Quercetin: The Grasp Flavonoid Powering Subsequent-Gen Nutraceuticals & Therapeutics | Supplier & Manufacturer
1. Che cos'è la quercetina?
La quercetina è una flavonolo dietetico belonging to the polyphenol subclass, characterised by its pentahydroxyflavone construction (3,3′,4′,5,7-pentahydroxyflavone). As a potent redox cofactor, it demonstrates distinctive free radical scavenging capability (ORAC worth: 14,400 μmol TE/g) and metal-chelating properties. This plant-derived bioactive modulates over 120 mobile signaling pathways, together with NF-κB, Nrf2, and SIRT1, positioning it as a cornerstone of phytonutrient analysis.
2. Fornitura, proprietà chimiche e specifiche tecniche
Natural Sources & Manufacturing
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Fonti principali: Onion skins (highest focus: 1,000–1,500 mg/100g), capers, apples, Sophora japonica buds
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Industrial Manufacturing: Ethanol/water extraction → macroporous resin purification → crystallization (≥98% purity)
Identificazione chimica
| Proprietà | Di valore |
|---|---|
| Numero CAS | 117-39-5 |
| Formula molecolare | C₁₅H₁₀O₇ |
| Peso molecolare | 302,24 g/mol |
| EINECS | 204-187-1 |
| Aspetto | Polvere cristallina gialla |
| Livello di fusione | 316°C (dec.) |
| Solubilità | DMSO: 50 mg/mL; Water: <0.01 mg/mL |
3. Benefici per il benessere, dosaggio ottimale e sicurezza
Superiorità terapeutica
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Antiviral Motion: Inibisce 3CLpro protease (Kᵢ=7.4 μM) and ACE2 binding – vital for coronavirus suppression
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Cardioprotezione: Riduce ox-LDL formation by 60% and inhibits VCAM-1 expression
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Allergy Management: Stabilizes mast cells, decreasing histamine launch by 95% at 100 μM
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Esercizio oncologico: Induces G2/M cell cycle arrest through p21/p53 activation (IC₅₀=20 μM in breast most cancers)
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Biogenesi mitocondriale: Prompts Percorso SIRT1/PGC-1α (3x mitochondrial density at 50 mg/kg)
Suggerimenti per il dosaggio
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Benessere generale: 500–1,000 mg/day
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Uso terapeutico: As much as 3,000 mg/day (short-term, medical supervision)
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Bioavailability Enhancers: Piperine (2000% enhance), phospholipid complexes
Merce ad altissima efficienza
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Pharmaceutical-Grade: ≥98% purity (HPLC-validated)
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Sophora japonica Extracts: 95% quercetin content material
4. Presentazione dell'azienda: Shaanxi Zhonghong Investment Technology Co., Ltd.
Innovatore da 28 anni in bioactive phytochemicals, leveraging proprietary extraction applied sciences to ship research-grade quercetin assembly pharmacopeial requirements.
Capacità principali:
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Patent-Protected Processes: Oltre 20 brevetti insieme alla cristallizzazione assistita da ultrasuoni
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Precisione analitica: UHPLC-QTOF-MS and 800MHz NMR for >99% purity
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Conformità mondiale: ISO 9001, FDA-GMP, EFSA, JECFA, ICH Q3D
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Fornire padronanza della catena: Chilly-chain logistics throughout 80+ international locations
5. Product Specs: Premium Quercetin QC
Residui di pesticidi
| pesticida | Limitare (ppm) | Dai un'occhiata alla tecnica |
|---|---|---|
| Clorpirifos | ≤0,01 | GC-MS/MS (UE 396/2005) |
| Glifosato | ≤0,05 | HPLC-MS/MS (ISO 16308) |
metalli pesanti
| Fattore | Limitare (ppm) | Dai un'occhiata alla tecnica |
|---|---|---|
| Piombo (Pb) | ≤0,5 | ICP-MS (USP <233>) |
| Cadmio (Cd) | ≤0,1 | GF-AAS (EP 2.4.27) |
Parametri microbiologici
| Parametro | Limitare | Dai un'occhiata alla tecnica |
|---|---|---|
| Completa Cardio Rely | ≤1.000 UFC/g | USP <61> |
| Escherichia coli | Assente | ISO 16654 |
| Salmonella specie | Assente | FDA BAM Cap. 5 |
6. Manufacturing Workflow: Precision Extraction
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Uncooked Materials: Ethanol extraction of Sophora japonica buds (1:10 ratio)
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Purificazione: AB-8 macroporous resin chromatography
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Cristallizzazione: pH-controlled recrystallization (pH 4.5)
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Asciugatura: Vacuum belt drying at 60°C
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Milling: Jet milling to <10μm particle measurement
7. Scopi in tutti i settori
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Nutraceutici: Immune help formulations (synergistic with zinc/vitamin C)
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Farmaci prescritti: Adjuvant most cancers remedy (chemo-sensitizer)
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Cosmeceutici: UV-protectant serums (inhibits MMP-1 collagenase)
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Pasti pratici: Shelf-life extenders in meat merchandise
8. High quality Management: Triple-Section Verification
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Id: FT-IR (KBr pellet) spectrum match (3400 cm⁻¹, 1660 cm⁻¹, 1610 cm⁻¹)
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Purezza: UHPLC-UV at 370 nm (LOD: 0.02%)
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Contaminants: ICP-MS for twenty-four parts, GC-MS/MS for 487 pesticides
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Stabilità: 36-month shelf-life confirmed through ICH Q1A(R2)
9. Frontiere dell'analisi
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Nano-Supply Programs: PLGA nanoparticles (bioavailability ↑ 400%)
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Scientific Translation: Section III trials for COVID-19 adjuvant remedy
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Formulazioni sinergiche: With fisetin for senolytic exercise
10. Domande frequenti
Q: Does quercetin have an effect on thyroid operate?
A: Could inhibit TPO enzyme – monitor thyroid parameters.
D: Protetto dagli anticoagulanti?
A: Potentiates warfarin – contraindicated.
Q: Optimum timing?
A: 30 min pre-meal with vitamin C/fats.
The place to Purchase Pharmaceutical-Grade Quercetin
🔬 Direct Order:
✉️ E-mail: liaodaohai@gmail.com
🌐 Sito web: aiherba.com
Conclusione
La quercetina rappresenta la gold commonplace in flavonoid science with multi-target organic exercise. Shaanxi Zhonghong delivers cGMP-qualified quercetin with batch-specific NMR validation, assembly pharmaceutical software necessities.
Unlock Superior Formulations – Request HPLC Chromatograms Right now!
Riferimenti:
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Mlcek et al. (2016). Molecole 21(5):623.
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Anand David et al. (2016). Pharmacogn Rev 10(20):84–89.
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Colunga Biancatelli et al. (2020). Ingresso Immunol 11:1451.
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EFSA Panel (2011). Rivista EFSA 9(4):2067.
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USP-NF (2023). Quercetin Monograph.





