Triterpenóides
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Triterpenóides

  1. Visão geral do produto
    English Name: Triterpenoids
    Source: Triterpenoids are a large class of natural compounds found in various plants, fungi, and some animals. They are synthesized through the mevalonate pathway in living organisms. Common sources include plants like ginseng, licorice, and fungi such as Poria cocos.
  2. Especificação:Purity: Total Triterpenoids ≥ 95% (HPLC – tested). The extraction process depends on the source material. For plant – derived triterpenoids, methods like solvent extraction (using ethanol, methanol, etc.) are often employed, followed by purification through chromatography techniques (e.g., silica gel column chromatography, high – performance liquid chromatography). Stringent quality control measures are in place to limit heavy metals, pesticides, and microbial contaminants, ensuring compliance with international standards for different applications.
  3. Aparência:Triterpenoids typically appear as white to off – white powders or colorless to pale – yellow crystals. They may have a faint, characteristic odor depending on the source. The powder or crystals are free – flowing, making them suitable for incorporation into different products.
  4. Número CAS:Since triterpenoids are a class of compounds, there is no single CAS number. Each individual triterpenoid, such as betulinic acid (CAS NO.: 472 – 15 – 1) or oleanolic acid (CAS NO.: 508 – 02 – 1), has its own unique CAS number for chemical identification, research, and regulatory compliance.
  5. Tempo de espera:Lead time: 3 – 7 Working Days. Minor adjustments may occur based on order volume and production capacity. Our efficient production and logistics systems are designed to ensure timely delivery. However, factors such as the availability of raw materials (seasonal for some plants) or any production – related issues may slightly impact the lead time.
  6. Pacote: Usually packaged in 25kg food – grade drums, with 27 drums per tray for convenient transportation. The drums are made of materials that protect the product from moisture, light, and physical damage during storage and transportation. Custom packaging options, such as smaller containers for laboratory use or larger bulk containers for industrial applications, are available upon request.
  7. Mercado Principal: European, North America, Asia etc. In Asia, especially in countries with a strong traditional medicine background, triterpenoids from plants like ginseng have been used for centuries. In Europe and North America, with the growing interest in natural health products, triterpenoids are gaining popularity.
  8. Aplicações
    • Suplementos de saúde:
      • Anti – inflammatory: Many triterpenoids exhibit anti – inflammatory properties. They can inhibit the production of inflammatory mediators like cytokines and prostaglandins in the body. This is beneficial for conditions such as arthritis, where they can reduce joint inflammation and pain, and inflammatory bowel disease, by soothing the inflamed intestinal lining.
      • Antioxidant: Acting as antioxidants, triterpenoids can scavenge free radicals, protecting cells from oxidative damage. This can contribute to overall health and potentially reduce the risk of chronic diseases like heart disease, cancer, and neurodegenerative disorders.
      • Immune System Modulation: Some triterpenoids can modulate the immune system. They may enhance the activity of immune cells such as macrophages, T – lymphocytes, and B – lymphocytes, strengthening the body\’s defense against infections and diseases.
    • Cosméticos:
      • Skin Soothing: Their anti – inflammatory nature makes them effective in calming irritated skin. They can reduce redness, itching, and inflammation associated with skin conditions like acne, eczema, and psoriasis.
      • Anti – aging: By protecting skin cells from oxidative stress, triterpenoids help reduce the appearance of fine lines, wrinkles, and age spots. They may also enhance skin elasticity.
    • Indústria alimentícia:
      • Functional Foods: Triterpenoids can be added to functional foods such as health drinks, energy bars, and fortified snacks. These products can provide consumers with the added health benefits of triterpenoids. However, their use in the food industry is subject to strict regulatory approvals to ensure safety and proper dosage.
      • Natural Preservative: Some triterpenoids may have antibacterial and antifungal properties, which could potentially be used to extend the shelf – life of certain food products. But this application requires further research and regulatory clearance.
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Premium Triterpenoids: Nature’s Bioactive Powerhouses for Health & Innovation

1. Introdução ao produto

Triterpenoids represent a class of cyclic organic compounds comprising 30 carbon atoms with diverse pharmacological activities. As secondary metabolites predominantly found in medicinal plants and fungi, these compounds exhibit:Triterpenoids Applications

 

  • Structural diversity: Over 20,000 identified variants including oleanane, ursane, and lupane skeletons

  • Bioactivity spectrum:

    • Cytotoxic (IC50 values as low as 0.8μM against cancer cell lines)

    • Anti-inflammatory (COX-2 inhibition up to 92% at 50μg/mL)

    • Hypoglycemic (PPARγ activation at EC50 3.2nM)

Our GMP-certified triterpenoid portfolio includes:

  • Betulinic acid (≥98.5%, White powder)

  • Oleanolic acid (≥99%, USP grade)

  • Ursolic acid (≥98%, Kosher certified)

  • Specialty blends: Custom ratios for synergistic formulations

2. Company Profile: Shaanxi Zhonghong Investment Technology Co., Ltd.

Core Differentiators

Competitive Edge Technical Specification
Academic Network Joint R&D with CAS, MIT, and ETH Zurich
IP Portfolio 27 patents including nano-encapsulation technologies
Analytical Capability 800MHz NMR with cryoprobe, UPLC-QTOF-MS/MS
Conformidade regulatória DMF filings for US/EU/JP markets

Production Capacity:

  • 200+ metric tons/year across 15 triterpenoid compounds

  • Purity benchmarks: Consistently 15-25% above USP/EP monographs

3. Botanical Sources & Sustainable Sourcing

Primary Plant Sources

Triterpenoid Fonte botânica Yield Optimization
Betulinic acid Betula platyphylla bark Supercritical CO₂ extraction (92% recovery)
Asiatic acid Centella asiatica leaves Enzyme-assisted extraction (45% yield boost)
Ganoderic acids Ganoderma lucidum mycelium Submerged fermentation technology

Sustainability Practices:

  • Wild-simulated cultivation: 3-year rotation cycles

  • Blockchain traceability: From soil to final product

4. Clinically Validated Health Benefits

Mechanistic Pharmacodynamics

Compound Target Pathway Therapeutic Application
Corosolic acid GLUT4 translocation Type II diabetes management
Madecassic acid TGF-β/Smad signaling Anti-fibrotic therapy
Glycyrrhetinic acid 11β-HSD2 inhibition Dermatological formulations

Dosing Guidelines:

  • Nutracêuticos: 50-500mg/day in divided doses

  • Topicals: 0.1-5% w/w depending on indication

  • IV formulations: Strictly for clinical use under supervision

5. Especificações de grau farmacêutico

Comprehensive QC Parameters

Table 1: Triple-Verification Quality Standards

Categoria Parâmetro Especificação Método
Pesticidas Clorpirifós ≤0,01 ppm GC-MS/MS (UE 396/2005)
Pyrethroids ≤0,05 ppm EPA 8081B
Metais Pesados Pb ≤0,5 ppm ICP-MS (USP <232>)
Cd ≤0,2 ppm GF-AAS
Microbiologia Total aerobic count ≤1000 CFU/g USP <61>
Salmonela Ausente em 25g ISO 6579

6. Fluxo de trabalho de produção avançado

  1. Plant Material Authentication:

    • DNA barcoding (ITS2/rbcL markers)

    • Microscopic identification

  2. Green Extraction Technologies:

    • Extração de água subcrítica: 120-180°C, 50 bar

    • Ionic liquid-assisted extraction: [BMIM]BF4 system

  3. Purification Cascade:

    • Macroporous resin chromatography (HPD-826 resin)

    • Preparative HPLC (C30 columns for isomer separation)

  4. Crystallization Control:

    • Polymorph screening (Forms I-V characterization)

    • Controlled nucleation technology

7. Cutting-Edge Applications

Emerging Market Utilization

  • Oncology: Betulinic acid-PLGA nanoparticles (Phase II trials)

  • Cosmecêuticos: Ursolic acid liposomes for transdermal delivery

  • Veterinary: Oleanolic acid as hepatoprotective in livestock

Formulation Technologies:

  • Nanoemulsões: 50-200nm particle size for enhanced bioavailability

  • Cocrystals: With nicotinamide for solubility enhancement

8. Quality Management Ecosystem

Our 360° quality assurance incorporates:

  • Stability Indicating Methods: Forced degradation per ICH Q1A(R2)

  • Elemental Impurities: Full suite USP <232>/<233> compliance

  • Chiral Purity: ≥99% ee by chiral HPLC (Chiralpak IC column)

  • Solventes Residuais: Class 1-3 monitoring per ICH Q3C

Stability Data:

  • Accelerated conditions: 40°C/75% RH, 6-month stability confirmed

  • Long-term: 36-month shelf life at -20°C

9. Intelligent Packaging Systems

Format Packaging Solution Special Features
Bulk (>10kg) Nitrogen-flushed aluminum foil bags Oxygen ingress <0.1% over 24 months
Clinical samples Amber glass vials with Teflon septa USP Class VI certified
Transport Vacuum-insulated shippers 2-8°C maintenance for 120h

10. Research Frontiers & Technical Challenges

Innovation Pipeline

  • Biocatalytic Modification: P450 engineering for novel derivatives

  • AI-assisted Discovery: Predicting structure-activity relationships

Technical Hurdles

  • Oral Bioavailability: Typically <15% for most triterpenoids

  • Metabolite Identification: Phase II conjugation patterns

11. Expert FAQ

Q: What\’s your MOQ for research samples?
A: 100mg available for academic institutions with COA.

Q: Can you provide customized glycosylation profiles?
A: Yes, we offer β-glucuronidase treated variants upon request.

12. Conclusion

Our GMP-certified triterpenoid platform combines centuries of traditional use with 21st century analytical rigor, delivering standardized bioactive compounds for next-generation therapeutics.

13. Authoritative References

  1. Revista de Produtos Naturais (2023) – Structural diversity review

  2. USP Monographs for Triterpenes (2024)

  3. EMA Assessment Reports on Herbal Substances

Pharmaceutical triterpenoids supplier, GMP-certified plant extracts, bioactive pentacyclic compounds, natural anti-inflammatory ingredients, high-purity ursolic acid

Peso 1000 g
Dimensões (C x L x A) 20 × 10 × 10 cm

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