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The Final Information to Trehalose: Science, Advantages & Premium Sourcing

1. What is Trehalose?

Trehalose (α-D-glucopyranosyl α-D-glucopyranoside) is a naturally occurring, non-reducing disaccharide sugar composed of two glucose molecules linked by a singular α,α-1,1-glycosidic bond. This distinctive molecular configuration underpins its outstanding stability and protecting properties, incomes it the nickname “nature’s protectant.” It capabilities as an important vitality supply and stress protectant in lots of organisms, from micro organism and fungi to bugs and crops, enabling survival below excessive circumstances like dehydration and warmth.

2. 제품 공급, 화학적 특성 및 식별

• 공급: Primarily derived commercially by means of the enzymatic hydrolysis of starch (from corn, potatoes, or tapioca) utilizing particular enzymes like maltooligosyl trehalose synthase (MTSase) and maltooligosyl trehalose trehalohydrolase (MTHase). Shaanxi Zhonghong sources premium non-GMO botanical starch.

• 화학적 특성: White crystalline powder, odorless, with a gentle sweetness (~45% of sucrose). Extremely soluble in water and sizzling ethanol, insoluble in most natural solvents.

• 주요 화학적 특성:

  • Distinctive Stability: Resists acid hydrolysis and decomposition by most α-glucosidases higher than sucrose. Non-reducing, minimizing Maillard reactions.

  • Excessive Glass Transition Temperature (Tg): Varieties secure glasses upon dehydration, essential for shielding biomolecules.

  • Osmoprotectant & Cryoprotectant: Protects cells and biomolecules towards osmotic stress and freezing injury.

  • 흡습성: Decrease than sucrose, enhancing dealing with properties.

• 신분증:

  • CAS 수량: 99-20-7

  • 분자 구성 요소(MF): C₁₂H₂₂O₁₁

  • 분자량(MW): 342.30 g/mol

  • EINECS 수량: 202-739-6

3. What is the Greatest Trehalose? Key Choice Standards

Selecting the best high quality trehalose is paramount for efficacy and security. Search for these attributes:

• 구성 및 순도: Go for ≥99.5% purity (dried foundation), minimizing impurities like glucose, maltose, or residual solvents that may impression efficiency or style. Shaanxi Zhonghong makes use of superior chromatography (HPLC, UPLC) to make sure ultra-high purity requirements exceeding business norms.

• 효능 및 준수성:

  • GRAS 스탠딩: Usually Acknowledged As Secure by the US FDA (GRN No. 000045).

  • JECFA: Accredited by the Joint FAO/WHO Knowledgeable Committee on Meals Components.

  • EU: Accredited as a Novel Meals (NF) and meals additive (E quantity E 965).

  • Kosher, Halal, Non-GMO: Important for broad market acceptance.

• 원산지 및 제조: Supply from respected producers with stringent GMP, ISO, or FSSC 22000 certifications. Clear provide chains and moral sourcing (e.g., non-GMO corn or tapioca) are important. Shaanxi Zhonghong leverages vertically built-in manufacturing below ISO-certified amenities.

• 이용: Extremely versatile.

  • 식사 및 음료: Add to formulations (baking, confectionery, dairy, drinks, sauces) for delicate sweetness, texture enhancement, moisture retention, taste/aroma stabilization, and shelf-life extension. Typical use ranges: 1-15%.

  • Cosmetics/Private Care: Incorporate into serums, lotions, lotions, hair care (1-5%) for moisturization (humectant), safety towards dehydration, and stabilization of lively elements.

  • Prescribed drugs/Biotech: Make use of as a stabilizer/excipient in vaccines, antibodies, diagnostic reagents, and cell tradition media (usually 1-10% w/v) for freeze-drying (lyoprotectant) and thermal safety.

  • 식이요법 식이 보충제: Typically utilized in powdered dietary supplements or capsules.

• 목표 시청자: Meals producers, beauty formulators, nutraceutical producers, pharmaceutical/biotech corporations, analysis establishments.

• 웰빙의 장점 및 메커니즘: Whereas primarily a purposeful ingredient, analysis suggests potential advantages:

  • 모바일 안전: Stabilizes proteins and lipid membranes, protects towards desiccation and oxidative stress by way of vitrification and preferential exclusion mechanisms.

  • Autophagy Induction: Some research point out trehalose could improve mobile autophagy clearance pathways, related to metabolic and neurodegenerative analysis (notice: human proof is evolving).

  • 치과 건강: Non-cariogenic (doesn’t promote tooth decay).

  • Mild on Digestion: Appropriate for people with sucrase deficiency (trehalase enzyme required).

• 매일의 소비와 안전: JECFA established an ADI of “not specified,” indicating excessive security at ranges consumed in meals. Typical consumption is low (grams per day). Excessive doses (>50g) could trigger osmotic laxative results in delicate people, much like different low-digestibility carbohydrates.

• 패싯 결과: Extraordinarily uncommon at typical use ranges. Potential for delicate gastrointestinal discomfort (bloating, fuel) at very excessive intakes.

• 지침: People with hereditary trehalase deficiency (uncommon) ought to keep away from giant quantities. Seek the advice of a doctor earlier than high-dose supplemental use.

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Trehalose Accomplice

Shaanxi Zhonghong stands as a premier, vertically built-in high-tech enterprise specializing within the analysis, growth, manufacturing, and world distribution of premium bio-active compounds, together with pharmaceutical-grade Trehalose. For 28 years, we have served the chemical, materials science, and life science sectors with excellence.

• 핵심 경험: Superior extraction, purification, and synthesis of plant-derived compounds and specialty carbohydrates.

• 제품 포트폴리오: In depth vary encompassing Natural Plant Extracts, Beauty Actives, Pharmaceutical Intermediates & APIs, Nutraceuticals, Meals & Beverage Components (Natural Sweeteners, Preservatives, Stabilizers), Natural Pigments, and high-purity requirements like Trehalose.

• Scientific Edge (R&D Limitations):

  • Joint Innovation: Strategic collaborations with 5 main universities, working devoted joint laboratories.

  • IP 포트폴리오: Possession of 20+ patented extraction, purification, and analytical applied sciences.

  • 독특한 화합물 라이브러리: Maintains a globally unique repository of uncommon bioactive molecules.

• Manufacturing & High quality Prowess:

  • Slicing-Edge Gear: Makes use of Excessive-Efficiency Liquid Chromatography (HPLC), Extremely-Efficiency Liquid Chromatography (UPLC), Superconducting Nuclear Magnetic Resonance (NMR), GC-MS, ICP-MS for unparalleled precision.

  • 순도 관리: Rigorous QC protocols guarantee purity requirements persistently surpass business averages by 20%+.

• 국제적 성취: Established distribution and partnership networks throughout 80+ international locations in Asia, Europe, and the Americas, offering personalized ingredient options to multinational pharmaceutical companies, main analysis establishments, and main FMCG manufacturers.

5. Trehalose Advantages: Purposeful & Well being Functions

• Purposeful Advantages:

  • Stabilizer: Distinctive safety for proteins, enzymes, vaccines, cells, lipids, and unstable compounds throughout processing, drying, freezing, and storage.

  • Humectant & Texturizer: Retains moisture, improves mouthfeel in meals, and enhances pores and skin hydration in cosmetics.

  • 단맛 조절제: Supplies clear, delicate sweetness with out aftertaste; reduces sugar content material.

  • Taste & Colour Protector: Minimizes Maillard browning and taste degradation.

  • Shelf-Life Extender: Protects integrity of delicate elements.

• Well being-Oriented Advantages (Analysis Supported):

  • Metabolic Analysis: Potential position in supporting mobile vitality metabolism and stress response pathways.

  • Ocular & Pores and skin Well being: Analysis explores topical advantages for dry eye and pores and skin barrier operate by way of hydration.

  • Biomedical Stabilization: Vital for preserving biologics, diagnostics, and regenerative medication merchandise.

6. Trehalose Dihydrate: Product Specs & High quality Management

Shaanxi Zhonghong’s Trehalose Dihydrate meets the best worldwide pharmacopeial requirements (USP, Ph. Eur., JP). Under is a abstract of our rigorous High quality Management testing:

Certificates of Evaluation (COA) Specs

7. 우수한 제조 과정

Shaanxi Zhonghong employs a classy, multi-stage enzymatic course of making certain most purity and yield:

1. Uncooked Materials Choice & Prep: Sourcing high-grade, non-GMO starch. Slurry preparation and liquefaction.

2. Enzymatic Conversion: Exact therapy with MTSase and MTHase enzymes below optimized circumstances (pH, temperature) to particularly convert starch into trehalose.

3. 탈색 및 여과: Removing of pigments and impurities utilizing activated carbon and precision filtration (ultrafiltration/nanofiltration).

4. Ion Trade Chromatography: Superior resin programs take away ionic impurities (salts, amino acids) and residual sugars.

5. Focus & Crystallization: Vacuum evaporation adopted by managed crystallization to type high-purity dihydrate crystals.

6. Centrifugation & Drying: Separation of crystals, washing, and mild fluidized mattress drying to realize exact moisture content material.

7. 분쇄 및 체질: Attaining constant particle measurement distribution for optimum performance.

8. Built-in High quality Management: In-process checks and ultimate launch testing towards stringent COA specs utilizing HPLC, UPLC, NMR, GC-MS, ICP-MS.

8. Numerous Utility Situations

• 식사 및 음료: Bakery (shelf-life, texture), confectionery (decreasing crystallization, gloss), dairy (ice cream stability, yogurt texture), drinks (taste safety, decreased browning), sauces & dressings (viscosity, consistency), purposeful meals.

• 화장품 및 개인 관리: Facial moisturizers, serums, anti-aging lotions, physique lotions, hair conditioners, shampoos, mascara (stopping drying), lip care. Features as humectant, stabilizer for actives (Vit C, peptides), protectant.

• Prescribed drugs & Biotechnology: Stabilizing excipient for injectables, vaccines, antibodies, diagnostic reagents, enzymes, cell tradition media, stem cells, tissues for transplantation. Vital for lyophilization (freeze-drying) processes.

• 건강기능식품 및 식이보충제: Ingredient in powdered dietary supplements, capsules, purposeful drink mixes.

• Agriculture & Animal Feed: Seed coating protectant, stress protectant in feed.

9. Uncompromising High quality Management (QC)

Shaanxi Zhonghong’s dedication to high quality is embedded at each stage, exceeding cGMP and ISO 9001 requirements. Our QC philosophy rests on:

• 조리되지 않은 재료 검사: Rigorous qualification and testing of all incoming botanical starch towards strict specs for id, purity, and contaminants.

• Course of Analytical Expertise (PAT): Actual-time monitoring of important course of parameters (pH, temp, strain, focus) by way of built-in sensors and automation to make sure batch consistency.

• State-of-the-Artwork Laboratory: Geared up with cutting-edge instrumentation: UPLC/HPLC (for assay and impurities), GC-MS (residual solvents, pesticides), ICP-MS (heavy metals), NMR (affirmation of construction and purity), Karl Fischer titrators (moisture), superior microbiological suites. Common calibration and methodology validation per ICH Q2(R1).

• 안정성 연구: Conducting ICH-compliant accelerated and long-term stability research to outline shelf life and storage circumstances.

• 추적성 및 문서화: Complete documentation from seed to cargo, making certain full traceability. Digital batch information and LIMS (Laboratory Data Administration System) integration.

• Third-Celebration Verification: Periodic audits and testing by accredited unbiased laboratories.

10. 안전한 포장 및 국제 물류

• 주요 포장: Meals-grade polyethylene liners inside multi-wall kraft paper baggage (25kg) or FDA-compliant polyethylene drums (50kg, 200kg). Non-obligatory vacuum packing for hygroscopic grades. Smaller portions accessible in HDPE bottles or double-bagged foil pouches (1kg, 5kg).

• 2차 포장: Palletized and stretch-wrapped, corrugated cartons for smaller items.

• 저장: Retailer in a cool (<25°C), dry (RH <65%), well-ventilated space away from direct daylight and powerful odors. Shelf life sometimes 36 months from date of manufacture in unopened authentic packaging.

• International Logistics: Environment friendly delivery by way of air, sea (FCL/LCL), or land freight. Experience in dealing with customs clearance, documentation (CoA, MSDS, Certificates of Origin, Well being Certs), and cold-chain necessities if vital. DDP/DAP choices accessible worldwide.

11. Deep Dive: Well being Mechanisms, Innovation & Analysis Frontiers

• 웰빙 메커니즘: Trehalose’s efficacy stems from its distinctive physicochemical properties:

  • Vitrification: Varieties an amorphous glassy state upon dehydration, bodily immobilizing biomolecules and stopping denaturation/unfolding.

  • Water Alternative Speculation: Its hydroxyl teams type hydrogen bonds with polar teams on proteins and membranes, changing water molecules and sustaining construction within the dry state.

  • Chemical Chaperoning: Immediately interacts with partially unfolded proteins, aiding appropriate refolding.

  • Autophagy Modulation: Analysis suggests it might activate TFEB (transcription issue EB), a grasp regulator of lysosomal biogenesis and autophagy, doubtlessly aiding clearance of protein aggregates (e.g., huntingtin, α-synuclein). Observe: Scientific significance in people is an lively analysis space.

• 무역 기능 및 기술 혁신:

  • Biobanking: Vital for secure long-term preservation of cells, tissues, and organs.

  • Superior Drug Supply: Stabilizing mRNA vaccines, lipid nanoparticles (LNPs), and delicate biologics.

  • Sustainable Formulations: Enabling pure preservative programs and decreasing reliance on artificial stabilizers.

  • Subsequent-Gen Diagnostics: Stabilizing enzymes and antibodies in lateral move assays and biosensors.

• 분석의 최전선과 과제:

  • Neurodegenerative Ailments: Exploring therapeutic potential in fashions of Parkinson’s, Huntington’s, and Alzheimer’s by way of autophagy enhancement and protein combination clearance.

  • Ophthalmic Therapeutics: Improvement of trehalose-based formulations for dry eye syndrome and corneal safety.

  • Agricultural Biotechnology: Engineering crops with enhanced trehalose biosynthesis for drought/chilly tolerance.

  • Supply Methods: Novel nano/micro-carriers using trehalose for focused supply.

  • Key Challenges: Optimizing bioavailability for systemic results, large-scale medical validation of well being advantages, cost-effective manufacturing scaling for area of interest therapeutic functions.

12. Trehalose FAQs (Regularly Requested Questions)

• Q1: Is trehalose pure?
  A: Sure, it happens naturally in lots of organisms. Business manufacturing sometimes makes use of enzymatic conversion from plant starch.

• Q2: Is trehalose secure?
  A: Sure, it’s acknowledged as secure (GRAS, JECFA, EU Novel Meals) for consumption in meals. It has a superb security profile at typical consumption ranges.

• Q3: Does trehalose trigger C. difficile infections?
  A: Some older research instructed a hyperlink, however intensive subsequent analysis and evaluations by EFSA and FDA have discovered no credible proof that dietary trehalose causes or exacerbates C. difficile infections in people. The pressure implicated utilized trehalose inefficiently.

• This fall: How candy is trehalose in comparison with sugar?
  A: Trehalose is mildly candy, roughly 45% as candy as desk sugar (sucrose).

• Q5: Can folks with diabetes eat trehalose?
  A: Trehalose has a comparatively low glycemic index (GI ~70, much like sucrose). It’s metabolized to glucose, so it must be accounted for in carbohydrate consumption like different sugars, below medical/dietetic steerage.

• Q6: What makes Shaanxi Zhonghong’s trehalose superior?
  A: Extremely-high purity (>99.5%), superior enzymatic course of, stringent QC exceeding pharmacopeial requirements (USP/Ph.Eur./JP), GMP manufacturing, full traceability, world regulatory compliance help, and technical experience.

• Q7: Can trehalose be utilized in cosmetics?
  A: Completely. It is a extremely efficient humectant and stabilizer for delicate actives, broadly utilized in skincare and haircare formulations.

• Q8: What is the shelf life?
  A: Sometimes 36 months when saved in unopened authentic packaging in a cool, dry place.

• Q9: The place can I purchase it? / Can I get a pattern?
  A: See part 13 beneath.

13. The place to Purchase Excessive-Purity Trehalose & Request Samples

Supply premium Trehalose Dihydrate straight from the producer: 산시 중홍 투자기술 유한회사

• Contact for Gross sales & Free Samples:

  • 이메일: liaodaohai@gmail.com

  • 웹사이트: www.aiherba.com

• What to Embrace: Specify amount necessities (pattern, bulk), supposed utility (meals, beauty, pharma), and any particular grade or certification wants (Kosher, Halal, USP, and so on.).

14. 결론

Trehalose is a flexible, secure, and scientifically fascinating disaccharide with unparalleled stabilizing properties. Its functions span meals preservation, beauty enhancement, and important roles in stabilizing life-saving prescription drugs and biotech merchandise. When sourcing trehalose, purity, course of integrity, and rigorous high quality management are non-negotiable for optimum efficiency and security. Shaanxi Zhonghong Investment Technology Co., Ltd., with its 28-year legacy, cutting-edge R&D, vertically built-in GMP manufacturing, and dedication to exceeding purity requirements, stands as a worldwide chief in offering premium Trehalose. We empower industries to innovate with confidence by means of dependable, high-performance elements backed by science and stringent high quality.

15. 참고문헌

1. US FDA GRAS Discover No. 000045: https://www.fda.gov/media/133663/download (Normally accessible by way of FDA GRAS Discover Stock)

2. EFSA Panel on Dietetic Merchandise, Diet and Allergy symptoms (NDA) (2011). Scientific Opinion on the protection of trehalose. EFSA 저널, 9(4), 2073.

3. Ohtake, S., & Wang, Y. J. (2011). Trehalose: present use and future functions. Journal of Pharmaceutical Sciences, 100(6), 2020-2053.

4. Richards, A. B., et al. (2002). Trehalose: a evaluation of properties, historical past of use and human tolerance, and outcomes of a number of security research. 식사 및 화학 독성학, 40(7), 871-898.

5. Chen, A., & Gibney, P. A. (2022). Trehalose: A evaluation of biosynthesis, metabolism and capabilities. Carbohydrate Analysis, 108523.

6. Collins, J., et al. (2022). Dietary trehalose and virulent Clostridioides difficile, a harmful liaison? The Lancet Infectious Ailments, 22(1), e1-e2. (Perspective on security debate)

7. Sakaguchi, M., et al. (2015). Neuroprotective results of trehalose by means of autophagy induction in a mobile mannequin of Huntington’s illness. 신경과학 편지, 595, 1-6. (Instance analysis space)

8. The USA Pharmacopeia (USP) – Trehalose Monograph.

9. European Pharmacopoeia (Ph. Eur.) – Trehalose Dihydrate Monograph.

10. Joint FAO/WHO Knowledgeable Committee on Meals Components (JECFA) – Specs for Trehalose.