH Q1A) underneath accelerated and long-term circumstances decide shelf-life and optimum storage parameters. Each batch undergoes full spectroscopic (NMR for structural elucidation if wanted), chromatographic, and microbiological testing, documented in a Сертификаты оценки (CoA) traceable to worldwide requirements (USP, EP, CP). Our ISO 9001-certified high quality administration system ensures traceability and steady enchancment.

9. Безопасная упаковка и мировая логистика

  • Упаковка: 1kg, 5kg food-grade HDPE bottles; 25kg HDPE drums. All nitrogen flushed и aluminum bag-lined for max oxidation safety. Customized packaging obtainable.

  • Хранилище: Retailer tightly sealed in unique packaging, shielded from mild and moisture at 2-8°C (refrigerated) for long-term stability. Quick-term (<6 months) at <25°C acceptable.

  • Логистика: Shipped globally by way of temperature-controlled logistics (chilly chain the place required). Compliant with all worldwide rules (REACH, FDA, COSMOS and so on.). Complete documentation offered.

10. Deep Dive: Well being Mechanisms, Purposes & Innovation

  • Механизм движения: (-)-α-Bisabolol exerts results by way of a number of pathways:

    • Modulates NF-κB and MAPK signaling cascades, suppressing pro-inflammatory cytokine manufacturing.

    • Inhibits key enzymes: Cyclooxygenase-2 (COX-2), 5-Lipoxygenase (5-LOX).

    • Demonstrates antioxidant exercise by quenching ROS/RNS.

    • Enhances penetration by way of lipid bilayer interplay.

    • Promotes re-epithelialization and granulation tissue formation in wounds.

  • Industrial Purposes & AIHerba Innovation: Past cosmetics, bisabolol enhances transdermal drug supply programs. AIHerba innovates by way of enantioselective synthesis pathways (for ultra-pure (-)-isomer), novel co-crystal formulations for enhanced stability/solubility, and sustained-release supply programs (e.g., lipid nanoparticles) built-in with our собственная библиотека соединений screening for synergistic combos.

  • Границы и проблемы анализа:

    • Границы: Exploring efficacy in neuroinflammatory circumstances, gastroprotective results, anti-cancer adjunct remedy (enhancing chemo efficacy/lowering negative effects), superior biomaterials (anti-inflammatory coatings for implants).

    • Проблемы: Scaling sustainable cultivation of high-bisabolol chamomile strains, cost-effective large-scale chiral purification, definitive medical dose-response research for particular therapeutic endpoints, long-term stability optimization in advanced formulations.

11. Часто задаваемые вопросы (FAQ)

  • Q: Is pure (-)-α-Bisabolol higher than artificial?

    • А: Sure, quite a few research point out pure (-)-α-Bisabolol possesses superior anti-inflammatory and skin-soothing efficacy in comparison with artificial racemic mixtures or different isomers resulting from its particular stereochemistry.

  • Q: What focus of Bisabolol is efficient in cosmetics?

    • А: Typical efficient concentrations vary from 0.2% to 2.0%. Efficacy relies on the formulation and desired impact; AIHerba gives software assist.

  • Q: Is Bisabolol secure for delicate pores and skin?

    • А: Completely. Natural (-)-α-Bisabolol is famend for its distinctive tolerance and efficacy in calming delicate, irritated, and reactive pores and skin.

  • Q: Does Bisabolol have any identified drug interactions?

    • А: Topical use has no vital reported interactions. Seek the advice of a doctor for potential interactions with oral medicines if used systemically (uncommon).

  • Q: How ought to I retailer AIHerba Bisabolol?

    • А: For optimum long-term stability and to stop oxidation, retailer tightly sealed, shielded from mild, and refrigerated (2-8°C). See CoA for particular batch suggestions.

  • Q: Is AIHerba Bisabolol compliant with worldwide requirements?

    • А: Sure. Our product meets or exceeds specs outlined in related USP/EP monographs (the place relevant), COSMOS, ISO, and is REACH/FDA compliant. Certificates obtainable.

12. The place to Purchase Premium (-)-α-Bisabolol
Supply the very best purity, naturally derived (-)-α-Bisabolol straight from the producer:

  • Веб-сайт: www.aiherba.com

  • Контакт: г-н Ляо Даохай

  • Электронная почта: liaodaohai@gmail.com

  • Запросить информацию о: Bulk pricing, samples, technical knowledge sheets (TDS), certificates of research (CoA), and formulation assist.

13. Заключение
(-)-α-Bisabolol stands as a cornerstone bioactive ingredient for light but highly effective soothing and anti inflammatory efficacy. AIHerba, используя 28 years of experience in phytochemistry and superior purification applied sciences, доставляет ultra-pure (>98%) pure (-)-α-Bisabolol. Sourced sustainably and validated by superconducting NMR, HPLC, and ICP-MS, our ingredient meets the stringent calls for of worldwide beauty, pharmaceutical, and analysis markets. Select AIHerba for unparalleled high quality, scientific assist, and a dedication to innovation in pure actives.

14. Ссылки

  1. Kamatou, G. P. P., & Viljoen, A. M. (2010). A evaluation of the applying and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. Journal of the American Oil Chemists’ Society, 87(1), 1-7.

  2. European Medicines Company (EMA) Evaluation Report on Matricaria recutita L., flos. (2015).

  3. Cavalieri, E., et al. (2004). Professional-apoptotic exercise of α-bisabolol in preclinical fashions of major human acute leukemia cells. The Journal of Medical Investigation, 114(3).

  4. Worldwide Group for Standardization (ISO). ISO 16128 – Tips on technical definitions and standards for pure and organic beauty substances.

  5. United States Pharmacopeia (USP) Normal Chapters: <561> Articles of Botanical Origin, <2023> Microbiological Examination of Nonsterile Merchandise.

  6. European Pharmacopoeia (Ph. Eur.) Monographs: 2.8.12 Microbiological examination of non-sterile merchandise, 2.4.8 Heavy Metals.

  7. Current Analysis (e.g., search PubMed.gov for “alpha-bisabolol mechanism”, “bisabolol pores and skin”, “bisabolol wound therapeutic” – 2023/2024 publications). AIHerba Inner Analysis & Stability Information.

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