White Willow Bark Extract

White Willow Bark Extract: Nature’s Historical Reply to Fashionable Discomforts

1. What is White Willow Bark Extract?
White Willow Bark Extract (Salix alba) is a bioactive botanical derived from the bark of the white willow tree. Traditionally revered as “nature’s aspirin,” its main lively constituent, salicina, undergoes metabolism to salicylic acid, delivering analgesic, anti-inflammatory, and antipyretic results. Not like artificial NSAIDs, it provides a gentler, time-released motion, making it a cornerstone of evidence-based phytotherapy.

2. Supply, Chemistry & Specs

• Botanical Supply: Salix alba L. (Salicaceae household)

• Chiave vivace: Salicin (usually standardized to 15-25%)

• CASO: 138-52-3 (Salicin)

• MF: C₁₃H₁₈O₇

• MW: 286.28 g/mol

• EINECS: 205-331-3

• Aspetto: Fantastic, hygroscopic powder; mild tan to off-white

• Solubilità: Soluble in water, ethanol; insoluble in non-polar solvents

3. Defining “Finest” White Willow Bark Extract: Key Standards
The optimum extract balances bioactive efficiency, security, and regulatory compliance:

• Standardizzazione: ≥ 15% Salicin content material (HPLC-UV validated).

• Efficacy (Compliant):

  • Ache Aid: Inhibits COX enzymes, lowering prostaglandin synthesis (J Ethnopharmacol. 2009).

  • Antinfiammatorio: Modulates TNF-α, IL-1β cytokines (Phytomedicine. 2010).

  • Antiossidante: Scavenges ROS by way of phenolic glycosides.

• Origine: Sustainably harvested European or North American Salix alba.

• Dosaggio: 120-240mg salicin every day (EMA monograph). Max 240mg/day.

• Utilizzo: Capsules/tablets, useful meals, topical analgesics.

• Goal Customers: Adults searching for pure joint/muscle assist.*

• Vital Contraindications:

  • Salicylate allergy or aspirin sensitivity.

  • Kids/teenagers (Reye’s syndrome danger).

  • Being pregnant, lactation, renal impairment, anticoagulant use (warfarin interplay).

• Risultati dell'aspetto: Uncommon GI upset at excessive doses; discontinue if tinnitus happens.

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Phytochemistry Accomplice
As a Innovatore da 28 anni in bioactive compounds, Zhonghong integrates cutting-edge science con international provide chain excellence. Our vertically managed course of ensures traceability from uncooked bark to GMP-certified extract.

• Competenze principali:

  • Deep Extraction Experience: Supercritical CO₂, ultrasonic-assisted ethanol/water extraction.

  • Purificazione: Industrial-scale preparative HPLC, membrane filtration.

  • Analytical Rigor:

    • HPLC-DAD/ELSD: Quantification of salicin, salicylic acid, flavonoids.

    • GC-MS: Residual solvent profiling (ICH Q3C).

    • ICP-MS: Heavy steel detection (ppb stage).

  • Patent Portfolio: 20+ patents protecting novel extraction methodologies (e.g., CN107118222A).

5. COA Specs: Assured Purity & Security

6. Flusso di lavoro di produzione superiore

1. Approvvigionamento: Ethically wildcrafted Salix alba bark (EU PEFC-certified).

2. Comminution: Cryogenic milling preserves thermolabile actives.

3. Estrazione: Dynamic maceration (food-grade ethanol/water, 70:30 v/v).

4. Focus: Low-temperature vacuum evaporators.

5. Standardizzazione: Salicin adjustment by way of chromatographic isolation.

6. Spray Drying: Maltodextrin provider (inlet temp ≤ 180°C).

7. Multisector Functions

• Nutraceutici: Joint well being dietary supplements (capsules, gummies).

• Cosmeceutici: Anti-redness serums, soothing lotions.

• Purposeful Meals: Ache-management drinks.

• Veterinary: Equine osteoarthritis assist.

8. Uncompromising High quality Management
Zhonghong’s QbD (High quality by Design) framework exceeds ISO 9001:2015. Each batch undergoes:

• Id Affirmation: HPTLC fingerprint vs. Salix alba reference normal (EMA/HMPC).

• Efficiency Assay: Salicin quantification by way of validated HPLC-UV (λ=270nm).

• Solventi residui: GC-FID per ICH Q3C (Class 2 solvents < 50ppm).

• Stabilità: ICH accelerated (40°C/75% RH) & real-time protocols.
  Nostro proprietary QC algorithms detect batch-to-batch variability at σ > 1.5, making certain pharmaceutical-grade consistency.

9. Well being Mechanisms & Analysis Frontiers

• MOA: Salicin → Saligenin → Hepatic conversion to salicylic acid → Systemic COX-1/COX-2 inhibition.

• Medical Proof: Meta-analysis confirms efficacy vs. placebo for power low-back ache (Cochrane Database 2016).

• Innovation: Nanoemulsion supply programs enhancing salicin bioavailability (Int J Nanomedicine 2021).

• Sfide: Standardizing polyphenol synergies (flavonoids, tannins) past salicin.

10. Imballaggio e logistica

• Main: Double polyethylene-lined kraft paper drums (25kg web).

• Magazzinaggio: <25°C; 40-60% RH; shielded from mild.

• Durata di conservazione: 24 months (validated).

• World Compliance: FDA GRAS, REACH, FSSC 22000, Kosher/Halal.

11. FAQ: Addressing Vital Queries

• Q: Is that this appropriate for vegetarians?
  A: Sure, solely plant-derived. Ethanol extraction is non-animal.

• Q: Typical lead time for bulk orders?
  A: 15-25 days post-PO affirmation (MOQ: 25kg).

• Q: Are you able to present salicin 25% + polyphenol complicated?
  A: Sure – our patented ZH-WB25+ consists of synergistic flavonoids.

• Q: Stability in liquid formulations?
  A: Use buffered pH 4.5-5.5; advocate antioxidants (e.g., ascorbyl palmitate).

12. Procure Premium White Willow Bark Extract
Contact Zhonghong At the moment:

• Posta elettronica: liaodaohai@gmail.com

• Internet: aiherba.com

• Request: COA documentation & FREE 100g SAMPLE (Technical grade accessible).

Conclusione
White Willow Bark Extract stays a gold-standard botanical analgesic with sturdy scientific validation. Zhonghong’s fusion of superior phytochemistry, ISO-certified QC, and international regulatory mastery delivers unmatched extract integrity for demanding nutraceutical, beauty, and useful meals functions.

Riferimenti

1. EMA/HMPC Monograph on Salix spp. (2017)

2. Chrubasik et al., Phytomedicine (2010)

3. USP-NF Basic Chapters <561>, <232>

4. Zhang et al., Int J Nanomedicine (2021); 16: 5143–5156

5. Gagnier et al., Cochrane Database Syst Rev (2016); CD004504

White Willow Bark Extract, Salicin Extract, Natural Anti-inflammatory, Plant Extract Provider, COA Specification