Alimentos Funcionais, Ingredientes para saúde e produtos farmacêuticos, Extratos naturais de plantas

Azadiractina de Neem

Visão geral do produto
English Name: Neem Azadirachtin
Botanical Source: Derived from the seeds of the neem tree (Azadirachta indica), which is native to the Indian subcontinent. Neem has a long history of use in traditional medicine and pest control in Asia.
Especificação:Purity: Azadirachtin ≥ 95% (HPLC – tested). Advanced extraction and purification techniques are employed to achieve this high – level purity. Stringent quality control measures are implemented to limit heavy metals, pesticides (other than its natural pesticidal properties), and microbial contaminants, ensuring compliance with international standards for various applications.
Aparência:It appears as a yellowish – brown to brownish – yellow powder. The powder has a characteristic, slightly bitter and pungent odor and is free – flowing, facilitating its incorporation into different products.
CAS NO.: 11141 – 17 – 6. This unique identifier is crucial for chemical identification, research, and regulatory compliance in the global market.
Tempo de espera: 3 a 7 dias úteis. Pequenos ajustes podem ocorrer com base no volume do pedido e na capacidade de produção. Nossos sistemas eficientes de produção e logística são projetados para garantir entregas pontuais.
PacoteCapacidade: 25 kg/tambor, com 27 tambores/bandeja. Os tambores são feitos de materiais de qualidade alimentar, proporcionando excelente proteção contra umidade, luz e danos físicos durante o armazenamento e o transporte. Opções de embalagem personalizadas estão disponíveis mediante solicitação.
Mercado Principal: European, North America, Asia etc. In Asia, especially in India, it has been used for centuries in traditional medicine and as a natural pesticide. In Europe and North America, with the growing interest in natural products for health and sustainable pest control, neem azadirachtin is gaining popularity.
Aplicações
- Suplementos de saúde:
  - Anti – inflammatory: Azadirachtin has shown anti – inflammatory properties. It can help reduce inflammation in the body, which may be beneficial for conditions such as arthritis, inflammatory bowel disease, and certain skin inflammations. By inhibiting inflammatory mediators, it alleviates pain and discomfort.
  - Antioxidante: Atuando como antioxidante, elimina os radicais livres, protegendo as células dos danos oxidativos. Isso pode contribuir para a saúde geral e potencialmente reduzir o risco de doenças crônicas, como doenças cardíacas e câncer.
  - Immune System Support: Some studies suggest that it may modulate the immune system, enhancing the body\’s defense against infections and diseases.
- Cosméticos:
  - Suavizante para a pele: Sua natureza anti-inflamatória o torna eficaz para acalmar a pele irritada. Pode reduzir a vermelhidão, a coceira e a inflamação associadas a doenças de pele como acne, eczema e psoríase.
  - Antienvelhecimento: Ao proteger as células da pele do estresse oxidativo, ajuda a reduzir o aparecimento de linhas finas, rugas e manchas da idade. Também pode melhorar a elasticidade da pele.
- Indústria alimentícia:
  - Natural Preservative: Due to its antibacterial and antifungal properties, it can potentially be used as a natural preservative in the food industry. It can help extend the shelf – life of certain food products by inhibiting the growth of spoilage – causing microorganisms. However, strict regulatory approvals are required for such applications.
  - Functional Foods: Although not yet widely used, if further research validates its safety and efficacy in a food – related context, it could be added to functional foods to provide potential health benefits. But this would need to meet strict regulatory requirements.

Categorias: Alimentos Funcionais, Ingredientes para saúde e produtos farmacêuticos, Extratos naturais de plantas Etiquetas: antienvelhecimento, Anti-inflamatório, Antioxidante, Suporte ao Sistema Imunológico, Conservante Natural, Suavizante para a pele

Neem Azadirachtin Extract: The Gold Standard in Natural Bioactive Solutions by Shaanxi Zhonghong Investment Technology Co., Ltd.

1. Introduction to Neem Azadirachtin Extract

Shaanxi Zhonghong Investment Technology Co., Ltd., a pioneer in bioactive compound manufacturing with 28 anos de experiência, introduces Neem Azadirachtin Extract—a potent, eco-friendly botanical ingredient derived from Azadirachta indica (neem). Renowned for its broad-spectrum biopesticidal and therapeutic properties, this extract is crafted using cutting-edge supercritical CO2 extraction and complies with global agricultural, pharmaceutical, and cosmetic standards. Serving 80+ countries, Shaanxi Zhonghong combines innovation, sustainability, and precision to deliver Azadirachtin solutions trusted by multinational agrochemical firms and research institutions.

2. Product Specifications & Quality Assurance

2.1 Technical Parameters

Categoria	Parâmetro	Especificação	Método de teste
Azadirachtin Content	Ingrediente ativo	≥30% (Customizable up to 60%)	HPLC (ISO 17025)
Resíduos de pesticidas	Clorpirifós	≤0,01 ppm	GC-MS (EPA 8081B)
	Imidacloprid	≤0,02 ppm	LC-MS/MS (EU 2021/808)
Metais Pesados	Chumbo (Pb)	≤1,0 ppm	ICP-MS (USP <232>)
	Cádmio (Cd)	≤0,3 ppm	AAS (AOAC 999.10)
Limites Microbianos	Contagem total de pratos	≤1.000 UFC/g	USP <61>
	Salmonela	Ausente em 25g	ISO 6579-1:2017

2.2 Material Composition

Fonte: Neem seeds sourced from organic farms in India (USDA/NOP-certified).
Extração: Supercritical CO2 extraction (40–50°C, 250–300 bar) for solvent-free, high-purity output.
Forma: Light-yellow powder (particle size: 80–120 mesh) or viscous liquid (water-soluble).

3. Production Process: Neem Azadirachtin Extract From Seed to Extract

Seed Selection: Neem kernels are sorted via AI-powered optical sorting to remove impurities.
Cold Pressing: Mechanical pressing at <40°C to retain heat-sensitive compounds.
Supercritical Extraction: CO2 extracts Azadirachtin under controlled pressure, yielding >98% purity.
Padronização: HPLC-guided blending to achieve target potency (30–60%Neem Azadirachtin Extract).
Liofilização: Freeze-drying to preserve bioactivity and extend shelf life (24 months at 25°C).

4. Health Benefits & Mechanism of Action

4.1 Biopesticidal Efficacy

Mode of Action: Inhibits insect molting by disrupting ecdysone synthesis and chitin formation.
Target Pests: Effective against Helicoverpa armigera, Plutella xylostella, and aphids (LC50: 50–100 ppm).

4.2 Therapeutic Applications

Anti-inflamatório: Suppresses COX-2 and TNF-α pathways (IC50: 10 μM).
Antimicrobiano: Disrupts bacterial biofilms (MIC: 0.5% against Staphylococcus aureus).

4.3 Demographic-Specific Benefits

Farmers: Reduces synthetic pesticide use by 70%, enhancing crop yield organically.
Cosmetic Users: Treats acne via sebum regulation (clinical trial: 30% reduction in lesions over 8 weeks).

5. Industry Applications & Innovations

5.1 Agriculture

Organic Farming: OMRI-listed foliar sprays for USDA Organic-certified crops.
Seed Treatment: Enhances germination rates by 25% (trials on wheat and rice).

5.2 Pharmaceuticals

Formulações: Delayed-release tablets for antiparasitic therapies (patent pending).

5.3 Cosmetics

Antienvelhecimento: Azadirachtin-loaded nanoliposomes boost collagen synthesis by 40% (in vitro studies).

6. Controle de Qualidade e Certificações

Shaanxi Zhonghong ISO 22000-certified facilities enforce a Five-Stage QC Protocol:

Raw Material Authentication: DNA barcoding and FTIR spectroscopy.
In-Process Monitoring: Real-time HPLC tracking of Neem Azadirachtin Extract content (±2% variance).
Teste de estabilidade: 36-month accelerated aging under ICH Q1A(R2) guidelines.
Triagem de Contaminantes: GC-MS/MS for 500+ pesticide residues (EU MRL compliance).
Third-Party Validation: Certified by EcoCert e COSMOS for organic integrity.

7. Usage Guidelines & Customer Success

7.1 Application Protocols

Agricultural Use: Dilute 1–2% v/v in water; apply weekly via fogging or drip irrigation.
Cosmetic Use: Incorporate 0.5–1% into serums or creams for acne-prone skin.

7.2 Client Testimonials

AgroTech Solutions, Germany: “Neem Azadirachtin Extract reduced pest resistance by 90% in our tomato farms.”
BioSkin Cosmetics, USA: “Customer complaints on acne dropped by 65% post-formulation.”

8. Logistics & Support

Embalagem: Nitrogen-flushed aluminum bags with desiccants (25 kg/drum).
Envio: Cold-chain logistics (15–20°C) for bulk orders.
Amostras: Free 100g R&D samples with CoA (Certificate of Analysis).
Quantidade mínima: 5 kg for commercial orders; 500g for research.

9. FAQs & Compliance

9.1 Certifications

Orgânico: USDA, EU Organic, and India Organic certified.
Segurança: GRAS Notice No. GRN 001025 (FDA).

9.2 FAQs

P: DoesNeem Azadirachtin Extract harm beneficial insects like bees?
UM: No, it selectively targets pests (LD50 for honeybees >100 μg/bee).
P: Shelf life under tropical conditions?
UM: Stable for 18 months at 30°C/85% RH in sealed packaging.

10. Research Trends & Challenges

Inovações: CRISPR-engineered neem trees for 2x higher Neem Azadirachtin Extract yield.
Desafios: Cost-effective scaling of CO2 extraction for smallholder farmers.

11. References

Revista de Química Agrícola e Alimentar: \”Azadirachtin’s Role in Sustainable Agriculture\” (2023).
WHO Guidelines on Botanical Pesticides (2022).

Shaanxi Zhonghong as the global leader in Neem Azadirachtin Extract innovation. By addressing agricultural, cosmetic, and pharmaceutical applications.

Peso	1000 g
Dimensões (C x L x A)	20 × 10 × 10 cm

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