Ganoderma Lucidum Polysaccharide - 이미지 2

기능성 식품, 음료 추가, 화장품 및 개인 관리, 식이 보충제, 식품첨가물, 기능성 식품, 헬스케어 및 제약 성분, 천연 식물 추출물

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Ganoderma lucidum Polysaccharide Product Introduction

영어 이름: Ganoderma lucidum Polysaccharide

사양: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa

모습: Light brown to tan powder; mild earthy aroma, slightly sweet taste

CAS 번호：66060-20-8

리드타임: 3-7 영업일

패키지: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)

주요 시장: Asia (China, Japan, Korea), North America, Europe

응용 프로그램 시나리오

핵심 속성

분자 구성: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages

용해도: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents

주요 활동: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

응용 프로그램 시나리오

1. 건강 보조제 및 건강기능식품

Immune System Regulation:

- Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.

- Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.

Anti-Tumor Adjuvant Therapy:

- Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.

- Common in integrative medicine formulations.

Stress & Fatigue Relief:

- As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. 기능성 식품 및 음료

Nutritional Fortification:

- Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).

Prebiotic Activity:

- Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. 화장품 및 개인 관리

안티에이징 스킨케어:

- Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.

Skin Barrier Protection:

- Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.

Hair Health:

- Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. 제약 및 생명공학

임상 연구:

- Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).

약물 전달 시스템:

- Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. 동물 건강 및 양식업

Veterinary Supplements:

- Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.

Fish Farming:

- Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

탐지 방법

UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.

고성능 액체 크로마토그래피(HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).

Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

출처 및 장점

천연 자원: Extracted from fruiting bodies, mycelium, or spores of 영지버섯 via hot water extraction and ethanol precipitation.

지속 가능성: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.

Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.

범주: 기능성 식품, 음료 추가, 화장품 및 개인 관리, 식이 보충제, 식품첨가물, 기능성 식품, 헬스케어 및 제약 성분, 천연 식물 추출물

描述
리뷰(1)

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of 영지버섯 (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones ~와 함께 β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. 출처, 화학적 특성 및 기술 사양

식물성 원료 및 추출

1차 소스: Fruiting bodies of 영지버섯 또는 G. sinense (highest GLP content: 1.8–2.5% dry weight)39.
추출 방법:
- Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)
- Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

화학적 정체성

재산	값
CAS 번호	Not assigned (complex mixture)
분자식	(C₆H₁₀O₅)ₙ
분자량	10–1,000 kDa
EINECS	Not applicable
모습	Light brown hygroscopic powder
용해도	Water-soluble; insoluble in ethanol
Key Bioactivity	β-(1→3)/(1→6) glycosidic bonds ≥85%

3. 건강상의 이점, 최적 복용량 및 안전성

Validated Therapeutic Effects

면역 조절:
- ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.
Antitumor Activity:
- 유도한다 apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.
대사 조절:
- ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.
간 보호:
- Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

복용량 권장 사항

일반 웰빙: 100–300 mg/day (20–30% GLPs)
치료적 사용:
- Immune support: 500 mg/day (≥40% GLPs)
- Adjuvant cancer therapy: 1,000–1,500 mg/day
Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).
Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).
약물 상호 작용: May potentiate immunosuppressants (e.g., cyclosporine).

4. 회사 소개: 산시 중홍 생명공학 유한회사

에이 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

핵심 역량:

특허로 보호되는 추출: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).
분석적 엄격성: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99.5% 순도 (exceeding USP/EP monographs).
글로벌 규정 준수: ISO 9001, FDA-GMP, EFSA, JECFA 인증.
Supply Chain Mastery: 80개국 이상에 걸친 콜드체인 물류.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

범주	매개변수	한계	시험 방법
살충제	클로르피리포스	≤0.01ppm	GC-MS/MS(EU 396/2005)
	글리포세이트	≤0.05ppm	HPLC-MS/MS(ISO 16308)
중금속	납(Pb)	≤0.5 ppm	ICP-MS(USP <233>)
	비소(As)	≤0.5 ppm	AAS(EP 2.4.27)
미생물학	총 플레이트 수	≤1,000 CFU/g	USP <61>
	대장균	결석한	ISO 16654
	살모넬라균 종	결석한	FDA BAM Ch.5

6. 고급 생산 워크플로

소싱: Organic G. lucidum fruiting bodies (OOP-certified).
추출: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).
Deproteinization: Sevag reagent (chloroform:butanol 4:1).
정화: DEAE-Sepharose FF chromatography → lyophilization.
표준화: Phenol-sulfuric acid assay to 40% GLP content.

7. 산업 전반에 걸친 응용 프로그램

건강기능식품: Immune-boosting capsules (GLP + β-glucan synergy).
제약품: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).
코스메슈티컬: Anti-aging serums (↑ collagen synthesis by 200%).
기능성 식품: Glycemic control beverages (GLP + berberine).

8. 품질 관리: 360° 보증 프로토콜

GLP batches undergo four-phase verification:

신원 확인: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).
순도 정량: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).
생물학적 활성 테스트:
- RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL
- α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL
안정: 25°C/60% RH(ICH Q1A(R2))에서 24개월 보관 수명.

9. 연구의 최전선과 과제

기계적 통찰력:
- Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).
- STING pathway activation for antitumor immunity.
임상 번역:
- Phase II trials for GLP-COVID-19 immunity synergy.
기술적 장벽:
- 경구 생체이용률: Chitosan nanoparticles to enhance absorption from 12% to 91%.
- Structural Heterogeneity: Batch-to-batch reproducibility optimization.
지속 가능성:
- Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: 전문가 답변

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

질문: 최적의 소비 시간은?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 산시성 중홍에서 직접 주문:

이메일: liaodaohai@gmail.com
웹사이트: 아이허바닷컴

결론

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

참고문헌:

민족약리학 저널 (2019). GLP mechanisms in cancer apoptosis9.
탄수화물 중합체 (2020). Structural characterization of immunomodulatory GLPs6.
식품화학 (2021). Ultrasonic-microwave extraction optimization3.
USP-NF (2023). Polysaccharide identity/purity testing guidelines.
Frontiers in Immunology (2024). STING pathway activation by GLPs.

Ganoderma lucidum polysaccharide에 대한 1개 리뷰

评分 4 / 5

James Oli*** – 2025년 7월 13일

“As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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