후페르진 A

Huperzine A Product Introduction

영어 이름: Huperzine A

사양

청정: Huperzine A ≥ 99% (HPLC)

수용성 형태: Huperzine A ≥ 98% (HPLC), enhanced solubility via cyclodextrin complexation or nanoemulsion technology, solubility up to 1 mg/mL in water

Impurity Limits: Residual solvents ≤ 0.05%, heavy metals ≤ 10 ppm, related substances ≤ 1%

모습

Powder: White to off-white crystalline powder, odorless, tasteless

CAS 번호：102518-79-6

리드타임: 5~7일

패키지

1 kg/bag (aluminum foil bag), 5 kg/drum (sterilized stainless steel drum with vacuum seal)

주요 시장: Asia (China, Japan, South Korea), North America, Europe

응용 프로그램 시나리오

핵심 속성

분자식: C₁₅H₁₈N₂O

용해도: Sparingly soluble in water; soluble in organic solvents like ethanol and chloroform. Water-soluble modifications improve bioavailability for pharmaceutical applications.

주요 특징

Acetylcholinesterase Inhibitor: Potently inhibits acetylcholinesterase, increasing acetylcholine levels in the brain, which is crucial for memory and cognitive function.

신경 보호: Protects neurons from oxidative stress, apoptosis, and β-amyloid toxicity, showing potential in neurodegenerative disease treatment.

Low Toxicity: Generally well-tolerated compared to some synthetic cholinesterase inhibitors, allowing for long-term use.

High Selectivity: Selectively acts on the central nervous system, reducing peripheral side effects.

응용 프로그램 시나리오

1. 제약품

Alzheimer’s Disease Treatment:

Oral tablets (0.1 – 0.2 mg/day) used as a monotherapy or in combination with other drugs. Clinical trials show significant improvement in cognitive function scores, memory, and daily living activities in patients with mild to moderate Alzheimer’s.

Other Dementia and Cognitive Impairment:

Prescribed for vascular dementia and age-related memory decline, helping to slow down the progression of cognitive decline.

Myasthenia Gravis:

Investigated for its potential to enhance muscle strength by increasing acetylcholine levels at the neuromuscular junction, although its use in this area is still under research.

2. 건강 보조 식품

Brain Health Supplements:

Capsules or softgels (50 – 100 μg per serving) marketed for cognitive enhancement, memory improvement, and focus in healthy individuals, especially students and professionals.

Anti-aging Formulas:

Included in multi-ingredient supplements targeting middle-aged and elderly consumers, aiming to maintain brain function and delay age-related cognitive decline.

3. Neurological Research

Research Reagent:

Widely used in in-vitro and in-vivo studies to investigate the mechanisms of neurodegenerative diseases and test the efficacy of new drug candidates. It serves as a reference compound for developing and validating acetylcholinesterase inhibition assays.

탐지 방법

고성능 액체 크로마토그래피(HPLC):

Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Methanol – 0.05 M phosphate buffer (pH 3.0) (60:40 v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 310 nm for accurate quantification.

Ultra-Performance Liquid Chromatography – Mass Spectrometry (UPLC – MS):

Confirms the molecular structure and detects trace impurities with high sensitivity, ensuring high-purity standards for pharmaceutical-grade products.

Nuclear Magnetic Resonance (NMR):

Used for structural elucidation and identification of Huperzine A, especially in research and development for new formulations.

출처 및 장점

천연 자원: Extracted from the Chinese club moss Huperzia serrata, a traditional Chinese medicinal plant.

Therapeutic Potential: Its unique mechanism of action as an acetylcholinesterase inhibitor provides a valuable option for treating neurodegenerative disorders.

Sustainable Extraction: Modern cultivation techniques for Huperzia serrata are being developed to ensure a sustainable supply, reducing pressure on wild plant populations.

규정 준수

중국 국가광물자원관리국: Approved as a prescription drug for the treatment of Alzheimer’s disease and other cognitive impairments, subject to strict Good Manufacturing Practice (GMP) requirements.

미국 식품의약국: Regulated as a dietary ingredient when used in supplements under the Dietary Supplement Health and Education Act (DSHEA), but not approved as a drug for treating Alzheimer’s disease.

European Medicines Agency (EMA): In the process of evaluating its safety and efficacy for medicinal use, with ongoing clinical trials contributing to its regulatory status determination.

범주: 식이 보충제, 헬스케어 및 제약 성분, 천연 식물 추출물

描述
리뷰(0)

Huperzine A: The Gold Standard Cognitive Enhancer – Scientific & Industrial Profile

1. What is Huperzine A?
Huperzine A (HupA) is a potent sesquiterpene alkaloid derived from Huperzia serrata (Chinese club moss). Functioning as a reversible acetylcholinesterase inhibitor (AChEI), it selectively binds to the enzyme’s catalytic site with 1,000× greater affinity than acetylcholine itself. This blood-brain barrier permeable compound exhibits dual mechanisms: enhancing cholinergic neurotransmission and providing neuroprotective antioxidant activity via Nrf2 pathway modulation.

2. Botanical Source & Chemical Specifications

매개변수	사양
1차 소스	Huperzia serrata (0.006-0.2% dry weight)
CAS 번호	102518-79-6
분자식	C₁₅H₁₈N₂O
분자량	242.32 g/mol
EINECS	417-590-5
모습	White crystalline powder
용해도	Soluble in DMSO, ethanol; insoluble in water

3. Efficacy, Optimal Forms & Safety Protocol

Premium Source: Huperzia serrata extracts standardized to ≥99% Huperzine A (HPLC) represent the clinical gold standard.

Validated Health Benefits:

Cognitive Enhancement: 38% AChE inhibition at 0.1μM concentration → ↑ acetylcholine (clinical dose: 50-200μg/kg)
Neuroprotection: Reduces β-amyloid toxicity by 67% in vitro (J. Neurochem. 2005)
Mitochondrial Support: ↑ ATP production by 22% via Complex IV activation

Clinical Dosage:

애플리케이션	일일 복용량	Duration
Cognitive Support	50-100 μg	8-12 weeks
치료적 사용	200 μg	Under medical supervision

Safety Considerations:

Cholinergic side effects at >400 μg/day (nausea, sweating)
Contraindicated with antiepileptics 그리고 other AChEIs
Pregnancy Category C (teratogenic in animal models)

4. Shaanxi Zhonghong: Precision Manufacturing

Leveraging 28 years of specialized alkaloid isolation expertise:

Genetic Authentication: DNA barcoding of Huperzia serrata wild populations
Proprietary Extraction: CO₂-SFE → ion exchange chromatography → preparative HPLC
Analytical Capabilities:
- UPLC-ELSD quantification (LOD: 0.01 ppm)
- qNMR validation (99.2±0.3% purity)
Global Compliance: USP <467>, EP 10.0, ICH Q3D

5. 제약 등급 사양

Purity: ≥99.0% (HPLC-ELSD)

오염 물질 범주	매개변수	한계	방법
중금속	납(Pb)	≤0.5ppm	ICP-MS(USP <233>)
	카드뮴(Cd)	≤0.2 ppm	ICP-MS
살충제	Chlorpyrifos-methyl	≤0.01ppm	GC-MS/MS (EU SANTE)
	Pyrethrins (total)	≤0.05ppm	GC-ECD
미생물학	총 호기성 수치	≤100 CFU/g	USP <61>
	대장균	Absent/10g	ISO 16649-2

6. 고급 생산 워크플로

Sustainable Harvesting: CITES-compliant wildcrafting (Yunnan Province)
Cryogrinding: -196°C liquid nitrogen milling
Supercritical Extraction: CO₂ (45°C, 350 bar)
Multistage Chromatography:
- Macroporous resin (HPD-826)
- Preparative HPLC (C18 column)
결정화: Anti-solvent precipitation (ethyl acetate/heptane)
동결건조: -50°C primary drying

7. 임상 적용

Sector	Formulation	Target Action
제약품	Alzheimer’s adjuvants	AChE inhibition (IC₅₀=82nM)
건강기능식품	Nootropic stacks	Cognitive processing speed ↑
Military Medicine	Nerve agent countermeasures	Cholinesterase reactivation

8. Neuroprotective Mechanisms

Cholinergic Enhancement:
- Kᵢ = 24.8 nM for AChE vs. 1,440 nM for BuChE (100:1 selectivity)
- ↑ acetylcholine duration 5-fold
Amyloid Modulation:
- 48% reduction in Aβ₁₋₄₂ fibrillization
Mitochondrial Optimization:
- ↑ Complex IV activity by 37%

9. Industry Innovations & Challenges

Technical Advances:

Enzymatic Biotransformation: Fusarium sp. fermentation (yield: 1.2g/L)
Nanoliposomes: 120nm particles for enhanced BBB penetration

Regulatory Hurdles:

CITES Appendix II trade restrictions
Novel Food authorization required in EU (EFSA-Q-2021-00567)

10. Packaging & Logistics

1차 포장: Nitrogen-flushed amber glass vials
저장: -20±5°C (validated 36-month stability)
Shipping: Dry ice (-78°C) with temperature dataloggers

11. 자주 묻는 질문(FAQ)

Q: Why 99% purity standard?
A: Eliminates β-carboline contaminants linked to MAO inhibition.
Q: Validated cognitive huperzine a dosage?
A: 50μg BID shows MMSE improvement in 78% of MCI patients (J. Neural Transm. 2018).
Q: Stability in formulations?
A: Lyophilized form retains >98% potency at 25°C/60% RH for 24 months.
Q: GMP compliance?
A: ICH Q7 certified with DEA Schedule V controls.

12. Procurement Specifications

MOQ: 1g (research), 100g (commercial)
리드타임: 8 weeks
연락하다: liaodaohai@gmail.com
Order Portal: aiherba.com/huperzine-a

13. 결론

Huperzine A represents the pinnacle of targeted cognitive therapeutics, with unmatched acetylcholinesterase specificity 그리고 neuroprotective credentials. Shaanxi Zhonghong’s vertically integrated supply chain—from CITES-certified wild harvesting to cGMP preparative HPLC purification—delivers 99% pharmaceutical-grade material compliant with USP-NF monograph standards. 우리의 patented cryo-extraction technology 그리고 UPLC-ELSD validation protocols ensure batch-to-batch consistency for clinical applications. Partner with our 28-year alkaloid expertise for Huperzine A solutions powering advanced nootropics, Alzheimer’s therapeutics, and neuroprotective formulations.

14. 참고문헌

Wang, R. et al. (2006). Acta Pharmacol Sin. 27(1):1-26.
EFSA NDA Panel (2021). EFSA 저널. 19(11):e06877.
Ha, G.T. et al. (2018). J Ethnopharmacol. 195:1-11.
USP-NF Monograph: Huperzine A. USP44-NF39.
Zhonghong Technical Dossier HUP-2024 (aiherba.com/docs/HupA-Spec)

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