Premium Triterpenoids: Nature’s Bioactive Powerhouses for Health & Innovation| Supplier & Manufacturer
1. 제품 소개
Triterpenoids represent a class of cyclic organic compounds comprising 30 carbon atoms with diverse pharmacological activities. As secondary metabolites predominantly found in medicinal plants and fungi, these compounds exhibit:
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Structural diversity: Over 20,000 identified variants including oleanane, ursane, and lupane skeletons
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Bioactivity spectrum:
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Cytotoxic (IC50 values as low as 0.8μM against cancer cell lines)
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Anti-inflammatory (COX-2 inhibition up to 92% at 50μg/mL)
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Hypoglycemic (PPARγ activation at EC50 3.2nM)
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우리의 GMP-certified triterpenoid portfolio 포함 사항:
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Betulinic acid (≥98.5%, White powder)
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Oleanolic acid (≥99%, USP grade)
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Ursolic acid (≥98%, Kosher certified)
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Specialty blends: Custom ratios for synergistic formulations
2. 회사 개요: 산시 중홍 투자 기술 유한회사
Core Differentiators
Competitive Edge | 기술 사양 |
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Academic Network | Joint R&D with CAS, MIT, and ETH Zurich |
IP 포트폴리오 | 27 patents including nano-encapsulation technologies |
분석 능력 | 800MHz NMR with cryoprobe, UPLC-QTOF-MS/MS |
규정 준수 | DMF filings for US/EU/JP markets |
Production Capacity:
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200+ metric tons/year across 15 triterpenoid compounds
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Purity benchmarks: Consistently 15-25% above USP/EP monographs
3. Botanical Sources & Sustainable Sourcing
Primary Plant Sources
Triterpenoid | 식물성 출처 | Yield Optimization |
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Betulinic acid | Betula platyphylla bark | Supercritical CO₂ extraction (92% recovery) |
Asiatic acid | 센텔라 아시아티카 leaves | Enzyme-assisted extraction (45% yield boost) |
Ganoderic acids | 영지버섯 mycelium | Submerged fermentation technology |
Sustainability Practices:
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Wild-simulated cultivation: 3-year rotation cycles
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Blockchain traceability: From soil to final product
4. Clinically Validated Health Benefits
기전적 약력학
Compound | Target Pathway | Therapeutic Application |
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Corosolic acid | GLUT4 translocation | Type II diabetes management |
Madecassic acid | TGF-β/Smad signaling | Anti-fibrotic therapy |
Glycyrrhetinic acid | 11β-HSD2 inhibition | Dermatological formulations |
Dosing Guidelines:
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건강기능식품: 50-500mg/day in divided doses
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Topicals: 0.1-5% w/w depending on indication
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IV formulations: Strictly for clinical use under supervision
5. 제약 등급 사양
Comprehensive QC Parameters
Table 1: Triple-Verification Quality Standards
범주 | 매개변수 | 사양 | 방법 |
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살충제 | 클로르피리포스 | ≤0.01ppm | GC-MS/MS(EU 396/2005) |
피레트로이드 | ≤0.05ppm | 환경보호청 8081B | |
중금속 | 납 | ≤0.5ppm | ICP-MS(USP <232>) |
CD | ≤0.2ppm | GF-AAS | |
미생물학 | Total aerobic count | ≤1000 CFU/g | USP <61> |
살모넬라균 | 25g에는 없음 | ISO 6579 |
6. 고급 생산 워크플로
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Plant Material Authentication:
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DNA barcoding (ITS2/rbcL markers)
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Microscopic identification
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Green Extraction Technologies:
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아임계수 추출: 120-180°C, 50 bar
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Ionic liquid-assisted extraction: [BMIM]BF4 system
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Purification Cascade:
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Macroporous resin chromatography (HPD-826 resin)
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Preparative HPLC (C30 columns for isomer separation)
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Crystallization Control:
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Polymorph screening (Forms I-V characterization)
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Controlled nucleation technology
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7. 최첨단 애플리케이션
Emerging Market Utilization
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종양학: Betulinic acid-PLGA nanoparticles (Phase II trials)
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코스메슈티컬: Ursolic acid liposomes for transdermal delivery
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수의사: Oleanolic acid as hepatoprotective in livestock
Formulation Technologies:
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나노에멀젼: 50-200nm particle size for enhanced bioavailability
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Cocrystals: With nicotinamide for solubility enhancement
8. Quality Management Ecosystem
우리의 360° quality assurance incorporates:
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Stability Indicating Methods: Forced degradation per ICH Q1A(R2)
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원소 불순물: Full suite USP <232>/<233> compliance
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Chiral Purity: ≥99% ee by chiral HPLC (Chiralpak IC column)
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잔류 용매: Class 1-3 monitoring per ICH Q3C
안정성 데이터:
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Accelerated conditions: 40°C/75% RH, 6-month stability confirmed
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장기적으로: 36-month shelf life at -20°C
9. Intelligent Packaging Systems
Format | 패키징 솔루션 | Special Features |
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Bulk (>10kg) | Nitrogen-flushed aluminum foil bags | Oxygen ingress <0.1% over 24 months |
Clinical samples | Amber glass vials with Teflon septa | USP Class VI certified |
수송 | Vacuum-insulated shippers | 2-8°C maintenance for 120h |
10. Research Frontiers & Technical Challenges
혁신 파이프라인
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Biocatalytic Modification: P450 engineering for novel derivatives
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AI-assisted Discovery: Predicting structure-activity relationships
기술적 장애물
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경구 생체이용률: Typically <15% for most triterpenoids
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대사산물 식별: Phase II conjugation patterns
11. 전문가 FAQ
Q: What’s your MOQ for research samples?
A: 100mg available for academic institutions with COA.
Q: Can you provide customized glycosylation profiles?
A: Yes, we offer β-glucuronidase treated variants upon request.
12. 결론
우리의 GMP-certified triterpenoid platform 결합하다 centuries of traditional use ~와 함께 21st century analytical rigor, delivering standardized bioactive compounds for next-generation therapeutics.
구매처 트리테르페노이드
We are your trusted partner for sourcing high-quality Triterpenoids
오늘 저희에게 연락해 조달 요구 사항을 논의하고, R&D용 무료 샘플을 요청하고, 경쟁력 있는 도매가를 받아보세요.
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웹사이트: www.aiherba.com
13. 권위 있는 참고문헌
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천연물 저널 (2023) – Structural diversity review
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USP Monographs for Triterpenes (2024)
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EMA Assessment Reports on Herbal Substances
Pharmaceutical triterpenoids supplier, GMP-certified plant extracts, bioactive pentacyclic compounds, natural anti-inflammatory ingredients, high-purity ursolic acid
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