카모마일 추출물
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카모마일 추출물

Chamomile Extract supplier bulk factory Wholesale buy Extract factory

  1. 영어 이름: Chamomile Extract
  1. 사양
    • 활성 화합물 함량:
      • Apigenin ≥ 2.0% (HPLC), Bisabolol ≥ 1.5% (HPLC), Chamazulene ≥ 0.5% (HPLC)
    • 용해도: Slightly soluble in water; highly soluble in ethanol (≥ 50 g/100 mL), propylene glycol, and most organic solvents
    • 외모 관련: 건조감량 ≤ 5%, 중금속 ≤ 10 ppm, 잔류용매 ≤ 0.5%
    • 입자 크기: 표준 분말 ≤ 100 μm; 더 나은 분산을 위해 미분말 ≤ 5 μm
  1. 모습
    • Light yellow to yellow – brown fine powder, with a characteristic floral and herbal aroma, distinct from chocolate
  1. CAS 번호
    • As a mixture, no single CAS number; individual components have separate numbers (e.g., Apigenin: 520 – 36 – 5, Chamazulene: 515 – 92 – 4)
  1. 리드타임: 5~7일
  1. 패키지
    • 1kg/가방(알루미늄 호일 백), 25kg/드럼(골판지 드럼 내부에 이중 PE 백)
  1. 주요 시장: Global market, with significant demand in Europe (Germany, France), North America, and Asia (Japan, South Korea), especially in the food, pharmaceutical, and cosmetics industries
  1. 응용 프로그램 시나리오

핵심 속성

  • 활성 성분:
    • 아피제닌: A flavonoid with potent antioxidant and anti – inflammatory properties.
    • α – Bisabolol: A sesquiterpene alcohol known for its soothing, antibacterial, and anti – irritant effects.
    • 카마줄렌: A blue – colored sesquiterpene with strong anti – inflammatory and wound – healing capabilities.
  • 주요 특징
    • 항산화 활성: 하이드록실 이온이나 슈퍼옥사이드 음이온과 같은 자유 라디칼을 제거하여 세포를 산화적 손상으로부터 보호합니다.
    • 항염증: Inhibits the production of pro – inflammatory cytokines (e.g., TNF – α, IL – 6), reducing tissue inflammation.
    • 항균제: Exhibits inhibitory effects against bacteria (e.g., 황색포도상구균) 및 곰팡이(예: 칸디다 알비칸스).
    • Skin – Soothing: Calms irritated skin, reduces redness, and promotes skin repair.

응용 프로그램 시나리오

1. 음식 및 음료

  • Beverage Ingredients:
    • Added to teas, herbal infusions, and fruit juices (0.1 – 0.5% concentration) for flavor enhancement and potential health benefits.
    • Used in functional beverages, such as stress – relief drinks, due to its calming properties.
  • Confectionery and Dairy Products:
    • Incorporated into candies, chocolates, and yogurt to impart a unique floral flavor and add antioxidant value.

2. 제약품

  • Over – the – Counter (OTC) Medicines:
    • Used in topical creams, ointments, and lotions for treating minor skin irritations, rashes, and sunburns (2 – 5% concentration).
    • Available as oral supplements in capsule or tablet form (200 – 500 mg per serving) for promoting relaxation and reducing mild anxiety.
  • 약초 요법:
    • A key ingredient in traditional herbal medicine for soothing digestive discomfort, such as indigestion and gastritis.

3. 화장품 및 개인 관리

  • 스킨케어 제품:
    • Serums, moisturizers, and face masks (1 – 3% concentration) formulated to hydrate, soothe, and anti – age the skin. It helps reduce the appearance of fine lines and wrinkles by protecting against oxidative stress.
    • Used in sensitive – skin products due to its gentle and anti – inflammatory nature.
  • 헤어 케어:
    • Shampoos and conditioners containing chamomile extract can lighten hair naturally, as well as soothe the scalp and reduce dandruff.

4. 동물 건강

  • Pet Care Products:
    • Added to pet shampoos and topical treatments to relieve itchy, irritated skin in dogs and cats.
    • Available as pet supplements to calm anxious pets during travel or stressful situations.
  • 가축 사료 첨가제:
    • Used in poultry and livestock feed (50 – 200 ppm) to improve feed palatability and enhance animal health through its antioxidant and anti – inflammatory effects.

탐지 방법

  • 고성능 액체 크로마토그래피(HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% formic acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 254 nm (for apigenin) and 230 nm (for chamazulene).
  • 가스크로마토그래피-질량분석법(GC-MS):
    • Used for the identification and quantification of volatile components like bisabolol, providing detailed information about the extract’s chemical profile.
  • 푸리에 변환 적외선 분광법(FTIR):
    • Helps in confirming the chemical structure of the active compounds by analyzing characteristic absorption peaks, ensuring product quality and authenticity.

출처 및 장점

  • 천연 자원: Extracted from the flowers of 마트리카리아 레쿠티타 (German chamomile) or 카메멜룸 노빌레 (Roman chamomile), which are widely cultivated in Europe, North America, and Asia.
  • 지속 가능한 생산: Chamomile is an easily – grown crop, and modern extraction techniques, such as supercritical CO₂ extraction, ensure high – quality products with minimal environmental impact.
  • 시장 수요: Its dual function as a flavoring agent and a bioactive ingredient drives high demand across multiple industries, making it a valuable natural product.

규정 준수

  • 미국 식품의약국: Regulated as a food additive and dietary supplement ingredient. Meets Good Manufacturing Practice (GMP) requirements for pharmaceutical – grade products.
  • EU 규정: Approved as a food flavoring substance and permitted for use in cosmetics under the Cosmetics Regulation (EC) No 1223/2009.
  • 중국 국가광물자원관리국: Permitted for use in food, pharmaceuticals, and cosmetics, subject to strict quality control and safety standards.
범주: , , , ,

Chamomile Extract: Nature’s Golden Elixir | Premium Standardized Ingredients

1. What is Chamomile Extract?

Chamomile Extract is a concentrated bioactive fraction derived primarily from the flowers of 카모밀라 마트리카리아 L. (German Chamomile) or 카메멜룸 노빌레 L. (Roman Chamomile). This complex phytochemical matrix is prized for its apigenin-rich composition, essential oils (including bisabolol oxides and chamazulene), and other bioactive flavonoids. It represents one of the most scientifically validated and globally utilized botanical extracts, with applications spanning 건강기능식품, 코스메슈티컬, 그리고 기능성 식품.

2. Source, Chemical Properties & Key Identifiers

  • Primary Botanical Source: 꽃의 카모밀라 마트리카리아 L. (German Chamomile – highest apigenin content) or 카메멜룸 노빌레 L. (Roman Chamomile).

  • 화학적 특성:

    • Key Constituents: Apigenin (and its glycosides, e.g., apigenin-7-O-glucoside), Apigenin-7-O-glucoside, α-Bisabolol, Chamazulene (blue derivative from matricin), Bisabolol oxides A & B, Flavonoids (luteolin, quercetin), Coumarins.

    • 화학 수업: Flavonoids (Apigenin), Sesquiterpenes (Bisabolols, Chamazulene), Coumarins.

    • 용해도: Water-soluble extracts (standardized for apigenin glycosides), oil-soluble fractions (essential oils, CO2 extracts), or standardized powders (spray-dried).

    • 안정: Light- and heat-sensitive (especially chamazulene). Requires cool, dark storage and often antioxidants/stabilizers.

  • Key Identifiers (Representative):

    • CAS Registry Number (Apigenin): 520-36-5

    • Molecular Formula (Apigenin): C₁₅H₁₀O₅

    • Molecular Weight (Apigenin): 270.24 g/mol

    • EINECS (Apigenin): 208-292-1

    • (Note: Full extract has no single CAS/EINECS; identifiers apply to specific markers)

3. 효능, 건강상의 이점, 복용량 및 안전성

  • "최고" 및 가장 높은 콘텐츠: The “best” extract depends on the application. Standardized Apigenin (4-6%) extracts are preferred for calmative and GI benefits. CO2 Supercritical Extracts (2-10% total sesquiterpenes/azulenes) excel in topical anti-inflammatory 응용 프로그램. 산시성 중홍 offers diverse specifications (e.g., 4% Apigenin, 10:1 Concentrate, Essential Oil, Full Spectrum).

  • Health Benefits (Evidence-Based):

    • Calming & Sleep Support: Modulates GABA_A receptors (apigenin), reduces anxiety, improves sleep quality.

    • GI Health: Soothes gastrointestinal irritation (bisabolol/chamazulene), reduces spasms, alleviates symptoms of dyspepsia.

    • 항염 및 항산화: Potently inhibits COX-2, LOX, and pro-inflammatory cytokines (TNF-α, IL-6); scavenges free radicals.

    • 피부 건강: Anti-irritant, wound healing (α-Bisabolol), antimicrobial, soothes eczema/dermatitis.

    • 항균제: Activity against Staph aureus, 칸디다 알비칸스.

    • 잠재적인 대사 지원: Emerging evidence for blood glucose regulation.

  • Typical Daily Intake (Oral): 220-1100 mg daily of standardized extract (e.g., 4% Apigenin), often divided. Tea: 1-4 cups daily (2-3g dried flowers/cup). Follow product label or practitioner guidance.

  • 주의사항 및 부작용:

    • 일반적으로 안전하다고 인정됨(GRAS). Rare mild GI upset or drowsiness.

    • 알레르기: Contraindicated in individuals with known allergy to Asteraceae/Compositae family plants (ragweed, chrysanthemums, marigolds).

    • 쿠마린 함량: Potential interaction with anticoagulants (warfarin). Use caution.

    • Pregnancy: Traditionally used but limited modern safety data; consult physician.

    • 품질이 필수입니다: Risk of pyrrolizidine alkaloid (PA) contamination in non-premium sources necessitates stringent testing by suppliers like 산시성 중홍.

4. Trusted Global Supplier: Shaanxi Zhonghong Investment Technology Co., Ltd.
산시 중홍 투자기술 유한회사 레버리지 28 years of phytochemistry expertise to deliver premium, research-backed Chamomile Extracts. As a vertically integrated 첨단기술 기업, we master the entire value chain from sustainable sourcing to advanced purification under cGMP 준수.

  • Core Strengths:

    • Scientific Innovation: 5 strategic university partnerships fuel cutting-edge extraction R&D. 20개 이상의 특허 protect proprietary isolation techniques.

    • 비교할 수 없는 순수함: HPLC-DAD-MS/MS 그리고 GC-MS quantification ensures apigenin/bisabolol standards exceed industry norms by 20%. ICP-MS guarantees ultra-low heavy metals.

    • 글로벌 규정 준수: 용품 pharma-grade ingredients meeting USP/EP/FCC standards to 80개국 이상 across nutraceutical, cosmetic, and functional food industries.

    • 수직적 통합: Controls quality from DNA-authenticated botanicals 에게 ISO 9001:2015 certified manufacturing.

  • 제품 포트폴리오: Apigenin-Standardized Extract (4%, 6%), Full Spectrum Extract (10:1), Organic Chamomile CO2 Extract, Chamomile Essential Oil, Chamomile Water.

5. Chamomile Extract Benefits: A Scientific Summary
Chamomile Extract delivers multisystem benefits validated by pharmacology:

  • Neuroscience: GABAergic modulation promotes calmness & restful sleep.

  • Gastroenterology: Spasmolytic & anti-inflammatory actions support digestive comfort.

  • 피부과: Bisabolol/chamazulene enhance skin barrier repair & reduce erythema.

  • Immunology: Dual antimicrobial & anti-inflammatory activity.

  • 대사: Emerging role in glycemic control pathways.

6. 사용 지침

  • 건강기능식품: Capsules, tablets, tinctures, sleep blends, digestive aids.

  • 화장품: Calming serums, after-sun products, sensitive skin creams, baby care.

  • 기능성 식품/음료: Teas, relaxation drinks, functional confectionery.

  • 복용량: Adhere to formulation-specific recommendations based on standardization.

7. Critical Safety Notes

  • Absolute Contraindication: Asteraceae/Compositae allergy.

  • 주의해서 사용하세요: Concurrent anticoagulant therapy (monitor INR).

  • 임신/수유: Consult healthcare provider despite traditional use.

  • 품질 보증: 파트너와 함께 certified suppliers (예를 들어, 산시성 중홍) 을 위한 PA-free, contaminant-tested extracts.

8. Premium Product Specifications

Table 1: Shaanxi Zhonghong Chamomile Extract Quality Standards (Example: 4% Apigenin)

범주 프로젝트 사양 시험 방법
살충제 잔류물 클로르피리포스 ≤ 0.01ppm GC-MS/MS (EU SANTE 11312/2021)
시페르메트린 ≤ 0.05ppm GC-MS/MS
Propargite ≤ 0.01ppm GC-MS/MS
총 DDT ≤ 0.05ppm GC-μECD
Pyrrolizidine Alkaloids (PAs) < 1.0 ppb Total PAs LC-MS/MS (USP <223>)
중금속 비소(As) ≤ 1.0ppm ICP-MS(USP <232>/ICH Q3D)
납(Pb) ≤ 3.0ppm ICP-MS
카드뮴(Cd) ≤ 0.5ppm ICP-MS
수은(Hg) ≤ 0.1ppm CV-AAS
미생물학 총 호기성 수치 ≤ 10⁴ CFU/g USP <61>
효모 및 곰팡이 ≤ 10² CFU/g USP <61>
대장균 1g에 없음 USP <62>
살모넬라균 종 10g에는 없음 ISO 6579-1
황색포도상구균 1g에 없음 USP <62>
Chemical Markers 아피제닌 ≥ 4.0% HPLC-DAD (Validated USP/EP)
α-비사볼올 ≥ 5.0% (in CO2 Extracts) GC-FID
건조 감량 ≤ 6.0% USP <731>
Total Ash ≤ 8.0% USP <281>
용매 잔류물 Conforms to USP <467> GC-HS-FID

9. Advanced Production Workflow

  1. 지속 가능한 소싱: Partner farms (EU/Organic certified) supply identity-preserved 카모밀라 마트리카리아 flowers. HPTLC/DNA barcoding verification.

  2. Gentle Drying: Low-temperature air drying (<40°C) preserves thermolabile actives.

  3. Precision Extraction: 최적화된 hydroethanolic percolation (apigenin) or Supercritical CO2 Extraction (sesquiterpenes/oils). 아임계수 추출 employed for high-yield fractions.

  4. Multistage Purification: 흡착 크로마토그래피 (macroporous resin) enriches apigenin. Molecular distillation refines essential oil fractions.

  5. Standardization & Stabilization: Precise HPLC-guided blending achieves target potency. Microencapsulation (cyclodextrins) enhances apigenin stability in powders.

  6. cGMP Processing: Closed-system spray drying (inlet ≤ 120°C) for powders; nitrogen-flushed packaging for oils.

  7. Comprehensive QC: Batch-specific CoA ~을 통해 UPLC-QTOF-MS (full metabolomics), GC×GC-TOFMS (volatiles), ICP-MS/MS (elementals), validated microbiological assays.

10. 다양한 응용 시나리오

  • Stress & Sleep Supplements: Nighttime formulas, anxiety relief capsules.

  • GI Health Products: IBS support, digestive bitters, anti-spasmodic blends.

  • Dermocosmetics: Rosacea creams, baby shampoo, post-procedure soothing gels, anti-aging serums (apigenin antioxidant).

  • Functional Beverages: Relaxation teas, sleep-inducing tonics.

  • 구강 관리: Anti-gingivitis mouthwashes.

  • Animal Health: Pet calming chews, equine wound gels.

11. Pharmaceutical-Grade Quality Control
Shaanxi Zhonghong’s QC protocol exceeds pharmacopeial standards: Raw material authentication via DNA metabarcoding (ITS2, matK) ensures species authenticity. In-process controls monitor critical quality attributes (CQAs): solvent ratios, temperature profiles, intermediate marker content (TLC/HPLC). Finished product release requires validated UPLC-PDA methods (ICH Q2(R1)) for apigenin quantification and LC-MS/MS for PA screening (LOD < 0.1 ppb). Stability chambers (ICH Q1A) conduct accelerated (40°C/75% RH) and long-term (25°C/60% RH) studies. Method transfer/verification supports global client audits. ISO 17025 accredited laboratory underpins data integrity (ALCOA+).

12. Protective Packaging & Global Logistics

  • 포장: Light-resistant amber glass bottles (oils), triple-layer foil-aluminum pouches (powders – 25kg), or nitrogen-flushed double drums (bulk). US FDA/EC 1935-compliant materials.

  • 저장: Controlled ambient (15-25°C), <60% RH. Oils stored at 4-8°C.

  • 기호 논리학: Cold chain solutions for temperature-sensitive extracts (2-8°C transport). DDP (Delivered Duty Paid) expertise to 80+ countries. Full documentation suite: CoA, GC-MS/HPLC chromatograms, MSDS, Certificate of Origin, Non-GMO/Allergen/PA-Free Statements.

13. Mechanism of Action & Industry Innovation

  • Pharmacology:

    • GABA_A Receptor Modulation: Apigenin binds benzodiazepine site → Cl⁻ influx → neuronal hyperpolarization.

    • 항염증: α-Bisabolol inhibits NF-κB & TNF-α; chamazulene scavenges leukotrienes.

    • GI Smooth Muscle Relaxation: Apigenin blocks Ca²⁺ influx → spasmolytic effect.

    • 항균제: Sesquiterpene lactones disrupt microbial membranes.

  • 산업 혁신:

    • 생물학적 이용 가능성 향상: 나노에멀젼 그리고 인지질 복합체 boost apigenin absorption (5-10x).

    • 녹색 화학: Enzyme-assisted extraction (cellulase/pectinase) increases yield while reducing solvent use.

    • Stability Technology: Antioxidant synergies (Rosemary CO2 extract + Tocopherols) extend shelf-life.

  • 연구의 최전선:

    • 종양학: Apigenin’s pro-apoptotic effects (PI3K/Akt pathway inhibition) in preclinical cancer models.

    • 신경 보호: Mitigation of Aβ-induced toxicity in Alzheimer’s models.

    • Microbiome Interactions: Impact on gut-brain axis signaling.

    • 표준화 복잡성: Correlating specific chemotypes (bisabolol oxide A vs B ratios) with clinical efficacy.

14. 자주 묻는 질문(FAQ)

  • Q: What’s the difference between German and Roman Chamomile extract?

    • 에이: German (Matricaria) is richer in apigenin/chamazulene, preferred for 항염증 effects. Roman (Chamaemelum) has higher esters (angelates), valued for aromatherapy/milder action.

  • Q: Is Chamomile Extract safe for children?

    • 에이: Generally safe in age-appropriate doses (e.g., teething gels). Verify PA-free status and avoid with Asteraceae allergy.

  • Q: Can I take Chamomile with blood thinners?

    • 에이: Consult your doctor. Coumarin content may potentiate warfarin; close INR monitoring required.

  • Q: Why choose Shaanxi Zhonghong’s Chamomile Extract?

    • 에이: Guaranteed PA-free (<1ppb), HPLC-standardized actives (apigenin/bisabolol), cGMP/ISO 9001 manufacturing, 28년의 전문성, 대학 지원 R&D, global regulatory support.

  • Q: Where to buy premium Chamomile Extract?

    • 에이: 연락하다 산시성 중홍 for B2B sales: Email: liaodaohai@gmail.com | Website: 아이허바닷컴.

15. Conclusion: The Gold Standard in Calmative Botanicals
Chamomile Extract remains a cornerstone of evidence-based phytotherapy. Its multimodal benefits—spanning neurological calm, GI comfort, and dermatological soothing—are unlocked only through scientifically rigorous production. 산시 중홍 투자기술 유한회사 sets the global benchmark with PA-free extracts, chromatographic standardization exceeding pharmacopeia, 그리고 vertically integrated quality control. 우리의 28-year legacy in bioactive compounds, 5 university alliances, 그리고 20개 이상의 특허 기술 deliver Chamomile ingredients of uncompromising purity and efficacy for premium health applications worldwide.

Source Pharmaceutical-Grade Chamomile Extract:

16. Select References

  1. Srivastava, J.K., et al. (2010). Chamomile: A herbal medicine of the past with bright future. 분자 의학 보고서, *3*(6), 895-901.

  2. Amsterdam, J.D., et al. (2009). Chamomile (마트리카리아 레쿠티타) may provide antidepressant activity… 임상 심리약리학 저널, *29*(4), 378-382.

  3. McKay, D.L., & Blumberg, J.B. (2006). A review of the bioactivity and potential health benefits of chamomile tea… 식물요법 연구, *20*(7), 519-530.

  4. European Medicines Agency (EMA). (2015). Assessment report on Matricaria recutita L., flos.

  5. USP-NF Monographs: Chamomile Flower, German.

  6. Avonto, C., et al. (2017). In Chemico Evaluation of Tea Tree Essential Oils and Chamomile Extracts for Pyrrolizidine Alkaloids. J. 농업. 식품 화학, *65*(14), 3087–3093.

  7. ICH Guidelines: Q1A(R2) Stability Testing, Q2(R1) Validation of Analytical Procedures.

  8. ISO 9271:2022 – Aromatic natural raw materials – Vocabulary. (Specific pharmacopeial methods and clinical studies should be referenced in formal product documentation).

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