천마 페놀 화합물
, , , , , ,

천마 페놀 화합물

Gastrodia Phenolic Compounds supplier bulk factory Wholesale Extract factory

  1. 영어 이름: Gastrodia Phenolic Compounds
  1. 사양
    • Total Phenolic Content: ≥ 15 – 30% (Folin – Ciocalteu method)
    • Major Components: p – Hydroxybenzaldehyde ≥ 5% (HPLC), p – Hydroxybenzoic acid ≥ 3% (HPLC), vanillic acid ≥ 2% (HPLC)
    • Water – soluble Powder: Solubility ≥ 90% in water, moisture ≤ 5%
  1. 모습
    • Light brown to yellowish – brown fine powder, mild herbal odor
  1. CAS 번호
    • p – Hydroxybenzaldehyde: 123 – 08 – 0
    • p – Hydroxybenzoic acid: 99 – 96 – 7
    • vanillic acid: 121 – 34 – 6
  1. 리드타임: 3~7일
  1. 패키지
    • 1kg/가방(알루미늄 호일 백), 25kg/드럼(골판지 드럼 내부에 이중 PE 백)
  1. 주요 시장: 아시아(중국, 일본, 한국), 북미, 유럽
  1. 응용 프로그램 시나리오

핵심 속성

  • 분자 구조: Composed of various phenolic acids and aldehydes with a benzene ring and hydroxyl groups
  • 용해도: Soluble in water, ethanol, and methanol; water – soluble formulations are ideal for beverage and pharmaceutical applications
  • 주요 특징
    • 항산화제: Scavenges free radicals such as DPPH and hydroxyl radicals, with an ORAC (Oxygen Radical Absorbance Capacity) value of 2000 – 3500 μmol Trolox equivalents/g.
    • 항염증: Inhibits the production of pro – inflammatory cytokines like TNF – α and IL – 6.
    • 신경 보호: Protects neurons from oxidative stress and apoptosis, potentially beneficial for neurodegenerative diseases.
    • 항균제: Exhibits inhibitory activity against certain bacteria and fungi, such as Staphylococcus aureus and Candida albicans.

응용 프로그램 시나리오

1. 제약품

  • Neurological Disorder Treatment:
    • Investigated for the treatment of stroke and epilepsy, as the neuroprotective properties help reduce brain damage and prevent seizure recurrence.
    • Used in combination with other drugs to enhance the treatment effect of Alzheimer’s disease by reducing oxidative stress in the brain.
  • Anti – inflammatory Formulations:
    • Incorporated into topical creams and ointments to relieve skin inflammation, such as eczema and dermatitis.

2. 건강 보조 식품

  • Antioxidant Supplements:
    • Capsules or tablets containing 200 – 500 mg of phenolic compounds in Gastrodia, marketed for general health maintenance and anti – aging, often combined with other antioxidants like vitamin C and E.
  • Brain Health Formulas:
    • Added to nootropic supplements to support cognitive function, memory, and focus.

3. 화장품 및 개인 관리

  • Anti – aging Products:
    • Serums and moisturizers (2 – 5% concentration) to protect skin from UV – induced damage, reduce the appearance of fine lines and wrinkles, and promote skin elasticity.
  • Antibacterial Skincare:
    • Used in facial cleansers and acne treatments to inhibit the growth of acne – causing bacteria.

4. 기능성 식품 및 음료

  • Antioxidant – Rich Beverages:
    • Added to fruit juices, tea – based drinks, and energy drinks at 0.5 – 1% concentration to enhance the antioxidant capacity and extend shelf life.
  • 강화 식품:
    • Incorporated into baked goods, cereals, and snacks to increase their nutritional value and provide health – promoting benefits.

탐지 방법

  • 고성능 액체 크로마토그래피(HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% phosphoric acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 280 nm for p – Hydroxybenzaldehyde, 254 nm for p – Hydroxybenzoic acid, and 325 nm for vanillic acid.
  • Folin – Ciocalteu Assay:
    • A colorimetric method to determine the total phenolic content, measuring absorbance at 765 nm.
  • 질량 분석법(MS):
    • Used in combination with HPLC (HPLC – MS) to confirm the molecular structure and identify trace phenolic compounds.

출처 및 장점

  • 천연 자원: 뿌리줄기에서 추출 천마 Blume, a traditional Chinese medicinal herb.
  • Multi – functional Benefits: Their diverse bioactivities make them suitable for various applications from medicine to consumer products.
  • 전통적 사용 검증: With a long history of use in traditional Chinese medicine, it provides a reliable foundation for modern applications.

규정 준수

  • 중국 국가광물자원관리국: Approved as a dietary supplement ingredient and used in traditional Chinese medicine formulations.
  • 미국 식품의약국: 보충제에 사용하는 경우 식품 성분으로 규제되며, GMP(우수 제조 기준) 요구 사항을 준수해야 합니다.
  • EU 화장품 규정: 화장품 성분으로 허용되나, 제품 유형에 따라 최대 농도에 제한이 있습니다.
범주: , , , , , ,

Gastrodia Phenolic Compounds: The Neuroprotective Powerhouse from Tian Ma

1. What Are Gastrodia Phenolic Compounds?

Gastrodia phenolic compounds are a bunch of bioactive phytochemicals primarily derived from 천마 Blume (天麻/Tian Ma), a revered medicinal orchid in Conventional Chinese language Medication (TCM). These compounds, together with gastrodin, parishins, and vanillyl alcohol derivatives, are clinically validated for his or her neuroprotective, antioxidant, and anti inflammatory properties, making them invaluable in fashionable nutraceuticals, prescription drugs, and cosmeceuticals.

2. 공급, 화학적 특성 및 주요 식별자

주요 공급

  • Botanical Origin: 천마 Blume (Orchidaceae household)

  • Plant Half Used: Dried rhizomes (underground stems)

  • Geographical Distribution: Yunnan, Guizhou, and Sichuan provinces (China) yield the highest-quality specimens

Key Chemical Constituents

Compound Chemical Class Relative Abundance
가스트로딘 Phenolic glycoside 40-60% of complete phenolics
Parishin A/B/C Gastrodin oligomers 15-25%
Vanillyl alcohol Easy phenol 5-10%
4-Hydroxybenzyl alcohol Benzyl spinoff 3-8%

Physicochemical Properties

  • 모습: White to mild yellow crystalline powder (gastrodin), brown viscous extract (complete phenolics)

  • 용해도: Water-soluble (gastrodin), ethanol-soluble (parishins)

  • 안정: Delicate to UV mild and oxidation; requires antioxidant safety

규제 식별자

매개변수 가스트로딘 Whole Phenolics
CAS 수량 62499-27-8 Not assigned (combination)
분자 방법 C₁₃H₁₈O₇ Variable
분자량 286.28 g/mol 200-1000 Da
EINECS 263-618-1 N/A

3. Premium High quality, Well being Benefits & Security

Greatest Sources & Efficiency

  • Highest-Yielding Strains: Wild G. elata from Yunnan incorporates 2-3% gastrodin by dry weight

  • Optimized Extracts: Superior CO₂ supercritical extraction yields ≥98% pure gastrodin

  • Gold Normal: HPLC-validated extracts with ≥50% complete phenolic content material

Proof-Primarily based Well being Benefits

  1. 신경 보호

    • Crosses the blood-brain barrier to cut back glutamate excitotoxicity

    • Upregulates BDNF and NGF for neuronal regeneration

    • Medical enchancment in Alzheimer’s (500mg/day) and vertigo (300mg/day)

  2. Cerebrovascular Safety

    • 억제한다 NF-κB pathway, lowering post-stroke irritation

    • Improves microcirculation in vascular dementia sufferers

  3. 항산화 결과

    • Scavenges OH· and O₂·⁻ radicals (ORAC worth ≥15,000 μmol TE/g)

  4. Analgesic Properties

    • 변조한다 TRPV1 수용체 for migraine reduction

Dosage Pointers

애플리케이션 일일 복용량 기간
인지 지원 200~400mg 8-12주
Acute circumstances 500-800 mg 4-6 weeks
Preventive care 100-200 mg Lengthy-term

Security Profile

  • GRAS 스탠딩: Typically Acknowledged as Protected at really helpful doses

  • 약물 상호작용: Could potentiate GABAergic medication (benzodiazepines)

  • 금기사항: Being pregnant (inadequate security knowledge)

4. Manufacturer Profile: Shaanxi Zhonghong Investment Technology Co., Ltd.

핵심 역량

  • 28 Years of specialised extraction experience

  • cGMP & ISO 13485 licensed amenities

  • Proprietary Applied sciences:

    • Molecularly imprinted polymers for gastrodin purification

    • Cryogenic grinding for phenolic preservation

고품질 인프라

  • 분석 능력:

    • UPLC-QTOF-MS for compound fingerprinting

    • 600MHz NMR for structural affirmation

  • Purity Requirements: Exceed pharmacopeial necessities by 20-30%

5. Product Specs (Pharmaceutical Grade)

High quality Management Parameters

수업 매개변수 사양 방법론을 살펴보세요
ID Gastrodin HPLC match ≥98% similarity USP <621>
청정 Whole phenolics ≥50% w/w UV-Vis (280nm)
중금속 납(Pb) ≤0.5ppm ICP-MS
카드뮴(Cd) ≤0.1ppm ICP-MS
미생물학 Whole cardio rely ≤1000 CFU/g USP <61>
칸디다 알비칸스 결석한 USP <62>

6. 우수한 제조 워크플로

  1. 소싱: 야생 수확 G. elata (3-year-old rhizomes)

  2. 전처리: Lyophilization at -40°C to protect phenolics

  3. 추출:

    • 주요한: Subcritical water extraction (120°C, 15MPa)

    • 반성: Macroporous resin adsorption (AB-8 resin)

  4. 정화:

    • Preparative HPLC (C18 column) for gastrodin isolation

    • Nanofiltration (3kDa MWCO) for parishin enrichment

  5. 표준화:

    • DSC for crystallinity verification

    • DPPH assay for antioxidant validation

7. 축소형 목적

제약 개선

  • Stroke Restoration: Intravenous gastrodin formulations (China FDA-approved)

  • Neurodegenerative Medication: Section III trials for Parkinson’s adjunct remedy

건강기능식품 혁신

  • Nootropic Stacks: Mixed with lion’s mane and bacopa

  • Sleep Formulation: Synergistic with melatonin (1:5 ratio)

Cosmeceutical Developments

  • Anti-Air pollution Serums: Chelates heavy metals by way of phenolic teams

  • Neurocosmetics: Reduces cortisol-induced pores and skin growing older

8. 분석 프런티어

기계적 발견

  • Intestine-Mind Axis: 변조한다 Akkermansia muciniphila populations

  • Epigenetics: HDAC inhibition by parishin metabolites

기술적 개선

  • Biocatalysis: Enzymatic glycosylation to reinforce bioavailability

  • Nano-delivery: PLGA nanoparticles for focused CNS supply

9. FAQ

Q: How does gastrodin examine to artificial nootropics?
A: Displays comparable neuroprotection to piracetam 없이 tolerance growth

Q: Can gastrodin change SSRIs for despair?
A: Adjunctive solely – enhances serotonin 없이 affecting reuptake

Q: Shelf life & storage?
에이: 36 months in amber glass at ≤25°C (desiccant included)

10. International Provide Chain

  • 포장: Nitrogen-flushed aluminum baggage (1-25kg)

  • 기호 논리학: -20°C transport obtainable for heat-sensitive batches

  • Regulatory Help: Full file preparation (FDA/EMA/China NMPA)

11. 결론

Gastrodia phenolics symbolize the subsequent frontier in neuroprotection, 결합 1,800 years of TCM knowledge ~와 함께 fashionable pharmacological validation. 산시성 중홍의 98% pure gastrodin units the business benchmark, backed by patented extraction applied sciences 그리고 end-to-end traceability.

연락하다: liaodaohai@gmail.com | www.aiherba.com

참고문헌

  1. CNS Neuroscience & Therapeutics (2023) – Gastrodin mechanisms in stroke

  2. 천연물 저널 (2022) – Parishin pharmacokinetics

  3. China Pharmacopoeia 2020 Version – Gastrodin monograph

리뷰

아직 리뷰가 없습니다.

상품을 구매한 로그인 고객만 상품평을 남길 수 있습니다.

관련 상품

滚动至顶部

견적 및 샘플 받기

请在浏览器中启用JavaScript来完成此表单。

견적 및 샘플 받기