Bioperina

Bioperine®: The Gold Standard in Bioavailability Enhancement – A Manufacturer’s Guide

1. What is Bioperine®?

Let’s cut through the noise. Bioperine® is not just black pepper extract. It’s a patented, clinically-studied ingredient derived from the fruits of Piper nigrum L. (black pepper) and standardized to contain ≥95% piperine. Think of it as the key that unlocks the full potential of your supplements. Its primary, and most valuable, function is to significantly enhance the bioavailability of other active compounds, making your formulations more effective and efficient.

2. Source, Chemistry & Specifications

• Fonte: Sourced from the dried fruits of Piper nigrum EU.

• Bioativo chave: Piperine (Standardized to ≥95%).

• Perfil químico:

  • Nº CAS: 94-62-2

  • MF: C₁₇H₁₉NO₃

  • MW: 285.34 g/mol

  • EINECS: 202-348-0

• Aparência: Off-white to pale yellow crystalline powder.

• Solubilidade: Soluble in ethanol and chloroform; sparingly soluble in water.

3. The Zhonghong Standard: Why Our Bioperine® is Best for B2B
Para nutraceutical ingredients suppliers e private label supplement manufacturers, consistency and proof are everything. Here’s what defines a premium-grade Bioperine®:

• Key Ingredient & Potency: ≥95% Piperine. This high level of purity is non-negotiable for reliable and potent bioavailability enhancement.

• Proven Efficacy (Compliant Claims):

  • Bioavailability Enhancer: Clinically shown to increase the absorption of various nutrients (e.g., Curcumin, CoQ10, Vitamins, Selenium).

  • Thermogenic Activity: Supports metabolic rate and nutrient utilization.

  • (Note: This product is not intended to diagnose, treat, cure, or prevent any disease. Structure/function claims must be compliant with local regulations).

• Optimal Use Level: Typically used at a 1-5% ratio relative to the active compound it is enhancing (e.g., 5-10mg of Bioperine® per 500mg of Curcumin). Dosage should be finalized based on the specific formulation.

• Origin & Quality: Proveniente de premium Piper nigrum and processed to meet stringent international standards.

• Aplicativo: Ideal for incorporation into tablets, capsules, and powder formulations for dietary supplements.

• Target Formulations: Essential for private label supplement manufacturers creating products with high-value actives like turmeric/curcumin, resveratrol, multivitamins, and cognitive health blends.

• Safety & Considerations:

  • Generally Recognized as Safe (GRAS): At recommended levels.

  • Interações medicamentosas: May affect the metabolism of certain pharmaceutical drugs by inhibiting cytochrome P450 enzymes and UDP-glucuronylation. Consult a medical expert if formulating for populations on medication.

  • Gravidez/Amamentação: Recommended to avoid high doses.

4. Zhonghong Biotech: Your Strategic Ingredient Partner
When you need a reliable bulk botanical extracts partner, you need more than a vendor. You need a technical expert. Tecnologia de Investimento Shaanxi Zhonghong Co., Ltd. is a certified fornecedor de ingredientes nutracêuticos with 28 years of experience in bioactive compound manufacturing.

• Especialização principal: We are specialists in the precision extraction and purification of plant-derived actives. Our portfolio is built for B2B:

  • Standardized Botanical Extracts (like Bioperine®)

  • Cosmetic Raw Material Supplier offerings

  • Ingredientes Nutracêuticos for supplements and functional foods

  • API Intermediates

• Our B2B Value Proposition:

  • Innovation-Driven: 20+ patents and university collaborations ensure we are at the forefront of extraction technology.

  • Garantia de qualidade: Our investment in Espectroscopia de HPLC e RMN guarantees a purity standard that is consistently 20% above common industry specs, providing you with a uncontested competitive edge.

  • Global B2B Network: Nós fornecemos wholesale botanical extracts e soluções personalizadas para Extratos de ervas OEM partners and major brands in over 80 countries.

5. Technical Insight: Mechanism of Action
Piperine’s primary mechanism is two-fold:

1. Inhibition of Metabolism: It inhibits the enzymes in the liver and intestine (e.g., CYP3A4, UGT) that would normally break down and eliminate other compounds before they enter the bloodstream.

2. Enhancing Absorption: It stimulates amino acid transporters in the intestinal lining and increases blood supply to the GI tract, facilitating greater uptake of co-administered supplements.

6. Uncompromising Quality Control: The COA
Our Quality Control is your formulation’s insurance policy. Every batch is rigorously tested.

Certificate of Analysis (COA) Summary – Bioperine® (≥95% Piperine)

7. Processo de produção avançado
Our GMP-compliant process ensures unmatched purity:

1. Fornecimento e preparação: Selection and cleaning of premium Piper nigrum frutas.

2. Extração: Solvent extraction optimized for maximum piperine yield.

3. Filtration & Concentration: Removal of impurities and concentration of the extract.

4. Cristalização e Purificação: Further refinement to achieve the ≥95% purity benchmark.

5. Padronização: Precise adjustment to meet the exact specification.

6. Drying & Milling: Conversion into a fine, free-flowing powder.

7. Liberação de controle de qualidade: The batch is only released after passing all critical quality parameters.

8. Application in Nutraceutical Formulations
This ingredient is a cornerstone for effective supplement design. Its primary application is in:

• Enhanced Absorption Formulas: Curcumin supplements, multivitamins, coenzyme Q10, resveratrol, and antioxidant blends.

• Weight Management Products: Leveraging its mild thermogenic properties.

• Nutrição Esportiva: To improve the uptake of amino acids and other performance nutrients.

9. B2B Packaging & Logistics

• Embalagem: Standard 25kg/fiber drum with double polyethylene liners. Customized packaging available for atacado e volume ordens.

• Armazenar: Store in a cool, dry place away from strong light.

• Prazo de validade: 24 months when stored correctly.

• Logística: We handle global shipping and all export documentation (COA, MSDS, Certificate of Origin) for seamless delivery to Fabricante de equipamento original (OEM) partners worldwide.

10. Partner with Us for Your Bulk Ingredient Needs
Zhonghong isn’t just a fornecedor; we’re your innovation partner. We provide:

• Competitive Bulk Pricing: Get a direct factory price for high-volume orders.

• Customization & OEM: Nós oferecemos Extratos de ervas OEM e soluções personalizadas tailored to your specific formulation requirements.

• Technical Support: Leverage our 28 years of expertise for your product development.

Contact Us for a Quote or to Request a Sample!

• Rede: www.aiherba.com

• E-mail: vendas@aiherba.com; liaodaohai@gmail.com

• Keywords: Bioperine supplier, bulk piperine, nutraceutical ingredients supplier, cosmetic raw material supplier, wholesale botanical extracts, private label supplement manufacturer, OEM herbal extracts, bulk organic ingredients.

11. FAQ for B2B Clients

• Q: What is your Minimum Order Quantity (MOQ) for bulk orders?
  A: Contact us for specific MOQ details. We offer flexible terms for atacado e volume partners.

• Q: Can you provide custom standardization for private label?
  A: Absolutely. As an Extratos de ervas OEM partner, we specialize in soluções personalizadas to meet your specific product specs.

• Q: Do you offer technical documentation and regulatory support?
  A: Yes. We provide full documentation (COA, MSDS) and can support with regulatory data for your market.

• Q: What is the lead time for large orders?
  A: Lead times vary based on order size. We maintain strategic stock for popular items and provide clear timelines for custom productions.

• Q: How do I start the qualification process?
  A: Email us at vendas@aiherba.com to request a amostra grátis and discuss your specific needs. Our technical team will guide you through the process.

12. Conclusão
In the competitive world of supplement manufacturing, ingredient efficacy is paramount. Bioperine® is a proven, powerful tool to differentiate your products and guarantee customer results. Sourcing from a technically advanced, reliable fabricante is critical. Zhonghong Biotech, with its scientific rigor, proven quality, and global B2B supply capability, is the optimal partner for nutraceutical ingredients suppliers e marca própria brands. Contact us today to discuss your project and request a sample.

Referências:

• Majeed, M., et al. (1999). Piperine, a bioavailability enhancer. US Patent 5,972,382.

• Shoba, G., et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Médica, 64(4), 353-356.

• Badmaev, V., et al. (2000). Piperine, an alkaloid derived from black pepper, increases serum response of beta-carotene during 14-days of oral supplementation. Nutrition Research, 20(3), 381-388.

• Johnson, J. J., et al. (2011). Enhancing the bioavailability of resveratrol by combining it with piperine. Nutrição Molecular e Pesquisa de Alimentos, 55(8), 1169-1176.