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알파-아르부틴

α-Arbutin supplier bulk factory Wholesale Extract factory

  1. 영어 이름: α-Arbutin,Alpha-Arbutin
  1. 사양
    • 제너럴 파우더: α-Arbutin ≥ 99% (HPLC), optical purity ≥ 98%
    • 수용성 분말: α-Arbutin ≥ 98% (HPLC), with a water-soluble 공급자 (e.g., cyclodextrin), solubility ≥ 100 g/L at 25°C
  1. 모습
    • General Powder: White crystalline powder, odorless
    • Water-soluble Powder: Off-white free-flowing powder
  1. CAS 번호:84380-01-8
  1. 리드타임: 3~7일
  1. 패키지
    • 1kg/봉투(알루미늄 호일 봉지), 25kg/드럼(골판지 드럼 내부에 2겹 PE 봉지)
  1. 주요 시장: Asia (특히 ~에 좋아요-beauty and J-beauty markets), North America, Europe
  1. 응용 프로그램 시나리오

핵심 속성

  • 분자 Formula: C₁₂H₁₆O₇
  • 용해도: Soluble in water, ethanol, and propylene glycol; the water-soluble formulation 전시 enhanced dissolution 속도
  • 열쇠 옵션:
    • Potent tyrosinase inhibitor, blocking melanin synthesis 추가의 성공적으로 than β-Arbutin (IC₅₀ = 0.2 mM)
    • Antioxidant properties, 방어하다 모공과 피부 from UV-induced oxidative stress
    • 꾸준한 산성에서 상황 (최적의 pH 4 – 6), 하지만 degrades in alkaline environments or at 과도한 temperatures (> 60°C)

응용 프로그램 시나리오

1. 화장품 & 사적인 케어

  • 피부 번개 상품:
    • Serums and Essences: 일반적으로 formulated at 2 – 5% 집중하다, 저하 어둡다 spots, melasma, and post-inflammatory hyperpigmentation. 의료 연구 현재의 a 30% 할인 in pigmentation after 8 weeks of use.
    • 자외선 차단제: Added at 1 – 2% 공급하다 태양열 안전 and anti-pigmentation 장점, 멎는 UV-induced melanin 조작.
    • 호분 로션: 혼합 ~와 함께 다른 기운찬 물질 like niacinamide and hyaluronic acid, 에 초점을 맞추다 일반적인 모공과 피부 brightening and hydration.
  • 안티-늙어가다 제형:
    • Inhibits collagen degradation 에 의해 가져온 자유 라디칼, 저하 외모 ~의 유리한 균주 and wrinkles when included in anti-aging masks and 로션.

2. 처방약

  • 피부과 Therapies:
    • 활용됨 prescription-strength 로션 (~만큼 4% 집중하다 in some 지역) for treating 극심한 색소침착 문제들 ~을 연상시키는 melasma and freckles.
    • Submit-surgical and post-peel 기능 to forestall 또는 규모를 줄이다 post-treatment hyperpigmentation, 일반적으로 혼합 with vitamin E.

3. 목적이 있는 식사 & 음료수

  • 경구 식이 보충제:
    • Capsules or tablets containing 500 mg of α-Arbutin, 일반적으로 paired with vitamin C 부스트하다 collagen synthesis and promote 모공과 피부 웰빙 ~에서 내부에.
  • Magnificence 음료수:
    • Added to low-calorie 음료수 at 0.5 – 1% 집중하다, marketed as “beauty-from-within” 상품 ~을 위한 일반적인 모공과 피부 brightening.

4. 산업 목적

  • Textile Dyeing:
    • 로서 순수한 mordant, α-Arbutin 활용될 수 있다 수리하다 염료에 재료, producing 온화한 그리고 꾸준한 coloration hues 없이 사용 중 harsh 화합물.
  • 생물농약:
    • Aqueous 옵션 of α-Arbutin (0.1 – 0.5%) 현재의 항진균 특성을 가지고 있어 적절한 사용될 in eco-friendly agricultural pest 관리.

발각 전략

  • 과도한능률 액체 크로마토그래피(HPLC):
    • 컬럼: C18(250×4.6mm, 5μm), 셀룰러 부분: Acetonitrile – Water (15:85, v/v), 개울 요금: 1.0 mL/min, Detection Wavelength: 280 nm
  • 질량 분석법(MS):
    • 사용된 확인하다 분자 건설 and purity, 특히 for pharmaceutical-grade α-Arbutin 상품.
  • 시차 주사 열량측정법(DSC):
    • Determines the melting 수준 (195 – 198°C for α-Arbutin), ~에 봉사하다 에게 확인하다 제품 고품질 and authenticity.

공급 & 이익

  • 조작: 주로 synthesized ~을 통해 enzymatic or chemical processes, 제공 보다 큰 purity and consistency 와 비교하여 순수한 추출 전략.
  • 효능: 그것은 건장한 억제성 영향 on tyrosinase 제안 빠른 and visual ~로 끝납니다 모공과 피부 lightening, making it a 가장 인기 있는 ingredient for high-end 웅대 상품.
  • 보안: 일반적으로 well-tolerated by most 모공과 피부 정렬, with a 감소하다 위협 of irritation 와 비교하여 another 美白 중개인.

규정 준수

  • 중국 국가광물자원관리국: Permitted as a 아름다움 성분과 함께 최대 집중하다 두 개 중% (requiring 보안 평가 ~을 위한 보다 큰 범위).
  • 유럽 연합 아름다움 규정(EC 1223/2009): Accredited 사용될 화장품에서 얽매다 of three% in leave-on 상품.
  • 미국 식품의약국: Tentatively labeled as an OTC ingredient for 모공과 피부 lightening, with 집중하다 제한 하면 평가.

Alpha-Arbutin: The Gold Normal in Pores and skin Lightening and Antioxidant Safety| Supplier & Manufacturer

1. What is Alpha-Arbutin?

Alpha-arbutin is a glycosylated hydroquinone spinoff famend for its potent pores and skin – lightening properties. In contrast to its counterpart, beta – arbutin, alpha – arbutin displays a better affinity for tyrosinase, the important thing enzyme concerned in melanin synthesis. This makes it simpler at decreasing hyperpigmentation, comparable to age spots, freckles, and melasma, with out inflicting important pores and skin irritation. Extensively used within the cosmetics business, alpha – arbutin has additionally proven antioxidant and anti – inflammatory results, positioning it as a multifunctional bioactive ingredient.

Alpha-Arbutin Applications
Alpha-Arbutin Purposes

2. 제품의 원산지 및 화학적 특성

2.1 공급

Alpha-arbutin could be extracted from varied crops, together with bearberry (아크토스타필로스 우바-우르시), blueberries (Vaccinium spp.), and cranberries (Vaccinium macrocarpon). Nevertheless, as a result of low pure content material in crops, most business alpha – arbutin is produced by way of biocatalysis or chemical synthesis. At Shaanxi Zhonghong Investment Technology Co., Ltd., we make the most of superior biocatalytic processes to make sure excessive – purity, sustainable manufacturing with minimal environmental influence.

2.2 화학적 프로필

  • CAS 수량: 84380 – 01 – 8
  • 분자식(MF): C₁₂H₁₆O₇
  • 분자량(MW): 272.25 g/mol
  • EINECS: 282 – 776 – 3
  • 신체 상태: White to off – white crystalline powder
  • 용해도: Soluble in water (5 – 10 g/L at 25°C), barely soluble in ethanol

3. Optimum Product, Well being Benefits, Dosage, Precautions and Aspect Results

3.1 Finest Merchandise and Content

The best – high quality alpha – arbutin merchandise sometimes have a purity of 98% or increased. Our firm leverages state – of – the – artwork purification methods, comparable to excessive – efficiency liquid chromatography (HPLC) and crystallization processes, to realize a purity stage 20% above the business common. This ensures most efficacy in pores and skin – lightening purposes and minimizes the danger of impurities inflicting antagonistic reactions.

3.2 Well being Benefits

3.2.1 Pores and skin Lightening

Alpha-arbutin inhibits tyrosinase exercise, blocking the conversion of tyrosine to melanin. By decreasing melanin manufacturing, it successfully lightens current darkish spots and prevents new pigmentation, resulting in a extra even pores and skin tone.

3.2.2 Antioxidant Safety

It acts as a free – radical scavenger, neutralizing reactive oxygen species (ROS) comparable to hydroxyl and superoxide radicals. This antioxidant property helps defend pores and skin cells from oxidative harm, which is related to untimely ageing, effective strains, and wrinkles.

3.2.3 Anti – Inflammatory Results

Alpha-arbutin can cut back the manufacturing of professional – inflammatory cytokines, soothing irritated pores and skin and selling a more healthy pores and skin barrier perform. This makes it appropriate for delicate pores and skin sorts vulnerable to irritation.

3.3 Beneficial Dosage

In beauty formulations, the standard focus of alpha – arbutin ranges from 0.5% to 2%. For direct software merchandise like serums or lotions, making use of a pea – sized quantity (roughly 1 – 2 grams) containing the suitable focus to the affected pores and skin areas a couple of times every day is widespread. Nevertheless, it is vital to comply with product – particular directions.

3.4 Precautions and Aspect Results

Alpha-arbutin is mostly nicely – tolerated. Nevertheless, in uncommon instances, it might trigger delicate pores and skin irritation, comparable to redness or itching, particularly in people with extremely delicate pores and skin. Extended publicity to daylight can cut back its effectiveness and enhance the danger of pores and skin harm, so sunscreen use is advisable when utilizing alpha – arbutin merchandise. Keep away from contact with eyes, and if unintended ingestion happens, search medical recommendation instantly.

4. Firm Introduction

With 28 years of expertise within the bioactive compound business, Shaanxi Zhonghong Investment Technology Co., Ltd. is a number one excessive – tech enterprise. Our operations span agile analysis and improvement, collaborative innovation, built-in manufacturing, and international advertising and marketing, serving the chemical, supplies, and life science sectors.
  • Analysis Edge: Our partnerships with 5 prime – tier universities by way of joint laboratories, together with over 20 patented applied sciences and a singular international compound library, drive steady innovation in alpha – arbutin manufacturing and software.
  • 기술적 우월성: Outfitted with state – of – the – artwork services, together with excessive – efficiency liquid chromatography (HPLC) and superconducting nuclear magnetic resonance spectrometers, we guarantee product purity requirements 20% increased than the business common.
  • 월드 어텐션: Our intensive community covers greater than 80 nations throughout Asia, Europe, and the Americas. We provide custom-made uncooked materials options for multinational pharmaceutical firms, analysis establishments, and beauty producers.

5. 제품 사양

Venture
이름
지시자
탐지 기술
살충제 잔류물
클로르피리포스
< 0.01ppm
가솔린 크로마토그래피-질량 분석법(GC-MS)
시페르메트린
< 0.02ppm
GC-MS
카르벤다짐
< 0.05ppm
과도한 효율성 액체 크로마토그래피 - 질량 분석법(HPLC - MS/MS)
중금속
납(Pb)
< 0.5ppm
유도 결합 플라즈마 질량 분석법(ICP-MS)
수은(Hg)
< 0.01ppm
냉증기 원자흡수분광법(CVAAS)
카드뮴(Cd)
< 0.05ppm
ICP-MS
미생물 오염
전체 실행 가능한 의존성
< 100 CFU/g
Normal microbiological plating methods
대장균
결석한
중합효소 연쇄 반응(PCR) 및 도금
살모넬라균
결석한
PCR 및 플레이팅
리스테리아 모노사이토제네스
결석한
PCR 및 플레이팅

6. 제조 과정

  1. Uncooked Materials Preparation: For biocatalytic manufacturing, choose excessive – high quality enzymes or microorganisms with excessive exercise for alpha – arbutin synthesis. Guarantee correct cultivation and activation of those organic catalysts.
  1. Biocatalysis or Chemical Synthesis: In biocatalysis, use enzymes to catalyze the response between hydroquinone and glucose to kind alpha – arbutin. In chemical synthesis, rigorously management response situations comparable to temperature, pH, and response time to advertise the formation of alpha – arbutin whereas minimizing by – product technology.
  1. 정화: Make use of a number of purification steps, together with filtration, extraction, and chromatography. HPLC is used to separate alpha – arbutin from impurities, guaranteeing excessive – purity product. Crystallization processes might also be utilized to additional refine the product.
  1. 건조 및 제형: Dry the purified alpha – arbutin beneath managed situations to take away moisture. Then, formulate it into completely different varieties in keeping with buyer necessities, comparable to effective powders, granules, or pre – blended options for cosmetics.
  1. High quality Inspection: Conduct complete high quality testing on the completed product, together with purity willpower, identification, and inspection of pesticide residues, heavy metals, and microbial contamination.

7. 응용 프로그램 시나리오

7.1 Cosmetics

  • Pores and skin – Lightening Merchandise: Alpha-arbutin is a key ingredient in serums, lotions, masks, and lotions designed to cut back hyperpigmentation and obtain a brighter, extra even complexion.
  • Anti – Growing old Formulations: Mixed with different antioxidants and anti – ageing substances, it helps fight oxidative stress and enhance pores and skin texture, decreasing the looks of effective strains and wrinkles.
  • Sunscreen and After – Solar Care: Its antioxidant properties make it appropriate for inclusion in sunscreens to boost UV safety and in after – solar merchandise to appease solar – broken pores and skin.

7.2 Prescribed drugs (Analysis – based mostly)

At the moment, alpha – arbutin is beneath investigation for potential purposes in treating pores and skin illnesses associated to irregular pigmentation, comparable to melasma and publish – inflammatory hyperpigmentation. Its anti – inflammatory and antioxidant results might also contribute to wound – therapeutic analysis.

8. 고품질 관리

High quality management is the cornerstone of our alpha – arbutin manufacturing. On the uncooked materials stage, we conduct strict inspections on enzymes, microorganisms, or chemical precursors, verifying their purity and exercise by way of biochemical assays and spectroscopic evaluation. Through the manufacturing course of, actual – time monitoring of response parameters (temperature, pH, response time) ensures constant product high quality. Within the purification part, HPLC is used for exact separation and purity willpower, with every batch of merchandise present process a number of rounds of study to make sure the absence of impurities. For ultimate product inspection, we carry out complete exams on chemical purity, microbial security, and heavy metallic content material, adhering to strict worldwide requirements. Our high quality management laboratory is licensed to ISO 9001 and follows Good Manufacturing Follow (GMP) pointers. By implementing a multi – step high quality management system, we assure that each batch of alpha – arbutin meets the very best high quality and security necessities, offering dependable merchandise to our prospects worldwide.

9. 포장 및 물류

  • 포장: Our alpha – arbutin merchandise are packaged in air – tight, moisture – resistant containers. For small orders, we use aluminum foil luggage or amber glass bottles, whereas for bulk orders, fiber drums are utilized. Every bundle is labeled with detailed data, together with product identify, batch quantity, purity, expiration date, and storage directions.
  • 저장: Retailer in a cool, dry place, away from direct daylight, at temperatures between 2 – 8°C. Below correct storage situations, the shelf lifetime of our alpha – arbutin merchandise can attain as much as 36 months.
  • 수송: We accomplice with dependable worldwide logistics suppliers to make sure quick and safe supply. Samples could be shipped through specific providers like DHL or FedEx inside 3 – 5 enterprise days, whereas bulk orders are transported by sea or air freight in keeping with buyer necessities.

10. Well being Efficacy Analysis, Industrial Application Innovation, and Challenges

10.1 분석 프런티어

  • Nano – Supply Techniques: Scientists are exploring nanoencapsulation methods to enhance the steadiness and bioavailability of alpha – arbutin, enabling higher penetration into the pores and skin and extra focused supply.
  • 혼합 요법: Analysis is underway to research the synergistic results of alpha – arbutin when mixed with different pores and skin – lively substances, comparable to vitamin C and niacinamide, for enhanced pores and skin – lightening and anti – ageing outcomes.

10.2 과제

  • 안정: Alpha-arbutin could be unstable beneath sure situations, comparable to excessive temperature or publicity to gentle. Creating extra secure formulations with out compromising its efficacy stays a problem.
  • 규정 준수: As a beauty ingredient, alpha – arbutin should adjust to varied worldwide rules relating to security, labeling, and efficacy claims. Guaranteeing constant compliance throughout completely different markets is essential for its widespread adoption.

11. 자주 묻는 질문

11.1 The place can I purchase Alpha-Arbutin?

  • We provide quite a lot of alpha – arbutin merchandise with completely different purity ranges and packaging choices to satisfy various buyer wants.

11.2 Is Alpha-Arbutin secure for all pores and skin sorts?

Alpha-arbutin is mostly secure for many pores and skin sorts. Nevertheless, people with extremely delicate pores and skin could expertise delicate irritation. It is advisable to carry out a patch check earlier than utilizing new merchandise containing alpha – arbutin.

11.3 Can Alpha-Arbutin be used throughout being pregnant?

There may be restricted analysis on the security of alpha – arbutin throughout being pregnant. Pregnant or nursing girls ought to seek the advice of a health care provider earlier than utilizing merchandise containing alpha – arbutin.

11.4 How lengthy does it take to see outcomes?

Seen pores and skin – lightening outcomes could take 4 – 8 weeks of constant use, because the pores and skin’s pure renewal cycle wants time to exchange pigmented cells with new, lighter – coloured ones.

12. 결론

Alpha-arbutin stands as a revolutionary ingredient within the magnificence and skincare business, providing efficient pores and skin – lightening, antioxidant, and anti – inflammatory advantages. As a number one producer, Shaanxi Zhonghong Investment Technology Co., Ltd. is dedicated to offering excessive – high quality alpha – arbutin merchandise, backed by superior expertise, strict high quality management, and intensive international attain. Whether or not for creating modern beauty merchandise or advancing dermatological analysis, our alpha – arbutin choices set the usual for excellence.

13. 참고문헌

  1. Kameyama, Okay., et al. (1995). Alpha – arbutin: A novel reversible tyrosinase inhibitor from the leaves of Vaccinium ashei. 농업 및 식품 화학 저널, 43(11), 2807 – 2810.
  1. Wang, Y., et al. (2018). Advances within the manufacturing and software of arbutin. 분자, 23(6), 1461.
  1. European Fee. (2019). Beauty Substances Database (CosIng). Retrieved from [CosIng official website]

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