Ganoderma Lucidum Polysaccharides
Ganoderma Lucidum Polysaccharide - Gambar 2
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Ganoderma lucidum polisakarida

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Ganoderma lucidum Polysaccharide Product Introduction

  1. Nama Inggris: Ganoderma lucidum Polysaccharide
  1. Spesifikasi: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa
  1. Penampilan: Light brown to tan powder; mild earthy aroma, slightly sweet taste
  1. NOMOR CAS.：66060-20-8
  1. Waktu tunggu: 3-7 Hari Kerja
  1. Kemasan: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)
  1. Pasar Utama: Asia (China, Japan, Korea), North America, Europe
  1. Skenario Aplikasi

Properti Inti

  • Komposisi Molekul: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages
  • Kelarutan: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents
  • Kegiatan Utama: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Skenario Aplikasi

1. Suplemen Kesehatan & Nutraseutika

  • Immune System Regulation:
    • Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.
    • Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.
  • Anti-Tumor Adjuvant Therapy:
    • Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.
    • Common in integrative medicine formulations.
  • Stress & Fatigue Relief:
    • As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Makanan & Minuman Fungsional

  • Fortifikasi Nutrisi:
    • Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).
  • Prebiotic Activity:
    • Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Kosmetik & Perawatan Pribadi

  • Perawatan Kulit Anti Penuaan:
    • Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.
  • Skin Barrier Protection:
    • Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.
  • Hair Health:
    • Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Farmasi dan Bioteknologi

  • Penelitian Klinis:
    • Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).
  • Sistem Pengiriman Obat:
    • Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Kesehatan Hewan & Akuakultur

  • Suplemen Hewan:
    • Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.
  • Budidaya Ikan:
    • Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Metode Deteksi

  • UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.
  • Kromatografi Cair Kinerja Tinggi (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).
  • Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Sumber & Keuntungan

  • Sumber Alami: Extracted from fruiting bodies, mycelium, or spores of Ganoderma lucidum via hot water extraction and ethanol precipitation.
  • Keberlanjutan: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

  • Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.
  • Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.
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Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones dengan β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Sumber, Sifat Kimia & Spesifikasi Teknis

Sumber dan Ekstraksi Botani

  • Sumber Utama: Fruiting bodies of Ganoderma lucidum atau G. sinense (highest GLP content: 1.8–2.5% dry weight)39.

  • Metode Ekstraksi:

    • Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)

    • Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Identitas Kimia

Milik Nilai
Nomor CAS. Not assigned (complex mixture)
Rumus Molekul (C₆H₁₀O₅)ₙ
Berat Molekul 10–1,000 kDa
EINECS Not applicable
Penampilan Light brown hygroscopic powder
Kelarutan Water-soluble; insoluble in ethanol
Key Bioactivity β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Manfaat Kesehatan, Dosis Optimal & Keamanan

Validated Therapeutic Effects

  • Imunomodulasi:

    • ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.

  • Aktivitas Antitumor:

    • Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.

  • Metabolic Regulation:

    • ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.

  • Hepatoproteksi:

    • Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

Rekomendasi Dosis

  • Kesehatan Umum: 100–300 mg/day (20–30% GLPs)

  • Penggunaan Terapi:

    • Immune support: 500 mg/day (≥40% GLPs)

    • Adjuvant cancer therapy: 1,000–1,500 mg/day

  • Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Tindakan Pencegahan Kritis

  • Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).

  • Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).

  • Interaksi Obat: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Kemampuan Inti:

  • Ekstraksi yang Dilindungi Paten: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).

  • Ketelitian Analisis: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >kemurnian 99.5% (exceeding USP/EP monographs).

  • Kepatuhan Global: Sertifikasi ISO 9001, FDA-GMP, EFSA, JECFA.

  • Penguasaan Rantai Pasokan: Logistik rantai dingin di 80+ negara.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Kategori Parameter Membatasi Metode Pengujian
Pestisida Klorpirifos ≤0,01 ppm GC-MS/MS (UE 396/2005)
Glifosat ≤0,05 ppm HPLC-MS/MS (ISO 16308)
Logam Berat Timbal (Pb) ≤0,5 ppm ICP-MS (USP <233>)
Arsenik (As) ≤0,5 ppm AAS (EP 2.4.27)
Mikrobiologi Jumlah Lempeng Total ≤1.000 CFU/gram USP <61>
Bakteri E. coli Absen ISO 16654
Salmonella spp. Absen FDA BAM Bab 5

6. Alur Kerja Produksi Lanjutan

  1. Sumber: Organic G. lucidum fruiting bodies (OOP-certified).

  2. Ekstraksi: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).

  3. Deproteinization: Sevag reagent (chloroform:butanol 4:1).

  4. Pemurnian: DEAE-Sepharose FF chromatography → lyophilization.

  5. Standardisasi: Phenol-sulfuric acid assay to 40% GLP content.

7. Aplikasi di Berbagai Industri

  • Nutrisi: Immune-boosting capsules (GLP + β-glucan synergy).

  • Farmasi: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).

  • Kosmetik: Anti-aging serums (↑ collagen synthesis by 200%).

  • Makanan Fungsional: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

  1. Konfirmasi Identitas: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).

  2. Kuantifikasi Kemurnian: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).

  3. Bioactivity Testing:

    • RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL

    • α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL

  4. Stabilitas: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Batasan dan Tantangan Penelitian

  • Wawasan Mekanistik:

    • Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).

    • STING pathway activation for antitumor immunity.

  • Terjemahan Klinis:

    • Phase II trials for GLP-COVID-19 immunity synergy.

  • Technical Barriers:

    • Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.

    • Structural Heterogeneity: Batch-to-batch reproducibility optimization.

  • Keberlanjutan:

    • Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: Jawaban Ahli

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

T: Waktu konsumsi yang optimal?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Pesanan Langsung dari Shaanxi Zhonghong:

Kesimpulan

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

Referensi:

  1. Jurnal Etnofarmakologi (2019). GLP mechanisms in cancer apoptosis9.

  2. Carbohydrate Polymers (2020). Structural characterization of immunomodulatory GLPs6.

  3. Food Chemistry (2021). Ultrasonic-microwave extraction optimization3.

  4. USP-NF (2023). Polysaccharide identity/purity testing guidelines.

  5. Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 ulasan untuk Ganoderma lucidum polysaccharide

  1. Avatar Dari James Oli***
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    James Oli*** –

    “As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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