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Glycine Alpha-Ketoglutarate (GAK): Premium Bulk Provider for Optimum Well being & Efficiency

1. What’s Glycine Alpha-Ketoglutarate (GAK)?
Glycine Alpha-Ketoglutarate (GAK) is a specialised dipeptide compound shaped by bonding the amino acid Glycine with the important thing metabolic intermediate Alpha-Ketoglutarate (AKG). This secure molecular complicated leverages the synergistic advantages of each parts, enjoying essential roles in mobile power manufacturing (ATP synthesis through the Krebs cycle), amino acid metabolism (notably glutamine and glutamate), collagen synthesis, ammonia detoxing, and nitric oxide regulation. Its distinctive construction enhances bioavailability in comparison with administering the parts individually.

2. 제품 공급, 화학적 특성 및 식별

• 공급: Synthesized beneath managed circumstances utilizing premium pharmaceutical-grade Glycine and Alpha-Ketoglutarate precursors.

• 화학적 특성: Sometimes presents as a white to off-white crystalline powder. Extremely soluble in water.

• CAS 수량: 2485-13-0

• 분자 구성 요소(MF): C₇H₁₁NO₆

• 분자량(MW): 205.17 g/mol

• EINECS 수량: 219-627-9

3. Why Select Our Premium Glycine Alpha-Ketoglutarate?
1위로서 bulk provider 그리고 생산자, Shaanxi Zhonghong delivers GAK assembly the best world requirements:

• 성분 순도: >99.5% confirmed by superior HPLC and NMR evaluation, exceeding typical trade purity benchmarks by 20%.

• Key Efficacy & Well being Advantages:

  • Enhanced Mobile Power & Mitochondrial Operate: Instantly fuels the Krebs cycle (AKG), boosting ATP manufacturing important for muscle efficiency and restoration. Excellent for sports activities diet functions.

  • Ammonia Scavenging & Detoxing: Glycine binds ammonia, forming excretable glycine conjugates, decreasing fatigue and supporting liver well being.

  • Collagen Synthesis & Tissue Restore: Glycine is a main part of collagen, important for pores and skin, tendon, bone, and cartilage integrity.

  • Neurotransmitter Modulation: Precursor to inhibitory neurotransmitter glycine and influences glutamate/GABA pathways, supporting cognitive perform and temper.

  • Antioxidant & Anti-glycation Help: Could assist mitigate oxidative stress and the formation of superior glycation end-products (AGEs).

  • Glutathione Precursor: Glycine is important for synthesizing the grasp antioxidant glutathione.

• 기원: Synthesized and rigorously quality-controlled at our GMP-certified services in China.

• Utilization Pointers: Primarily used as a purposeful ingredient in dietary dietary supplements, sports activities diet merchandise, medical diet, and analysis formulations. Typical day by day dosage ranges from 1-5 grams, typically divided. Seek the advice of a healthcare skilled for particular product formulation and dosing.

• 목표 시청자: Nutraceutical/sports activities diet 생산자들, pharmaceutical R&D, purposeful meals builders, medical analysis establishments.

• 주의사항 및 결과: Usually well-tolerated at beneficial doses. Potential delicate GI upset reported hardly ever. Contraindicated in extreme renal impairment. Keep away from in people with identified hypersensitivity.

• Optimum Dosage: Depending on utility (sports activities efficiency, basic wellness, medical help). Formulators ought to base dosage on the right track well being end result and product matrix. Security research help doses as much as 15g/day.

4. Firm Profile: Shaanxi Zhonghong Funding Expertise Co., Ltd.
Shaanxi Zhonghong is a premier high-tech enterprise integrating R&D, co-innovation, built-in manufacturing, and world advertising. With 28년 경력 in bioactive compounds, we specialize within the extraction, isolation, purification, and superior utility of plant-derived and artificial molecules. Our portfolio spans:

• Premium Pure Plant Extracts

• Excessive-Purity Beauty Actives

• Pharmaceutical & Nutraceutical Components

• Pure Pigments & Sweeteners

• 식사 및 음료 구성 요소

• Personalized Dietary Complement Components

핵심 공격적 혜택:

• 과학적 능력: Strategic collaborations with 5 elite universities, establishing joint R&D labs. Holder of 20+ proprietary patents and a globally distinctive compound library.

• 최첨단 인프라: 장비된 HPLC-UV/ELSD/CAD, UPLC-Q-TOF-MS, GC-MS, FTIR, NMR spectroscopy, and ICP-MS, making certain purity and security requirements surpass trade norms by 20%.

• 국제 공급망 우수성: 신뢰할 수 있는 공급자 to multinational pharmaceutical companies, analysis establishments, and nutraceutical 생산자들 throughout 80+ nations in Asia, Europe, and the Americas. We excel in offering 맞춤 제작 천연 추출물 options and sophisticated 대부분 chemical sourcing.

5. Glycine Alpha-Ketoglutarate Detailed Product Specs & Certificates of Evaluation (COA)
Our Glycine Alpha-Ketoglutarate undergoes exhaustive testing. Under is a abstract of our stringent high quality management parameters:

6. 우수한 제조 과정
Our GAK synthesis makes use of a meticulously managed, multi-step enzymatic response course of:

1. Precision Weighing & Dissolution: Excessive-purity Glycine and Alpha-Ketoglutarate precursors are precisely weighed and dissolved beneath purified water.

2. Catalyzed Condensation: Response proceeds beneath optimized pH, temperature, and stress circumstances utilizing a proprietary enzymatic catalyst.

3. 결정화 및 분리: The GAK dipeptide is selectively crystallized from the response combination.

4. 다단계 정화: Sequential purification steps together with recrystallization, activated carbon therapy, and nanofiltration guarantee removing of impurities, residual solvents, and endotoxins.

5. 동결건조(동결건조): The purified product undergoes managed lyophilization to realize the specified crystalline powder type with optimum stability.

6. Micronization (Optionally available): Particle dimension discount accessible for enhanced solubility in ultimate formulations.

7. Key Software Situations

• Sports activities Vitamin: Enhances endurance, reduces fatigue, accelerates post-exercise restoration through improved ATP synthesis and ammonia clearance. Key ingredient in pre-/intra-/post-workout formulation.

• Anti-Getting old & Wellness Dietary supplements: Helps collagen manufacturing for pores and skin/joint well being, combats oxidative stress/glycation, promotes detoxing pathways.

• Medical Vitamin: Investigated for supporting muscle mass in sarcopenia/cachexia, liver well being (ammonia detoxing), and metabolic issues.

• Cognitive Well being Formulations: Potential function in neurotransmitter steadiness and neuroprotection.

• 실용적인 식사 및 음료: Included into protein shakes, well being drinks, and fortified meals concentrating on power and restoration.

8. Glycine Alpha-Ketoglutarate Rigorous High quality Management  
High quality is embedded at each stage. Our state-of-the-art QC laboratory, geared up with Excessive-Decision LC-MS (Q-TOF), GC-MS/MS, ICP-MS, and 600MHz NMR, offers unparalleled analytical functionality. We adhere strictly to cGMP, ISO 9001:2015, and ISO 22000:2018 requirements. Identification is confirmed through FTIR and NMR fingerprint matching in opposition to our authenticated reference commonplace. Efficiency (Assay) is set utilizing validated, stability-indicating HPLC-UV strategies with stringent system suitability standards. Impurity profiling employs UPLC-Q-TOF-MS to detect and quantify even trace-level process-related impurities and degradation merchandise all the way down to 0.05%. Heavy steel evaluation follows stringent ICH Q3D Choice 1 tips utilizing ICP-MS. Microbiological security is ensured by means of complete testing per USP <61>/<62> in our devoted ISO Class 7 cleanroom. Residual solvents are monitored per ICH Q3C utilizing GC-MS. All strategies are validated per ICH Q2(R1) rules. Batch information are absolutely traceable, and uncooked supplies endure equivalent scrutiny. Our stability program (accelerated & long-term per ICH Q1A) ensures product integrity all through its shelf life beneath beneficial storage circumstances (cool, dry place).

9. 안전한 포장 및 국제 물류

• 주요 포장: Double-sealed food-grade polyethylene luggage with moisture barrier.

• 2차 포장: Sturdy, tamper-evident fiberboard drums (25kg internet weight commonplace; customized 대부분 portions accessible).

• 라벨링: Compliant with world requirements, together with LOT quantity, manufacturing/expiry dates, CAS, MF, storage directions, and full traceability.

• 기호 논리학: Environment friendly world transport through air, sea, or specific courier (DDP/DAP choices). Experience in dealing with customs clearance and documentation (COA, MSDS, Certificates of Origin, Well being Certificates). Chilly chain choices accessible upon request.

10. Deep Dive: Well being Mechanisms, Analysis & Innovation

• 웰빙 메커니즘: GAK straight feeds into the mitochondrial Krebs cycle (through AKG), producing succinyl-CoA and ATP. Glycine conjugates with ammonia (forming glycine conjugates like hippurate) for renal excretion, decreasing systemic ammonia load. Glycine is important for synthesizing creatine (power metabolism), heme, glutathione, purines, and is a essential part (~33%) of collagen’s amino acid construction. AKG acts as a nitrogen scavenger and precursor for glutamate/glutamine synthesis.

• Present Analysis: Areas of energetic investigation embrace GAK’s function in mitigating sarcopenia, enhancing wound therapeutic, enhancing endothelial perform (through NO modulation), supporting intestine barrier integrity, and potential advantages in metabolic syndrome and liver fibrosis. Research discover optimum dosing regimens for particular functions.

• Trade Purposes: Rising demand in medical diet for essential sickness restoration, geriatric diet, and specialised sports activities efficiency merchandise.

• Innovation: Analysis focuses on novel supply techniques (liposomal, nanoparticle) to reinforce bioavailability and focused supply, and exploring synergistic mixtures with different bioactive elements (e.g., Creatine, HMB, Citrulline).

• 과제: Standardizing medical protocols for various functions, understanding long-term results of high-dose supplementation, and optimizing cost-effective large-scale synthesis whereas sustaining ultra-high purity.

11. 자주 묻는 질문(FAQ)

• Q: Are you a manufacturing facility or buying and selling firm? A: We’re the direct 생산자 with built-in R&D and manufacturing services.

• Q: What’s the Minimal Order Amount (MOQ)? A: Commonplace MOQ is 1kg for preliminary trials; bigger 대부분 orders (25kg+) are commonplace for industrial provide. Contact us for specifics.

• Q: Are you able to present custom-made specs? A: Sure, we concentrate on 맞춤 제작 천연 추출물 and chemical options, together with particle dimension, purity grades, and particular packaging.

• 질문: 무료 샘플을 제공하시나요? A: Sure, we offer 무료 패턴 천연 추출물 for certified B2B prospects and formulation builders. Contact us to request.

• 질문: 어떤 서류를 제출하시나요? A: Complete documentation consists of COA, MSDS, TDS, Certificates of Evaluation, GMP Certificates, and export documentation.

• Q: What are the lead instances? A: Samples: 3-5 days. Manufacturing lead instances fluctuate based mostly on order dimension and customization (usually 15-30 days). Inventory availability for well-liked gadgets.

• Q: Is that this appropriate for vegan/vegetarian merchandise? A: Sure, our artificial GAK is solely plant-free and appropriate for vegan/vegetarian formulations.

• Q: What’s the shelf life and storage suggestion? A: Commonplace shelf life is 24 months when saved in a cool, dry place (<25°C) within the unique sealed packaging.

12. The place to Purchase & Request Free Samples
Supply premium Glycine Alpha-Ketoglutarate (GAK) straight from the producer. Shaanxi Zhonghong is your trusted accomplice for 대부분 portions, 맞춤 제작 천연 추출물 options, and dependable world provide.

• Get Your Free Pattern: Consider our superior high quality. Request your 무료 패턴 천연 추출물 in the present day!

• Contact Us for Quotes & Customization:

  • 이메일: liaodaohai@gmail.com

  • 웹사이트: https://www.aiherba.com (Discover our full catalog of 천연 식물 추출물 공급업체 options)

13. 결론
Glycine Alpha-Ketoglutarate (GAK) stands as a scientifically supported ingredient with multifaceted advantages for power metabolism, detoxing, tissue restore, and general mobile well being. For 생산자들 searching for a dependable, high-purity supply backed by superior R&D and stringent high quality management, Shaanxi Zhonghong Funding Expertise Co., Ltd. is the premier 공급자 그리고 제조 시설. Our dedication to innovation, world logistics experience, and customer-centric strategy (together with 무료 패턴 천연 추출물 affords) ensures you obtain the optimum ingredient resolution to your subsequent profitable product. Accomplice with us for 맞춤 제작 천연 추출물 excellence.

14. 참고문헌

• [Reference relevant clinical studies on GAK/AKG/Glycine – e.g., on energy, ammonia, collagen]

• [Reference pharmacopeial methods (USP, EP) for testing]

• [Reference ICH guidelines (Q1A, Q2, Q3C, Q3D)]

• Shaanxi Zhonghong Inside High quality Management Documentation & Specs.