캄프토테신
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캄프토테신

Camptothecin (CPT) 98%—Trusted Manufacturer for Oncology APIs & Advanced Bioactive Extracts

  1. 영어 이름: Camptothecin
  1. 사양
    • 청정: Camptothecin ≥ 98% (HPLC); High – purity grade: ≥ 99% (HPLC)
    • 용해도: Sparingly soluble in water (approx. 0.1 mg/mL at 25°C), soluble in DMSO, NMP (N – Methyl – 2 – pyrrolidone) and alkaline solutions. Water – soluble derivatives (e.g., sodium salt) have improved solubility.
    • 녹는점: 260 – 264°C (decomposes)
    • 잔류 용매: DMSO ≤ 0.5%, NMP ≤ 0.5%
    • 중금속: ≤ 10ppm
    • 입자 크기: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for enhanced bioavailability in formulations
  1. 모습
    • Pale yellow to yellowish – green crystalline powder, odorless
  1. CAS 번호：7689 – 03 – 4
  1. 리드타임: 7~10일
  1. 패키지
    • 100 mg/vial (sterile glass vial), 1 g/aluminum foil – lined bag; stored under nitrogen to prevent oxidation
  1. 주요 시장: Global pharmaceutical and research markets, with significant demand in North America, Europe, and Asia, especially in oncology research and drug development
  1. 응용 프로그램 시나리오

핵심 속성

  • 분자식: C₂₀H₁₆N₂O₄
  • 화학 구조: A pentacyclic quinoline alkaloid, featuring a unique camptothecin ring system with a lactone moiety, which is crucial for its biological activity.
  • 주요 특징
    • Topoisomerase Inhibitor: Specifically targets DNA topoisomerase I, preventing the religation of DNA strands during replication, leading to DNA damage and cell death in rapidly dividing cells.
    • 항종양 활성: Potent cytotoxic effects against a wide range of cancer cell lines, including colorectal, lung, ovarian, and pancreatic cancers.
    • pH – Dependent Stability: The lactone ring is stable in acidic conditions (pH < 4.5) but undergoes hydrolysis to the carboxylate form in neutral and basic environments, reducing its biological activity.
    • 고효능: Low therapeutic doses are required due to its strong inhibitory effect on DNA replication, but this also necessitates careful handling to manage potential toxicity.

응용 프로그램 시나리오

1. 종양학 연구

  • Pre – clinical Studies:
    • Widely used in in – vitro cell culture experiments and in – vivo animal models to study the mechanism of action of topoisomerase I inhibitors, screen for new anticancer drugs, and evaluate the efficacy of combination therapies.
  • 약물 개발:
    • Serves as a lead compound for the development of second – generation and third – generation camptothecin – based drugs. Many clinically used anticancer drugs, such as irinotecan and topotecan, are synthetic derivatives of camptothecin with improved solubility, stability, and reduced toxicity.

2. 제약 산업

  • Anticancer Drug Synthesis:
    • As an intermediate in the production of camptothecin – derived drugs. Chemical modifications are made to the camptothecin structure to enhance its pharmacological properties, such as increasing water solubility, stabilizing the lactone ring, and improving targeting ability.
  • 품질 관리:
    • Used as a reference standard for the analysis and quality control of camptothecin – based drugs, ensuring the consistency and purity of pharmaceutical products.

3. 생물의학 연구

  • DNA Replication and Repair Studies:
    • Helps researchers understand the processes of DNA replication, repair, and the role of topoisomerases in maintaining genomic stability. By inhibiting topoisomerase I, scientists can study the cellular responses to DNA damage and the activation of various repair pathways.
  • Drug Resistance Research:
    • Investigated to understand the mechanisms of drug resistance in cancer cells towards camptothecin and its derivatives. This knowledge can guide the development of strategies to overcome resistance and improve treatment outcomes.

탐지 방법

  • 고성능 액체 크로마토그래피(HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% formic acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 254 nm for quantification.
  • Ultra – 성능 액체 크로마토그래피 – 질량 분석법(UPLC – MS):
    • Used for the identification and quantification of camptothecin and its metabolites in biological samples. It provides high – sensitivity and high – resolution analysis, crucial for pharmacokinetic and pharmacodynamic studies.
  • 푸리에 변환 적외선 분광법(FTIR):
    • Helps in confirming the chemical structure of camptothecin by analyzing the characteristic absorption peaks of its functional groups, ensuring the integrity of the compound during production and storage.

출처 및 장점

  • 천연 자원: Originally isolated from the bark and wood of the Chinese tree Camptotheca acuminata. However, due to the low content of camptothecin in the plant (0.01 – 0.03%) and environmental concerns, semi – synthesis and total synthesis methods are now commonly used.
  • 치료적 잠재력: Its unique mechanism of action makes it a valuable starting point for the development of highly effective anticancer drugs, contributing significantly to the field of oncology.
  • 연구 유틸리티: A crucial tool in biomedical research, enabling a deeper understanding of fundamental biological processes related to DNA metabolism and cancer biology.

규정 준수

  • 미국 식품의약국: Regulated as an investigational new drug (IND) for research purposes and as a pharmaceutical ingredient for approved camptothecin – based drugs. Stringent regulations govern its use in clinical trials and commercial production to ensure patient safety.
  • EU 규정: Subject to strict regulations under the European Medicines Agency (EMA). Clinical trials involving camptothecin and its derivatives must comply with Good Clinical Practice (GCP) guidelines, and marketing authorization is required for commercial use.
  • 중국 국가광물자원관리국: Monitored closely in China, especially for drugs derived from camptothecin. The extraction, synthesis, and clinical application of camptothecin – related products need to meet national pharmaceutical standards and regulatory requirements.
범주: ,

Camptothecin – High-Purity Bioactive Extract for Pharmaceutical R&D and Advanced Formulations

Camptothecin (CPT) is a naturally occurring alkaloid originally isolated from Camptotheca acuminata. Today, it remains a critical precursor for the synthesis of topoisomerase-I inhibitor drugs such as irinotecan 그리고 topotecan, widely researched in oncology and cellular biology.
~에 AIHerba®(산시성 중홍투자기술유한회사), we manufacture high-purity camptothecin 아래에 GMP-aligned standards, serving pharmaceutical companies, research institutes, nutraceutical developers, and biotechnology innovators.

1. 제품 개요

  • 제품명: 캄프토테신

  • CAS 번호: 7689-03-4

  • 식물 출처: Camptotheca acuminata (Happy Tree)

  • 사양: 95% / 98% HPLC

  • 모습: 노란색 결정성 분말

  • 기원: 중국

  • Supply Form: Bulk powder for industrial, pharmaceutical & research use

  • 최소주문수량: 1–5 kg (bulk orders negotiable)

Our factory operates with 28년 이상의 추출 경험, using 초임계 CO₂ 추출, precision purification, and low-temperature crystallization to protect the molecule’s stability.

2. Key Benefits & Functional Properties

Expert Review – Dr. L. Meng, PhD, Natural Products Chemistry (quoted with permission)
“Camptothecin’s unique lactone ring makes it one of the most studied plant-derived compounds in cancer biology. High purity is essential for consistent activity, and only GMP-controlled extraction can achieve pharmaceutical-grade reliability.”

핵심 속성

  1. Topoisomerase-I Inhibition
    Widely used as a reference compound in oncology research (NIH, PubMed: PMID 2684270).

  2. Supports Drug Development Pipelines
    Essential precursor for semi-synthetic clinical drugs including irinotecan (CPT-11) and topotecan.

  3. Cellular Stress Response Studies
    Extensively used in apoptosis, DNA repair, and cell-cycle disruption research (NIH, PMID 2153155).

  4. High Purity = Stability
    Residual solvent control and crystalline structure guarantee better assay performance.

3. Health-Related Research Insights

While Camptothecin is not a dietary supplement, it is one of the most influential natural products in anti-tumor drug discovery.
Research suggests potential roles in:

  • DNA replication interference

  • Anti-proliferative activity

  • In vitro anti-tumor mechanism modeling

  • Precision oncology tool compound applications

(References linked below.)

4. Traditional Botanical Background

Camptotheca acuminata has been referenced in traditional Chinese medicine literature as far back as the 17th century, used historically for “heat-clearing” and detoxifying functions—long before scientists isolated camptothecin in 1966.

5. Recommended Usage (For Industrial & Research Applications Only)

  • 제약 R&D: 95–98% HPLC

  • Reference Standard: 98%

  • Formulation Input: For precursor synthesis only

  • Cosmetic R&D: Typically micro-dosed in high-tech anti-aging prototypes (not consumer-facing due to regulations)

Not intended for direct consumption.

6. Best Formulation Guidelines

  • 용해도: Poor water solubility; dissolve in DMSO, ethanol, or formulated carriers

  • 안정: Protect lactone ring—avoid high pH

  • 호환성: Sensitive to oxidation

  • Ideal Use: Oncology model systems, biosimilar pathway research, early-stage drug formulation

7. COA-Style Quality Specification Table

A. General Specifications

목 사양 방법
모습 노란색 결정성 분말 시각적
분석법(HPLC) ≥ 98.0% HPLC
수분 ≤ 2.0% 칼 피셔
금연 건강 증진 협회 ≤ 0.5% USP <281>

B. Pesticide Residues

살충제 이름 한계(mg/kg) 시험 방법
유기염소계(DDT, BHC) ≤ 0.1 GC-MS
유기인산염 ≤ 0.2 GC-MS
카바메이트 ≤ 0.5 LC-MS/MS
피레트로이드 ≤ 0.5 GC-MS

C. 중금속

목 한계 시험 방법
납(Pb) ≤ 2ppm ICP-MS
비소(As) ≤ 1ppm ICP-MS
카드뮴(Cd) ≤ 1ppm ICP-MS
수은(Hg) ≤ 0.1ppm ICP-MS
총 중금속 ≤ 10ppm USP <231>

D. 미생물학적 검사

목 한계 방법
총 플레이트 수 ≤ 1,000 CFU/g USP <2021>
효모 및 곰팡이 ≤ 100 CFU/g USP <2021>
대장균 부정적인 USP <2022>
살모넬라균 부정적인 USP <2022>
황색포도상구균 부정적인 USP <2022>

8. Manufacturing Process (Summary)

Step-by-Step Flow

  1. Raw Material Harvesting – Sustainably cultivated Camptotheca acuminata

  2. 건조 및 분쇄 – Low-temperature handling to preserve alkaloids

  3. 용매 추출 (Ethanol/water or SC-CO₂)

  4. 농축 및 여과

  5. 정화 (Resin column → crystallization)

  6. HPLC Standardization

  7. Drying & Micronization

  8. Final QC Testing

  9. Packaging in GMP Workshops

This process ensures 추적성, 고순도, 그리고 lot-to-lot consistency — essential for pharmaceutical buyers.

9. 보관 및 유통기한

  • 저장: Store at 2–8°C, sealed, protected from light and humidity

  • 유통기한: 24–36 months unopened

  • 포장:

    • 1kg 알루미늄 호일 백

    • 25 kg drum

    • Customized packaging available

10. 샘플 정책, 최소 주문 수량 및 물류

  • 무료 샘플 허브 추출물: 10–20 g for QC testing

  • 최소주문수량: 1 kg (research), 5–25 kg (bulk manufacturing)

  • 리드타임: 3–5 days for stock items

  • 기호 논리학: International express, air freight, and temperature-controlled shipping available

  • 거래 조건: EXW, FOB, CIF

11. 적용 산업 및 사용 사례

Camptothecin is typically used in:

제약 R&D

  • Oncology drug precursor

  • Reference standard

  • Topoisomerase inhibitor studies

Biotechnology & Laboratory Research

  • Cell-death pathway modeling

  • Antitumor screening

  • DNA repair studies

Cosmetic R&D

  • Advanced anti-aging experimental formulas
    (Only for 화장품용 GMP 인증 식물 추출물 research groups.)

Functional Food Developers

Not for ingestion, but relevant for 건강 보조 식품 원료 제조업체 R&D departments.

12. Why Choose AIHerba® as Your Camptothecin Supplier

  1. GMP 인증 제조업체 with 28+ years experience

  2. Factory-direct price and traceable raw material base

  3. Bulk supply with consistent purity and stable batches

  4. Strict QC + third-party testing upon request

  5. Custom extraction services ~을 위한 맞춤형 허브 추출물 projects

  6. Global shipping with regulatory support

We serve hundreds of clients across pharmaceuticals, biotechnology, cosmetics, and academic research.

13. 자주 묻는 질문(FAQ)

Q1. Is your Camptothecin suitable for pharmaceutical manufacturing?
Yes. Our 98% grade is produced in GMP facilities and suitable for precursor synthesis.

Q2. Do you offer technical documents?
COA, HPLC chromatograms, MSDS, and process documentation can be provided.

Q3. Can I buy small research quantities?
Yes. MOQ begins at 1 kg with 무료 샘플 사용 가능.

Q4. Can you support custom purity levels?
We can adjust specs for OEM/ODM partners and research institutions.

Q5. Do you provide wholesale pricing?
예. Wholesale and bulk price tiers are available depending on quantity.

14. 과학적 참고문헌

(PubMed / NIH / FDA official sources)

  1. Wall ME et al. 과학, 1966 — Discovery of camptothecin. (PubMed: 5916656)

  2. Hsiang YH et al. Topoisomerase-I inhibition mechanism. (PubMed: 2684270)

  3. Pommier Y. DNA repair pathways in CPT action. (PubMed: 2153155)

  4. FDA Orange Book – Camptothecin derivatives regulatory data.

Contact & Ordering

AIHerba® | 산시성 중홍투자기술유한회사.
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com
GMP 인증 공급업체, 제조업체, 그리고 공장 of high-purity plant extracts.

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