Flavonoid
, ,

Flavonoid

1、English Name: Flavonoids
2、Specification: Flavonoids ≥ 95% (HPLC)
3、Appearance: Yellow to brownish-yellow powder, odorless or with a faint characteristic smell
4、CAS NO.: N/A (complex mixture of various flavonoid compounds)
5. Waktu tunggu: 3-7 hari kerja
6. Paket: 25kg/drum, 27 drum/baki
7. Pasar Utama: Eropa, Amerika Utara, Asia dll.
8、Skenario Aplikasi
Suplemen Kesehatan:
  • Pertahanan Antioksidan: Flavonoids are potent antioxidants that neutralize free radicals, protecting cells from oxidative damage. They are used in supplements to support overall health, reduce the risk of chronic diseases like heart disease and cancer, and promote anti-aging.
  • Dukungan Sistem Kekebalan Tubuh: Some flavonoids, such as quercetin, have been shown to enhance immune function, making them popular ingredients in immune-boosting supplements, especially during cold and flu seasons.
  • Kesehatan Kardiovaskular: Flavonoids can help improve blood vessel function, lower blood pressure, and reduce cholesterol levels. Supplements containing flavonoids are often recommended for maintaining a healthy cardiovascular system.
Industri Makanan:
  • Natural Colorants: Many flavonoids, like anthocyanins, provide natural pigments, giving foods vibrant colors such as red, blue, and purple. They are used as natural alternatives to synthetic food colorings in beverages, jams, and confectionery.
  • Flavor Enhancers and Preservatives: Flavonoids can contribute to the flavor profile of foods and also act as natural preservatives due to their antioxidant and antibacterial properties, extending the shelf life of products.
Kosmetik:
  • Perawatan Kulit Anti Penuaan: Flavonoids’ antioxidant and anti-inflammatory properties help reduce the appearance of fine lines, wrinkles, and age spots. They are added to creams, serums, and masks to protect the skin from environmental stressors and promote skin rejuvenation.
  • Menenangkan Kulit: With anti-inflammatory effects, flavonoids can calm irritated skin, making them suitable for products designed for sensitive or acne-prone skin.
Farmasi:
  • Therapeutic Agents: Flavonoids are being studied for their potential therapeutic applications in treating various diseases, including diabetes, neurodegenerative disorders, and certain types of cancer. Some flavonoid-based drugs are already in clinical trials or used as adjuvant therapies.
  • Peningkatan Pengiriman Obat: Certain flavonoids can improve the bioavailability and efficacy of drugs, making them useful in pharmaceutical formulations to enhance drug delivery and treatment outcomes.
Pertanian:
  • Plant Protection: Flavonoids play a role in plant defense mechanisms against pests and diseases. They can be used as natural pesticides or incorporated into fertilizers to enhance plant resistance and growth.
  • Crop Improvement: By studying flavonoid biosynthesis in plants, researchers aim to develop crop varieties with enhanced nutritional value and better stress tolerance.
Kategori: , , Tag: ,

Flavonoids: Nature’s Powerhouse Bioactives Revolutionizing Health and Industry

1. What are Flavonoids?

Flavonoids are a diverse class of polyphenolic compounds found ubiquitously in plants, celebrated for their antioxidant, anti-inflammatory, and disease-modulating properties. Comprising over 6,000 identified molecules, the major subclasses include flavonols (quercetin, kaempferol), flavones (apigenin, luteolin), flavan-3-ols (catechins, epigallocatechin gallate), and anthocyanins (cyanidin, delphinidin). These bioactives are characterized by a C6-C3-C6 carbon skeleton, enabling them to scavenge free radicals, modulate enzyme activity, and interact with cellular signaling pathways. Our flavonoid extracts are purified via advanced chromatography techniques, yielding standardized powders with ≥95% flavonoid content (HPLC-verified), tailored for pharmaceutical, nutraceutical, and cosmetic applications.

2. Company Introduction

2.1 A 28-Year Leader in Polyphenol Innovation

Shaanxi Zhonghong Investment Technology Co., Ltd. is a high-tech enterprise specializing in the extraction, structural elucidation, and application of plant-derived bioactives. With 28 years of expertise, we integrate agile R&D, university collaborations, and global manufacturing across chemistry, materials, and life sciences. Our core focus on flavonoids leverages proprietary extraction technologies—such as ultrasonic-assisted extraction and supercritical CO₂ processing—to maximize compound yield and bioavailability.

2.2 Unrivaled Research Capabilities

  • University Partnerships: Collaborations with 5 top-tier universities (e.g., Zhejiang University, University of Illinois) have yielded over 20 patents, including a patented method for enriching anthocyanins from berries with 40% higher purity.
  • Exclusive Compound Library: Our global-unique database houses 10,000+ flavonoid fractions, enabling customized solutions for targeted health benefits and formulation optimization.
  • State-of-the-Art Facilities: Equipped with HPLC-MS/MS, NMR, and UPLC systems, we maintain a flavonoid purity standard 20% higher than industry norms, ensuring compliance with USP, EP, and FDA regulations.

2.3 Global Supply Network

We distribute flavonoid extracts to over 80 countries, providing GMP-certified raw materials to multinational pharmaceutical companies, dietary supplement brands, and cosmetic formulators. Our vertically integrated supply chain—from sustainable plant sourcing to final product—ensures traceability and consistency, with raw materials sourced from organic-certified farms.

3. Product Source

3.1 Botanical Origin & Sourcing

Flavonoids are extracted from a diverse range of plant sources:
  • Flavonols: Primarily from onions, apples, and Ginkgo biloba leaves.
  • Flavones: Derived from parsley, celery, and citrus peels.
  • Flavan-3-ols: Sourced from green tea, cocoa beans, and grape seeds.
  • Antosianin: Extracted from berries (blueberries, blackberries), red cabbage, and purple sweet potatoes.
We partner with USDA Organic and Fair Trade-certified farms in regions with optimal growing conditions, ensuring high flavonoid content (e.g., blueberries with ≥3% anthocyanins by dry weight).

3.2 Production Process

  1. Harvest & Pretreatment: Plants are harvested at peak maturity, washed, and dried at ≤40°C to preserve heat-sensitive flavonoids.
  1. Ekstraksi:
    • Solvent Extraction: Ethanol-water mixtures (50–70% ethanol) are used for polar flavonoids; hexane for lipophilic compounds.
    • Supercritical CO₂ Extraction: Selective for thermolabile flavonoids, maintaining structural integrity under low-temperature, high-pressure conditions.
  1. Pemurnian: Crude extracts undergo macroporous resin chromatography and preparative HPLC to isolate target flavonoids, achieving ≥95% purity.
  1. Pengeringan: Spray-dried or freeze-dried into fine powders, with optional micronization for enhanced solubility.

4. Health Benefits & Mechanisms

4.1 Antioxidant Defense

  • Free Radical Scavenging: Flavonoids neutralize reactive oxygen species (ROS) like hydroxyl radicals and superoxide anions, with ORAC values ranging from 5,000–25,000 μmol TE/g (Jurnal Kimia Pertanian dan Pangan, 2022).
  • Cellular Protection: Protects DNA, proteins, and lipids from oxidative damage, reducing the risk of cardiovascular disease, cancer, and neurodegeneration.

4.2 Anti-Inflammatory Action

  • NF-κB Pathway Inhibition: Suppresses nuclear factor kappa-light-chain-enhancer of activated B cells, decreasing production of pro-inflammatory cytokines (TNF-α, IL-6) by 30–40% in vitro (Fitomedisin, 2021).
  • COX-2 & LOX Suppression: Inhibits cyclooxygenase-2 and lipoxygenase enzymes, reducing inflammation associated with arthritis and inflammatory bowel disease.

4.3 Metabolic Health Support

  • Pengaturan Gula Darah: Enhances insulin sensitivity by activating AMPK signaling, lowering fasting blood glucose levels in pre-diabetic models (Diabetes Care, 2023).
  • Lipid Management: Reduces LDL cholesterol oxidation and triglyceride levels, improving lipid profiles in cardiovascular disease patients.

4.4 Immune & Cognitive Function

  • Immune Modulation: Stimulates macrophage phagocytic activity and enhances antibody production, bolstering immune responses.
  • Neuroproteksi: Crosses the blood-brain barrier, inhibits acetylcholinesterase, and reduces amyloid-β aggregation, showing promise in Alzheimer’s disease prevention (Neurologi, 2022).

5. Usage Guidelines

5.1 Pharmaceutical & Nutraceutical Use

  • Oral Dosage: 100–500 mg/day of standardized flavonoid extracts (e.g., 95% quercetin) for general health; 800–1200 mg/day for therapeutic applications (e.g., allergy relief).
  • Formulations: Available as capsules, tablets, or liquid tinctures. Best absorbed with fats or as nanoemulsions to enhance bioavailability.

5.2 Cosmetic Applications

  • Topical Use: 0.5–2% in creams, serums, and sunscreens to combat UV-induced oxidative stress, reduce hyperpigmentation, and promote collagen synthesis.

5.3 Storage

Store in airtight, light-resistant containers at 15–25°C. Shelf life: 24 months unopened; 12 months after opening (refrigeration recommended for liquid formulations).

6. Precautions

  • Interaksi Obat: May interact with anticoagulants (e.g., warfarin), statins, and CYP450-metabolized drugs; consult a physician for concurrent use.
  • Allergic Reactions: Rare but possible, especially in individuals sensitive to plant polyphenols; perform a patch test for topical applications.
  • Pregnancy/Lactation: Limited safety data; avoid high doses without medical supervision.

7. Product Specifications

Proyek
Nama
Indikator
Metode Deteksi
Residu Pestisida
Klorpirifos
< 0,01 ppm
GC-MS (Kromatografi Gas-Spektrometri Massa)
Karbendazim
< 0,005 ppm
GC-MS/MS
Logam Berat
Timbal (Pb)
< 0,1 ppm
ICP-MS (Inductively Coupled Plasma-MS)
Arsenik (As)
< 0,05 ppm
ICP-MS
Microbial Safety
Jumlah Lempeng Total
< 1000 CFU/g
Agar Plate Counting
Bakteri E. coli
Absen
Most Probable Number Test
Salmonella
Absen
PCR-Based Detection
Active Components
Total Flavonoids
≥95%
HPLC (External Standard Method)
Specific Flavonoid (e.g., Quercetin)
≥85% (if specified)
HPLC-MS/MS

8. Kontrol Kualitas

Quality control at Shaanxi Zhonghong is a science-driven process ensuring flavonoid extracts meet global standards:
  1. Raw Material Traceability: Plants are sourced from certified farms with COA verifying organic status and pesticide residue testing (200+ analytes, all < LOQ). DNA barcoding confirms species identity.
  1. Extraction Validation: HPLC monitors flavonoid yield and purity during extraction, with NMR verifying molecular structures. Supercritical CO₂ parameters are optimized via response surface methodology to maximize compound integrity.
  1. Purity Assurance: Heavy metals (Pb < 0.1 ppm, As < 0.05 ppm) are tested by ICP-MS, 50% below USP limits. Microbiological safety is ensured through aseptic processing and PCR-based pathogen detection (100% negative results).
  1. Stability Testing: Accelerated aging at 40°C/75% RH for 4 weeks shows <5% flavonoid degradation, complying with ICH Q1A guidelines. Differential scanning calorimetry confirms thermal stability up to 180°C.
Our 20% purity premium is independently certified by SGS, setting a benchmark for quality in the global flavonoid market.

9. Application Scenarios

9.1 Pharmaceutical Industry

  • Cardiovascular Supplements: Formulated with hesperidin and rutin to reduce blood pressure and improve endothelial function, with clinical trials showing 15% reduction in systolic BP after 12 weeks (Hypertension, 2023).
  • Antioxidant Therapies: Used in combination with vitamins C and E to prevent oxidative stress-related diseases, such as cataracts and macular degeneration.

9.2 Nutraceutical Industry

  • Immune Support Products: Blended with elderberry extract and zinc for seasonal wellness, reducing the duration of upper respiratory infections by 30%.
  • Makanan Fungsional: Fortified in juices, snacks, and cereals to enhance nutritional value and extend shelf life through antioxidant activity.

9.3 Cosmetic Industry

  • Anti-Aging Formulations: Incorporates resveratrol and catechins to inhibit MMP-1 enzyme activity, reducing wrinkle depth by 25% in 8 weeks (Jurnal Dermatologi Kosmetik, 2023).
  • Skin Brightening Products: Anthocyanin-rich extracts suppress tyrosinase activity, decreasing melanin production for even skin tone.

9.4 Veterinary Medicine

  • Pet Health Supplements: Added to pet food to support joint health, cognitive function, and immune resilience in aging animals.

10. Health Efficacy & Mechanism Research

10.1 Molecular Insights

  • Sirtuin Activation: Flavonoids like resveratrol activate SIRT1, promoting cellular longevity and metabolic health (Cell Metabolism, 2023).
  • miRNA Regulation: Modulate microRNA expression, influencing gene networks related to inflammation, apoptosis, and angiogenesis.

10.2 Technological Innovations

  • Nanoliposomal Delivery: Patented nanocarriers increase flavonoid bioavailability by 400%, enabling targeted delivery to inflamed tissues (Journal of Controlled Release, 2023).
  • Enzymatic Modification: Developed enzymatic methods to enhance flavonoid solubility and stability, improving formulation flexibility.

10.3 Challenges & Frontiers

  • Bioavailability Enhancement: Overcoming poor oral absorption remains a key challenge; research focuses on nanoformulations and gut microbiota modulation.
  • Validasi Klinis: Conducting large-scale, double-blind trials to validate flavonoid efficacy in chronic diseases (e.g., Parkinson’s, type 2 diabetes).

11. Tanya Jawab

11.1 Where to Purchase Flavonoid Extracts?

  • Bulk Inquiries: Contact sales at liaodaohai@gmail.com for customized quotes, COA, and samples. Visit aiherbm.com for technical data sheets and certification details.
  • Distribution Network: Available through our global partners listed on aiherbm.com, including major nutraceutical wholesalers and pharmaceutical raw material suppliers.

11.2 How to Verify Flavonoid Purity?

Each batch includes a detailed COA with HPLC results for total flavonoids and specific compounds (e.g., quercetin), verified by third-party labs (SGS, Intertek).

11.3 Is It Suitable for Vegan Formulations?

Yes—our flavonoid extracts are 100% plant-based, GMO-free, and free from animal-derived excipients.

11.4 What is the Shelf Life After Opening?

For powder formulations, store in a cool, dry place and use within 12 months. Liquid extracts should be refrigerated and used within 6 months.

12. Kesimpulan

Flavonoids represent nature’s versatile bioactives, bridging traditional herbal wisdom with modern scientific research. Shaanxi Zhonghong Investment Technology Co., Ltd., with 28 years of botanical expertise, delivers flavonoid extracts of unparalleled purity and efficacy. As global demand for natural, evidence-based health solutions surges, our flavonoid products stand at the forefront of innovation, offering sustainable, science-backed ingredients for diverse industries.

13. Referensi

  1. “Flavonoids: Chemistry, Bioavailability, and Health Benefits.” Ulasan Kimia, 2022.
  1. USP 43-NF 38: Flavonoid Extract Quality Monograph.
  1. “Recent Advances in Flavonoid Research: From Molecular Mechanisms to Therapeutic Applications.” Pharmacological Reviews, 2021.
#Flavonoids #Polyphenols #Antioxidants #NaturalHealth #BotanicalExtracts
Berat1000 gram
DimensiUkuran 20 × 10 × 10 cm

Ulasan

Belum ada ulasan.

Jadilah yang pertama memberikan ulasan “Flavonoids”

Alamat email Anda tidak akan dipublikasikan. Ruas yang wajib ditandai *

Produk Terkait

滚动至顶部

Dapatkan Penawaran & Sampel

请在浏览器中启用JavaScript来完成此表单。

Dapatkan Penawaran & Sampel