라파마이신

라파마이신

Rapamycin factory supplier bulk Wholesale Extract factory

  1. 영어 이름: Rapamycin (also known by its brand name Sirolimus—pronounced “ray-puh-MY-sin”; it’s a prescription-only medication, not a supplement!)
  1. 사양
    • 청정: ≥ 99.5% (HPLC tested—pharmaceutical grade, critical for consistent medical effects)
    • 형태: Available as oral tablets (0.5mg, 1mg, 2mg), oral solution (1mg/mL), or injectable for research use
    • 용해도: Insoluble in water; dissolves well in ethanol, DMSO, and vegetable oils (formulated into tablets/solutions for medical use)
    • 불순물: ≤ 0.1% (strict pharmaceutical standards—no harmful byproducts)
    • Storage Stability: Stable for 2+ years when stored at 2–8°C (refrigerated, away from light/moisture)
  1. 모습: White to off-white crystalline powder (pure form) or white/cream tablets (pharmaceutical form). It has a mild, neutral aroma—분명히 no chocolate aroma! Odorless in tablet form, so it’s easy to take as prescribed.
  1. CAS 번호: 53123-88-9 (this is the official CAS for rapamycin—critical for pharmaceutical labeling and regulatory compliance)
  1. 리드타임: 3–7 Working Days (for pharmaceutical distributors; research-grade versions also in stock, but note: prescription-only for medical use)
  1. 패키지:
    • Pharmaceutical: Blister packs (10 tablets/ pack) or amber glass bottles (oral solution) to protect from light
    • Research-grade: 1g/10g amber glass vials (light-resistant, airtight) or 25kg sealed pharmaceutical drums (for bulk medical manufacturing)
  1. 주요 시장: Global (Europe, North America, Asia)—used in hospitals and clinics for organ transplants, cancer treatment, and rare diseases. Research-grade versions are popular in biotech labs.
  1. 응용 프로그램 시나리오 (Critical Note: Rapamycin is a prescription drug—must be used under medical supervision)

Key Features (Medical Focus)

  • Immunosuppressant Power: Slows the immune system to prevent organ rejection (e.g., kidney, liver transplants)—saves lives post-transplant
  • Anti-Cancer Effects: Inhibits cell growth—used to treat rare cancers (e.g., renal cell carcinoma, mantle cell lymphoma)
  • Targeted Action: Works on the mTOR pathway (a key cell growth regulator)—fewer off-target side effects than older immunosuppressants
  • Pharmaceutical Grade Only: No over-the-counter versions—requires a doctor’s prescription to ensure safe dosing
  • 연구 잠재력: Studied for age-related diseases (e.g., Alzheimer’s) in labs, but these uses are not yet approved for medical practice

Industry Applications (Medical & Research Only)

  1. Organ Transplant Medicine
    • Kidney/Liver Transplants: Prescribed daily (0.5–2mg) to prevent immune rejection—often combined with other immunosuppressants (e.g., tacrolimus) for better results
    • Heart/Lung Transplants: Used in select cases to support long-term graft survival (dosing adjusted for patient weight/health)
  1. Oncology (Cancer Treatment)
    • Rare Cancers: Prescribed for advanced renal cell carcinoma (kidney cancer) or mantle cell lymphoma—slows tumor growth by blocking mTOR
    • Kaposi’s Sarcoma: Used to treat this AIDS-related cancer in patients who can’t tolerate other treatments
  1. Rare Disease Treatment
    • Tuberous Sclerosis Complex (TSC): Approved for treating seizures and kidney tumors in adults/children with TSC—targets abnormal cell growth caused by TSC mutations
    • Lymphangioleiomyomatosis (LAM): A rare lung disease—reduces lung lesions and improves breathing in affected patients
  1. 생명공학 연구
    • Age-Related Disease Studies: Used in labs to study mTOR’s role in aging, Alzheimer’s, and Parkinson’s—no approved medical use for these yet
    • Cell Biology: A tool for researching cell growth and survival pathways (common in academic and pharmaceutical labs)
  1. Veterinary Medicine (Specialized)
    • Pet Organ Transplants: Rarely used in dogs/cats post-kidney transplants (veterinarian-prescribed, adjusted for animal size)

Critical Safety Note

Rapamycin has serious side effects (e.g., increased infection risk, high cholesterol, kidney issues) and interacts with many drugs. It is not a supplement—do not use without a doctor’s prescription and close medical monitoring.
범주:

Rapamycin: Pharmaceutical-Grade mTOR Inhibitor for Research & Medical Applications – Manufacturer & Exporter Guide

1. What is Rapamycin?
For research institutions and pharmaceutical companies exploring longevity and immune modulation, Rapamycin (Sirolimus) represents one of the most significant discoveries in molecular biology. This macrocyclic lactone compound, originally isolated from Streptomyces hygroscopicus found in Easter Island soil, has revolutionized our understanding of cellular metabolism and aging processes. As a potent mTOR (mechanistic target of rapamycin) inhibitor, it serves as a critical tool for research into aging, cancer, and autoimmune disorders. While primarily used as an immunosuppressant drug in transplant medicine, its research applications continue to expand into novel therapeutic areas.

2. 출처, 화학 및 사양

  • 원천: Fermentation product of Streptomyces hygroscopicus

  • 화학적 정체성: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

  • 화학 프로필:

    • CAS 번호: 53123-88-9

    • MF: C₅₁H₇₉NO₁₃

    • MW: 914.17 g/mol

    • EINECS: 610-535-3

  • 모습: 흰색에서 미백색의 결정성 분말

  • 용해도: DMSO, 에탄올에 용해 가능; 물에는 용해 불가

3. Research and Pharmaceutical Applications
Important Notice: Rapamycin is a prescription drug with significant side effects and must be used only under medical supervision. This information is for research purposes only.

  • Key Mechanism: Potent and specific inhibitor of mTOR pathway

  • Research Applications:

    • Longevity Research: Investigating effects on lifespan extension

    • Oncology Research: Studying tumor suppression mechanisms

    • Immunology Research: Exploring immune system modulation

    • Metabolic Studies: Researching metabolic pathway regulation

  • Pharmaceutical Grade: ≥98% purity for research applications

  • Storage Requirements: -20°C protected from light

  • 손질: Requires specialized handling and containment procedures

4. Zhonghong Biotech: Your Research Compound Partner
Sourcing high-purity rapamycin requires pharmaceutical-grade expertise.산시 중홍 투자기술 유한회사 brings 28 years of experience in advanced compound production to serve the global research community.

  • 기술적 역량:

    • Fermentation Expertise: Advanced fermentation technology for consistent production

    • Purification Technology: Chromatographic purification to pharmaceutical standards

    • 품질 보증: Comprehensive analytical testing and characterization

  • 규정 준수: Meets ISO 9001 and cGMP standards

5. Scientific Significance: mTOR Inhibition Mechanism
Rapamycin’s research value stems from its unique mechanism:

  • Forms complex with FKBP12 protein

  • Binds to and inhibits mTORC1 specifically

  • Modulates protein synthesis and cell growth

  • Influences autophagy and metabolic processes

6. 제약품 수준의 품질 보증
Our rigorous quality control ensures research-ready material:

Certificate of Analysis (COA) Summary – Rapamycin (Research Grade)

범주 매개변수 사양 시험 방법
신원 HPLC 보유 일치 참조 HPLC-UV
시험 Rapamycin Content ≥ 98.0% HPLC-UV
청정 관련 물질 ≤ 2.0% HPLC-UV
안전 중금속 ≤ 10ppm ICP-MS
잔류 용매 Meet ICH Guidelines GC-MS
미생물학 Endotoxin < 0.5 EU/mg LAL Test
불임 Sterile Membrane Filtration

7. 고급 제조 공정
Our pharmaceutical-grade production ensures highest quality:

  1. 발효: Controlled fermentation of Streptomyces hygroscopicus

  2. 추출: Solvent extraction of crude product

  3. 정화: 다단계 크로마토그래피 정제

  4. 결정화: Controlled crystallization process

  5. 동결건조: Freeze-drying for stability

  6. 품질 관리: 종합적인 분석 테스트

8. Research Applications

  • Academic Research: University and institutional research programs

  • 제약 R&D: Drug discovery and development

  • Biotech Research: Molecular biology and biochemistry studies

  • Medical Research: Translational medicine investigations

9. Specialized Handling & Logistics

  • 포장: Sealed vials with argon atmosphere

  • 저장: -20°C protected from light and moisture

  • Shipping: Cold chain logistics with temperature monitoring

  • 선적 서류 비치: Comprehensive research-use documentation

10. Research Partnership Opportunities
우리는 제공합니다:

  • Research-grade materials for scientific investigation

  • Technical documentation for research applications

  • Custom quantities for research programs

  • Analytical support for research projects

Contact Our Scientific Team:

11. Research FAQ

  • Q: What purity grade do you offer?
    A: We provide research-grade rapamycin with ≥98% purity

  • Q: Do you provide analytical data?
    A: Yes, comprehensive COA and characterization data provided

  • Q: What’s the minimum order quantity?
    A: MOQ varies based on research requirements

  • Q: Do you offer custom synthesis?
    A: We offer custom quantities and specialized packaging

  • Q: What documentation is provided?
    A: Full analytical data, MSDS, and research-use documentation

12. Important Disclaimer
Rapamycin is a potent pharmaceutical compound with significant side effects. It must be used only by qualified researchers in appropriate facilities following all safety guidelines. This product is for research use only and not for human consumption.

결론
Rapamycin remains a cornerstone compound in molecular biology research and pharmaceutical development. Zhonghong’s pharmaceutical-grade manufacturing capabilities ensure consistent, high-quality material for research applications. Our commitment to quality and technical excellence makes us a reliable partner for the research community.

Contact us for research inquiries and availability.

참고문헌:

  1. Brown, E.J., et al. (1994). A mammalian protein targeted by G1-arresting rapamycin. 자연

  2. Sabatini, D.M., et al. (1994). RAFT1: A mammalian protein that binds to FKBP12. 셀

  3. Blagosklonny, M.V., et al. (2019). Rapamycin for longevity. 노화

  4. US Pharmacopeia. (2023). Sirolimus monograph. USP-NF

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