Ganoderma Lucidum Polysaccharides
Ganoderma Lucidum Polysaccharide - Imagem 2
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Polissacarídeo de Ganoderma lucidum

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Ganoderma lucidum Polysaccharide Product Introduction

  1. Nome em inglês: Ganoderma lucidum Polysaccharide
  1. Especificação: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa
  1. Aparência: Light brown to tan powder; mild earthy aroma, slightly sweet taste
  1. CAS NO.：66060-20-8
  1. Tempo de espera: 3-7 dias úteis
  1. Pacote: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)
  1. Mercado Principal: Asia (China, Japan, Korea), North America, Europe
  1. Cenários de Aplicação

Propriedades principais

  • Composição Molecular: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages
  • Solubilidade: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents
  • Atividades principais: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Cenários de Aplicação

1. Suplementos de saúde e nutracêuticos

  • Immune System Regulation:
    • Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.
    • Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.
  • Anti-Tumor Adjuvant Therapy:
    • Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.
    • Common in integrative medicine formulations.
  • Stress & Fatigue Relief:
    • As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Alimentos e Bebidas Funcionais

  • Nutritional Fortification:
    • Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).
  • Prebiotic Activity:
    • Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Cosméticos e Cuidados Pessoais

  • Anti-Aging Skincare:
    • Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.
  • Skin Barrier Protection:
    • Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.
  • Hair Health:
    • Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Produtos Farmacêuticos e Biotecnologia

  • Pesquisa Clínica:
    • Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).
  • Sistemas de administração de medicamentos:
    • Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Saúde Animal e Aquicultura

  • Suplementos Veterinários:
    • Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.
  • Piscicultura:
    • Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Métodos de detecção

  • UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.
  • Cromatografia Líquida de Alta Eficiência (CLAE): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).
  • Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Fonte e Vantagens

  • Fonte natural: Extracted from fruiting bodies, mycelium, or spores of Ganoderma lucidum via hot water extraction and ethanol precipitation.
  • Sustentabilidade: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

  • Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.
  • Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.
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Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones with β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Fonte, Propriedades Químicas e Especificações Técnicas

Fontes e Extração Botânica

  • Fonte primária: Fruiting bodies of Ganoderma lucidum ou G. sinense (highest GLP content: 1.8–2.5% dry weight)39.

  • Métodos de Extração:

    • Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)

    • Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Chemical Identity

Propriedade Valor
Nº CAS. Not assigned (complex mixture)
Fórmula molecular (C₆H₁₀O₅)ₙ
Peso molecular 10–1,000 kDa
EINECS Not applicable
Aparência Light brown hygroscopic powder
Solubilidade Water-soluble; insoluble in ethanol
Key Bioactivity β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Benefícios para a saúde, dosagem ideal e segurança

Validated Therapeutic Effects

  • Immunomodulation:

    • ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.

  • Antitumor Activity:

    • Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.

  • Regulação Metabólica:

    • ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.

  • Hepatoprotection:

    • Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

Recomendações de dosagem

  • General Wellness: 100–300 mg/day (20–30% GLPs)

  • Uso Terapêutico:

    • Immune support: 500 mg/day (≥40% GLPs)

    • Adjuvant cancer therapy: 1,000–1,500 mg/day

  • Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

  • Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).

  • Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).

  • Interações medicamentosas: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

UM 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Capacidades Essenciais:

  • Extração protegida por patente: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).

  • Rigor Analítico: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99,5% pureza (exceeding USP/EP monographs).

  • Conformidade global: Certificações ISO 9001, FDA-GMP, EFSA, JECFA.

  • Supply Chain Mastery: Logística de cadeia fria em mais de 80 países.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Categoria Parâmetro Limite Método de teste
Pesticidas Clorpirifós ≤0,01 ppm GC-MS/MS (UE 396/2005)
Glifosato ≤0,05 ppm HPLC-MS/MS (ISO 16308)
Metais Pesados Chumbo (Pb) ≤0,5 ppm ICP-MS (USP <233>)
Arsênio (As) ≤0,5 ppm AAS (EP 2.4.27)
Microbiologia Contagem total de pratos ≤1.000 UFC/g USP <61>
E. coli Ausente ISO 16654
Salmonela spp. Ausente FDA BAM Cap. 5

6. Fluxo de trabalho de produção avançado

  1. Sourcing: Organic G. lucidum fruiting bodies (OOP-certified).

  2. Extração: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).

  3. Deproteinization: Sevag reagent (chloroform:butanol 4:1).

  4. Purificação: DEAE-Sepharose FF chromatography → lyophilization.

  5. Padronização: Phenol-sulfuric acid assay to 40% GLP content.

7. Aplicações em diversos setores

  • Nutracêuticos: Immune-boosting capsules (GLP + β-glucan synergy).

  • Produtos farmacêuticos: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).

  • Cosmecêuticos: Anti-aging serums (↑ collagen synthesis by 200%).

  • Alimentos Funcionais: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

  1. Confirmação de identidade: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).

  2. Quantificação de Pureza: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).

  3. Bioactivity Testing:

    • RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL

    • α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL

  4. Estabilidade: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Fronteiras e desafios da pesquisa

  • Insights Mecanicistas:

    • Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).

    • STING pathway activation for antitumor immunity.

  • Tradução Clínica:

    • Phase II trials for GLP-COVID-19 immunity synergy.

  • Technical Barriers:

    • Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.

    • Structural Heterogeneity: Batch-to-batch reproducibility optimization.

  • Sustentabilidade:

    • Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: Respostas de especialistas

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

P: Qual é o melhor horário para consumir?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Pedido direto de Shaanxi Zhonghong:

Conclusão

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

Referências:

  1. Revista de Etnofarmacologia (2019). GLP mechanisms in cancer apoptosis9.

  2. Polímeros de Carboidratos (2020). Structural characterization of immunomodulatory GLPs6.

  3. Química dos Alimentos (2021). Ultrasonic-microwave extraction optimization3.

  4. USP-NF (2023). Polysaccharide identity/purity testing guidelines.

  5. Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 avaliação de Ganoderma lucidum polysaccharide

  1. Avatar De James Oli***
    评分 4 &sol; 5

    James Oli*** –

    “As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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