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알파-아르부틴

α-Arbutin Product Introduction

  1. 영어 이름: α-Arbutin,Alpha-Arbutin
  1. 사양
    • General Powder: α-Arbutin ≥ 99% (HPLC), optical purity ≥ 98%
    • Water-soluble Powder: α-Arbutin ≥ 98% (HPLC), with a water-soluble carrier (e.g., cyclodextrin), solubility ≥ 100 g/L at 25°C
  1. 모습
    • General Powder: White crystalline powder, odorless
    • Water-soluble Powder: Off-white free-flowing powder
  1. CAS 번호:84380-01-8
  1. 리드타임: 3~7일
  1. 패키지
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double-layer PE bag inside cardboard drum)
  1. 주요 시장: Asia (especially in K-beauty and J-beauty markets), North America, Europe
  1. 응용 프로그램 시나리오

핵심 속성

  • 분자식: C₁₂H₁₆O₇
  • 용해도: Soluble in water, ethanol, and propylene glycol; the water-soluble formulation shows enhanced dissolution speed
  • 주요 특징:
    • Potent tyrosinase inhibitor, blocking melanin synthesis more effectively than β-Arbutin (IC₅₀ = 0.2 mM)
    • Antioxidant properties, protecting skin from UV-induced oxidative stress
    • Stable in acidic conditions (optimal pH 4 – 6), but degrades in alkaline environments or at high temperatures (> 60°C)

응용 프로그램 시나리오

1. 화장품 및 개인 관리

  • Skin Lightening Products:
    • Serums and Essences: Commonly formulated at 2 – 5% concentration, reducing dark spots, melasma, and post-inflammatory hyperpigmentation. Clinical studies show a 30% reduction in pigmentation after 8 weeks of use.
    • 자외선 차단제: Added at 1 – 2% to provide both sun protection and anti-pigmentation benefits, preventing UV-induced melanin production.
    • Whitening Creams: Combined with other active ingredients like niacinamide and hyaluronic acid, targeting overall skin brightening and hydration.
  • 노화 방지 제형:
    • Inhibits collagen degradation caused by free radicals, reducing the appearance of fine lines and wrinkles when included in anti-aging masks and creams.

2. 제약품

  • Dermatological Treatments:
    • Used in prescription-strength creams (up to 4% concentration in some regions) for treating severe pigmentation disorders such as melasma and freckles.
    • Post-surgical and post-peel applications to prevent or reduce post-treatment hyperpigmentation, often combined with vitamin E.

3. 기능성 식품 및 음료

  • 경구 보충제:
    • Capsules or tablets containing 500 mg of α-Arbutin, often paired with vitamin C to enhance collagen synthesis and promote skin health from within.
  • Beauty Drinks:
    • Added to low-calorie beverages at 0.5 – 1% concentration, marketed as “beauty-from-within” products for overall skin brightening.

4. 산업용 응용 분야

  • Textile Dyeing:
    • As a natural mordant, α-Arbutin can be used to fix dyes on fabrics, producing light and stable color hues without the use of harsh chemicals.
  • Biopesticides:
    • Aqueous solutions of α-Arbutin (0.1 – 0.5%) show antifungal properties, making it suitable for use in eco-friendly agricultural pest control.

탐지 방법

  • 고성능 액체 크로마토그래피(HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – Water (15:85, v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 280 nm
  • 질량 분석법(MS):
    • Used to confirm the molecular structure and purity, especially for pharmaceutical-grade α-Arbutin products.
  • Differential Scanning Calorimetry (DSC):
    • Determines the melting point (195 – 198°C for α-Arbutin), helping to verify product quality and authenticity.

출처 및 장점

  • Production: Mainly synthesized through enzymatic or chemical processes, offering higher purity and consistency compared to natural extraction methods.
  • Efficacy: Its strong inhibitory effect on tyrosinase provides rapid and visible results in skin lightening, making it a preferred ingredient for high-end beauty products.
  • 안전: Generally well-tolerated by most skin types, with a lower risk of irritation compared to some other 美白 agents.

규정 준수

  • 중국 국가광물자원관리국: Permitted as a cosmetic ingredient with a maximum concentration of 2% (requiring safety assessment for higher levels).
  • EU Cosmetic Regulation (EC 1223/2009): Approved for use in cosmetics, with a limit of 3% in leave-on products.
  • 미국 식품의약국: Tentatively classified as an OTC ingredient for skin lightening, with concentration limits under review.

Alpha-Arbutin: The Gold Standard in Skin Lightening and Antioxidant Protection

1. What is Alpha-Arbutin?

Alpha-arbutin is a glycosylated hydroquinone derivative renowned for its potent skin – lightening properties. Unlike its counterpart, beta – arbutin, alpha – arbutin exhibits a higher affinity for tyrosinase, the key enzyme involved in melanin synthesis. This makes it more effective at reducing hyperpigmentation, such as age spots, freckles, and melasma, without causing significant skin irritation. Widely used in the cosmetics industry, alpha – arbutin has also shown antioxidant and anti – inflammatory effects, positioning it as a multifunctional bioactive ingredient.

Alpha-Arbutin Applications
Alpha-Arbutin Applications

2. Product Origin and Chemical Properties

2.1 출처

Alpha-arbutin can be extracted from various plants, including bearberry (Arctostaphylos uva-ursi), blueberries (Vaccinium spp.), and cranberries (Vaccinium macrocarpon). However, due to the low natural content in plants, most commercial alpha – arbutin is produced through biocatalysis or chemical synthesis. At Shaanxi Zhonghong Investment Technology Co., Ltd., we utilize advanced biocatalytic processes to ensure high – purity, sustainable production with minimal environmental impact.

2.2 Chemical Profile

  • CAS 번호: 84380 – 01 – 8
  • 분자식(MF): C₁₂H₁₆O₇
  • 분자량(MW): 272.25 g/mol
  • EINECS: 282 – 776 – 3
  • Physical State: White to off – white crystalline powder
  • 용해도: Soluble in water (5 – 10 g/L at 25°C), slightly soluble in ethanol

3. Optimal Product, Health Benefits, Dosage, Precautions and Side Effects

3.1 Best Products and Content

The highest – quality alpha – arbutin products typically have a purity of 98% or higher. Our company leverages state – of – the – art purification techniques, such as high – performance liquid chromatography (HPLC) and crystallization processes, to achieve a purity level 20% above the industry average. This ensures maximum efficacy in skin – lightening applications and minimizes the risk of impurities causing adverse reactions.

3.2 Health Benefits

3.2.1 Skin Lightening

Alpha-arbutin inhibits tyrosinase activity, blocking the conversion of tyrosine to melanin. By reducing melanin production, it effectively lightens existing dark spots and prevents new pigmentation, leading to a more even skin tone.

3.2.2 Antioxidant Protection

It acts as a free – radical scavenger, neutralizing reactive oxygen species (ROS) such as hydroxyl and superoxide radicals. This antioxidant property helps protect skin cells from oxidative damage, which is associated with premature aging, fine lines, and wrinkles.

3.2.3 Anti – Inflammatory Effects

Alpha-arbutin can reduce the production of pro – inflammatory cytokines, soothing irritated skin and promoting a healthier skin barrier function. This makes it suitable for sensitive skin types prone to inflammation.

3.3 Recommended Dosage

In cosmetic formulations, the typical concentration of alpha – arbutin ranges from 0.5% to 2%. For direct application products like serums or creams, applying a pea – sized amount (approximately 1 – 2 grams) containing the appropriate concentration to the affected skin areas once or twice daily is common. However, it’s important to follow product – specific instructions.

3.4 Precautions and Side Effects

Alpha-arbutin is generally well – tolerated. However, in rare cases, it may cause mild skin irritation, such as redness or itching, especially in individuals with highly sensitive skin. Prolonged exposure to sunlight can reduce its effectiveness and increase the risk of skin damage, so sunscreen use is recommended when using alpha – arbutin products. Avoid contact with eyes, and if accidental ingestion occurs, seek medical advice immediately.

4. Company Introduction

With 28 years of experience in the bioactive compound industry, Shaanxi Zhonghong Investment Technology Co., Ltd. is a leading high – tech enterprise. Our operations span agile research and development, collaborative innovation, integrated manufacturing, and global marketing, serving the chemical, materials, and life science sectors.
  • Research Edge: Our partnerships with 5 top – tier universities through joint laboratories, along with over 20 patented technologies and a unique global compound library, drive continuous innovation in alpha – arbutin production and application.
  • Technological Superiority: Equipped with state – of – the – art facilities, including high – performance liquid chromatography (HPLC) and superconducting nuclear magnetic resonance spectrometers, we ensure product purity standards 20% higher than the industry average.
  • 글로벌 리치: Our extensive network covers more than 80 countries across Asia, Europe, and the Americas. We offer customized raw material solutions for multinational pharmaceutical companies, research institutions, and cosmetic manufacturers.

5. 제품 사양

프로젝트
이름
지시자
검출 방법
살충제 잔류물
클로르피리포스
< 0.01ppm
가스크로마토그래피-질량분석법(GC-MS)
시페르메트린
< 0.02ppm
GC-MS
카르벤다짐
< 0.05ppm
High – Performance Liquid Chromatography – Mass Spectrometry (HPLC – MS/MS)
중금속
납(Pb)
< 0.5ppm
Inductively Coupled Plasma – Mass Spectrometry (ICP – MS)
수은(Hg)
< 0.01ppm
저온 증기 원자 흡수 분광법(CVAAS)
카드뮴(Cd)
< 0.05ppm
ICP – MS
미생물 오염
총 생존 가능 수
< 100 CFU/g
표준 미생물 도금 기술
대장균
결석한
중합효소 연쇄 반응(PCR) 및 도금
살모넬라균
결석한
PCR 및 플레이팅
리스테리아 모노사이토제네스
결석한
PCR 및 플레이팅

6. Production Process

  1. Raw Material Preparation: For biocatalytic production, select high – quality enzymes or microorganisms with high activity for alpha – arbutin synthesis. Ensure proper cultivation and activation of these biological catalysts.
  1. Biocatalysis or Chemical Synthesis: In biocatalysis, use enzymes to catalyze the reaction between hydroquinone and glucose to form alpha – arbutin. In chemical synthesis, carefully control reaction conditions such as temperature, pH, and reaction time to promote the formation of alpha – arbutin while minimizing by – product generation.
  1. 정화: Employ multiple purification steps, including filtration, extraction, and chromatography. HPLC is used to separate alpha – arbutin from impurities, ensuring high – purity product. Crystallization processes may also be applied to further refine the product.
  1. Drying and Formulation: Dry the purified alpha – arbutin under controlled conditions to remove moisture. Then, formulate it into different forms according to customer requirements, such as fine powders, granules, or pre – mixed solutions for cosmetics.
  1. Quality Inspection: Conduct comprehensive quality testing on the finished product, including purity determination, identification, and inspection of pesticide residues, heavy metals, and microbial contamination.

7. 응용 프로그램 시나리오

7.1 Cosmetics

  • Skin – Lightening Products: Alpha-arbutin is a key ingredient in serums, creams, masks, and lotions designed to reduce hyperpigmentation and achieve a brighter, more even complexion.
  • Anti – Aging Formulations: Combined with other antioxidants and anti – aging ingredients, it helps combat oxidative stress and improve skin texture, reducing the appearance of fine lines and wrinkles.
  • Sunscreen and After – Sun Care: Its antioxidant properties make it suitable for inclusion in sunscreens to enhance UV protection and in after – sun products to soothe sun – damaged skin.

7.2 Pharmaceuticals (Research – based)

Currently, alpha – arbutin is under investigation for potential applications in treating skin diseases related to abnormal pigmentation, such as melasma and post – inflammatory hyperpigmentation. Its anti – inflammatory and antioxidant effects may also contribute to wound – healing research.

8. 품질 관리

Quality control is the cornerstone of our alpha – arbutin production. At the raw material stage, we conduct strict inspections on enzymes, microorganisms, or chemical precursors, verifying their purity and activity through biochemical assays and spectroscopic analysis. During the production process, real – time monitoring of reaction parameters (temperature, pH, reaction time) ensures consistent product quality. In the purification phase, HPLC is used for precise separation and purity determination, with each batch of products undergoing multiple rounds of analysis to ensure the absence of impurities. For final product inspection, we perform comprehensive tests on chemical purity, microbial safety, and heavy metal content, adhering to strict international standards. Our quality control laboratory is certified to ISO 9001 and follows Good Manufacturing Practice (GMP) guidelines. By implementing a multi – step quality control system, we guarantee that every batch of alpha – arbutin meets the highest quality and safety requirements, providing reliable products to our customers worldwide.

9. Packaging and Logistics

  • 포장: Our alpha – arbutin products are packaged in air – tight, moisture – resistant containers. For small orders, we use aluminum foil bags or amber glass bottles, while for bulk orders, fiber drums are utilized. Each package is labeled with detailed information, including product name, batch number, purity, expiration date, and storage instructions.
  • Storage: Store in a cool, dry place, away from direct sunlight, at temperatures between 2 – 8°C. Under proper storage conditions, the shelf life of our alpha – arbutin products can reach up to 36 months.
  • 해운: We partner with reliable international logistics providers to ensure fast and secure delivery. Samples can be shipped via express services like DHL or FedEx within 3 – 5 business days, while bulk orders are transported by sea or air freight according to customer requirements.

10. Health Efficacy Research, Industrial Application Innovation, and Challenges

10.1 Research Frontiers

  • Nano – Delivery Systems: Scientists are exploring nanoencapsulation techniques to improve the stability and bioavailability of alpha – arbutin, enabling better penetration into the skin and more targeted delivery.
  • 복합 치료: Research is underway to investigate the synergistic effects of alpha – arbutin when combined with other skin – active ingredients, such as vitamin C and niacinamide, for enhanced skin – lightening and anti – aging results.

10.2 Challenges

  • 안정: Alpha-arbutin can be unstable under certain conditions, such as high temperature or exposure to light. Developing more stable formulations without compromising its efficacy remains a challenge.
  • 규정 준수: As a cosmetic ingredient, alpha – arbutin must comply with various international regulations regarding safety, labeling, and efficacy claims. Ensuring consistent compliance across different markets is crucial for its widespread adoption.

11. 자주 묻는 질문

11.1 Where can I buy Alpha-Arbutin?

  • We offer a variety of alpha – arbutin products with different purity levels and packaging options to meet diverse customer needs.

11.2 Is Alpha-Arbutin safe for all skin types?

Alpha-arbutin is generally safe for most skin types. However, individuals with highly sensitive skin may experience mild irritation. It’s recommended to perform a patch test before using new products containing alpha – arbutin.

11.3 Can Alpha-Arbutin be used during pregnancy?

There is limited research on the safety of alpha – arbutin during pregnancy. Pregnant or nursing women should consult a doctor before using products containing alpha – arbutin.

11.4 How long does it take to see results?

Visible skin – lightening results may take 4 – 8 weeks of consistent use, as the skin’s natural renewal cycle needs time to replace pigmented cells with new, lighter – colored ones.

12. 결론

Alpha-arbutin stands as a revolutionary ingredient in the beauty and skincare industry, offering effective skin – lightening, antioxidant, and anti – inflammatory benefits. As a leading manufacturer, Shaanxi Zhonghong Investment Technology Co., Ltd. is committed to providing high – quality alpha – arbutin products, backed by advanced technology, strict quality control, and extensive global reach. Whether for developing innovative cosmetic products or advancing dermatological research, our alpha – arbutin offerings set the standard for excellence.

13. 참고문헌

  1. Kameyama, K., et al. (1995). Alpha – arbutin: A novel reversible tyrosinase inhibitor from the leaves of Vaccinium ashei. 농업 및 식품 화학 저널, 43(11), 2807 – 2810.
  1. Wang, Y., et al. (2018). Advances in the production and application of arbutin. Molecules, 23(6), 1461.
  1. European Commission. (2019). Cosmetic Ingredients Database (CosIng). Retrieved from [CosIng official website]

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